Invited seminar at the University of the Basque Country, Spain: Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes

Activity: Talk or presentation typesPublic lecture/debate/seminar

Description

One of the most challenging issues of pharmaceutical sciences is the poor aqueous solubility of drugs, since a considerable percentage of both approved molecules and emerging active candidates are poorly soluble in water1. Despite the high pharmacological activity these drugs may have, their limited water solubility leads to poor absorption and consequently to sub-therapeutic drug concentrations in target tissues. The formulation of drug nanocrystals (NC) has emerged as one the most promising approaches for increasing the biopharmaceutical performance of hydrophobic drugs2. Initially aimed at increasing the absorption of drugs administered orally, NC have been increasingly utilised to allow drug delivery via multiple routes, namely, parenteral injections, transdermal, ocular, intranasal, and pulmonary3. This seminar aims to demonstrate the journey of the NC technology from simpler applications in enhancing the bioavailability of drugs when administered via the oral route, to newer emerging strategies, where NC are combined with various drug delivery platforms to enable controlled systemic and topical drug delivery, with application in the treatment of a wide variety of diseases.
Period20 Oct 2022
Held atUniversidad del Pais Vasco, Spain
Degree of RecognitionInternational

Keywords

  • Nanocrystals
  • Oral
  • Transdermal
  • Mucosal