Research Output

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Meeting abstract
2013

The Interlaboratory Robustness Of Next-Generation Sequencing (IRON) Study Phase II: Deep-Sequencing Analyses Of Hematological Malignancies Performed In 8,867 Cases By An International Network Involving 27 Laboratories

Kohlmann, A., Martinelli, G., Hofmann, W-K., Kronnie, G., Chiaretti, S., Preudhomme, C., Tagliafico, E., Hernandez, J., Gabriel, C., Lion, T., Vandenberghe, P., Polakova, K. M., Bene, M-C., Brueggemann, M., Cazzaniga, G., Yeoh, A., Lehmann, S., Ernst, T., Leibundgut, E. O., Ozbek, U. & 8 others, Mills, K. I., Dugas, M., Thiede, C., Spinelli, O., Foroni, L., Jansen, J. H., Hochhaus, A. & Haferlach, T., 15 Nov 2013, In : Blood. 122, 21, p. 743-743

Research output: Contribution to journalMeeting abstract

2012

Activation of and dependence on ataxia telangiectasia mutated kinase in PTEN-deficient tumor cells

McCabe, N., Walker, S. M., Goffard, N., Wikstrom, K., Greenan, C., McLean, E., McDyer, F. A., Keating, K. E., James, I., Harrison, T., Mullan, P. B., Harkin, D. P., Chen, C. & Kennedy, R. D., 20 May 2012, In : Journal of Clinical Oncology. 30, 15, S, 1 p.

Research output: Contribution to journalMeeting abstract

A PROGNOSTIC SIGNATURE FOR PTEN-DEFICIENT GLIOBLASTOMAS

Gonda, D. D., Li, J., McCabe, N., Walker, S., Goffard, N., Wikstrom, K., McLean, E., Greenan, C., Delaney, T., McCarthy, M., McDyer, F., Keating, K. E., James, I. F., Harrison, T., Mullan, P., Harkin, D. P., Carter, B. S., Kennedy, R. & Chen, C. C., Oct 2012, In : Journal of Neuro-Oncology. 14, 6, p. 98 1 p.

Research output: Contribution to journalMeeting abstract

Arrested Differentiation in Acute Myeloid Leukemia (AML) with Silenced Ankyrin Repeat and SOCS Box Protein 3 (ASB3) Expression

Logan, G., Rapin, N., Porse, B. T., Percy, M. J. & Mills, K. I., 16 Nov 2012, In : Blood. 120, 21, p. - 2 p.

Research output: Contribution to journalMeeting abstract

Breaking DNA and killing cells with exotic types of radiation

Schettino, G., Timson, D. J., Currell, F. J. & Kavanagh, J. N., 2012, In : International Journal of Molecular Medicine. 30, p. S12-S12 1 p.

Research output: Contribution to journalMeeting abstract

Differential Expression of SHP-1 Levels in Chronic Phase and Advanced Disease CML and in AML Patients

Kaeda, J. S., Oberender, C., Neuman, D., Kim, T., Mills, K. I., Serra, A., Hemmati, P., Schleede, R., Overkamp, T., Ringel, F., Pretzsch, T., Turkmen, S., Schwarz, M., Arnold, R., Doerken, B. & le Coutre, P., 16 Nov 2012, In : Blood. 120, 21, p. - 2 p.

Research output: Contribution to journalMeeting abstract

Distinct Chromosomal Alterations Segregate with SEPT6 Expression Levels in Leukaemia

Chatham, L. R., Todd, C. B., Hillan, K. J., Mills, K., Hall, P. A. & Russell, H., Mar 2012, In : Journal of Pathology. 226, p. S14-S14 1 p.

Research output: Contribution to journalMeeting abstract

Epigenetic Silencing of BCL2, ETS1, IL27RA and DICER1 in Low-Risk MDS Patients

del Rey, M., O'Hagan, K., Dellett, M., Aibar, S., Colyer, H. A. A., Eugenia Alonso, M., Diez-Campelo, M., Armstrong, R. N., Sharpe, D. J., Gutierrez, N. C., Luis Garcia, J., de las Rivas, J., Mills, K. I. & Hernandez-Rivas, J. M., 16 Nov 2012, In : Blood. 120, 21, p. - 2 p.

