Over the last 9 years, Dr Margariti has developed significant expertise in stem cell biology, with particular emphasis on cell reprogramming, chromatin remodelling, cell signalling and endothelial cell biology. Her postdoctoral training was in the Cardiovascular Division of the BHF Centre of Excellence at King’s College London (KCL). In 2013 she has been appointed as a Lecturer in the Centre of Experimental Medicine (CEM) in Queen’s University Belfast (QUB). Dr Margariti is working in the CEM which provides a vibrant and growing research centre focused on vascular biology. The Centre has now moved into a purpose-designed £32M Research building (~4,742m2) partly funded by a Wellcome Trust-Wolfson Capital Award. Dr Margariti has published a number of high-quality papers, and the impact of her research has been recognised by several prestigious awards, including the PAPANIKOLAOU Prize from the Hellenic Medical Society (October 2012, for significant contribution to medical research) and the prize for outstanding performance and scientific research awarded by the KCL (December 2012). Dr Margariti has recently (September 2014) been awarded a BBSRC new Investigator Award to study the underlying mechanisms of direct reprogramming. She has recently visited and established collaborations with two of the leading cell reprogramming laboratories in the world. Prof Deepak Srivastava in University of California, San Francisco (UCSF), who is internationally renowned for his studies in cell reprogramming, and Prof George Daley, the Director of the Stem Cell Transplantation Program at Children’s Hospital Boston in Harvard Medical School, whose group are world leaders in the studies in development and cellular reprogramming.
Dr Margariti’s research program is based on the remarkable idea of direct reprogramming which will allow her to realise fundamental principles of cell reprogramming and establish homogeneous populations of endothelial cells. Damage to endothelial cells is a hallmark of the onset of vascular disease (including cardiovascular diseases and diabetic complications) which is a leading cause of mortality and morbidity worldwide. Cell therapy strategies that aim to recover vascular function are being increasingly explored as viable therapeutic avenues. Development of fast and robust new methodologies that produce well-characterised, homogenous, clinical-grade cells suitable for tissue repair/re-modelling would have great utility. Her research team have generated patient-specific iPS cells and PiPS cells and they now have exciting novel data and they are working towards to develop a remarkable new highly efficient strategy of cell reprogramming. Importantly, the potential of the reprogrammed endothelial cells to enhance angiogenesis and neovascularisation and to promote perfusion of ischemic tissue will be established.
Dr Margariti’s research will demonstrate the therapeutic potential of “re-born” reprogrammed endothelial cells which would have transforming consequences for regenerative and personalised medicine.
The road to novel regenerative therapy using direct reprogramming approaches will be challenging and hard, but the journey has already begun...
2014 BBSRC NEW INVESTIGATOR AWARD
2013 First Contact Initiative Grant from the European Society of Cardiology.
2012 Prize for outstanding performance and scientific research awarding from the
Cardiovascular Division, BHF Centre King’s College London UK.
2012 PAPANIKOLAOU Prize for significant contribution to Medical research
awarding from the Hellenic Medical Society in London, UK.
2011 Travel award for best abstract submitted, from the ESC council, 6th European
Meeting for Vascular Biology & Medicine 21-24 September Krakow, Poland.
2008 Michael Davies Young Investigator Award Finalist presenter. Spring Meeting
3-4 April Oxford, UK.
2007 First prize for best poster presentation, European Vascular Genomic Network
2006 First prize for best poster presentation, European Vascular Genomic Network
2006 Best Log Book during PhD studies, St. George’s University of London, UK.
2015 Invited Speaker at University of Strathclyde.
2014 St George’s London University, Invited Lecture; “Stem Cells, Cardiovascular Disease and Regenerative Medicine”.
2013 In Gladstone Institute of Cardiovascular Research in University of California, San Francisco (UCSF), 15th November 2013, a talk “on Cell Reprogramming and Regenerative Medicine”.
2013 Atherosclerosis Gordon Research Conference (GRC) in Stowe, Vermont, USA, at the Stoweflake Resort and Conference Center, June 16-21, a talk on “Epigenetic therapies in cardiovascular disease”.
2013 St George’s London University, Lecture on Stem Cells and Regenerative Medicine, 20th March 2013, London, UK
2013 BHF Centres of Excellence Synergy Meeting, 4th February 2013, Oxford, UK. A talk on “Cell Reprogramming”.
2012 Guest invitation in 3rd Annual “Induced Pluripotent Stem Cells: Production and Utility in Regenerative Medicine 2nd Oct, Stevenage Bioscience Catalyst, Stevanage, UK.
2012 Small Artery Network (SmArt) Vascular Progenitors in Biology and Medicine conference, September 13-15, University of Fribourg, Switzerland.
2012 European Workshop on Proteomics and Vascular Biology, March 27th-29th, King’s College London, UK.
2012-present Member of International Society of Stem cell Research
2009-present Member of British Society for Cardiovascular Research
2008-present Early Career member of American Heart Association
2004-present Member of Institute of Biomedical Science
2003-present Associate member of Royal Society of Chemistry
2003-present Member of the Biochemical Society
- PGCHET in QUB COMPLETED June 2015
- Associate Fellow of the Higher Education Academy (AFHEA); Recognition Reference: PR064209 17/12/2013
- Postgraduate Certificate in Academic Practice in Higher Education Module Enhancing Academic Practice (7TTY0023) awarded from King’s College London November 2013.
