Systems based approaches to unravelling neuropeptide-receptor interactions in nematodes, supplementary datasets

  • Fiona McKay (Creator)

Dataset

Description

Figure S2.1: Nematode neuropeptide-like protein (NLP) sequelogue alignments from Caenorhabditis elegans and parasitic nematodes.
Figure S2.2: Putative novel Allatostatin-C like Caenorhabditis elegans sequences identified in this study (NLP-87-90).
Figure S2.3: FMRFamide-like peptide (FLP) sequelogue alignments from Caenorhabditis elegans and parasitic nematodes.
Table S2.1: Parasite genomes mined for Neuropeptide ligands.
Table S2.2: Caenorhabditis elegans Neuropeptide-like protein sequences used as query sequences in BLAST searches.
Table S2.3: Gene IDs for nlp-gene sequelogues identified in nine species of parasitic nematode.
Table S2.4: Caenorhabditis elegans Neuropeptide-like protein (NLP) sequelogue presence in four Caenorhabditis spp.
Table S2.5: Gene IDs for flp-gene sequelogues identified in Necator americanus and Ascaris suum.
Figure S3.1: Highly conserved nematode FMRF-amide like peptide (FLP) and neuropeptide-like protein (NLP) sequelogue alignments from all available nematode
genomes (WormBase ParaSite).
Table S3.1: The Caenorhabditis elegans neuropeptide GPCR complement of nine species of parasitic nematode identified through Hidden Markov Model
searches of predicted protein datasets.
Table S3.2: Presence/absence table used to predict ligand-receptor interactions in parasitic nematodes.
Table S3.3: Interaction values (likelihood of interaction) for ligand-receptor interactions in parasitic nematodes.
Table S3.4: Parasite genomes mined for ligands and receptors.
Table S3.5: Ligand gene IDs pan-phylum.
Table S3.6: Receptor gene IDs pan-phylum.
Table S4.1: Nematode (Caenorhabditis elegans and Ascaris suum) neuropeptide effects on the ovijector muscle of A. suum.
Table S4.1-4.15; Table S4.1-4.16: Ascaris suum FLP and NLP effects on ovijector contraction frequency, amplitude, and tension.

Note files are csv and pdf files
Date made available2021
PublisherQueen's University Belfast

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