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2020

Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study

McCain, R. S., McManus, D. T., McQuaid, S., James, J. A., Salto-Tellez, M., Reid, N. B., Craig, S., Chisambo, C., Bingham, V., McCarron, E., Parkes, E., Turkington, R. C. & Coleman, H. G., 01 Jan 2020, In : Cancer Causes and Control. 31, 1, p. 1-11

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A novel next generation sequencing approach to improve sarcoma diagnosis

McConnell, L., Houghton, O., Stewart, P., Gazdova, J., Srivastava, S., Kim, C., Catherwood, M., Strobl, A., Flanagan, A. M., Oniscu, A., Kroeze, L. I., Groenen, P., Taniere, P., Salto-Tellez, M. & Gonzalez, D., 11 Feb 2020, In : Modern Pathology .

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1 Citation (Scopus)

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, In : EMBO Reports. e49254.

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3 Citations (Scopus)
40 Downloads (Pure)

Author Correction: Acute and chronic hypoxia differentially predispose lungs for metastases

Reiterer, M., Colaço, R., Emrouznejad, P., Jensen, A., Rundqvist, H., Johnson, R. S. & Branco, C., 28 Jan 2020, In : Scientific Reports. 10, 1, 5 p., 1627.

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Comparison of molecular assays for HPV testing in oropharyngeal squamous cell carcinomas: a population-based study in Northern Ireland

Craig, S., Anderson, L., Moran, M., Graham, L., Currie, K., Rooney, K., Robinson, M., Bingham, V., Cuschieri, K., McQuaid, S., Schache, A., Jones, T., McCance, D., Salto-Tellez, M., McDade, S. & James, J., Jan 2020, In : Cancer Epidemiology, Biomarkers, & Prevention. 29, 1, p. 31-38

Research output: Contribution to journalArticle

1 Citation (Scopus)

Development of a conceptual framework to improve sexual wellbeing communication in routine prostate cancer care

McCaughan, E., Parahoo, K., Flannagan, C., Maguire, R., Connaghan, J., Steele, M., Thompson, S., Jain, S., Kirby, M., Brady, N. & O'Connor, S. R., 20 Jan 2020, In : Patient Education and Counseling.

Research output: Contribution to journalArticle

Dual Erb B Inhibition in Oesophago-gastric Cancer (DEBIOC): A phase I dose escalating safety study and randomised dose expansion of AZD8931 in combination with oxaliplatin and capecitabine chemotherapy in patients with oesophagogastric adenocarcinoma

Thomas, A., Virdee, P. S., Eatock, M., Lord, S. R., Falk, S., Anthoney, D. A., Turkington, R. C., Goff, M., Elhussein, L., Collins, L., Love, S., Moschandreas, J. & Middleton, M. R., Jan 2020, In : European Journal of Cancer. 124, p. 131-141 11 p.

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FLIP(L): the pseudo‐caspase

Smyth, P., Sessler, T., Scott, C. & Longley, D., 24 Feb 2020, In : FEBS journal.

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1 Citation (Scopus)
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5 Downloads (Pure)
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8 Downloads (Pure)

Machine learning to predict early recurrence after oesophageal cancer surgery

on behalf of the OCCAMS Consortium, 30 Jan 2020, In : British Journal of Surgery.

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Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019 [Formula presented]

Gillessen, S., Attard, G., Beer, T. M., Beltran, H., Bjartell, A., Bossi, A., Briganti, A., Bristow, R. G., Chi, K. N., Clarke, N., Davis, I. D., de Bono, J., Drake, C. G., Duran, I., Eeles, R., Efstathiou, E., Evans, C. P., Fanti, S., Feng, F. Y., Fizazi, K. & 52 others, Frydenberg, M., Gleave, M., Halabi, S., Heidenreich, A., Heinrich, D., Higano, C. T. S., Hofman, M. S., Hussain, M., James, N., Kanesvaran, R., Kantoff, P., Khauli, R. B., Leibowitz, R., Logothetis, C., Maluf, F., Millman, R., Morgans, A. K., Morris, M. J., Mottet, N., Mrabti, H., Murphy, D. G., Murthy, V., Oh, W. K., Ost, P., O'Sullivan, J. M., Padhani, A. R., Parker, C., Poon, D. M. C., Pritchard, C. C., Reiter, R. E., Roach, M., Rubin, M., Ryan, C. J., Saad, F., Sade, J. P., Sartor, O., Scher, H. I., Shore, N., Small, E., Smith, M., Soule, H., Sternberg, C. N., Steuber, T., Suzuki, H., Sweeney, C., Sydes, M. R., Taplin, M. E., Tombal, B., Türkeri, L., van Oort, I., Zapatero, A. & Omlin, A., Apr 2020, In : European Urology. 77, 4, p. 508-547 40 p.

