Research Output

2019

The Effect of Aclidinium on Symptoms Including Cough in COPD: A Phase IV, DoubleBlind, Placebo-Controlled, Parallel-Group Study

Smith, J. A., McGarvey, L., Morice, A. H., Birring, S. S., Wedzicha, J. A., Notari, M., Zapata, A., Segarra, R., Seoane, B. & Jarreta, D., 05 Apr 2019, In : American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
5 Downloads (Pure)
2018
Open Access
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1 Citation (Scopus)
68 Downloads (Pure)

The evolutionary landscape of colorectal tumorigenesis

The S:CORT Consortium, 31 Aug 2018, In : Nature Ecology and Evolution. 2, 10, p. 1661-1672 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2017

Antibody-induced internalization of the human respiratory syncytial virus fusion protein

Leemans, A., De Schryver, M., Van der Gucht, W., Heykers, A., Pintelon, I., Hotard, A. L., Moore, M. L., Melero, J. A., McLellan, J. S., Graham, B., Broadbent, L., Power, U. F., Caljon, G., Cos, P., Maes, L. & Delputte, P., 03 May 2017, In : Journal of Virology.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
244 Downloads (Pure)

Bacterial proteases and haemostasis dysregulation in the CF lung

Reihill, J. A., Moreland, M., Jarvis, G. E., McDowell, A., Einarsson, G. G., Elborn, J. S. & Martin, S. L., Jan 2017, In : Journal of Cystic Fibrosis. 16, 1, p. 49-57 9 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
186 Downloads (Pure)

Characterisation of eppin function: expression and activity in the lung

Scott, A., Glasgow, A., Small, D., Carlile, S., McCrudden, M., McLean, D., Brown, R., Doherty, D., Lundy, F., Hamid, U., O'Kane, C., McAuley, D., Brodlie, M., Tunney, M., Elborn, J., Irwin, C., Timson, D., Taggart, C. & Weldon, S., 13 Jul 2017, In : European Respiratory Journal. 50, 1, 1601937.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
129 Downloads (Pure)

DNA vaccination for cervical cancer; a novel technology platform of RALA mediated gene delivery via polymeric microneedles.

Ali, A. A., McCrudden, C. M., McCaffrey, J., McBride, J. W., Cole, G., Dunne, N. J., Robson, T., Kissenpfennig, A., Donnelly, R. F. & McCarthy, H. O., Apr 2017, In : Nanomedicine: Nanotechnology, Biology and Medicine. 13, 3, p. 921-932 12 p.

Research output: Contribution to journalArticle

Open Access
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31 Citations (Scopus)
221 Downloads (Pure)

High-volume haemofiltration for sepsis in adults

Borthwick, E. M., Hill, C. J., Rabindranath, K. S., Maxwell, A. P., McAuley, D. F. & Blackwood, B., 31 Jan 2017, In : The Cochrane database of systematic reviews. 1, 42 p., CD008075.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
325 Downloads (Pure)

Interventions to prevent steroid-induced osteoporosis and osteoporotic fractures in Duchenne muscular dystrophy (Review)

Bell, J. M., Shields, M., Watters, J., Hamilton, A., Beringer, T., Elliott, M., Quinlivan, R., Tirupathi, S. & Blackwood, B., 24 Jan 2017, In : Cochrane database of systematic reviews (Online). 1, CD010899.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
239 Downloads (Pure)

Long-term general and cardiovascular safety of tiotropium/olodaterol in patients with moderate to very severe chronic obstructive pulmonary disease

Buhl, R., Magder, S., Bothner, U., Tetzlaff, K., Voß, F., Loaiza, L., Vogelmeier, C. F. & McGarvey, L., Jan 2017, In : Respiratory Medicine. 122, p. 58-66 9 p.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
203 Downloads (Pure)
Open Access
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3 Citations (Scopus)
258 Downloads (Pure)

Procedural and short-term safety of bronchial thermoplasty in clinical practice evidence from a national registry and Hospital Episode Statistics

Burn, J., Sims, A. J., Keltie, K., Patrick, H., Welham, S. A., Heaney, L. G. & Niven, R. M., 14 Feb 2017, In : Journal of Asthma. 54, 8, p. 872-879

Research output: Contribution to journalArticle

9 Citations (Scopus)

Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells.

