Increased diagnosis and detection rates of carcinoma in situ of the breast

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@article{a822b30ec2f14386ac2a5d25d2df8f7a,
title = "Increased diagnosis and detection rates of carcinoma in situ of the breast",
keywords = "Oncology, Cancer Research",
author = "{Cooper (nee Glover)}, Janine and F.J. Bannon and C.M. Hughes and M.M. Cantwell and H. Comber and A. Gavin and S. Deady and L.J. Murray",
year = "2012",
doi = "10.1007/s10549-012-1975-y",
volume = "133",
number = "2",
pages = "779--784",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",

}

RIS

TY - JOUR

T1 - Increased diagnosis and detection rates of carcinoma in situ of the breast

A1 - Cooper (nee Glover),Janine

A1 - Bannon,F.J.

A1 - Hughes,C.M.

A1 - Cantwell,M.M.

A1 - Comber,H.

A1 - Gavin,A.

A1 - Deady,S.

A1 - Murray,L.J.

AU - Cooper (nee Glover),Janine

AU - Bannon,F.J.

AU - Hughes,C.M.

AU - Cantwell,M.M.

AU - Comber,H.

AU - Gavin,A.

AU - Deady,S.

AU - Murray,L.J.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - The purpose of this study was to identify trends in the diagnosis of carcinoma in situ (CIS) of the breast in the United Kingdom (UK) and the Republic of Ireland (ROI) and to examine the impact of mammography. Data on cases of newly diagnosed CIS of the breast and mode of detection (screen detected or not) were obtained, where available, from regional cancer registries between 1990 and 2007. Age-standardised diagnosis rates for the UK and the ROI, and regional screen detected diagnosis rates were compared by calculating the annual percentage change (APC) over time. The APC of the diagnosis rate amongst women aged 50-64 years (original screening age group) showed a significant 5.9% increase in the UK (1990-2007) and 11.5% increase in the ROI (1994-2007). The rate of diagnosis (50-64 years) stabilized in the UK between 2005 and 2007 and was substantially higher than in other western populations with national screening programmes. The APC of the diagnosis rate amongst those aged 65-69 years showed a significant 12.4% increase in the UK (1990-2007) and 10.3% increase in the ROI (1994-2007). amongst women aged 50-74 years in the UK, approximately 4,300 cases of CIS (˜90% ductal carcinoma in situ) were diagnosed in 2007. Our analyses have shown that screen detected CIS contributed primarily to the increase in diagnosis of CIS of the breast. The high diagnosis rate of screen detected CIS of the breast underlines the need for further research into lesion and patient characteristics that are related to progression of CIS to invasive disease to better target treatment. © 2012 Springer Science+Business Media, LLC.

AB - The purpose of this study was to identify trends in the diagnosis of carcinoma in situ (CIS) of the breast in the United Kingdom (UK) and the Republic of Ireland (ROI) and to examine the impact of mammography. Data on cases of newly diagnosed CIS of the breast and mode of detection (screen detected or not) were obtained, where available, from regional cancer registries between 1990 and 2007. Age-standardised diagnosis rates for the UK and the ROI, and regional screen detected diagnosis rates were compared by calculating the annual percentage change (APC) over time. The APC of the diagnosis rate amongst women aged 50-64 years (original screening age group) showed a significant 5.9% increase in the UK (1990-2007) and 11.5% increase in the ROI (1994-2007). The rate of diagnosis (50-64 years) stabilized in the UK between 2005 and 2007 and was substantially higher than in other western populations with national screening programmes. The APC of the diagnosis rate amongst those aged 65-69 years showed a significant 12.4% increase in the UK (1990-2007) and 10.3% increase in the ROI (1994-2007). amongst women aged 50-74 years in the UK, approximately 4,300 cases of CIS (˜90% ductal carcinoma in situ) were diagnosed in 2007. Our analyses have shown that screen detected CIS contributed primarily to the increase in diagnosis of CIS of the breast. The high diagnosis rate of screen detected CIS of the breast underlines the need for further research into lesion and patient characteristics that are related to progression of CIS to invasive disease to better target treatment. © 2012 Springer Science+Business Media, LLC.

KW - Oncology

KW - Cancer Research

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84863717870&partnerID=8YFLogxK

U2 - 10.1007/s10549-012-1975-y

DO - 10.1007/s10549-012-1975-y

M1 - Article

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 2

VL - 133

SP - 779

EP - 784

ER -

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