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      Interests

      My interests are in translational research in acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS). These studies are aimed at improving diagnosis, prognosis and prediction of therapeutic responses. 

      Research Statement

      The molecular and cytogenetic abnormalities in Acute myeloid leukaemia (AML) and Myelodysplastic syndromes (MDS) are increasingly well defined and these are being implicated in stratification for diagnosis and prognosis. My current research invovles the integrated analysis of the molecular consequences of epigenetic therapies such as DNA methyltransferase inhibitors or histone deacetylase inhibitors tgene expression.   These analyses will guide further studies into developing rational epigenetic sensitised therapeutic combinations. 

      In addition, we have a series of studies being undertaken to identify repurposed therapies to target different sub-groups of AML and MDS.   These are being done alongside studies introducing clinically relevant mutations using the CRISPR-cas mechanism to produce isogenic cell lines to further understand the molecular disruption caused by the mutation.  New directions of research involve investigating the role of DNA repair in sub-cohorts of MDS and AML.

      Several studies are being undertaken in collaboration with previous members of the EU funded COST Action on translating genomic and epigenetic studies of MDS and AML (EuGESMA) with partners in Salamanca, Spain, Copenhagen, Denmark and Ulm, Germany.

      Current funding is from the Leukaemia & Lymphoma NI (LLNI), Cancer Research UK, Department of Education and Learning (DEL) and with other other recent funding from Bloodwise, Queen's University Belfast, Cancer Research UK, and the R&D Division of the NI HSC.   The laboratory is also an associated member of the IMI2 funded HARMONY project.

      Teaching

      Acting Deputy Director:  Centre for Biomedical Science Education

      Associate Director for Undergraduate Teaching (CCRCB)

      Coordinator for the CCRCB Summer School Programme (2012-2015)

      Module coordinator for Pathobiology (BM2023) and Cellular & Molecular Haematology (BM3039)

      Teaching contributions to Pathobiology (BM2023) and Cellular & Molecular Haematology (BM3039).

      Module coordinator within the MSc in Computational Biology and Bioinformatics and the MSc in Molecular Pathology

      Frequent Journals

      • British Journal of Haematology

        ISSNs: 0007-1048, 1365-2141

        Additional searchable ISSN (Electronic): 1365-2141

        WILEY-BLACKWELL PUBLISHING, INC

        Scopus rating (2016): SJR 2.09 SNIP 1.536

        Journal

      • Blood

        ISSNs: 0006-4971, 1528-0020

        Additional searchable ISSN (Electronic): 1528-0020

        AMER SOC HEMATOLOGY

        Scopus rating (2016): SJR 5.842 SNIP 2.479

        Journal

      • Leukemia

        ISSNs: 0887-6924, 1476-5551

        Additional searchable ISSN (Electronic): 1476-5551

        NATURE PUBLISHING GROUP

        Scopus rating (2016): SJR 4.929 SNIP 2.213

        Journal

      • Haematologica

        ISSNs: 0390-6078, 1592-8721

        Additional searchable ISSN (Electronic): 1592-8721

        FERRATA STORTI FOUNDATION

        Scopus rating (2016): SJR 2.811 SNIP 1.687

        Journal

      • Oncotarget

        ISSNs: 1949-2553

        Impact Journals

        Scopus rating (2016): SJR 1.927 SNIP 1.056

        Journal

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      Contribution to conference papers, events and activities

      ID: 46280