Wellcome Wolfson Institute for Experimental Medicine

2022

A 2,7-dichlorofluorescein derivative to monitor microcalcifications

Tholen, P., Brown, C. N., Keil, C., Bayir, A., Zeng, H-H., Haase, H., Thompson, R. B., Lengyel, I. & Yücesan, G., 01 Nov 2022, In: Molecular Systems Design & Engineering. 11, p. 1415-1421

Research output: Contribution to journal › Article › peer-review

Open Access

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A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial

STARRT-AKI Investigators, 25 Aug 2022, In: Critical Care. 26, 255.

Research output: Contribution to journal › Article

Open Access

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A Comparative Analysis of Phenotypes Derived from Genes or Biomedical Literature in COVID-19

Steenson, S., Hawthorne, C. & Lopez-Campos, G., 06 Jun 2022, MEDINFO 2021: One World, One Health – Global Partnership for Digital Innovation. Otero, P., Scott, P., Martin, S. Z. & Huesing, E. (eds.). Vol. 290. p. 1092-1093 2 p. (Studies in health technology and informatics).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Open Access

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A complex epigenome-splicing crosstalk governs epithelial-to-mesenchymal transition in metastasis and brain development

Sahu, S. K., Agirre, E., Inayatullah, M., Mahesh, A., Tiwari, N., Lavin, D. P., Singh, A., Strand, S., Diken, M., Luco, R. F., Belmonte, J. C. I. & Tiwari, V. K., 08 Aug 2022, In: Nature Cell Biology. 24, 8, p. 1265-1277 13 p.

Research output: Contribution to journal › Article › peer-review

Activation of the Non-canonical Inflammasome in Mouse and Human Cells

Bezbradica, J. S., Coll, R. C. & Boucher, D., 01 Jan 2022, The Inflammasome: Methods and Protocols. Abdul-Sater, A. A. (ed.). Springer, p. 51-63 (Methods in molecular biology (Clifton, N.J.); vol. 2459).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

A Human and Rhesus Macaque Interferon-Stimulated Gene Screen Shows That Over-Expression of ARHGEF3/XPLN Inhibits Replication of Hepatitis C Virus and Other Flavivirids

Bamford, C. G. G., Aranday-Cortes, E., Sanchez-Velazquez, R., Mullan, C., Kohl, A., Patel, A. H., Wilson, S. J. & McLauchlan, J., Aug 2022, In: Viruses. 14, 8, 1655.

Research output: Contribution to journal › Article › peer-review

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Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker‐high and ‐low severe asthma

Khalfaoui, L., Symon, F. A., Couillard, S., Hargadon, B., Chaudhuri, R., Bicknell, S., Mansur, A. H., Shrimanker, R., Hinks, TS. C., Pavord, I. D., Fowler, S. J., Brown, V., McGarvey, L. P., Heaney, L. G., Austin, C. D., Howarth, P. H., Arron, J. R., Choy, D. F. & Bradding, P., 25 May 2022, (Early online date) In: Allergy.

Research output: Contribution to journal › Article › peer-review

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Altered Differentiation and Inflammation Profiles Contribute to Enhanced Innate Responses in Severe COPD Epithelium to Rhinovirus Infection

Guo-Parke, H., Linden, D., Mousnier, A., Scott, I. C., Killick, H., Borthwick, L. A., Fisher, A. J., Weldon, S., Taggart, C. C. & Kidney, J. C., 25 Feb 2022, In: Frontiers in Medicine. 9, 741989.

Research output: Contribution to journal › Article › peer-review

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An endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells

Broadbent, L., Bamford, C. G. G., Lopez Campos, G., Manzoor, S., Courtney, D., Ali, A., Touzelet, O., McCaughey, C., Mills, K. & Power, U. F., 18 Apr 2022, In: PLoS ONE. 17, 4, e0266412.

