PPE Group for PRP research study - organised through the local charity, Versus Arthritis

Press/Media: Public Engagement Activities


Area of research – treatment, primarily improved pain management, of knee osteoarthritis (KOA) in primary care; injection therapies. 

Purpose - To pilot and evaluate the patient acceptability of recruiting to a study comparing 3 intra-articular (IA) platelet-rich plasma (PRP) injections for the symptomatic treatment of KOA over 12 months of follow-up versus 1 IA PRP injection or 1 IA corticosteroid (with local anaesthetic) injection, both at baseline. A secondary outcome measure will be to get a signal of efficacy for the intervention, IA PRP injections, in the symptomatic treatment of KOA to allow planning for the next step in the intervention development, a fully powered randomised controlled trial.  

Primary outcome measure – rates of recruitment, completion of study measures and retention to the trial as well as patient acceptability of the interventions. 

Secondary outcomes 
Qualitative feedback on the interventions from participants via one-to-one interviews and/or focus groups. 
Symptoms of KOA assessed via the VAS pain score and KOOS and WOMAC questionnaires assessed at 6 weeks and 3, 6, 9 and 12 months.
Recorded analgesia use via review of primary care medical records and prescriptions as well as rates of primary care attendance and secondary care referral for KOA over 12 months of follow-up. 
Initial assessment of health economic outcomes, including:
• Generic health related quality of life measured using the EQ-5D-5L at 6 weeks and 3, 6, 9 and 12 months of follow-up.
• Health service use using study specific service use log and questionnaires. 

Period01 Jan 2021

Media contributions


Media contributions

  • TitlePPE group organised for future research project
    Degree of recognitionNational
    Media name/outletVersus Arthritis charity
    Media typeOther
    Country/TerritoryUnited Kingdom
    PersonsNeil Heron


  • Patient and public involvement
  • PPE group
  • platelet rich plasma injections
  • knee osteoarthritis
  • corticosteroid injections
  • intra-articular