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3 Citations (Scopus)

Multifocal breast cancers are more prevalent in BRCA2 versus BRCA1 mutation carriers

McCrorie, A. D., Ashfield, S., Begley, A., Mcilmunn, C., Morrison, P. J., Boyd, C., Eccles, B., Greville-Heygate, S., Copson, E. R., Cutress, R. I., Eccles, D. M., Savage, K. I. & McIntosh, S. A., 05 Feb 2020, In : Journal of Pathology: Clinical Research. 8 p.

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Optimum Imaging Strategies for Advanced Prostate Cancer: ASCO Guideline

Trabulsi, E. J., Rumble, R. B., Jadvar, H., Hope, T., Pomper, M., Turkbey, B., Rosenkrantz, A. B., Verma, S., Margolis, D. J., Froemming, A., Oto, A., Purysko, A., Milowsky, M. I., Schlemmer, H-P., Eiber, M., Morris, M. J., Choyke, P. L., Padhani, A., Oldan, J., Fanti, S. & 10 others, Jain, S., Pinto, P. A., Keegan, K. A., Porter, C. R., Coleman, J. A., Bauman, G. S., Jani, A. B., Kamradt, J. M., Sholes, W. & Vargas, H. A., 15 Jan 2020, In : Journal of Clinical Oncology : official journal of the American Society of Clinical Oncology.

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Propagation of human prostate tissue from induced pluripotent stem cells

Hepburn, A. C., Curry, E. L., Moad, M., Steele, R. E., Franco, O. E., Wilson, L., Singh, P., Buskin, A., Crawford, S. E., Gaughan, L., Mills, I. G., Hayward, S. W., Robson, C. N. & Heer, R., 14 Mar 2020, In : Stem cells translational medicine. 13 p.

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Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

Schuemann, J., Bagley, A., Berbeco, R., Bromma, K., Butterworth, K. T., Byrne, H., Chithrani, D. B., Cho, S. H., Cook, J. R., Favaudon, V., Gholami, Y. H., Gargioni, E., Hainfeld, J. F., Hespeels, F., Heuskin, A-C., Ibeh, U. M., Kuncic, Z., Kunjachan, S., Lacombe, S., Lucas, S. & 22 others, Lux, F., McMahon, S. J., Nevozhay, D., Ngwa, W., Payne, J. D., Penninckx, S., Porcel, E., Prise, K. M., Rabus, H., Ridwan, S. M., Rudek, B., Sanche, L., Singh, B., Smilowitz, H. M., Sokolov, K. V., Sridhar, S., Stanishevskiy, Y., Sung, W., Tillement, O., Virani, N. A., Yantasee, W. & Krishnan, S., 07 May 2020, In : Physics in Medicine and Biology.

Research output: Contribution to journalArticle

Serum profiling identifies ibrutinib as a treatment option for young adults with B-cell acute lymphoblastic leukaemia

Jordaens, S., Cooksey, L., Bonney, S., Orchard, L., Coutinho, M., Van Tendeloo, V., Mills, K. I., Orchard, K. & Guinn, B-A., 29 Apr 2020, In : British Journal of Haematology. 189, 3, p. 500-512 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells

Perdreau-Dahl, H., Progida, C., Barfeld, S. J., Guldsten, H., Thiede, B., Arntzen, M., Bakke, O., Mills, I. G., Krauss, S. & Morth, J. P., 13 Mar 2020, In : Communications Biology. 3, 1, p. 123

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The 'Good Friday Agreement' and cancer research on the island of Ireland: Evidence for the impact of a tripartite cancer research partnership

Lewison, G., Gavin, A., McCallion, K., McDermott, R., Sullivan, R. & Lawler, M., 27 Feb 2020, In : European journal of cancer (Oxford, England : 1990). 129, p. 15-22 8 p.

Research output: Contribution to journalArticle

The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)

Roberts, J. Z., Holohan, C., Sessler, T., Fox, J., Crawford, N., Riley, J. S., Khawaja, H., Majkut, J., Evergren, E., Humphreys, L. M., Ferris, J., Higgins, C., Espona-Fiedler, M., Moynagh, P., McDade, S. S. & Longley, D. B., 20 Apr 2020, In : Cell Death and Differentiation.