Research output: Contribution to journal › Article › peer-review

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An evolutionary conserved detoxification system for membrane lipid–derived peroxyl radicals in Gram-negative bacteria

Naguib, M., Feldman, N., Zarodkiewicz, P., Shropshire, H., Biamis, C., El-Halfawy, O. M., McCain, J., Dezanet, C., Decout, J-L., Chen, Y., Cosa, G. & Valvano, M. A., 17 May 2022, In: PLoS biology. 20, 5, e3001610.

Research output: Contribution to journal › Article › peer-review

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Antimicrobial resistance in urinary pathogens and culture-independent detection of trimethoprim resistance in urine from patients with urinary tract infection

Somorin, Y. M., Weir, N-J. M., Pattison, S. H., Crockard, M. A., Hughes, C. M., Tunney, M. M. & Gilpin, D. F., 24 May 2022, In: BMC Microbiology. 22, 144.

Research output: Contribution to journal › Article › peer-review

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A randomised trial of the effects on recruitment and retention of including a wet-ink signature and photograph in the patient invitation letter for a clinical trial: results from a Study Within a Trial (SWAT 3 and SWAT 53) [version 1; peer review: awaiting peer review]

Anand, R., Bradley, J., O'Neill, B., McAuley, D. F. & Clarke, M., 11 Feb 2022, In: F1000Research.

Research output: Contribution to journal › Article › peer-review

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A Self-Cleaning Material That Rapidly Kills Viruses

Coey, D., 2022, (Submitted).

Research output: Contribution to conference › Poster

Assessing cough symptom severity in refractory or unexplained chronic cough: findings from patient focus groups and an international expert panel

Kum, E., Guyatt, G. H., Munoz, C., Beaudin, S., Li, S-A., Abdulqawi, R., Badri, H., Boulet, L-P., Chen, R., Dicpinigaitis, P., Dupont, L., Field, S. K., French, C. L., Gibson, P. G., Irwin, R. S., Marsden, P., McGarvey, L., Smith, J. A., Song, W-J., O'Byrne, P. M. & 1 others, Satia, I., 14 Mar 2022, (Early online date) In: ERJ Open Research. 8, 1, 17 p.

Research output: Contribution to journal › Article › peer-review

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Association Between Atrial Uptake on Cardiac Scintigraphy With Technetium-99m-Pyrophosphate Labeled Bone-Seeking Tracers and Atrial Fibrillation

Hussain, M., Krywanczyk, A., Donnellan, E., Martyn, T., Hassan, O. A., Alkharabsheh, S., Watson, C., Tang, W. H., Kwon, D., Cremer, P., Cheng, F., Kanj, M., Griffin, B., Tan, C., Rodriguez, E. R., Hanna, M., Jaber, W. & Collier, P., 17 May 2022, In: Circulation. Cardiovascular imaging. 15, 5, p. 294-303

Research output: Contribution to journal › Article › peer-review

Baseline plasma IL-18 may predict simvastatin treatment response in patients with ARDS: a secondary analysis of the HARP-2 randomised clinical trial

Boyle, A. J., Ferris, P., Bradbury, I., Conlon, J., Shankar-Hari, M., Rogers, A. J., O'Kane, C. M. & McAuley, D. F., 07 Jun 2022, In: Critical Care. 26, 1, p. 164 8 p.

Research output: Contribution to journal › Article › peer-review

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"Be afraid - be very afraid": Passive air drying of nebulizer parts in cystic fibrosis (CF) - Occult microbiological risks of contamination with Pseudomonas aeruginosa from calyptrate flies (Musca domestica &Calliphora vomitoria)

Moore, J. E. & Millar, B. C., 03 Mar 2022, (Early online date) In: The Journal of Hospital Infection.

