Narrative
Research within the Northern Ireland Barrett’s oesophagus Register demonstrated that cancer risk in this disease was substantially lower than previously thought. It identified clinico-pathological characteristics and potential biomarkers that allow Barrett’s patients to be stratified into those with higher and lower cancer risk. This research has influenced recommendations from Gastroenterological Associations in the UK and USA and resulted in altered clinical practice nationally and internationally, in which costly routine endoscopic surveillance is now targeted to Barrett’s oesophagus patients with the highest cancer risk.| Impact status | Ongoing |
|---|---|
| Category of impact | Health Impact, Quality of Life Impact |
Related content
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Research output
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Mortality in Barrett's oesophagus: Results from a population based study
Research output: Contribution to journal › Article › peer-review
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Risk of malignant progression in Barrett’s esophagus patients: results from a large population-based study
Research output: Contribution to journal › Article › peer-review
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Phase 3 Population-Based Study Reveals New Risk-Stratification Biomarker Panel for Barrett's Esophagus
Research output: Contribution to journal › Meeting abstract › peer-review
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The incidence of esophageal cancer and high-grade dysplasia in Barrett's esophagus: A systematic review and meta-analysis
Research output: Contribution to journal › Article › peer-review
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TP53 and progression from Barrett's metaplasia to oesophageal adenocarcinoma in a UK population cohort
Research output: Contribution to journal › Article › peer-review