Developmental Studies BMS3003: (3rd Year Human Biology Students) Three Lectures
- Stem cells
- Short and Long Non-Coding RNAs
MRes SCM8063: Cardiovascular Biology and Disease (MRes Students) Two Lectures
- Genetically Modified Animals in Cardiovascular Research
Specialist Lecture Series in Experimental Medicine SCM8059: (Postgraduate level) One Lecture
- Genetically Modified Animals
MRes SCM8064: Translational Cardiovascular Medicine (MRes Students): Two Lectures
- Stem Cell Biology 2
- Regenerative Medicine
Lectures for the New Postgraduate Students in CEM SCM8056:
- Health and Safety
- Tissue Culture Techniques
I am contributing as a tutor in The MED1013 Foundations of Clinical Practise I: Gene Molecules and Processes (GMP) module which is delivered to Year 1 Medical Students:
- Problem solving with Genes, Molecules and Processes
- Problems in Clinical Genetics
- Student Oral Presentations
- Problems in Biochemical Medicine
Managing Portfolios for 16 Medical Students (Personal Tutor)
1. Generation of Induced Pluripotent Stem cells from Blood cells based on Novel Methods
a. From Healthy Volunteers
b. From Patient-Specific Groups
2. Elucidation of the Mechanisms of Vascular Cell Differentiation
a. RNA Binding Proteins
b. Regulation of mRNA Splicing
c. Small Peptides
3. Establishing Robust Direct Reprogramming approaches towards Vascular Cell lineages
a. Transcriptional Regulation
b. Epigenetic Modulation
c. Metabolic Switch
4. Regenerative Medicine; Test the functional Properties of the Reprogrammed Vascular Cells in vivo and propose potential therapeutic strategies to treat Vascular Disease
c. Vascular Injury/ Myocardial Infarction
d. In vivo Reprogramming
Dr Letizia Gulino 2015-Present
Project: Investigate the Underlying Mechanisms of Direct Reprogramming towards Vascular Cell Lineages
Dr Sophia Kelaini 2014-Present
Project: Direct reprogramming towards Vascular Cell lineages; A Merging Approach
Miss Rachel Caines 2015-Present
Project: Dedifferentiated or re-Born Again? Elucidating the chromatin remodelling mechanisms during endothelial cell reprogramming for cardiovascular therapy (BHF Studentship)
Miss Marta Vilà-González 2014-Present
Project: Diabetic macular oedema: insight into the disease and iPSC for the stratifications of its treatment based on novel technologies
Miss Amy Cochrane 2013-Present
Project: Mechanisms of vascular cell differentiation from induced Pluripotent stem Cells (iPS cells); RNA binding Proteins
Mr Thomas Noteman 2014-2015
Project: Elucidate the Unique Epigenetic Signature of reprogramming endothelial cells derived from Induced Pluripotent Stem Cells for use in Cardiovascular Therapy and Personalised Medicine
Mr Philip McCaughey 2013-2014
Project: Mechanisms of vascular cell differentiation; Regenerative Medicine
Miss Fiona Cunningham 2015-2016
Miss Emma Martelli 2015-2016
Miss Daiana Drehmer (Science without Borders programme) 2015-2016
Mr Andrew Carmichael 2015-2016
Mr Peter Crossley (Intercalated BSc) 2015-2016
Mr Sean Mc Mahon (Intercalated BSc) 2014-2015
Miss Karin Yeoh 2014-2015
Mr Wilson Cheah (Intercalated BSc) 2013-2014
Miss Azah Kadir 2015
Miss Medine Gumustas (Erasmus Student) 2015
Mr Gabriel Pena Machado (Science without Borders programme) 2015
Miss Rachel Caines 2014
Miss Rebekah Craig (Nuffield Research Placement) 2014
Prof Alan Stitt Centre for Experimental Medicine Queen’s University Belfast, UK
Dr David Grieve Centre for Experimental Medicine, Queen’s University Belfast, UK
Prof Noemi Lois Clinical Professor Centre for Experimental Medicine, Queen’s University Belfast, UK
Dr Sandra McAllister Clinical Lecturer Centre for Experimental Medicine, Queen’s University Belfast, UK
Prof George Daley Boston Children’s Hospital Harvard Medical School, Boston, USA
Dr Thorsten Schlaeger Head of pluripotent stem cells Core Facility Boston Children’s Hospital Harvard Medical School, USA
Prof Deepak Srivastava Gladstone Institute of Cardiovascular Research in University of California, San Francisco, USA
Dr Alisha Holloway (Bioinformatics Core) Gladstone Institute of Cardiovascular Research in University of California, San Francisco, USA
Prof Qingbo Xu BHF Centre of Excellence King’s College London, UK
Dr Lingfang Zeng BHF Centre of Excellence King’s College London, UK
Dr Anna Zampetaki BHF Centre of Excellence King’s College London, UK
Prof John McCarron University of Strathclyde, Glasgow, UK
Dr Steve Shnyder Institute of Cancer Therapeutics University of Bradford, UK
Research output: Contribution to conference › Abstract
Research output: Contribution to journal › Article
Significant improvement of direct reprogramming efficacy of fibroblasts into progenitor endothelial cells by ETV2 and hypoxia
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Additional searchable ISSN (Electronic): 1524-4636
Lippincott Williams and Wilkins
Scopus rating (2015): SJR 3.356 SNIP 1.522
Additional searchable ISSN (Electronic): 1083-351X
American Society for Biochemistry and Molecular Biology Inc.
Scopus rating (2015): SJR 3.151 SNIP 1.136
Additional searchable ISSN (Electronic): 1549-4918
Scopus rating (2015): SJR 3.438 SNIP 1.459
Additional searchable ISSN (Electronic): 1522-1563
American Physiological Society
Scopus rating (2015): SJR 1.893 SNIP 0.97
Additional searchable ISSN (Electronic): 1524-4571
Lippincott Williams and Wilkins
Scopus rating (2015): SJR 5.755 SNIP 2.213