Research output: Contribution to journalMeeting abstract

Mapping the Interaction Between FLIP and FADD

Majkut, J., Holohan, C., Sgobba, M., Haigh, D. & Longley, D., Nov 2012, In : European Journal of Cancer. 48, p. 30-30 1 p.

Research output: Contribution to journalMeeting abstract

17 Citations (Scopus)

MODELS OF BYSTANDER SIGNALLING BETWEEN PRIMARY ASTROCYTES AND GLIOMA CELLS: EFFECTS ON SURVIVAL AND MIGRATION/INVASION

Al Rashid, S. T., Mashal, S., Taggart, L., Clarke, E., Flannery, T. & Prise, K. M., Sep 2012, In : Journal of Neuro-Oncology. 14, p. 12-12 1 p.

Research output: Contribution to journalMeeting abstract

PREDICTORS OF STEM CELL-MEDIATED RADIATION RESISTANCE IN HUMAN GLIOBLASTOMAS - AN IMMUNOHISTOCHEMICAL STUDY

Singh, P., McQuaid, S., Al-Rashid, S., Prise, K., Herron, B., Healy, E., Shoakazemi, A., Donnelly, M., McConnell, R., Harney, J., Conkey, D., McGrath, E., Lunsford, L. D., Kondziolka, D., Niranjan, A., Kano, H., Hamilton, R. & Flannery, T., Sep 2012, In : Journal of Neuro-Oncology. 14, p. 6-6 1 p.

Research output: Contribution to journalMeeting abstract

36 Citations (Scopus)

Rational targeting of Inhibitor of Apoptosis Proteins for effective therapy of malignant pleural mesothelioma

Crawford, N., Holohan, C., Waugh, D. & Longley, D., Nov 2012, In : European Journal of Cancer. 48, p. 26

Research output: Contribution to journalMeeting abstract

The HDAC Inhibitor Vorinostat Down-regulates c-FLIP and Sensitizes Human Non-small Cell Lung Carcinoma Cell Lines to Ionising Radiation

McLaughlin, K. A. J., Prise, K. M., Johnston, P. G., Longley, D. B. & Stasik, I., Nov 2012, In : European Journal of Cancer. 48, p. 28-28 1 p.

Research output: Contribution to journalMeeting abstract

1 Citation (Scopus)
2011

An evaluation of siRNA screening in identification of targets in PTEN deficient tumor cells

McCabe, N., Walker, S. M., Wikstrom, K., Greenan, C., McLean, E., Delaney, T., McCarthy, M., Cochrane, D., Wilson, C., Davison, T. S., McDyer, F. A., Jellema, G. L., Goffard, N., James, I., Harrison, T., Mullan, P. B., Harkin, D. P. & Kennedy, R. D., 20 May 2011, In : Journal of Clinical Oncology. 29, 15, 1 p.

Research output: Contribution to journalMeeting abstract

A subtype representing activated ATM signalling in PTEN-null tumours

McCabe, N., Walker, S., Goffard, N., Wikstrom, K., Greenan, C., McDyer, F., Hill, L., Deharo, S., Harkin, D. P. & Kennedy, R., Oct 2011, In : European Journal of Cancer. 47, 4, p. S23 1 p.

Research output: Contribution to journalMeeting abstract

Nutrition and epigenetic change in belfast elderly longitudinal free-living ageing study (BELFAST)

Drysdale, C., Dellett, M., Murphy, A., Mills, K. & Rea, M., Sep 2011, In : Irish journal of medical science. 180, p. S344-S344 1 p.

