Patrick G Johnston Centre for Cancer Research

Research output

Research output per year 1986 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025

• 150949 Citations
• 161 h-index
• 2816 Article
• 136 Meeting abstract
• 123 Paper
• 101 Poster
• 370 More
  • 89 Review article
  • 50 Chapter
  • 40 Editorial
  • 36 Letter
  • 36 Patent
  • 32 Comment/debate
  • 31 Conference contribution
  • 15 Abstract
  • 13 Book
  • 12 Chapter (peer-reviewed)
  • 7 Literature review
  • 3 Other contribution
  • 2 Book/Film/Article review
  • 1 Other report
  • 1 Short survey
  • 1 Special issue
  • 1 Working paper

Research output per year

Research output per year

Search results

• 2024

  Evaluating the cost-effectiveness of the Northern Ireland Bowel Cancer Screening Programme

  Adair, O., McFerran, E., Lawler, M. & Lamrock, F., 28 Oct 2024.

  Research output: Contribution to conference › Poster

  Open Access

  File
  24 Downloads (Pure)
• 2023

  A comparison of international modelling methods to evaluate health economics of colorectal cancer screening: a systematic review

  Adair, O., Lamrock, F., McFerran, E. & Lawler, M., 21 May 2023.

  Research output: Contribution to conference › Poster › peer-review

  Open Access

  File

  • Health 100%
  • Systematic Review 100%
  • Colorectal Cancer Screening 100%
  • Paper 100%
  • Comparison 100%
  61 Downloads (Pure)

• Are tertiary lymphoid structures reliable biomarkers in squamous cell carcinomas of the head and neck?

  Khoshsorour, F., McCombe, K., Greene, C., James, J. & Craig, S., 31 Jan 2023.

  Research output: Contribution to conference › Poster › peer-review

• Bowel cancer registry data made whole: filling in the blanks through imputation in Northern Ireland

  Adair, O., McFerran, E., Lawler, M. & Lamrock, F., 15 May 2023.

  Research output: Contribution to conference › Poster

  File

  • Cancer Registry 100%
  • Survival Rate 100%
  • Lifespan 40%
  • Gaussian Distribution 20%
  • Sample Survey 20%
  11 Downloads (Pure)

• Does batch testing impact the quality of multiplex immunofluorescence staining in large epidemiological cohorts of formalin-fixed paraffin embedded tissues?

  James, H., Loughrey, P. B., McCombe, K., Salto-Tellez, M. & Craig, S., 31 Jan 2023.

  Research output: Contribution to conference › Poster › peer-review

  Open Access

  File
  1 Downloads (Pure)

• LymphoSight: an artificial intelligence QuPath companion application for the automated detection of tertiary lymphoid structures

  McCombe, K., Craig, S., Gault, R. & James, J., 09 Sept 2023.

  Research output: Contribution to conference › Poster › peer-review
• 2022

  Can multiplex immunofluorescence compete with gold standard immunohistochemistry for accurate biomarker quantification in pituitary neuroendocrine tumour tissue?

  James, H., Loughrey, P. B., McCombe, K., McArdle, A., Viratham Pulsawatdi, A., Corr, F., Greene, C., Salto-Tellez, M. & Craig, S., 11 Nov 2022.

  Research output: Contribution to conference › Poster › peer-review

• G protein selectivity and gene regulation by US28 are shaped by the presence or absence of chemokines

  Daly, C., Heukers, R., Evergren, E., J Smit, M. & Plouffe, B., 28 Mar 2022.

  Research output: Contribution to conference › Poster › peer-review

• Imputing Missing Confidential Data without the use of Multiple Imputation

  Adair, O., Lamrock, F., Lawler, M. & McFerran, E., 16 May 2022.

  Research output: Contribution to conference › Poster › peer-review

  Open Access

  File

  • Mortality 100%
  • Age 100%
  • Groups 100%
  • Missing At Random 100%
  • Missing Data 100%
  36 Downloads (Pure)

• Maximising development of high quality, high throughput, multiplex immunofluorescence assays for in situ biomarker quantification and spatial biology analysis in large population based studies

  McArdle, A., Loughrey, P. B., Craig, S., Corr, F., McCombe, K., French, D., Salto-Tellez, M., Maxwell, P. & James, J., 21 Sept 2022.

  Research output: Contribution to conference › Poster › peer-review

• Model performance doesn’t tell the full story – putting AI metrics under the microscope

  McCombe, K., Craig, S., Gault, R. & James, J., 21 Sept 2022.

