Research Output

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Meeting abstract
2018

A phase I dose escalation multi-centre study of crizotinib (MET inhibitor) combined with binimetinib (MEK inhibitor) in patients with advanced solid tumours

Wilson, R., Dass, P. H., Van Schaeybroeck, S., Elez, E., Quinton, A., Jones, R., Houlden, J., Collins, L., Roberts, C., Love, S., Lawler, M., Di Nicolantonio, F., Grayson, M., Bardelli, A., Laurent=puig, P., Maughan, T., Tabernero, J., Peeters, M., Middleton, M. & Rolfo, C., Nov 2018, In : European Journal of Cancer. 103, Suppl 1, p. e140-e141

Research output: Contribution to journalMeeting abstract

CHALLENGE-UK: A UK cohort of the colon health and lifelong exercise change study: A phase III randomised control trial.

Brown, M., Yates, T., Forde, C., Adams, R., Booth, C., Courneya, K., Donnelly, M., O'Callaghan, C., Russell, A., Storey, D., Thomas, A., Wilson, R. & Coyle, V., Nov 2018, In : Journal of sports sciences. 36, S1, p. 22

Research output: Contribution to journalMeeting abstract

2017

Association of a DNA damage response deficiency (DDRD) assay with prognosis in resected esophageal and gastric adenocarcinoma

Turkington, R., Knight, L., Douglas, R., Blayney, J., Stevenson, L., McManus, D., McCavigan, A., Walker, S., Bornschein, J., McRae, S., Noble, F., Underwood, T., O'Neill, R., McQuaid, S., Arthur, K., James, J., Eatock, M., Harkin, D., Fitzgerald, R. C. & Kennedy, R., 01 May 2017, In : Journal of Clinical Oncology : official journal of the American Society of Clinical Oncology. 35, 15_suppl, p. 4026-4026 1 p., 4026.

Research output: Contribution to journalMeeting abstract

Conditional survival probability in patients with resected oesophageal adenocarcinoma receiving neoadjuvant chemotherapy

Turkington, R., Graham, D., Bannon, F., Noble, F., O'Neill, R., Blayney, J., Underwood, T., Kennedy, R. & Fitzgerald, R. C., 11 Oct 2017, In : Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 27, supp6, p. vi222 1 p.

Research output: Contribution to journalMeeting abstract

Open Access

Mammographic surveillance in family history patients: Do low cancer detection rates justify the high numbers of breast cancers detected?

Madden-McKee, C., Culleton, G., Hinds, G. & McIntosh, S., May 2017, In : European Journal of Surgical Oncology. 43, 5, p. S26-S27 2 p.

Research output: Contribution to journalMeeting abstract

PD-L1 Expression and Response to Neo-Adjuvant Chemotherapy in Esophageal Adenocarcinoma

Parkes, E., Blayney, J., mccarron, E., Douglas, R., Stevenson, L., McManus, D., McQuaid, S., Arthur, K., James, J., Salto-Tellez, M., Noble, F., Underwood, T., O'Neill, R., Fitzgerald, R. C., Kennedy, R. & Turkington, R., 01 May 2017, In : Journal of Clinical Oncology. 35, 15 supplement, p. 4023-4023 4023.

Research output: Contribution to journalMeeting abstract

2016

Abstract OT3-02-07: Neo-DDRD: A biomarker-driven neoadjuvant feasibility study in breast cancer

McIntosh, SA., Parkes, EE., James, CR., Lioe, T., Lowry, K., Keating, KE., Khambata-Ford, S. & Kennedy, RD., 15 Feb 2016, In : Cancer Research. 76, 4 Supplement, OT3-02-07.

Research output: Contribution to journalMeeting abstract

An exploration of men’s experiences of undergoing active surveillance for favourable-risk prostate cancer: a mixed methods study protocol

Ruane-McAteer, E., O'Sullivan, J., Porter, S. & Prue, G., Mar 2016, In : Psycho-oncology. 25, S1, p. 16-17 2 p.