Research output: Contribution to journal › Letter › peer-review

Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome

McKelvey, M. C., Abladey, A. A., Small, D. M., Doherty, D. F., Williams, R., Scott, A., Spek, C. A., Borensztajn, K. S., Holsinger, L., Booth, R., O'Kane, C. M., McAuley, D. F., Taggart, C. C. & Weldon, S., 01 Apr 2022, In: American Journal of Respiratory and Critical Care Medicine. 205, 7, p. 769-782 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

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Characterizing the effective reproduction number during the COVID-19 pandemic: Insights from Qatar's experience

Bsat, R., Chemaitelly, H., Coyle, P., Tang, P., Hasan, M. R., Al Kanaani, Z., Al Kuwari, E., Butt, A. A., Jeremijenko, A., Kaleeckal, A. H., Latif, A. N., Shaik, R. M., Nasrallah, G. K., Benslimane, F. M., Al Khatib, H. A., Yassine, H. M., Al Kuwari, M. G., Al Romaihi, H. E., Al-Thani, M. H., Al Khal, A. & 3 others, Bertollini, R., Abu-Raddad, L. J. & Ayoub, H. H., 05 Feb 2022, In: Journal of global health. 12, 05004.

Research output: Contribution to journal › Article › peer-review

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Circulating biomarkers for management of cancer therapeutics related cardiac dysfunction

Tonry, C., Russel-Hallinan, A., McCune, C., Collier, P., Harbinson, M., Dixon, L. & Watson, C. J., 31 May 2022, (Early online date) In: Cardiovascular Research.

Research output: Contribution to journal › Article › peer-review

Open Access

Clinical features and predictive biomarkers for bladder cancer in patients with type 2 diabetes presenting with haematuria

Tonry, C. L., Evans, R. M., Ruddock, M. W., Duggan, B., McCloskey, O., Maxwell, A. P., O'Rourke, D., Boyd, R. E., Watt, J., Reid, C. N., Curry, D. J., Stevenson, M., Young, M. K., Jamison, C. S., Gallagher, J., Fitzgerald, S. P., Lamont, J. & Watson, C. J., 22 May 2022, (Early online date) In: Diabetes/Metabolism Research and Reviews. e3546.

Research output: Contribution to journal › Article › peer-review

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Comparative analysis of Vibrio cholerae isolates from Ghana reveals variations in genome architecture and adaptation of outbreak and environmental strains

Adade, N. E., Aniweh, Y., Mosi, L., Valvano, M. A., Duodu, S. & Dela Ahator, S., 13 Oct 2022, In: Frontiers in Microbiology. 13, 16 p., 998182.

Research output: Contribution to journal › Article › peer-review

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Comparative study of subcutaneous, intramuscular, and oral administration of bovine pathogenic Escherichia coli bacterial ghost vaccine in mice

Mu, J., Lei, L., Zheng, Y., Li, D., Li, J., Fu, Y., Wang, G. & Liu, Y., 14 Nov 2022, (Early online date) In: Frontiers in Immunology. 13, 14 p., 1008131.

Research output: Contribution to journal › Article › peer-review

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Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells

Llorián-Salvador, M., Byrne, E. M., Szczepan, M., Little, K., Chen, M. & Xu, H., 14 Jul 2022, In: Journal of Neuroinflammation. 19, 17 p., 182.

Research output: Contribution to journal › Article › peer-review

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CONCERNS FOR PEOPLE WITH CYSTIC FIBROSIS (PWCF) WHEN TRAVELLING PRE COVID-19

O'Doherty, M., O'Neill, D., Rendall, J. C., Moore, J. E. & Millar, B. C., 01 Jan 2022, In: The Ulster medical journal. 91, 1, p. 53-55

Research output: Contribution to journal › Letter › peer-review

Open Access

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Co-ordinated multidisciplinary intervention to reduce time to successful extubation for children on mechanical ventilation: the SANDWICH cluster stepped wedge RCT

Blackwood, B., Morris, K. P., Jordan, J., McIlmurray, L., Agus, A., Boyle, R., Clarke, M., Easter, C., Feltbower, R. G., Hemming, K., Macrae, D., McDowell, C., Murray, M., Parslow, R., Peters, M. J., Phair, G., Tume, L. N., Walsh, T. S. & McAuley, D. F., Mar 2022, In: Health Technology Assessment. 26, 18, 148 p.

