Danny McAuley

      Professor Danny McAuley

      Clinical Professor

      Phone: 028 90635794, +44 (0)28 9097 6385

      For media contact email comms.office@qub.ac.uk
      or call +44(0)2890 973091.

      1. 2017
      2. Early online date

        Late mortality after acute hypoxic respiratory failure

        Prescott, H. C., Sjoding, M. W., Langa, K. M., Iwashyna, T. J. & McAuley, D. F. 05 Aug 2017 In : Thorax. 8 p.

        Research output: Contribution to journalArticle

      3. Published

        Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study

        Laffey, J. G. , Madotto, F. , Bellani, G. , Pham, T. , Fan, E. , Brochard, L. , Amin, P. , Arabi, Y. M. , Bajwa, E. K. , Bruhn, A. , Cerny, V. , Clarkson, K. , Heunks, L. M. , Kurahashi, K. , Laake, J. H. , Lorente, J. A. , McNamee, L. , Nin, N. , Palo, J. E. , Piquilloud, L. & 10 others Qiu, H., Jiménez, J. I. S., Esteban, A., McAuley, D. F., van Haren, F., Ranieri, M., Rubenfeld, G. D., Wrigge, H., Slutsky, A. S. & Pesenti, A. 01 Aug 2017 In : The Lancet Respiratory Medicine. 5, 8, p. 627-638 12 p.

        Research output: Contribution to journalArticle

      4. Forthcoming
      5. Forthcoming
      6. Forthcoming

        Quantifying the effects of prior acetyl-salicylic acid on sepsis-related deaths: An individual patient data meta-analysis using propensity matching

        Trauer , J. , Muhi , S. , Al Harbi, S. A. , Arabi, Y. M. , Boyle, A. J. , Cartin-Ceba, R. , Chen, W. , Chen, Y-T. , Falcone, M. , Gajic, O. , Godsell, J. , Ng Gong, M. , Kor, D. , Lösche, W. , McAuley, D. , O'Neal Jr, H. R. , Osthoff, M. , Otto, G. P. , Sossdorf, M. , Tsai, M-J. & 8 others Valerio-Rojas, J. C., van der Poll, T., Violi, F., Ware, L., F. Widmer, A., Wiewel, M. A., Winning, J. & Eisen, D. P. 14 Jul 2017 In : Critical Care Medicine.

        Research output: Contribution to journalArticle

      7. Early online date
      8. Published

        Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial

        McAuley, D. F., Cross, L. J. M., Hamid, U., Gardner, E., Elborn, J. S., Cullen, K. M., Dushianthan, A., Grocott, M. P. W., Matthay, M. A. & O'Kane, C. M. Jun 2017 In : The Lancet Respiratory Medicine. 5, 6, p. 484-491

        Research output: Contribution to journalArticle

      9. Published

        Variation in definition of prolonged mechanical ventilation

        Rose, L., McGinlay, M., Amin, R., Burns, K. E. A., Connelly, B., Hart, N., Jouvet, P., Katz, S., Leasa, D., Mawdsley, C., McAuley, D. F., Shultz, M. J. & Blackwood, B. Jun 2017 In : Respiratory Care. 62, 8

        Research output: Contribution to journalArticle

      10. Published

        Simvastatin for patients with acute respiratory distress syndrome long-term outcomes and cost-effectiveness from a randomised controlled trial

        Agus, A., Hulme, C., Verghis, R. M., McDowell, C., Jackson, C., O'Kane, C., Laffey, J. G. & McAuley, D. F. 17 May 2017 In : Critical Care. 21, 108, 10 p.

        Research output: Contribution to journalArticle

      11. Published

        An official American Thoracic Society/European Society of intensive care medicine/society of critical care medicine clinical practice guideline: Mechanical ventilation in adult patients with acute respiratory distress syndrome

        Fan, E. , Del Sorbo, L. , Goligher, E. C. , Hodgson, C. L. , Munshi, L. , Walkey, A. J. , Adhikari, N. K. J. , Amato, M. B. P. , Branson, R. , Brower, R. G. , Ferguson, N. D. , Gajic, O. , Gattinoni, L. , Hess, D. , Mancebo, J. , Meade, M. O. , McAuley, D. F. , Pesenti, A. , Ranieri, V. M. , Rubenfeld, G. D. & 12 others Rubin, E., Seckel, M., Slutsky, A. S., Talmor, D., Thompson, B. T., Wunsch, H., Uleryk, E., Brozek, J., Brochard, L. J., American Thoracic Society, European Society of Intensive Care Medicine & Society of Critical Care Medicine 01 May 2017 In : American Journal of Respiratory and Critical Care Medicine. 195, 9, p. 1253-1263 11 p.