Research output: Contribution to journalMeeting abstract

The Discovery of CD44R as a Marker for Gastric Cancer Stem Cells

Teng, E., Lau, W. M., Chong, H. S., Lopez, K. A., Tay, A. Y., Salto-Tellez, M., Wang, T. T., So, B. Y. J. & Chan, S. L., May 2011, In : Gastroenterology. 140, 5, p. S830-S830 1 p.

Research output: Contribution to journalMeeting abstract

37 Citations (Scopus)

THE EXPERIENCE AND COPING BEHAVIOURS OF MEN WITH PROSTATE CANCER RECEIVING COMBINED RADIOTHERAPY AND HORMONE TREATMENT

McCaughan, E., McSorley, O., Parahoo, K., Prue, G., O'Sullivan, J., Bunting, B. & McKenna, H., Oct 2011, In : Journal of mens health. 8, 3, p. 235-235 1 p.

Research output: Contribution to journalMeeting abstract

2010

Activin B functions downstream of BRCA1 in stem cell maintenance

Murray, M. M., Buckley, N. & Harkin, P., May 2010, In : Breast Cancer Research. 12, 1, p. S3 1 p.

Research output: Contribution to journalMeeting abstract

Identification of molecular subtypes within a formalin-fixed, paraffin-embedded breast cancer tumour cohort

Mulligan, J. M., McDyer, F., Deharo, S., Farztdinov, V., Halfpenny, I., Delaney, T., Couch, F., Quinn-O'Brien, J., Harkin, P. & Kennedy, R., May 2010, In : Breast Cancer Research. 12, p. S11-S11 1 p.

Research output: Contribution to journalMeeting abstract

Microarray based expression profiling of BRCA1 mutated breast tumours using a breast cancer specific array to identify a profile of BRCA1-deficiency

Lamers, E., Irwin, G. W., McDyer, F. A., Mulligan, J. M., Couch, F. J., Kennedy, R. D., Harkin, D. P., Quinn-O'Brien, J. & Kennedy, R., Nov 2010, In : EJC SUPPLEMENTS. 8, 7, p. 197-198 2 p.

Research output: Contribution to journalMeeting abstract

2009

BRCA1 protein expression as a predictor of outcome following chemotherapy in sporadic epithelial ovarian cancer (EOC)

Carser, J. E., Quinn-O'Brien, J., Michie, C. O., McCluggage, W. G., Williams, A. R., Mullan, P., Gourley, C. M. & Harkin, P., 20 May 2009, In : Journal of Clinical Oncology. 27

Research output: Contribution to journalMeeting abstract

2008

Lung cancer DSA: A platform for discovery of biomarkers in lung cancer

Tanney, A., Kennedy, R. & Kennedy, R., 20 May 2008, In : Journal of Clinical Oncology. 26, 15, p. - 1 p.

Research output: Contribution to journalMeeting abstract

Proteasome inhibition in high-grade glioma treatment: A strategy for simultaneous tumoricidal activity, temolozamide chemosensitization, and radiation sensitization

Chen, C. C., Kennedy, R., Kesari, S., Kung, A. & D'Andrea, A., Jun 2008, In : Neurosurgery. 62, 6, p. 1423-1423 1 p.

Research output: Contribution to journalMeeting abstract

Regulation of cyclin D1 by the BRCA1-BARD1 complex

Murray, MM. & Harkin, DP., 13 May 2008, In : Breast Cancer Research. 10, (Suppl 2), p. S13-S14 2 p., P22.

Research output: Contribution to journalMeeting abstract

Role of human epidermal receptor targeted therapies in chemo-sensitization of oesophageal adenocarcinoma cells

Campbell, L., Van Schaeybroeck, S., Kyula, J., Eatock, M. & Johnston, P., Oct 2008, In : EJC SUPPLEMENTS. 6, p. 157-157 1 p.

Research output: Contribution to journalMeeting abstract

13 Citations (Scopus)
2007

Interleukin-8/CXCR2 signaling plays an important role in conferring resistance of prostate cancer cells to chemotherapy

Wilson, C., Wilson, T., Johnston, P., Longley, D. & Waugh, D., 2007, In : Molecular Cancer Therapeutics. 6, 1 p., A179.