Research output: Contribution to journal › Article › peer-review

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Cough hypersensitivity and chronic cough

Chung, K. F., McGarvey, L., Song, W-J., Chang, A. B., Lai, K., Canning, B. J., Birring, S. S., Smith, J. A. & Mazzone, S. B., 30 Jun 2022, In: Nature reviews. Disease primers. 8, 45.

Research output: Contribution to journal › Review article › peer-review

Open Access

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Decision support system to evaluate ventilation in the acute respiratory distress syndrome (DeVENT study)-trial protocol

Patel, B., Mumby, S., Johnson, N., Falaschetti, E., Hansen, J., Adcock, I., McAuley, D., Takata, M., Karbing, D. S., Jabaudon, M., Schellengowski, P. & Rees, S. E., 17 Jan 2022, In: Trials. 23, 1, 18 p., 47.

Research output: Contribution to journal › Article › peer-review

Open Access

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Defective antifungal immunity in patients with COVID-19

Morton, C. O., Griffiths, J. S., Loeffler, J., Orr, S. & White, P. L., 30 Nov 2022, (Early online date) In: Frontiers in Immunology. 13, 1080822.

Research output: Contribution to journal › Article › peer-review

Open Access

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Demographic, Clinical, and Patient-Reported Outcome Data From Two Global, Phase 3 Trials of Chronic Cough

Dicpinigaitis, P. V., Birring, S. S., Blaiss, M., McGarvey, L. P., Morice, A. H., Pavord, I. D., Satia, I., Smith, J. A., La Rosa, C., Li, Q., Nguyen, A. M., Schelfhout, J., Tzontcheva, A. & Muccino, D., 13 May 2022, (Early online date) In: Annals of Allergy, Asthma and Immunology.

Research output: Contribution to journal › Article › peer-review

Diagnostic Value of Mid-regional Pro-adrenomedullin (MR-proADM) as a Biomarker of Invasive Bacterial Infection in Children: A Systematic Review

Corr, M. P., Fairley, D., McKenna, J. P., Shields, M. D. & Waterfield, T., 04 Apr 2022, In: BMC Pediatrics. 22, 176.

Research output: Contribution to journal › Article › peer-review

Open Access

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Duration of immune protection of SARS-CoV-2 natural infection against reinfection

Chemaitelly, H., Nagelkerke, N., Ayoub, H. H., Coyle, P., Tang, P., Yassine, H. M., Al-Khatib, H. A., Smatti, M. K., Hasan, M. R., Al-Kanaani, Z., Al-Kuwari, E., Jeremijenko, A., Kaleeckal, A. H., Latif, A. N., Shaik, R. M., Abdul-Rahim, H. F., Nasrallah, G. K., Al-Kuwari, M. G., Butt, A. A., Al-Romaihi, H. E. & 4 others, Al-Thani, M. H., Al-Khal, A., Bertollini, R. & Abu-Raddad, L. J., 30 Sep 2022, (Early online date) In: Journal of Travel Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

Duration of mRNA vaccine protection against SARS-CoV-2 Omicron BA.1 and BA.2 subvariants in Qatar

Chemaitelly, H., Ayoub, H. H., AlMukdad, S., Coyle, P., Tang, P., Yassine, H. M., Al-Khatib, H. A., Smatti, M. K., Hasan, M. R., Al-Kanaani, Z., Al-Kuwari, E., Jeremijenko, A., Kaleeckal, A. H., Latif, A. N., Shaik, R. M., Abdul-Rahim, H. F., Nasrallah, G. K., Al-Kuwari, M. G., Butt, A. A., Al-Romaihi, H. E. & 4 others, Al-Thani, M. H., Al-Khal, A., Bertollini, R. & Abu-Raddad, L. J., 02 Jun 2022, In: Nature Communications. 13, 3082.