        Research output: Contribution to journalArticle

      12. Early online date
      13. Published

        Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis

        Morel, J., Hargreaves, I., Brealey, D., Neergheen, V., Backman, J. T., Lindig, S., Bläss, M., Bauer, M., McAuley, D. F. & Singer, M. Apr 2017 In : Clinical science (London, England : 1979). 131, 8, p. 747-758

        Research output: Contribution to journalArticle

      14. Published
      15. Forthcoming

        Characterisation of eppin function: expression and activity in the lung

        Scott, A., Glasgow, A., Small, D., Carlile, S., McCrudden, M., McLean, D., Brown, R., Doherty, D., Lundy, F., Hamid, U., O'Kane, C., McAuley, D., Brodlie, M., Tunney, M., Elborn, J., Irwin, C., Timson, D., Taggart, C. & Weldon, S. 29 Mar 2017 In : European Respiratory Journal. 50, 1, 11 p., 1601937. , 1601937

        Research output: Contribution to journalArticle

      16. Published

        High-volume haemofiltration for sepsis in adults

        Borthwick, E. M., Hill, C. J., Rabindranath, K. S., Maxwell, A. P., McAuley, D. F. & Blackwood, B. 31 Jan 2017 In : The Cochrane database of systematic reviews. 1, 42 p., CD008075. , CD008075

        Research output: Contribution to journalArticle

      17. Early online date

        Aspirin reduces lipopolysaccharide induced pulmonary inflammation in human models of ARDS

        Hamid, U., Krasnodembskaya, A., Fitzgerald, M., Shyamsundar, M., Kissenpfennig, A., Scott, C., Lefrancais, E., Mark R, L., Verghis, R., Scott, J., Simpson, A. J., McNamee, J., McAuley, D. & O'Kane, C. M. 12 Jan 2017 In : Thorax. 10 p.

        Research output: Contribution to journalArticle

      18. Published

        Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study

        Bellani, G. , Laffey, J. G. , Pham, T. , Madotto, F. , Fan, E. , Brochard, L. , Esteban, A. , Gattinoni, L. , Bumbasirevic, V. , Piquilloud, L. , van Haren, F. , Larsson, A. , McAuley, D. F. , Bauer, P. R. , Arabi, Y. M. , Ranieri, M. , Antonelli, M. , Rubenfeld, G. D. , Thompson, B. T. , Wrigge, H. & 2 others Slutsky, A. S. & Pesenti, A. 01 Jan 2017 In : American Journal of Respiratory and Critical Care Medicine. 195, 1, p. 67-77 11 p.

        Research output: Contribution to journalArticle

      19. Published

        Current practice in the management of new-onset atrial 1 fibrillation in critically ill patients: A UK-wide survey

        Chean, C. S., McAuley, D., Gordon, A. C. & Welters, I. D. 2017 In : Critical Care.

        Research output: Contribution to journalShort survey

      20. 2016
      21. Early online date

        Statin therapy for acute respiratory distress syndrome: an individual patient data meta-analysis of randomised clinical trials

        Nagendran, M., McAuley, D., Kruger, P. S., Papazian, L., Truwit, J. D., Laffey, J. G., Thompson, B. T., Clarke, M. & Gordon, A. C. 21 Dec 2016 In : Intensive Care Medicine.

        Research output: Contribution to journalArticle

      22. 16S pan-bacterial PCR can accurately identify patients with ventilator-associated pneumonia

        Conway Morris, A., Gadsby, N., McKenna, J. P., Hellyer, T. P., Dark, P., Singh, S., Walsh, T. S., McAuley, D. F., Templeton, K., Simpson, A. J. & McMullan, R. 14 Dec 2016 In : Thorax.

        Research output: Contribution to journalArticle

      23. Published

        Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study

        Laffey, J. G. , Bellani, G. , Pham, T. , Fan, E. , Madotto, F. , Bajwa, E. K. , Brochard, L. , Clarkson, K. , Gattinoni, L. , Heunks, L. M. , Kurahashi, K. , Laake, J. H. , Larsson, A. , McAuley, D. F. , McNamee, L. , Nin, N. , Qiu, H. , Ranieri, M. , Rubenfeld, G. D. , Thompson, B. T. & 4 others Wrigge, H., Slutsky, A. S., Pesenti, A. & LUNG SAFE Investigators and the ESICM Trials Group Dec 2016 In : Intensive Care Medicine. 42, 12, p. 1865-1876 12 p.