Research output: Contribution to journalMeeting abstract

Open Access
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2 Citations (Scopus)
136 Downloads (Pure)

Breast cancer outcomes following predictive BRCA testing in Northern Ireland

Hinds, G., Irwin, G., McFaul, L., Stewart, R., Morton, L., Savage, K. I., Morrison, P. J. & McIntosh, S. A., Jun 2016, In : Current Oncology. 23, 3, p. e298 P043.

Research output: Contribution to journalMeeting abstract

6 Citations (Scopus)

Chemoprevention in BRCA1 Mutation Carriers—A Proof-of-Concept Study

Campbell, A., Savage, K., McIntosh, S. & Harkin, D., May 2016, In : Current Oncology. 23, 3, p. e290 1 p.

Research output: Contribution to journalMeeting abstract

Identification of potentially pathogenic variants in candidate breast and ovarian cancer susceptibility genes in BRCAX patients

Savage, A. L., Chenevix-Trench, G., Jun Li, J., McDade, S. S., Morrison, P. J., McIntosh, S. A., Harkin, D. P. & Savage, K. I., Jun 2016, In : Current Oncology. 23, 3, p. e308 1 p., P089.

Research output: Contribution to journalMeeting abstract

Loss of Function Cohesin Complex Gene Mutations Create Neomorphic Cell States Advantageous to Oncogeneisis

Smith, J., Savage, K., Thompson, A. & Mills, K., 22 Oct 2016, In : Blood. 128, p. 1564-1565 2 p.

Research output: Contribution to journalMeeting abstract

MErCuRIC1: A phase 1a study of MEK1/2 inhibitor PD-0325901 with cMET inhibitor crizotinib in patients with advanced solid tumours

Wilson, R., Middleton, M., Houlden, J., Van Schaeybroeck, S., Rolfo, C., Elez, E., Taieb, J., Andre, T., Bardelli, A., Laurent=puig, P., Tabernero, J., Peeters, M., Maughan, T., Roberts, C., Love, S., Lawler, M., Salto-Tellez, M., Grayson, M., Popovici, V. & Di Nicolantonio, F., 08 Oct 2016, In : Annals of Oncology (2016) 27 (6): 149-206. .

Research output: Contribution to journalMeeting abstract

Open Access
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20 Downloads (Pure)

Preclinical radiotherapy technology, dosimetry and treatment planning

Butterworth, K., Ghita, M., McGarry, C. K., Jain, S., Hanna, G. G., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., Apr 2016, In : Radiotherapy and Oncology. 119, Supplement 1 , p. S238-S239 2 p.

Research output: Contribution to journalMeeting abstract

The Utility of Post-Chemotherapy PET Scans in Resectable Oesophageal Adenocarcinoma

Turkington, R., McManus, D., David, C., Napier, E., Kennedy, A., Carey, D., Clements, B., Harrison, C., Purcell, C., Eatock, M. & Kennedy, R., 22 Sep 2016, In : British Journal of Surgery.

Research output: Contribution to journalMeeting abstract

Vorinostat Does Not Improve Outcome in Patients with Acute Myeloid Leukemia and High Risk Myelodysplasia Treated with Azacitidine: Results of the UK Trials Acceleration Programme Ravva Trial

Craddock, C., Houlton, A. E., Ferguson, P., Raghavan, M., Fox, S., Dudley, L., Quek, L. S., Cavenagh, J. D., Dennis, M., Wheatley, K., Vyas, P., McMullin, M. F., Pillai, S. P., Kelly, R., Siddique, S., Wheatley, K. & Vyas, P., 30 Nov 2016, In : Blood. 128, 22, p. 1065

Research output: Contribution to journalMeeting abstract

Open Access
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1 Downloads (Pure)
2015

Cabozantinib attenuates CXCL8-driven macrophage dependent migration and invasion of PTEN-deficient prostate cancer cells

Neisen, J. L., McCabe, N., Kennedy, R. D. & Waugh, D. JJ., 01 Jan 2015, In : Cancer Research. 75, 1 Suppl, A49.