Research output: Contribution to journal › Article › peer-review

Open Access

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Early-phase clinical trials in a pandemic: learning from the response to COVID-19

NIHR Respiratory Translational Research Collaboration network, Jul 2022, In: The Lancet. Respiratory medicine. 10, 7, p. 625-627

Research output: Contribution to journal › Comment/debate › peer-review

Educational Needs of European Intensive Care Nurses with Respect to Multicultural Care: A Mix-Method Study

Gutysz-Wojnicka, A., Ozga, D., Barkestad, E., Benbenishty, J., Blackwood, B., Breznik, K., Filej, B., Jarošová, D., Kaučič, B. M., Nytra, I., Smrke, B., Zeleníková, R. & Dobrowolska, B., 10 Jan 2022, In: International Journal of Environmental Research and Public Health. 19, 2, 724.

Research output: Contribution to journal › Article › peer-review

Open Access

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Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 omicron infections

Qassim, S. H., Chemaitelly, H., Ayoub, H. H., AlMukdad, S., Tang, P., Hasan, M. R., Yassine, H. M., Al-Khatib, H. A., Smatti, M. K., Abdul-Rahim, H. F., Nasrallah, G. K., Al-Kuwari, M. G., Al-Khal, A., Coyle, P., Kaleeckal, A. H., Shaik, R. M., Latif, A. N., Al-Kuwari, E., Jeremijenko, A., Butt, A. A. & 4 others, Bertollini, R., Al-Romaihi, H. E., Al-Thani, M. H. & Abu-Raddad, L. J., 01 Aug 2022, In: Journal of Travel Medicine. 29, 6, taac068.

Research output: Contribution to journal › Article › peer-review

Open Access

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Efficacy and safety of gefapixant, a P2X₃ receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials

COUGH-1 and COUGH-2 Investigators, 05 Mar 2022, In: The Lancet. 399, 10328, p. 909-923 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

198 Downloads (Pure)

Epidemiology and outcome of pressure injuries in critically ill patients with chronic obstructive pulmonary disease: A propensity score adjusted analysis

DecubICUs Study Teamthe European Society of Intensive Care Medicine (ESICM) Trials Group, May 2022, In: International Journal of Nursing Studies. 129, 104222.

Research output: Contribution to journal › Article › peer-review

ePS3.05 Induced levofloxacin resistance persists in evolved lineages of Pseudomonas aeruginosa isolates from people with cystic fibrosis after exposure to other inhaled antibiotics

Sloan, C. M., Sherrard, L. J., Einarsson, G. G., Tunney, M. M. & Downey, D. G., 01 Jun 2022, In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 21, Supplement 1, p. S50 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spike

Cantoni, D., Murray, M. J., Kalemera, M. D., Dicken, S. J., Stejskal, L., Brown, G., Lytras, S., Coey, J. D., McKenna, J., Bridgett, S., Simpson, D., Fairley, D., Thorne, L. G., Reuschl, A-K., Forrest, C., Ganeshalingham, M., Muir, L., Palor, M., Jarvis, L., Willett, B. & 10 others, Power, U. F., McCoy, L. E., Jolly, C., Towers, G. J., Doores, K. J., Robertson, D. L., Shepherd, A. J., Reeves, M. B., Bamford, C. G. G. & Grove, J., 06 Oct 2022, In: EMBO Reports. 23, 10, e54322.

Research output: Contribution to journal › Article › peer-review

Open Access

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Exploring Molecular Mechanisms Within Biomedical Literature

Glendinning, N., Hawthorne, C., Beck, S. & Lopez-Campos, G., 06 Jun 2022, MEDINFO 2021: One World, One Health – Global Partnership for Digital Innovation. Otero, P., Scott, P., Martin, S. Z. & Huesing, E. (eds.). Vol. 290. p. 1094-1095 (Studies in health technology and informatics).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Open Access

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Exploring the topology of cytoplasmic membrane proteins involved in lipopolysaccharide biosynthesis by in silico and biochemical analyses