Research output: Contribution to journalMeeting abstract

Molecular profiling from FFPE tissue: Stratification of the Stage II colorectal cancer population

Kerr, P., Black, J., von Frese, J., Tanney, A., Proutski, V., O'Sullivan, J., Wilson, R., Kay, E., Mulligan, K., Kennedy, R., Johnston, P., Harkin, P. & Kennedy, R., Dec 2007, In : Molecular Cancer Therapeutics. 6, 12, p. 3571S-3571S 1 p.

Research output: Contribution to journalMeeting abstract

Targeting Fanconi anemia/BRCA pathway defects in cancer therapeutics

Kennedy, R. & D'Andrea, A. D., Dec 2007, In : Molecular Cancer Therapeutics. 6, 12, p. 3631S-3631S 1 p.

Research output: Contribution to journalMeeting abstract

The interaction between Src-family kinase inhibition and chemotherapy in colorectal cancer cell lines

Van Schaeybroeck, S., Holohan, C., Kyula, J., Longley, D. & Johnston, P., Nov 2007, In : Molecular Cancer Therapeutics. 6, 1 p., B252.

Research output: Contribution to journalMeeting abstract

The role of ADAM-17 in chemotherapy-induced EGFR activation

Kyula, J., Van Schaeybroeck, S., Holohan, C., Longley, D. & Johnston, P., 2007, In : Molecular Cancer Therapeutics. 6, 1 p., B117.

Research output: Contribution to journalMeeting abstract

2006

482 POSTER c-FLIP regulates the interaction between interferon-gamma and doxorubicin in breast cancer cells

Rogers, K., Thomas, M., Johnston, P. & Longley, D., Nov 2006, In : European Journal of Cancer Supplements. 4, 12, p. 147 1 p.

Research output: Contribution to journalMeeting abstract

7 Citations (Scopus)

A small interfering ribonucleic acid-based approach to characterize brain tumor resistance to radiation therapy

Chen, C. C., Kennedy, R. & D'Andrea, A., Aug 2006, In : Neurosurgery. 59, 2, p. 485-485 1 p.

Research output: Contribution to journalMeeting abstract

BRCA1 transcriptionally regulates genes associated with the basal breast cancer phenotype

Quinn, JE., James, CR., Gorskii, JJ., Mullan, PB. & Harkin, DP., 01 Nov 2006, In : Breast Cancer Research. 8, Suppl 2, p. S1 1 p., S4.

Research output: Contribution to journalMeeting abstract

CD44 regulates the expression of the cysteine protease Cathepsin K: implications for bone metastasis of breast cancer

Hill, A., McFarlane, S., Johnston, P. & Waugh, D., Nov 2006, In : EJC SUPPLEMENTS. 4, 12, p. 17-17 1 p.

Research output: Contribution to journalMeeting abstract

Focal adhesion kinase is a key signalling intermediate in interleukin-8 promoted chemotaxis and adhesion of prostate cancer cells to bone marrow endothelium

McFarlane, S., Seaton, A., Chacko, A., Johnston, P. G., Montironi, R. & Waugh, D. J., Nov 2006, In : EJC SUPPLEMENTS. 4, 12, p. 18-18 1 p.

Research output: Contribution to journalMeeting abstract

Modifier genetics in zebrafish identify Chk1 and an associated survival pathway as targets for pharmacotherapy of MDS/AML with P53 mutations.

Sidi, S., Hagen, A. T., Kennedy, R., Imamura, S., Kishi, S., Kanki, J., D'Andrea, A. & Look, A. T., 16 Nov 2006, In : Blood. 108, 11, p. 416A-416A 1 p.

Research output: Contribution to journalMeeting abstract

2005

Functional interaction between FANCD2 and ATM in the DNA damage response.

Margossian, SP., Ho, G., Kennedy, R. & D'Andrea, AD., 16 Nov 2005, In : Blood. 106, 11, p. 56A-56A 1 p.