Omar, S., Clarke, R., Abdullah, H., Brady, C., Corry, J., Winter, H., Touzelet, O., Power, U. F., Lundy, F., McGarvey, L. P. A. & Cosby, S. L., 10 Feb 2017, In : PLoS ONE. 12, 2, 21 p., e0171681.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
204 Downloads (Pure)

The LpxL acyltransferase is required for normal growth and penta-acylation of lipid A in Burkholderia cenocepacia

Mohamed, Y. F., Hamad, M., Ortega, X. P. & Valvano, M. A., Apr 2017, In : Molecular Microbiology. 104, 1, p. 144-162

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
84 Downloads (Pure)

Tropical ulcer plant treatments used by Papua New Guinea's Apsokok nomads

Prescott, T. A. K., Homot, P., Lundy, F. T., Patrick, S., Cámara-Leret, R. & Kiapranis, R., 03 May 2017, In : Journal of Ethnopharmacology. 205, p. 240-245 6 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
216 Downloads (Pure)
2016

A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome

Aubert, D. F., Xu, H., Yang, J., Shi, X., Gao, W., Li, L., Bisaro, F., Chen, S., Valvano, M. A. & Shao, F., 11 May 2016, In : Cell host & microbe. 19, 5, p. 664-674 11 p.

Research output: Contribution to journalArticle

Open Access
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61 Citations (Scopus)
193 Downloads (Pure)

A comparison of different pre-lysis methods and extraction kits for recovery of Stretococcus agalacticae (Lancefield group B Streptococcus) DNA from whole blood

Burke, R. M., McKenna, J. P., Cox, C., Coyle, P. V., Shields, M. D. & Fairley, D. J., Oct 2016, In : Journal of Microbiological Methods. 129, p. 103-108 6 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
648 Downloads (Pure)

Acute Respiratory Distress Syndrome

Mac Sweeney, R. & McAuley, D. F., 28 Apr 2016, In : Lancet. 15 p.

Research output: Contribution to journalArticle

Open Access
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114 Citations (Scopus)
1173 Downloads (Pure)

Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review

Cruickshank, M., Henderson, L., MacLennan, G., Fraser, C., Campbell, M., Blackwood, B., Gordon, A. & Brazzelli, M., Apr 2016, In : Health Technology Assessment. 20, 25, p. 1-118 118 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Altered lung microbiota profiles are associated with disease severity, exacerbation frequency and neutrophilic inflammation in bronchiectasis: B16. CYSTIC FIBROSIS (CF) AND NON-CF BRONCHIECTASIS

Dicker, A. J., Fong, C., Crichton, M., Cassidy, A., Suarez-Cuartin, G., Sibila, O., Einarsson, G. G., Ibrahim, W., Elborn, J. S. & Palmer, C. NA., 2016, p. A2879-A2879.

Research output: Contribution to conferenceAbstract

Antimicrobial activity of a novel liposomal azithromycin formulation against clinical CF respiratory isolates

Bashi, Y. D., Payne, J., McGrath, S. J., Elborn, J. S., Tunney, M. M. & Kett, V. L., Jun 2016, In : Journal of Cystic Fibrosis. 15, S1, p. S49 1 p., ePs06.6.

Research output: Contribution to journalMeeting abstract

Open Access
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135 Downloads (Pure)

ArnT proteins that catalyse the glycosylation of lipopolysaccharide share common features with bacterial N-oligosaccharyltransferases

Tavares-Carreón, F., Mohamed, Y. F., Andrade, A. & Valvano, M. A., 2016, In : Glycobiology. 26, 3, p. 286-300 15 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
99 Downloads (Pure)

A Secretory Leukocyte Protease Inhibitor Variant with Improved Activity against Lung Infection

Camper, N., Glasgow, A. M. A., Osbourn, M., Quinn, D. J., Small, D. M., McLean, D. T., Lundy, F. T., Elborn, J. S., McNally, P., Ingram, R. J., Weldon, S. & Taggart, C. C., May 2016, In : Mucosal immunology. 9, 3, p. 669-676

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
263 Downloads (Pure)

Asthma control and exacerbations: two different sides of the same coin. two different sides of the same coin