Research output: Contribution to journalMeeting abstract

Cautionary tale of active surveillance in intermediate-risk patients: Overall and cause-specific survival in the Sunnybrook experience

Musunuru, H. B., Klotz, L., Vespirini, D., Zhang, L., Mamedov, A., Sethukavalan, P., Jethava, V., Yamamoto, T., Jain, S. & Loblaw, D. A., 01 Mar 2015, In : Journal of Clinical Oncology. 33, 7 Suppl, 163.

Research output: Contribution to journalMeeting abstract

Comparison of active surveillance with other treatment options for low-risk prostate cancer

Musunuru, H. B., Morton, G., Klotz, L., Vespirini, D., Cheung, P., Chung, H. T., Zhang, L., Mamedov, A., Sethukavalan, P., Jethava, V., D'Alimonte, L., Deabreu, A., Jain, S., Yamamoto, T. & Loblaw, D. A., 01 Mar 2015, In : Journal of Clinical Oncology. 33, 7 Suppl, 178.

Research output: Contribution to journalMeeting abstract

ID: 263 Loss of IL-6/Stat3 signalling drives metastatic prostate cancer in mice and men

Pencik, J., Schlederer, M., Gruber, W., Unger, C., Walker, S., Chalaris, A., Marie, I., Hassler, M. R., Javaheri, T., Aksov, O., Blayney, J., Mazal, P., Grebien, F., Egger, G., Poli, V., Eferl, R., Kennedy, R., Fend, F., Scharpf, M., Braun, M. & 14 others, Perner, S., Levy, D. E., Malcolm, T., Turner, SD., Haitel, A., Susani, M., Moazzami, A., Rose-John, S., Aberger, F., Merkel, O., Morrigi, R., Culig, Z., Dolznig, H. & Kenner, L., Nov 2015, In : Cytokine. 76, 1, p. 112 1 p.

Research output: Contribution to journalMeeting abstract

MErCuRIC1: A Phase I study of MEK1/2 inhibitor PD-0325901 with cMET inhibitor crizotinib in RASMT and RASWT (with aberrant c-MET) metastatic colorectal cancer (mCRC) patients.

Van Schaeybroeck, S., Rolfo, C., Elez, E., Kelly, S., Houlden, J., Collins, L., Love, S., Andre, T., lawler, M., Di Nicolantonio, F., Grayson, M., Popovici, V., Bardelli, A., Laurent=puig, P., Salto-Tellez, M., Maughan, T., Tabernero, J., Peeters, M., Wilson, R. & Middleton, M., 2015, In : Journal of Clinical Oncology. 33, (suppl; abstr TPS3632)

Research output: Contribution to journalMeeting abstract

Modulation of mutated cohesin complex gene expression in acute myeloid leukaemia cell lines

Smith, J. S., Liberante, F. G., Thompson, A. & Mills, K. I., 19 Apr 2015, In : British Journal of Haematology. 169, Supplement s1, p. 87

Research output: Contribution to journalMeeting abstract

Molecular Classification of the invasive front in colorectal cancer

McArt, D., Dunne, P., Kay, E., O'Grady, A., Barrett, H., Arthur, K., Longley, D., Hamilton, P. W., Waugh, D. J., Lawler, M., Johnston, P. G., Salto-Tellez, M. & Van Schaeybroeck, S., 20 May 2015, In : Journal of Clinical Oncology. 33, Suppl 15, 3573.

Research output: Contribution to journalMeeting abstract

Sector analysis to provide additional spatial information on the permanent prostate brachytherapy learning curve

Yoosuf, A. B. M., Jonnada, S., Napier, E., Byrne, M. M., Flynn, M. A., Workman, G., Mitchell, D. M. & Jain, S., 01 Mar 2015, In : Journal of Clinical Oncology. 33, 7 Suppl, 93.

