Member of the Wellcome Trust Case Control Consortium 2

O'Neill, F. (Contributor)

Activity: Consultancy typesContribution to the work of national or international committees and working groups

Description

To perform a Genome-Wide Association (GWA) study in a large case-control psychosis sample (n=2,738 cases; n=5,200 controls). This is a scientific collaboration between groups at Trinity College Dublin (TCD) (Corvin/Gill), Virginia Commonwealth University (VCU) (Riley/Kendler), Queens University Belfast (QUB) (O'Neill) and the Wellcome Trust Case Control Consortium (WTCCC). The goals being to: Identify common genetic variants that contribute to schizophrenia (SZ) in this population. Annotate associated variants and perform systems analyses to extract pathway 'signals' from noise in the primary data. Perform joint analysis with copy number variation (CNV) data at 2 million-probe resolution, to comprehensively investigate common genomic variation in SZ. Analyse a broader psychoses phenotype to establish if susceptibility extends to related disorders (e.g. bipolar disorders) or maps better to specific illness dimensions (e.g. affective or psychotic symptoms) than to clinical diagnosis. Replicate primary or secondary findings in available datasets.
Period2009 → …
Work forWellcome Trust Genome Campus, United Kingdom