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The Tissue-Sparing Effect of Spatially Fractionated X-rays for Maintaining Spermatogenesis: A Radiobiological Approach for the Preservation of Male Fertility after Radiotherapy

Fukunaga, H., Kaminaga, K., Sato, T., Watanabe, R., Ogawa, T., Yokoya, A. & Prise, K. M., 11 Apr 2020, In : Journal of Clinical Medicine. 9, 4

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The translational landscape of ground state pluripotency

Atlasi, Y., Jafarnejad, S. M., Gkogkas, C. G., Vermeulen, M., Sonenberg, N. & Stunnenberg, H. G., 01 Apr 2020, In : Nature Communications. 11, p. 1617 1617.

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Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation

Pechstein, A., Tomilin, N., Friedrich, K., Vorontsova, O., Sopova, E., Evergren, E., Haucke, V., Brodin, L. & Shupliakov, O., 25 Feb 2020, In : Cell Reports. 30, 8, p. 2594-2602, e1-e3 12 p.

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2019

Acute and chronic hypoxia differentially predispose lungs for metastases

Reiterer, M., Colaço, R., Emrouznejad, P., Jensen, A., Rundqvist, H., Johnson, R. S. & Branco, C., 15 Jul 2019, In : Scientific Reports. 9, 15 p., 10246.

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2 Citations (Scopus)
118 Downloads (Pure)

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Lux, F., Tran, V. L., Thomas, E., Dufort, S., Rossetti, F., Martini, M., Truillet, C., Doussineau, T., Bort, G., Denat, F., Boschetti, F., Angelovski, G., Detappe, A., Crémillieux, Y., Mignet, N., Doan, B-T., Larrat, B., Meriaux, S., Barbier, E., Roux, S. & 28 others, Fries, P., Müller, A., Abadjian, M-C., Anderson, C., Canet-Soulas, E., Bouziotis, P., Barberi-Heyob, M., Frochot, C., Verry, C., Balosso, J., Evans, M., Sidi-Boumedine, J., Janier, M., Butterworth, K., McMahon, S., Prise, K., Aloy, M-T., Ardail, D., Rodriguez-Lafrasse, C., Porcel, E., Lacombe, S., Berbeco, R., Allouch, A., Perfettini, J-L., Chargari, C., Deutsch, E., Le Duc, G. & Tillement, O., 01 Jan 2019, In : British Journal of Radiology. 92, 1093, 19 p., 20180365.

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13 Citations (Scopus)
238 Downloads (Pure)

Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications

Hill, M., Twigg, M., Sheridan, E. A., Hardy, J. G., Elborn, J. S., Taggart, C. C., Scott, C. J. & Migaud, M. E., 02 Aug 2019, In : Pharmaceutics. 11, 8, 12 p., 379.

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1 Citation (Scopus)
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Altered splicing and cytoplasmic levels of tRNA synthetases in SF3B1-mutant myelodysplastic syndromes as a therapeutic vulnerability

Liberante, F. G., Lappin, K., Barros, E. M., Vohhodina, J., Grebien, F., Savage, K. I. & Mills, K. I., 25 Feb 2019, In : Scientific Reports. 9, 13 p., 2678.

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4 Citations (Scopus)
145 Downloads (Pure)

An evaluation of techniques for dose calculation on cone beam computed tomography

Giacometti, V., King, R. B., Agnew, C. E., Irvine, D. M., Jain, S., Hounsell, A. R. & McGarry, C. K., 26 Feb 2019, In : British Journal of Radiology. 92, 1096, 11 p., 20180383.

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5 Citations (Scopus)
27 Downloads (Pure)

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

Wilkinson, R., Burden, R., McDowell, S., McArt, D., McQuaid, S., Bingham, V., Williams, R., Cox, O., O'Connor, R., McCabe, N., Kennedy, R., Buckley, N. E. & Scott, C., 28 Jun 2019, In : Journal of Oncology.

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1 Citation (Scopus)
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Arterial thrombosis in Philadelphia-negative myeloproliferative neoplasms predicts second cancer. A case-control study

De Stefano, V., Ghirardi, A., Masciulli, A., Carobbio, A., Palandri, F., Vianelli, N., Rossi, E., Betti, S., Di Veroli, A., Iurlo, A., Cattaneo, D., Finazzi, G., Bonifacio, M., Scaffidi, L., Patriarca, A., Rumi, E., Casetti, I. C., Stephenson, C. I. M., Guglielmelli, P., Elli, E. M. & 23 others, Palova, M., Rapezzi, D., Erez, D., Gomez, M., Wille, K., Perez-Encinas, M., Lunghi, F., Angona, A., Fox, M-L., Beggiato, E., Benevolo, G., Carli, G., Cacciola, R., McMullin, M. F., Tieghi, A., Recasens, V., Isfort, S., Marchetti, M., Griesshammer, M., Alvarez-Larran, A., Vannucchi, A. M., Rambaldi, A. & Barbui, T., 23 Dec 2019, In : Blood.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations

George, S. L., Izquierdo, E., Campbell, J., Koutroumanidou, E., Proszek, P., Jamal, S., Hughes, D., Yuan, L., Marshall, L. V., Carceller, F., Chisholm, J. C., Vaidya, S., Mandeville, H., Angelini, P., Wasti, A., Bexelius, T., Thway, K., Gatz, S. A., Clarke, M., Al-Lazikani, B. & 17 others, Barone, G., Anderson, J., Tweddle, D. A., Gonzalez, D., Walker, B. A., Barton, J., Depani, S., Eze, J., Ahmed, S. W., Moreno, L., Pearson, A., Shipley, J., Jones, C., Hargrave, D., Jacques, T. S., Hubank, M. & Chesler, L., Nov 2019, In : European journal of cancer (Oxford, England : 1990). 121, p. 224-235 12 p.

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4 Citations (Scopus)
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A Workbench using Evolutionary Genetic Algorithms for analyzing association in TCGA Data

Gilmore, A., Alderdice, M., Savage, K., O’Reilly, P. G., Roddy, A., Dunne, P., Lawler, M., McDade, S., Waugh, D. & McArt, D., 13 Feb 2019, In : Cancer Research.

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1 Citation (Scopus)
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Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia

Davide Rossi, 01 Aug 2019, In : HAEMATOLOGICA.

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4 Citations (Scopus)
114 Downloads (Pure)

Borderline estrogen receptor-positive breast cancers in black and white women

Benefield, H. C., Allott, E. H., Reeder-Hayes, K. E., Perou, C. M., Carey, L. A., Geradts, J., Sun, X., Calhoun, B. C. & Troester, M. A., 19 Nov 2019, In : Journal of the National Cancer Institute.

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CDK9 Inhibition Induces a Metabolic Switch that Renders Prostate Cancer Cells Dependent on Fatty Acid Oxidation

Itkonen, H. M., Poulose, N., Walker, S. & Mills, I. G., 01 Jul 2019, In : Neoplasia . 21, 7, p. 713-720 8 p.

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3 Citations (Scopus)
82 Downloads (Pure)
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10 Citations (Scopus)
110 Downloads (Pure)

Defining the molecular evolution of extrauterine high grade serous carcinoma

Beirne, J. P., McArt, D. G., Roddy, A., McDermott, C., Ferris, J., Buckley, N. E., Coulter, P., McCabe, N., Eddie, S. L., Dunne, P. D., O'Reilly, P., Gilmore, A., Feeney, L., Ewing, D. L., Drapkin, R. I., Salto-Tellez, M., Kennedy, R. D., Harley, I. J. G., McCluggage, W. G. & Mullan, P. B., 04 Sep 2019, In : Gynecologic Oncology. 155, 2, p. 305-317 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Diagnostic workflow for hereditary erythrocytosis and thrombocytosis

McMullin, M. F., 06 Dec 2019, In : Hematology (United States). 2019, 1, p. 391-396 6 p.

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Differential Relapse Patterns for Non-small Cell Lung Cancer Subtypes Adenocarcinoma and Squamous Cell Carcinoma: Implications for Radiation Oncology

McAleese, J., Taylor, A., Walls, G. M. & Hanna, G. G., 01 Oct 2019, In : Clinical Oncology. 31, 10, p. 711-719 9 p.

Research output: Contribution to journalArticle

DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy

Gilmore, E., McCabe, N., Kennedy, R. & Parkes, E., 19 Jun 2019, In : Journal of Oncology.

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4 Citations (Scopus)
129 Downloads (Pure)

Drivers of AR indifferent anti-androgen resistance in prostate cancer cells

Handle, F., Prekovic, S., Helsen, C., Van den Broeck, T., Smeets, E., Moris, L., Eerlings, R., Kharraz, S. E., Urbanucci, A., Mills, I. G., Joniau, S., Attard, G. & Claessens, F., 24 Sep 2019, In : Scientific Reports. 9, 11 p., 13786.

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2 Citations (Scopus)
94 Downloads (Pure)
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Evidence for etiologic subtypes of breast cancer in the Carolina Breast Cancer Study

Benefield, H. C., Zabor, E. C., Shan, Y., Allott, E. H., Begg, C. B. & Troester, M. A., 08 Aug 2019, In : Cancer Epidemiology Biomarkers & Prevention.

Research output: Contribution to journalArticle

1 Citation (Scopus)
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1 Citation (Scopus)
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