Monjarás Feria, J. & Valvano, M. A., 24 Sep 2022, Lipopolysaccharide Transport. Methods and Protocols. Sperandeo, P. (ed.). Springer, p. 71-82 12 p. (Methods in molecular biology (Clifton, N.J.); vol. 2548).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Extracorporeal carbon dioxide removal for acute respiratory failure: a review of potential indications, clinical practice and open research questions

Combes, A., Brodie, D., Aissaoui, N., Bein, T., Capellier, G., Dalton, H. J., Diehl, J-L., Kluge, S., McAuley, D. F., Schmidt, M., Slutsky, A. S. & Jaber, S., Oct 2022, In: Intensive Care Medicine. 48, p. 1308–1321

Research output: Contribution to journal › Article › peer-review

Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation Effect on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure-Reply

McNamee, J. J., Brodie, D. & McAuley, D. F., 04 Jan 2022, In: JAMA : the journal of the American Medical Association. 327, 1, p. 84-85

Research output: Contribution to journal › Comment/debate › peer-review

Factors influencing resilience to postoperative delirium in adults undergoing elective orthopaedic surgery

Bowman, E. M. L., Cardwell, C., McAuley, D. F., McGuinness, B., Passmore, A. P., Beverland, D., Zetterberg, H., Schott, J. M. & Cunningham, E. L., 16 Jun 2022, (Early online date) In: British Journal of Surgery.

Research output: Contribution to journal › Article › peer-review

Open Access

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Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs

Wang, W., Bale, S., Wei, J., Yalavarthi, B., Bhattacharyya, D., Yan, J. J., Abdala-Valencia, H., Xu, D., Sun, H., Marangoni, R. G., Herzog, E., Berdnikovs, S., Miller, S. D., Sawalha, A. H., Tsou, P-S., Awaji, K., Yamashita, T., Sato, S., Asano, Y., Tiruppathi, C. & 4 others, Yeldandi, A., Schock, B. C., Bhattacharyya, S. & Varga, J., 26 Oct 2022, In: Nature Communications. 13, 16 p., 6358.

Research output: Contribution to journal › Article › peer-review

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Ficus septica exudate, a traditional medicine used in Papua New Guinea for treating infected cutaneous ulcers: in vitro evaluation and clinical efficacy assessment by cluster randomised trial

Deli, J., González-Beiras, C., Guldan, G. S., Moses, R. L., Dally, J., Moseley, R., Lundy, F. T., Corbacho-Monne, M., Walker, S. L., Cazorla, M. U., Ouchi, D., Fang, R., Briggs, M., Kiapranis, R., Yahimbu, M., Mitjà, O. & Prescott, T. A. K., May 2022, In: Phytomedicine. 99, 154026.

Research output: Contribution to journal › Article › peer-review

First glanders cases detected in Nepal underscore the need for surveillance and border controls

Koiral, P., Maharjan, M., Manandhar, S., Pandey, K. R., Deshayes, T., Wang, G., Valvano, MA. & Laroucau, K., 06 Apr 2022, In: BMC Veterinary Research. 18, 132.

Research output: Contribution to journal › Article › peer-review

Open Access

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Flexible, disposable photocatalytic plastic films for the destruction of viruses

Han, R., Coey, J. D., O'Rourke, C., Bamford, C. G. G. & Mills, A., Oct 2022, In: Journal of Photochemistry and Photobiology B: Biology. 235, 112551.

Research output: Contribution to journal › Article › peer-review

Open Access

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Genome-wide transcriptome profiling of human trabecular meshwork cells treated with TGF-β2

Callaghan, B., Lester, K., Lane, B., Fan, X., Goljanek-Whysall, K., Simpson, D. A., Sheridan, C. & Willoughby, C. E., 10 Jun 2022, In: Scientific Reports. 12, 9564.

Research output: Contribution to journal › Article › peer-review

Open Access

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Wellcome Wolfson Institute for Experimental Medicine

Research output

Search results