Research output: Contribution to journalMeeting abstract

The molecular and therapeutic relevance of SF3B1 in myelodysplastic syndrome

Lappin, K. M., Liberante, F. G., Savage, K. I. & Mills, K. I., 19 Apr 2015, In : British Journal of Haematology. 169, Supplement s1, p. 87 1 p.

Research output: Contribution to journalMeeting abstract

2014

314: BCLAF1; a multi-faceted protein involved DNA repair, apoptosis and autophagy

Barros, E., Savage, K. S. & Harkin, D. P., Jul 2014, In : European Journal of Cancer. 50, Supp 5, p. S75 1 p.

Research output: Contribution to journalMeeting abstract

Abstract 1905: Defining a therapeutic classification of breast cancer by actionable targets

Salto-Tellez, M., Boyle, D. P., McArt, D., Irwin, G., Wilhelm-Benartzi, C. C., Lloe, T. G., Minter, M., McQuaid, S., Mullan, P., Kennedy, R. D., Hamilton, P. & Harkin, D. P., 01 Oct 2014, In : Cancer Research. 74, 19 (Suppl), 1905.

Research output: Contribution to journalMeeting abstract

A preoperative clinical staging and metabolic imaging model to predict prognosis in early-stage esophageal adenocarcinoma

Turkington, R. C., Blayney, J. K., Jalil, A., Goody, R. B., Papafili, A., Henderson, C., McManus, D., Johnston, P., Kennedy, R. & Eatock, M. M., 20 Jan 2014, In : Journal of Clinical Oncology. 32, 3 (Suppl), 1 p.

Research output: Contribution to journalMeeting abstract

A sector-based postimplant dosimetric comparison of sagittal and axial ultrasound-guided source placement during I-125 permanent prostate brachytherapy

Yoosuf, A. B. M., Mitchell, D. M., Byrne, M. M., Flynn, M. A., Napier, E., Jain, S. & Workman, G., 01 Feb 2014, In : Journal of Clinical Oncology. 32, 4 Suppl, 262.

Research output: Contribution to journalMeeting abstract

Association between ColDx assay result and recurrence-free interval in stage II colon cancer patients on CALGB (Alliance) 9581

Niedzwiecki, D., Frankel, W., Venook, A. P., Ye, X., Friedman, P. N., Goldberg, R. M., Mayer, R. J., Colacchio, T. A., Kennedy, R., Davison, T., O'Brien, E. J., Mulligan, J., Johnston, P. G., Harkin, D. P., Schilsky, R. L., Bertagnolli, M. M. & Innocenti, F., 20 Jan 2014, In : Journal of Clinical Oncology. 32, 3 (suppl), 1 p.

Research output: Contribution to journalMeeting abstract

Automated tumour annotation and analysis for molecular pathology using TissueMark (R)

Hamilton, P., Wang, Y., McCleary, D., Diamond, J., Regan, E., Montgomery, N., Tunstall, J., Boyle, D., Loughrey, M. & Salto-Tellez, M., 14 Aug 2014, In : Virchows Archiv. 465, 1, p. S329-S329 1 p.

Research output: Contribution to journalMeeting abstract

BRCA1 as a regulator of global cell metabolism - identifying functional targets through integromic analysis

Powell, A., Savage, K. I. & Harkin, D. P., Jul 2014, In : European Journal of Cancer. 50, 5, p. S77 1 p.

Research output: Contribution to journalMeeting abstract

Discovery of prognostic and predictive tissue biomarkers in patients with resectable esophageal cancer

MacGregor, T. P., Gillies, R. S., Sahgal, N., Chetty, R., Wang, L-M., Turkington, R. C., Maynard, N. D., Mchugh, P. J., Kennedy, R., Middleton, M. R. & Sharma, R. A., 20 Jan 2014, In : Journal of Clinical Oncology. 32, 3 (Suppl), 1 p.