Heaney, L. G. & Brisk, R., Jan 2016, In : Current Opinon in Pulmonary Medicine. 22, 1, p. 32-37 6 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Behavior change theory, content and delivery of interventions to enhance adherence in chronic respiratory disease: A systematic review

McCullough, A. R., Ryan, C., Macindoe, C., Yii, N., Bradley, J. M., O'Neill, B., Elborn, J. S. & Hughes, C. M., Jul 2016, In : Respiratory Medicine. 116, p. 78-84 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Biodentine Reduces Tumor Necrosis Factor Alpha-induced TRPA1 Expression in Odontoblastlike Cells

El Karim, I. A., McCrudden, M. T. C., McGahon, M. K., Curtis, T. M., Jeanneau, C., Giraud, T., Irwin, C. R., Linden, G. J., Lundy, F. T. & About, I., Apr 2016, In : Journal of Endodontics. 42, 4, p. 589-595 7 p.

Research output: Contribution to journalArticle

File
8 Citations (Scopus)
331 Downloads (Pure)

Breaking ground; year 2

Ingram, R. & Barnett-Vanes, A., 2016, (Accepted) How to complete a PhD in the medical and clinical sciences. Wiley-Blackwell

Research output: Chapter in Book/Report/Conference proceedingChapter

CD4+ T Cells Targeting Dominant and Cryptic Epitopes from Bacillus anthracis Lethal Factor

Ascough, S., Ingram, R. J., Chu, K. K. Y., Musson, J. A., Moore, S. J., Gallagher, T., Baillie, L., Williamson, E. D., Robinson, J. H., Maillere, B., Boyton, R. J. & Altmann, D. M., Jan 2016, In : Frontiers in Microbiology. 6, 12 p., 1506.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
206 Downloads (Pure)
Open Access
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291 Downloads (Pure)

Cigarettes, e-cigarettes and Pseudomonas aeruginosa: Interactions in the CF lung?

McGown, K-A., Bengoechea, J., Dumigan, A., Elborn, J. S., Tunney, M. M. & Gilpin, D., Jun 2016, In : Journal of Cystic Fibrosis. 15, Supplement 1, p. S65 1 p.

Research output: Contribution to journalMeeting abstract

Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation

Moazed, F., Burnham, E. L., Vandivier, R. W., O'Kane, C. M., Shyamsundar, M., Hamid, U., Abbott, J., Thickett, D. R., Matthay, M. A., McAuley, D. F. & Calfee, C. S., 02 Feb 2016, In : Thorax. 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Closed circuit rebreathing to achieve inert gas wash-in for multiple breath wash-out

Horsley, A. R., O'Neill, K., Downey, D. G., Elborn, J. S., Bell, N. J., Smith, J. & Owers-Bradley, J., 09 Feb 2016, In : ERJ Open. 2, 1, 8 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
237 Downloads (Pure)

Community dynamics and the lower airway microbiota in stable chronic obstructive pulmonary disease, smokers and healthy non-smokers

Einarsson, G. G., Comer, D. M., McIlreavey, L., Parkhill, J., Ennis, M., Tunney, M. M. & Elborn, J. S., 12 Aug 2016, In : Thorax. 71, p. 795-803

Research output: Contribution to journalArticle

53 Citations (Scopus)
Open Access
104 Citations (Scopus)

Connectivity Mapping (ssCMap) To Predict A20 Inducing Drugs: Anti-inflammatory Action In Cystic Fibrosis

Malcomson, B., Wilson, H., Thillaiyampalan, G., Barsden, R., Donegan, S., El Banna, A., Elborn, J., Ennis, M., Kelly, C., Zhang, S-D. & Schock, B., 28 Jun 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. E3725–E3734 10 p.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
162 Downloads (Pure)

Correction: Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation

De Majumdar, S., Yu, J., Fookes, M., McAteer, S. P., Llobet, E., Spence, S. F. S., Monaghan, A., Kissenpfennig, A., Ingram, R. J., Bengoechea, J., Gally, D. L., Fanning, S., Elborn, J. S. & Schneiders, T., 11 May 2016, In : PLoS Pathogens. 12, 5, p. e1005649

Research output: Contribution to journalArticle

Open Access
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173 Downloads (Pure)