  Research output: Contribution to conference › Poster › peer-review

• The Impact of COVID-19 on Colorectal Cancer Screening in Northern Ireland

  Waller, Z., McFerran, E., Lamrock, F., Bannon, F. & Lawler, M., 15 May 2022.

  Research output: Contribution to conference › Poster › peer-review

  Open Access

  File

  • Malignant Neoplasm 100%
  • Colorectal Cancer Screening 100%
  • COVID-19 100%
  • Colonoscopy 87%
  • Polyp 50%
  38 Downloads (Pure)
• 2021

  CATHEPSIN V SUPPRESSES GATA3 PROTEIN EXPRESSION IN LUMINAL A BREAST CANCER

  Sereesongsaeng, N., McDowell, S., Scott, C. & Burden, R., Mar 2021.

  Research output: Contribution to conference › Poster

• Characterisation of Cathepsin S as a novel therapeutic target in Triple Negative Breast Cancer.

  McDowell, S., Burden, R., Buckley, N. E. & Scott, C., Mar 2021.

  Research output: Contribution to conference › Poster

• Characteristics and Demographics of Patients in NI 2018-2019 Oesophago-Gastric Cancer Audit

  Hawkins, S., Walker, A., Lavery, A., Turkington, R., Gavin, A. & Coleman, H., 08 Dec 2021.

  Research output: Contribution to conference › Poster

  • Patient 100%
  • Stomach Cancer 100%
  • Age 17%
  • Male 17%
  • Symptom 17%

• Dissecting the role of Cathepsin S in DNA damage repair deficient tumours.

  Gallaher, S., Burden, R., Williams, R. & Scott, C., Feb 2021.

  Research output: Contribution to conference › Poster

• Epigenetic remodelling by class 1 HDAC inhibitors increases response to androgen signalling inhibitors in prostate cancer

  Forsythe, N., McDade, S., Jain, S. & LaBonte Wilson, M., 03 Dec 2021.

  Research output: Contribution to conference › Poster

• Investigating the role of Cathepsin S in Triple-Negative Breast Cancer.

  McDowell, S., Glass, K., Coulter, P., Burden, R., Buckley, N. E. & Scott, C., Feb 2021.

  Research output: Contribution to conference › Poster

• Investigating the role of Cathepsin S in Triple-Negative Breast Cancer.

  McDowell, S., Glass, K., Coulter, P., Burden, R., Buckley, N. E. & Scott, C., Mar 2021.

  Research output: Contribution to conference › Poster

• Real world outcomes in cancer patients with COVID-19 infection: Northern Ireland experience

  Feeney, L., Lavery, A., Hamilton, A., O'Neill, C., Walls, G., Taylor, K. & Turkington, R., 08 Nov 2021.

  Research output: Contribution to conference › Poster › peer-review
• 2020

  A robust immunophenotyping multiplex workflow for immunohistochemistry and digital image analysis

  James, J., Viratham Pulsawatdi, A., Craig, S., Bingham, V., Humphries, M., McCombe, K., Richman, S. & Quirke, P., 2020.

  Research output: Contribution to conference › Poster › peer-review

• Assessment of PDL-1 Expression by Digital Pathology demonstrates prognostic significance for overall survival in Triple Negative Breast Cancer and a novel association with overall survival in ER-/Her2+ breast cancer.

  James, J., Humphries, M., Craig, S., Bingham, V., McQuaid, S. & Buckley, N. E., 2020.

  Research output: Contribution to conference › Poster › peer-review

• Improving the diagnostic accuracy of the PDl-1 test with image analysis and multiplex hybridisation.

  James, J., Abdullahi Sidi, F., Humphries, M., Bingham, V., Craig, S., McQuaid, S., James, J. & Salto-Tellez, M., 2020.

  Research output: Contribution to conference › Poster › peer-review

• Poster: The impact of the COVID-19 pandemic on clinical exercise oncology trials in Belfast

  Brown, M., O'Connor, D., Jain, S. & Prue, G., 17 Nov 2020.

  Research output: Contribution to conference › Poster › peer-review

  Open Access

• The impact of image analysis and multiplex hybridisation on PDL-1 diagnostic case triage.

  James, J., Humphries, M., Bingham, V., Abdullahi Sidi, F., Craig, S., McQuaid, S. & Salto-Tellez, M., 2020.

  Research output: Contribution to conference › Poster › peer-review

• To Score or Not to Score? Is Ki-67 Analysis Worthwhile in Pituitary Neuroendocrine Tumours?