        Research output: Contribution to journalArticle

      24. Early online date

        Peptoid Efficacy against Polymicrobial Biofilms Determined by Using Propidium Monoazide-Modified Quantitative PCR

        Luo, Y., Bolt, H. L., Eggimann, G. A., McAuley, D. F., McMullan, R., Curran, T., Zhou, M., Jahoda, C., Cobb, S. L. & Lundy, F. T. 30 Nov 2016 In : ChemBioChem. 9 p.

        Research output: Contribution to journalArticle

      25. Early online date

        Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness: a randomised controlled trial (The REVIVE trial)

        McDowell, K., O'Neill, B., Blackwood, B., Clarke, C., Gardner, E., Johnston, P., Kelly, M., McCaffrey, J., Mullan, B., Murphy, S., Trinder, T. J., Lavery, G., McAuley, D. F. & Bradley, J. M. 15 Nov 2016 In : Thorax.

        Research output: Contribution to journalArticle

      26. Early online date
      27. Published

        Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis

        Gordon, A. C., Perkins, G. D., Singer, M., McAuley, D. F., Orme, R. M. L., Santhakumaran, S., Mason, A. J., Cross, M., Al-Beidh, F., Best-Lane, J., Brealey, D., Nutt, C. L., McNamee, J. J., Reschreiter, H., Breen, A., Liu, K. D. & Ashby, D. 05 Oct 2016 In : New England Journal of Medicine. 11 p.

        Research output: Contribution to journalArticle

      28. Forthcoming
      29. Published

        Effectiveness of a biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use: protocol for a randomised controlled trial (VAPrapid-2): Study protocol for a randomised controlled trial

        Hellyer, T. P., Anderson, N. H., Parker, J., Dark, P., van den Broeck, T., Singh, S., McMullan, R., Agus, A., Emerson, L. M., Blackwood, B., Gossain, S., Walsh, T., Perkins, G., Conway Morris, A., McAuley, D. F. & Simpson, A. J. 16 Jul 2016 In : Trials. 17, 8 p., 318. , 318

        Research output: Contribution to journalArticle

      30. Published
      31. Early online date
      32. Early online date

        Acute Respiratory Distress Syndrome

        Mac Sweeney, R. & McAuley, D. F. 28 Apr 2016 In : Lancet. 15 p.

        Research output: Contribution to journalArticle

      33. Published

        Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

        Bellani, G., Laffey, J. G., Pham, T., Fan, E., Brochard, L., Esteban, A., Gattinoni, L., van Haren, F., Larsson, A., McAuley, D. F., Ranieri, M., Rubenfeld, G. D., Thompson, B. T., Wrigge, H., Slutsky, A. S., Pesenti, A. & LUNG SAFE Investigators 23 Feb 2016 In : JAMA : the journal of the American Medical Association. 315, 8, p. 788-800 13 p.

        Research output: Contribution to journalArticle

      34. Published
      35. Early online date

        Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation

        Moazed, F., Burnham, E. L., Vandivier, R. W., O'Kane, C. M., Shyamsundar, M., Hamid, U., Abbott, J., Thickett, D. R., Matthay, M. A., McAuley, D. F. & Calfee, C. S. 02 Feb 2016 In : Thorax. 8 p.

        Research output: Contribution to journalArticle

      36. Published

        Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by β2-agonists, corticosteroids, and critical illness

        Scott, J., Harris, G. J., Pinder, E. M., Macfarlane, J. G., Hellyer, T. P., Rostron, A. J., Conway Morris, A., Thickett, D. R., Perkins, G. D., McAuley, D. F., Widdrington, J. D., Wiscombe, S., Baudouin, S. V., Roy, A. I., Linnett, V. C., Wright, S. E., Ruchaud-Sparagano, M. H. & Simpson, A. J. 01 Feb 2016 In : The Journal of allergy and clinical immunology. 137, 2, p. 535-544 10 p.

        Research output: Contribution to journalArticle

      37. 2015
      38. Published
      39. Published
      40. Published

        Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome

        Toner, P., McAuley, D. F. & Shyamsundar, M. 23 Oct 2015 In : Critical Care. 19, 1, 9 p., 374. , 374

        Research output: Contribution to journalArticle

      41. Published

        Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation

        Spence, S. , Greene, M. K. , Fay, F. , Hams, E. , Saunders, S. P. , Hamid, U. , Fitzgerald, M. , Beck, J. , Bains, B. K. , Smyth, P. , Themistou, E. , Small, D. M. , Schmid, D. , O'Kane, C. M. , Fitzgerald, D. C. , Abdelghany, S. M. , Johnston, J. A. , Fallon, P. G. , Burrows, J. F. , McAuley, D. F. & 2 others Kissenpfennig, A. & Scott, C. J. 02 Sep 2015 In : Science Translational Medicine. 7, 303, 12 p.