Research output: Contribution to journalMeeting abstract

Overexpression of the SEPT9_v4 isoform confers resistance to microtubule-interacting drugs

Russell, SEH., Chacko, A., McDade, SS., Chanduloy, S., Kennedy, R., Church, S. & Hall, PA., Oct 2005, In : Journal of Pathology. 207, p. 4-4 1 p.

Research output: Contribution to journalMeeting abstract

2004

Septin 9 interacts with cytoskeletal factors leading to altered cell migration and resistance to microtubule-disrupting drugs

Hall, PA., Chacko, AD., Chanduloy, S., Church, SW., Kennedy, RD. & Russell, SEH., Sep 2004, In : Journal of Pathology. 204, p. 10A-10A 1 p.

Research output: Contribution to journalMeeting abstract

2003

CD44 Expression on prostate cancer cells correlates with adhesion to bone marrow endothelial cells.

Draffin, J. E., Hill, A., Johnston, P. G. & Waugh, D. J., 01 Dec 2003, In : Clinical Cancer Research. 9, 16, p. 6181S-6181S 1 p.

Research output: Contribution to journalMeeting abstract

Inhibition of an intracrine interleukin-8 signalling loop decreases prostate cancer cell proliferation.

Hamill, M., Murphy, C., Pettigrew, J., Maxwell, P., Seaton, A., Macmanus, C., McFarlane, S., Johnston, P. G., Santinelli, A., Montironi, R. & Waugh, D. J., 01 Dec 2003, In : Clinical Cancer Research. 9, 16, p. 6242S-6242S 1 p.

Research output: Contribution to journalMeeting abstract

Selective activation of MAPK pathways promotes the growth of metastatic prostate cancer cells by interleukin-8 (IL-8)

Hamill, M., Messenger, J., McFarlane, S., Murphy, C., Draffin, J., Johnston, P. G. & Waugh, D., 14 Mar 2003, In : The FASEB Journal. 17, 4, p. A222-A222 1 p.

Research output: Contribution to journalMeeting abstract

2002

Identification of 5-FU inducible genes in tumour cell lines by cDNA mircroarray

Maxwell, P. J., Longley, D. B., Boyer, J., Latif, T., Allen, W., Lynch, M., Harkin, D. P. & Johnston, P. G., Jun 2002, In : British Journal of Cancer. 86, 1, p. S21 1 p.

Research output: Contribution to journalMeeting abstract

Interleukin-8 (IL-8) promotes autocrine growth of prostate cancer cells

Hamill, M., Messenger, J., Monaghan, M., Draffin, J., Johnston, P. & Waugh, D., Jun 2002, In : British Journal of Cancer. 86, p. S93-S94 2 p.

Research output: Contribution to journalMeeting abstract

Interleukin-8 (IL-8) promotes the growth of metastatic prostate cancer cells

Hamill, M., Messenger, J., Monaghan, M., Draffin, J., Johnston, P. & Waugh, D., Nov 2002, In : European Journal of Cancer. 38, p. S139-S139 1 p.

Research output: Contribution to journalMeeting abstract

2001

ckit-positive cells in the guinea-pig bladder

McCloskey, KD. & Gurney, AM., Nov 2001, In : Journal of Physiology. 536, p. 95P-95P 1 p.

Research output: Contribution to journalMeeting abstract

2000

Cardiac hypertrophy and hypotension induced by systemic alpha(1B)-adrenergic receptor overactivity.

Zuscik, M., Chalothorn, D., Hellard, D., Waugh, D., Plow, E., Piascik, M. & Perez, D., 11 May 2000, In : The FASEB Journal. 14, 8, p. A1412-A1412 1 p.

Research output: Contribution to journalMeeting abstract

C-kit-positive cells in lymphatic vessels

McCloskey, KD., Hollywood, MA., Thornbury, KD., Ward, SM. & McHale, NG., Nov 2000, In : Journal of Physiology. 528P, p. 11P-11P 1 p.

Research output: Contribution to journalMeeting abstract