Research output: Contribution to journalMeeting abstract

From trial to practice: The Northern Ireland cancer center experience with abiraterone acetate in men with metastatic castration resistant prostate cancer

El-Helali, A., Das, P., Jain, S., Mitchell, D. M., Shum, L., Stewart, D. P. & O'Sullivan, J. M., 29 May 2014, In : Journal of Clinical Oncology. 32, 15 Suppl, e16101.

Research output: Contribution to journalMeeting abstract

Pro-angiogenic CXCL8 signalling underpins microenvironment-induced relapse to anti-androgen therapy of prostate cancer

McKechnie, M., Maxwell, P. J. & Waugh, D. J. J., 01 Oct 2014, In : Cancer Research. 74 , Suppl 19, 2254.

Research output: Contribution to journalMeeting abstract

Pro-inflammatory CXCL8 signalling potentiates survival of K-Ras mutant colorectal cancer cells

Campbell, L. M., Oladipo, O., Maxwell, P. J., Longley, D., Wilson, R. H. & Waugh, D. J. J., 01 Oct 2014, In : Cancer Research. 74, Suppl 19, 5267.

Research output: Contribution to journalMeeting abstract

Rational targeting of Inhibitor of Apoptosis Proteins (IAPs)for effective therapy of colorectal cancer

Crawford, N. T., Dunne, P. D., Johnston, P. G., Waugh, D. J. & Longley, D. B., 01 Oct 2014, In : Cancer Research. 74, Suppl 19, 2290.

Research output: Contribution to journalMeeting abstract

The prognostic and therapeutic value of EpHA2 in early colorectal cancer (CRC).

Dasgupta, S., Van Schaeybroeck, S., Dunne, P., McArt, D., Fenning, C., Ong, C. W., Arthur, K., Salto-Tellez, M., Wilson, R. & Johnston, P., 2014, In : Journal of Clinical Oncology. 32, (suppl; abstr 3581)

Research output: Contribution to journalMeeting abstract

The role of JAK1/2-STAT3 as acute resistance mechanism to MEK inhibition in BRAF-mutant colorectal cancer cell lines.

Celtikci, B., Carson, R., Johnston, P. & Van Schaeybroeck, S., 2014, In : Journal of Clinical Oncology. 32, (suppl; abstr 3594)

Research output: Contribution to journalMeeting abstract

2013

A PROSPECTIVE PROTOCOL FOR SIMULTANEOUS GENOMIC TESTING IN PATIENTS WITH NON-SMALL CELL LUNG CANCER

Lopez-Rios, F., Conde, E., Angulo, B., Martinez, R., Mcgready, C., O'Hara, G., Anderson, N., Maxwell, P. & Salto-Tellez, M., Nov 2013, In : Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 8, p. S1074-S1074 1 p.

Research output: Contribution to journalMeeting abstract

Bladder cancer diagnostic algorithms in hematuria populations.

Stevenson, M., Reid, C., Duggan, B., Ruddock, M. & Williamson, K. E., 15 Apr 2013, In : Cancer Research. 73, 8, 1 p.

Research output: Contribution to journalMeeting abstract

DNA damage response deficiency signature predicts response to platinum-based therapy in ovarian cancer

Hill, L. A., Mulligan, J. M., Deharo, S., Keating, K. E., McDyer, F. A., Davison, T. S., Gourley, C., Harkin, D. P. & Kennedy, R. D., Sep 2013, In : European Journal of Cancer. 49, 2, p. S196-S196 1 p.

Research output: Contribution to journalMeeting abstract

Stereotactic Body Radiation Therapy (SBRT) for Primary Non-Small Cell Lung Cancer (NSCLC) and Pulmonary Metastases: Analysis of Outcomes and Predictive Factors for Local Control

Thibault, I., Poon, I., Erler, D., Kim, A., Keller, B., Yeung, L., Jain, S., Soliman, H., Lochray, F. & Cheung, P., 01 Oct 2013, In : International Journal of Radiation: Oncology - Biology - Physics. 87, 2, p. S532-S533

Research output: Contribution to journalMeeting abstract