Effectiveness of a biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use: protocol for a randomised controlled trial (VAPrapid-2): Study protocol for a randomised controlled trial

Hellyer, T. P., Anderson, N. H., Parker, J., Dark, P., van den Broeck, T., Singh, S., McMullan, R., Agus, A., Emerson, L. M., Blackwood, B., Gossain, S., Walsh, T., Perkins, G., Conway Morris, A., McAuley, D. F. & Simpson, A. J., 16 Jul 2016, In : Trials. 17, 1, 8 p., 318.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
140 Downloads (Pure)

Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma

BTS Severe Asthma Network, 01 Sep 2016, In : Respiratory Medicine. 118, p. 46-52

Research output: Contribution to journalArticle

4 Citations (Scopus)
Open Access
File
13 Citations (Scopus)
571 Downloads (Pure)

Efficacy and safety of lumacaftor/ivacaftor combination therapy in patients with cystic fibrosis homozygous for Phe508del CFTR by pulmonary function subgroup

VX-809 TRAFFIC Study group & TRANSPORT Study Group, Aug 2016, In : The Lancet Respiratory Medicine. 4, 8, p. 617-626

Research output: Contribution to journalArticle

Open Access
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65 Citations (Scopus)
379 Downloads (Pure)

EGFR interacts with the fusion protein of respiratory syncytial virus strain 2-20 and mediates infection and mucin expression.

Currier, M. G., Lee, S., Stobart, C. C., Hotard, A. L., Villenave, R., Meng, J., Pretto, C., Shields, M. D., Nguyen, M. T., Todd, S. O., Chi, M. H., Hammonds, J., Krumm, S. A., Spearman, P., Plemper, R. K., Sakamoto, K., Peebles, R. S., Power, U. F. & Moore, M. L., 06 May 2016, In : PLoS Pathogens. 12, 5

Research output: Contribution to journalArticle

Open Access
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20 Citations (Scopus)
193 Downloads (Pure)

Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by β2-agonists, corticosteroids, and critical illness

Scott, J., Harris, G. J., Pinder, E. M., Macfarlane, J. G., Hellyer, T. P., Rostron, A. J., Conway Morris, A., Thickett, D. R., Perkins, G. D., McAuley, D. F., Widdrington, J. D., Wiscombe, S., Baudouin, S. V., Roy, A. I., Linnett, V. C., Wright, S. E., Ruchaud-Sparagano, M. H. & Simpson, A. J., 01 Feb 2016, In : The Journal of allergy and clinical immunology. 137, 2, p. 535-544 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Exhaled breath temperature measurement and asthma control in children prescribed inhaled corticosteroids: A cross sectional study

Hamill, L., Ferris, K., Kampande, K., McConaghy, L., Douglas, I., McGovern, V. & Shields, M. D., Jan 2016, In : Pediatric Pulmonology. 51, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
Open Access
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4 Citations (Scopus)
408 Downloads (Pure)

Fetal umbilical artery Doppler pulsatility index and childhood neurocognitive outcome at 12 years

Mone, F., McConnell, B., Thompson, A., Segurado, R., Hepper, P., Stewart, M. C., Dornan, J. C., Ong, S., McAuliffe, F. M. & Shields, M. D., 15 Jun 2016, In : BMJ Open. 6, 6

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
579 Downloads (Pure)

Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection

Detalle, L., Stohr, T., Palomo, C., Piedra, P. A., Gilbert, B. E., Mas, V., Millar, A., Power, U. F., Stortelers, C., Allosery, K., Melero, J. A. & Depla, E., Jan 2016, In : Antimicrobial Agents and Chemotherapy. 60, 1, p. 6-13 8 p.

Research output: Contribution to journalArticle

Open Access
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73 Citations (Scopus)
311 Downloads (Pure)

Genomic meningococcal load in the nasopharynx of children with meningococcal disease

Bourke, T. W., McKenna, J. P., Coyle, P. V., Fairley, D. J. & Shields, M. D., May 2016, In : The Pediatric Infectious Disease Journal. 35, 5, p. 577-579

Research output: Contribution to journalArticle

Open Access
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221 Downloads (Pure)
Open Access
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18 Citations (Scopus)
866 Downloads (Pure)