        Research output: Contribution to journalArticle

      42. Published
      43. Published

        A randomized clinical trial of ascorbic acid in open abdominal aortic aneurysm repair

        Duffy, M. J., O'Kane, C. M., Stevenson, M., Young, I. S., Harkin, D. W., Mullan, B. A. & McAuley, D. F. 01 Jul 2015 In : Intensive Care Medicine. 3, 15 p., 30. , 30

        Research output: Contribution to journalArticle

      44. Published

        Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome

        Li, J. T., Melton, A. C., Su, G., Hamm, D. E., LaFemina, M., Howard, J., Fang, X., Bhat, S., Huynh, K-M., O'Kane, C., Ingram, R. J., Muir, R. R., McAuley, D. F., Matthay, M. A. & Sheppard, D. Jul 2015 In : Journal of immunology. 195, 1, p. 87-95 9 p.

        Research output: Contribution to journalArticle

      45. Published

        A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung

        Glasgow, A. M. A., Small, D. M., Scott, A., McLean, D. T., Camper, N., Hamid, U., Hegarty, S., Parekh, D., O'Kane, C., Lundy, F. T., McNally, P., Elborn, J. S., McAuley, D. F., Weldon, S. & Taggart, C. C. May 2015 In : Thorax. 70, 5, p. 426-32 7 p.

        Research output: Contribution to journalArticle

      46. Published

        Rapid detection of health-care-associated bloodstream infection in critical care using multipathogen real-time polymerase chain reaction technology: a diagnostic accuracy study and systematic review

        Warhurst, G., Dunn, G., Chadwick, P., Blackwood, B., McAuley, D., Perkins, G. D., McMullan, R., Gates, S., Bentley, A., Young, D., Carlson, G. L. & Dark, P. May 2015 In : Health Technology Assessment. 19, 35, 172 p.

        Research output: Contribution to journalArticle

      47. Published

        Reciting the months of the year backwards: what is a 'normal' score?

        Cunningham, E. L., Passmore, A. P., McAuley, D. F. & McGuinness, B. May 2015 In : Age and Ageing. 44, 3, p. 537-538 2 p.

        Research output: Contribution to journalArticle

      48. Published

        Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis

        Boyle, A. J., Di Gangi, S., Hamid, U. I., Mottram, L-J., McNamee, L., White, G., Cross, L. J. M., McNamee, J. J., O'Kane, C. M. & McAuley, D. F. 23 Mar 2015 In : Critical Care. 19, 8 p., 109. , 109

        Research output: Contribution to journalArticle

      49. Published
      50. Published

        Accuracy of LightCycler SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis

        Dark, P., Blackwood, B., Gates, S., McAuley, D., Perkins, G. D., McMullan, R., Wilson, C., Graham, D., Timms, K. & Warhurst, G. Jan 2015 In : Intensive Care Medicine. 41, 1, p. 21-33 13 p.

        Research output: Contribution to journalArticle

      51. Published

        Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia

        Hellyer, T. P. , Conway Morris, A. , McAuley, D. F. , Walsh, T. S. , Anderson, N. H. , Singh, S. , Dark, P. , Roy, A. I. , Baudouin, S. V. , Wright, S. E. , Perkins, G. D. , Kefala, K. , Jeffels, M. , McMullan, R. , O'Kane, C. M. , Spencer, C. , Laha, S. , Robin, N. , Gossain, S. , Gould, K. & 10 others Ruchaud-Sparagano, M-H., Scott, J., Browne, E. M., MacFarlane, J. G., Wiscombe, S., Widdrington, J. D., Dimmick, I., Laurenson, I. F., Nauwelaers, F. & Simpson, A. J. Jan 2015 In : Thorax. 70, 1, p. 41-47 7 p.

        Research output: Contribution to journalArticle

      52. Published

        A Functional Variant of Elafin With Improved Anti-inflammatory Activity for Pulmonary Inflammation

        Small, D. M., Zani, M. L., Quinn, D. J., Dallet-Choisy, S., Glasgow, A. M. A., O'Kane, C., Mcauley, D. F., Mcnally, P., Weldon, S., Moreau, T. & Taggart, C. C. 2015 In : Molecular therapy : the journal of the American Society of Gene Therapy. 23, 1, p. 24-31 8 p.

