Narrative
Research led by Professor Shields and colleagues at Queen’s University Belfast has resulted in changes in the treatment of children with cough and wheezing disorders and has been a major contributor to International Asthma and Cough Guideline statements. Wheezing affects up to one third of children. Research studies that demonstrated that viral induced wheezing (VIW) or isolated cough were not associated with persistent airway inflammation led to a change in recommendations for anti-asthma therapy, such that the use of high dose inhaled corticosteroids (ICS) was no longer recommended in such cases. Furthermore, the dangers of very high dose ICS were better recognized and the upper recommended dose of steroids for use in treatment of classical childhood asthma was reduced accordingly.Impact status | Ongoing |
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Category of impact | Health Impact, Quality of Life Impact |
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Research output
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Bronchoalveolar lavage findings suggest two different forms of childhood asthma
Research output: Contribution to journal › Article › peer-review
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Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate
Research output: Contribution to journal › Article › peer-review
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Investigating paediatric airways by non-bronchoscopic lavage: Normal cellular data
Research output: Contribution to journal › Article › peer-review
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Exhaled nitric oxide correlates with airway eosinophils in childhood asthma
Research output: Contribution to journal › Article › peer-review
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Monitoring growth in asthmatic children treated with high dose inhaled glucocorticoids does not predict adrenal suppression
Research output: Contribution to journal › Article › peer-review
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Chronic cough in children: bronchoalveolar lavage findings
Research output: Contribution to journal › Article › peer-review