        Research output: Contribution to journalArticle

      53. Published

        Evaluating early administration of the hydroxymethylglutaryl-CoA reductase inhibitor simvastatin in the prevention and treatment of delirium in critically ill ventilated patients (MoDUS trial): Study protocol for a randomized controlled trial

        Casarin, A., McAuley, D. F., Alce, T. M., Zhao, X., Ely, E. W., Jackson, J. C., McDowell, C., Agus, A., Murphy, L. & Page, V. J. 2015 In : Trials. 16, 218, 11 p.

        Research output: Contribution to journalArticle

      54. 2014
      55. Published

        A national survey of the diagnosis and management of suspected ventilator-associated pneumonia

        Browne, E. M., Hellyer, T. P., Baudouin, S. V., Conway Morris, A., Linnett, V. C., McAuley, D. F., Perkins, G. D. & Simpson, A. J. 01 Dec 2014 In : BMJ Open Respiratory Research. 1, 1, e000066. , e000066

        Research output: Contribution to journalArticle

      56. Published

        Simvastatin in the Acute Respiratory Distress Syndrome

        McAuley, D. F., Laffey, J. G., O'Kane, C. M., Perkins, G. D., Mullan, B., Trinder, T. J., Johnston, P., Hopkins, P. A., Johnston, A. J., McDowell, C., McNally, C. & the HARP-2 Investigators, for the Irish Critical Care Trials Group 30 Oct 2014 In : New England Journal of Medicine. 371, p. 1695-1703

        Research output: Contribution to journalArticle

      57. Published

        Academic medicine - revolution, evolution or extinction?

        Irwin, G. W., Spence, R. A. J., McAuley, D. F., Kennedy, R. D., Gardiner, K. R. & Elborn, J. S. Sep 2014 In : The Ulster Medical Journal. 83, 3, p. 141-5 5 p.

        Research output: Contribution to journalArticle

      58. Published

        miR-31 Dysregulation in Cystic Fibrosis Airways Contributes to Increased Pulmonary Cathepsin S Production

        Weldon, S., McNally, P., McAuley, D. F., Oglesby, I. K., Wohlford-Lenane, C. L., Bartlett, J. A., Scott, C. J., McElvaney, N. G., Greene, C. M., McCray, P. B. & Taggart, C. C. 15 Jul 2014 In : American Journal of Respiratory and Critical Care Medicine. 190, 2, p. 165-174 10 p.

        Research output: Contribution to journalArticle

      59. Published

        Keratinocyte Growth-Factor Promotes Epithelial Survival and Resolution in a Human Model of Lung Injury

        Shyamsundar, M., McAuley, D. F., Ingram, R. J., Gibson, D. S., O'Kane, D., McKeown, S. T., Edwards, A., Taggart, C., Elborn, J. S., Calfee, C. S., Matthay, M. A. & O'Kane, C. M. 15 Jun 2014 In : American Journal of Respiratory and Critical Care Medicine. 189, 12, p. 1520-1529 10 p.

        Research output: Contribution to journalArticle

      60. Published
      61. Published

        An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): Protocol for a randomized controlled trial

        L'E Orme, R. M., Perkins, G. D., McAuley, D. F., Liu, K. D., Mason, A. J., Morelli, A., Singer, M., Ashby, D. & Gordon, A. C. 02 Jun 2014 In : Trials. 15, 10 p., 199. , 199

        Research output: Contribution to journalArticle

      62. Published

        The statistical significance of randomized controlled trial results is frequently fragile: A case for a Fragility Index

        Walsh, M., Srinathan, S. K., McAuley, D. F., Mrkobrada, M., Levine, O., Ribic, C., Molnar, A. O., Dattani, N. D., Burke, A., Guyatt, G., Thabane, L., Walter, S. D., Pogue, J. & Devereaux, P. J. 01 Jun 2014 In : Journal of Clinical Epidemiology. 67, 6, p. 622-628 7 p.

        Research output: Contribution to journalArticle

      63. Published

        Respiratory Infections Cause the Release of Extracellular Vesicles: Implications in Exacerbation of Asthma/COPD

        Eltom, S., Dale, N., Raemdonck, K. R. G., Stevenson, C. S., Snelgrove, R. J., Sacitharan, P. K., Recchi, C., Wavre-Shapton, S., McAuley, D. F., O'Kane, C., Belvisi, M. G. & Birrell, M. A. Jun 2014 In : PloS one. 9, 6, 11 p., e101087. , e101087

        Research output: Contribution to journalArticle

      64. Published

        Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation

        McAuley, D. F., Curley, G. F., Hamid, U. I., Laffey, J. G., Abbott, J., McKenna, D. H., Fang, X., Matthay, M. A. & Lee, J. W. 01 May 2014 In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 306, 9

        Research output: Contribution to journalArticle

      65. Published

        Extracorporeal carbon dioxide removal for patients with acute respiratory failure secondary to the acute respiratory distress syndrome: a systematic review

        Fitzgerald, M., Millar, J., Blackwood, B., Davies, A., Brett, S. J., McAuley, D. F. & McNamee, J. J. May 2014 In : Critical Care. 18 , 222

        Research output: Contribution to journalArticle

      66. Published

        Effectiveness of a programme of exercise on physical function in survivors of critical illness following discharge from the ICU: study protocol for a randomised controlled trial (REVIVE)

        O'Neill, B., McDowell, K., Bradley, J., Blackwood, B., Mullan, B., Lavery, G., Agus, A., Murphy, S., Gardiner, E. & McAuley, D. F. 27 Apr 2014 In : Trials. 15, 8 p., 146. , 146

        Research output: Contribution to journalArticle

      67. Published

        How Outcomes Are Defined in Clinical Trials of Mechanically Ventilated Adults and Children

        Blackwood, B., Clarke, M., McAuley, D. F., McGuigan, P. J., Marshall, J. C. & Rose, L. 15 Apr 2014 In : American Journal of Respiratory and Critical Care Medicine. 189, 8, p. 886-893 8 p.

        Research output: Contribution to journalArticle

      68. Published

        Statin Use and Risk of Delirium in the Critically Ill

        Page, V. J., Davis, D., Zhao, X. B., Norton, S., Casarin, A., Brown, T., Ely, E. W. & McAuley, D. F. 15 Mar 2014 In : American Journal of Respiratory and Critical Care Medicine. 189, 6, p. 666-673 8 p.

        Research output: Contribution to journalArticle

      69. Published

        The Beta Agonist Lung Injury Trial Prevention: A Randomized Controlled Trial

        Perkins, G. D., Gates, S., Park, D., Gao, F., Knox, C., Holloway, B., McAuley, D. F., Ryan, J., Marzouk, J., Cooke, M. W., Lamb, S. E. & Thickett, D. R. 15 Mar 2014 In : American Journal of Respiratory and Critical Care Medicine. 189, 6, p. 674-683 10 p.

        Research output: Contribution to journalArticle

      70. Published

        Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia

        Asmussen, S., Ito, H., Traber, D. L., Lee, J. W., Cox, R. A., Hawkins, H. K., McAuley, D. F., McKenna, D. H., Traber, L. D., Zhuo, H., Wilson, J., Herndon, D. N., Prough, D. S., Liu, K. D., Matthay, M. A. & Enkhbaatar, P. 2014 In : Thorax. 69, 9, p. 819-825 7 p.

        Research output: Contribution to journalArticle

      71. 2013
      72. Published

        Combined dysfunctions of immune cells predict nosocomial infection in critically ill patients

        Conway Morris, A., Anderson, N., Brittan, M., Wilkinson, T. S., McAuley, D. F., Antonelli, J., McCulloch, C., Barr, L. C., Dhaliwal, K., Jones, R. O., Haslett, C., Hay, A. W., Swann, D. G., Laurenson, I. F., Davidson, D. J., Rossi, A. G., Walsh, T. S. & Simpson, A. J. Nov 2013 In : British Journal of Anaesthesia. 111, 5, p. 778-87 10 p.

        Research output: Contribution to journalArticle

      73. Published

        Beta-Agonist Lung injury TrIal-2 (BALTI-2): a multicentre, randomised, double-blind, placebo-controlled trial and economic evaluation of intravenous infusion of salbutamol versus placebo in patients with acute respiratory distress syndrome

        Gates, S., Perkins, G. D., Lamb, S. E., Kelly, C., Thickett, D. R., Young, J. D., McAuley, D. F., Snaith, C., McCabe, C., Hulme, C. T. & Gao Smith, F. Sep 2013 In : Health Technology Assessment. 17, 38, p. v-vi, 1-87

        Research output: Contribution to journalArticle

      74. Published

        Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): A randomised, double-blind, placebo-controlled trial

        Page, V. J., Ely, E. W., Gates, S., Zhao, X. B., Alce, T., Shintani, A., Jackson, J., Perkins, G. D. & McAuley, D. F. Sep 2013 In : The Lancet Respiratory Medicine. 1, 7, p. 515-523 9 p.

        Research output: Contribution to journalArticle

      75. Published

        Pharmacological treatments in ARDS; a state-of-the-art update

        Boyle, A. J., Sweeney, R. M. & McAuley, D. F. 20 Aug 2013 In : BMC Medicine. 11, 7 p., 166. , 166

        Research output: Contribution to journalArticle

      76. Published

        A randomized controlled trial of peripheral blood mononuclear cell depletion in experimental human lung inflammation

        Barr, L. C., Brittan, M., Morris, A. C., McAuley, D. F., McCormack, C., Fletcher, A. M., Richardson, H., Connell, M., Patel, D., Wallace, W. A. H., Rossi, A. G., Davidson, D. J., Manson, L., Turner, M., Hirani, N., Walsh, T. S., Anderson, N. H., Dhaliwal, K. & Simpson, A. J. 15 Aug 2013 In : American Journal of Respiratory and Critical Care Medicine. 188, 4, p. 449-55 7 p.

        Research output: Contribution to journalArticle

      77. Published

        Moral distress in end-of-life care in the intensive care unit: Research Protocol.

        St Ledger, U., Begley, A., Reid, J., Prior, L., McAuley, D. & Blackwood, B. Aug 2013 In : Journal of Advanced Nursing. 69, 8, p. 1869-1880 12 p.

        Research output: Contribution to journalArticle

      78. Published

        Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury

        McAuley, D. F., O'Kane, C. M., Craig, T. R., Shyamsundar, M., Herwald, H. & Dib, K. 19 Jul 2013 In : BMC Pulmonary Medicine. 13, 6 p., 47. , 47

        Research output: Contribution to journalArticle

      79. Published
      80. Published

        Role responsibilities in mechanical ventilation and weaning in pediatric intensive care units: a national survey

        Blackwood, B., Junk, C., Lyons, J., McAuley, D. & Rose, L. May 2013 In : American Journal of Critical Care. 22, 3, p. 189-197 9 p.

        Research output: Contribution to journalArticle

      81. Published
      82. Published

        Statins and sepsis: potential benefit but more unanswered questions

        O'Kane, C. M., Perkins, G. D. & McAuley, D. F. 01 Apr 2013 In : American Journal of Respiratory and Critical Care Medicine. 187, 7, p. 672-674

        Research output: Contribution to journalArticle

      83. Published

        Proteolytic cleavage of elafin by 20S proteasome may contribute to inflammation in acute lung injury

        Kerrin, A., Weldon, S., Chung, A. H-K., Craig, T., Simpson, A. J., O'Kane, C. M., McAuley, D. F. & Taggart, C. C. Apr 2013 In : Thorax. 68, 4, p. 315-21 7 p.

        Research output: Contribution to journalArticle

      84. Published

        Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction – a randomised placebo-controlled trial (KARE): study protocol

        Cross, L. J. M., O'Kane, C. M., McDowell, C., Elborn, J. J., Matthay, M. A. & McAuley, D. F. 18 Feb 2013 In : Trials. 14, 51. , 51

        Research output: Contribution to journalArticle

      85. Published

        High-volume haemofiltration for sepsis (Review).

        Borthwick, E. M. J., Hill, C. J., Rabindranath , K. S., Maxwell, A. P., McAuley, D. F. & Blackwood, B. 31 Jan 2013 In : Cochrane Database of Systematic Reviews. 1, 1, 36 p., CD008075. , CD008075

        Research output: Contribution to journalArticle

      86. Published

        Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomised placebo controlled trial

        Shyamsundar, M., McAuley, D., Shields, M. O., MacSweeney, R., Duffy, M., Johnston, J. R., McGuigan, J., Backman, J. T., Calfee, C., Matthay, M. M., Griffiths, M. J., Elborn, S. & O'Kane, C. 2013 In : Annals of Surgery.

        Research output: Contribution to journalArticle

      87. Published

        Innate Lymphoid Cells Are The Predominant Producers of IL-17A In Acute Lung Injury

        Muir, R., McAuley, D. & Ingram, B. 2013

        Research output: Contribution to conferencePoster

      88. 2012
      89. Published

        Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung

        Wilkinson, T. S., Morris, A. C., Kefala, K., O'Kane, C. M., Moore, N. R., Booth, N. A., McAuley, D., Dhaliwal, K., Walsh, T. S., Haslett, C., Sallenave, J-M. & Simpson, A. J. Dec 2012 In : Chest. 142, 6, p. 1425-32 8 p.

        Research output: Contribution to journalArticle

      90. Published

        A novel subpopulation of monocyte-like cells in the human lung after LPS inhalation.

        Brittan, M., Barr, L., Conway Morris, A., Duffin, R., Rossi, F., Johnston, S., Anderson, N., Hirani, N., Rossi, A. G., Haslett, C., Dhaliwal, K., McAuley, D. & Simpson, A. J. 01 Jul 2012 In : The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. in press, 1, p. 206-214 9 p.

        Research output: Contribution to journalArticle

      91. Published

        Effect of intravenous beta-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial

        Smith, F. G., Perkins, G. D., Gates, S., Young, D., McAuley, D., Tunnicliffe, W., Khan, Z. & Lamb, S. E. 21 Jan 2012 In : Lancet. 379, 9812, p. 229-235 7 p.

        Research output: Contribution to journalArticle

      92. Published

        Accuracy of LightCycler® SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review protocol

        Dark, P., Wilson, C., Blackwood, B., McAuley, D., Perkins, G., McMullan, R., Gates, S. & Warhurst, G. 01 Jan 2012 In : BMJ Open. 2, 1, p. e000392 1 p.

        Research output: Contribution to journalArticle

      93. Published

        Foxp3+ macrophages do they exist?

        Spence, S., Osbourn, M., Magorrian, S., Cross, M., McAuley, D., Kissenpfennig, A. & Ingram, B. 2012

        Research output: Contribution to conferencePoster

      94. Published

        Foxp3+ Macrophages; do they exist?

        Spence, S., Osbourn, M., Magorrian, S., Cross, M., McAuley, D., Kissenpfennig, A. & Ingram, B. 2012

        Research output: Contribution to conferencePoster

      95. Published
      96. Published
      97. Published

        Risk factors for acute organ failure in ICU patients with single organ (respiratory) dysfunction or failure: an international, prospective, cohort study

        Terblanche, M., Kruger, P., Di Gangi, S., Gearay, S., Filfeather, L., Ferguson, N., Pearse, R., Beale, R., Rhodes, A., Brett, S. & McAuley, D. 2012 In : Critical Care. in press

        Research output: Contribution to journalArticle

      98. Published

        The Role of Lymphocytes in Acute Lung Injury

        Muir, R., Cross, M., O'Kane, C., Craig, T., Shyamsundar, M., McAuley, D. & Ingram, B. 2012

        Research output: Contribution to conferenceOther

      99. 2011
      100. Published

        Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1)

        Noah, M. A. , Peek, G. J. , Finney, S. J. , Griffiths, M. J. , Harrison, D. A. , Grieve, J. , Sadique, M. Z. , Sekhon, J. S. , McAuley, D. , Firmin, R. K. , Harvey, C. , Cordingley, J. J. , Price, S. , Vuylsteke, A. , Jenkins, D. P. , Noble, D. W. , Bloomfield, R. , Walsh, T. S. , Perkins, G. D. , Menon, D. & 2 others Taylor, B. L. & Rowan, K. M. 19 Oct 2011 In : JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 306, 15, p. 1659-1668 10 p.

        Research output: Contribution to journalArticle

      101. Published

        Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo.

        Scott, A., Weldon, S., Buchanan, P. J., Schock, B., Ernst, R. K., McAuley, D., Tunney, M., Irwin, C., Elborn, S. & Taggart, C. 18 Oct 2011 In : PLoS ONE. 6(10), 10, p. e26525 1 p., e26525. , e26525

        Research output: Contribution to journalArticle

      102. Published

        Mechanical ventilation roles and responsibilities in Europe

        Rose, L., Blackwood, B., Egerod, I., Haugdahl, H., Hofhuis, J., Isfort, M., Kydonaki, K., Schubert, M., Sperlinga, R., Spronk, P., Storli, S., McAuley, D. & Schultz, M. Oct 2011

        Research output: Contribution to conferencePaper

      103. Published
      104. Published

        Benefits of statins in the critically ill: promising but not proven.

        McGuigan, P. J., O'Kane, C. & McAuley, D. Jun 2011 In : Critical Care Medicine. 39(6), 6, p. 1599-1600 2 p.

        Research output: Contribution to journalArticle

      105. Published

        C5a-mediated neutrophil phagocytic dysfunction is RhoA-dependent and predicts nosocomial infection in critically ill patients.

        Conway Morris, A., Brittan, M., Wilkinson, T. S., McAuley, D., Antonelli, J., McCulloch, C., Barr, L., Daliwall, K., Jones, R. O., Haslett, C., Hay, A. & Swann, D. G. 12 May 2011 In : Blood. 117 No.19, 19, p. 5178-5188 11 p.

        Research output: Contribution to journalArticle

      106. Published
      107. Published

        Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury

        Seeley, E. J., McAuley, D., Eisner, M., Miletin, M., Zhuo, H. J., Matthay, M. A. & Kallet, R. H. 22 Apr 2011 In : Respiratory Research. 12, p. 52 1 p., 52. , 52

        Research output: Contribution to journalArticle

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