  James, J. & Loughrey, P. B., 09 Sept 2020, p. AEP671.

  Research output: Contribution to conference › Poster › peer-review
• 2019

  Assessing the Impact of Non-coding Mutations on Hereditary Breast Cancer Gene Function and Risk

  Ali, R., Savage, A., McIlmunn, C., Harkin, P., McIntosh, S. & Savage, K., 21 Feb 2019.

  Research output: Contribution to conference › Poster › peer-review

  File

  • Neoplasm 100%
  • Gene Function 100%
  • Breast Cancer 100%
  • Tumor Gene 100%
  • RNA Sequencing 100%
  57 Downloads (Pure)

• Characterisation of Cathepsin S in Triple Negative Breast Cancer.

  McDowell, S., Burden, R., Buckley, N. E. & Scott, C., Mar 2019.

  Research output: Contribution to conference › Poster

• Costs of Emergency admissions in the last year of life for people dying of cancer in Northern Ireland

  McFerran, E., Cairnduff, V., Gavin, A. & Lawler, M., 23 Aug 2019, (Accepted).

  Research output: Contribution to conference › Poster

  • Life 100%
  • Health Care Cost 100%
  • Malignant Neoplasm 100%
  • Emergency 100%
  • End of Life Care 100%

• Digital pathology and artificial intelligence integration: creating images for convolutional neural networks using the digital image analysis software QuPath

  James, J., McCombe, K., Craig, S., Rajendran, S., Quezada-Marin, J., Viratham Pulsawatdi, A., Humphries, M., Bingham, V., McQuaid, S., Salto-Tellez, M. & Gault, R., 05 Dec 2019.

  Research output: Contribution to conference › Poster › peer-review

• Dissecting the role of Cathepsin S in DNA damage repair deficient tumours.

  Gallaher, S., Burden, R., Williams, R. & Scott, C., Nov 2019.

  Research output: Contribution to conference › Poster

• Dissecting the role of Cathepsin S in DNA damage repair deficient tumours.

  Burden, R., Gallaher, S., Williams, R. & Scott, C., Feb 2019.

  Research output: Contribution to conference › Poster

• Integration of class I HDAC inhibitors into current treatments for prostate cancer.

  Manley, J. & LaBonte Wilson, M., 25 Aug 2019.

  Research output: Contribution to conference › Poster › peer-review

• Prostate-specific phantom for radiomic features quality assurance

  Osman, S., Russell, E., King, R., Cole, A., McGrath, C., Jain, S., Hounsell, A., Prise, K. & McGarry, C., Apr 2019, p. S526-S527.

  Research output: Contribution to conference › Poster › peer-review

  Open Access

  File
  141 Downloads (Pure)

• Unravelling the Role of Cathepsin S in DNA Damage Repair Deficient Tumours

  Gallaher, S., Wilkinson, R., Buckley, N. E., Burden, R., Williams, R. & Scott, C., Feb 2019.

  Research output: Contribution to conference › Poster
• 2018

  Chemoprevention in BRCA1 mutation carriers (CIBRAC): A proof of concept clinical trial

  Campbell, A., Savage, K. & McIntosh, S., 2018.

  Research output: Contribution to conference › Poster › peer-review

  Open Access

• Development and characterization of CV6-168, a novel and selective dUTPase inhibitor that enhances the antitumour efficacy of TS-targeted therapies

  LaBonte Wilson, M., 18 Sept 2018.

  Research output: Contribution to conference › Poster › peer-review

• Dissecting the role of Cathepsin S in DNA damage repair deficient tumours.

  Gallaher, S., Scott, C., Burden, R. & Williams, R., Nov 2018.

  Research output: Contribution to conference › Poster

• Expanding the potential for epigenetic therapies in combination with current standard-of-care therapy for prostate cancer.

  Manley, J., Mills, I., McDade, S., Waugh, D. & LaBonte Wilson, M., 13 Nov 2018.

  Research output: Contribution to conference › Poster › peer-review

• Imbalanced nucleotide metabolism sensitizes breast cancer cells to standard of care chemotherapy.

  Davison, C., Ladner, R., Chevallier, O., Carson, R., Oliver Esteve, J. A., Elliott, C., Mullan, P., Wilson, R., Savage, K. & LaBonte Wilson, M., Apr 2018.

  Research output: Contribution to conference › Poster › peer-review

• Inhibition of dUTPase induces a state of nucleotide pool and DNA repair imbalance that sensitizes triple negative breast cancer cells to standard of care chemotherapies.

  Davison, C., Knowlson, C., McKechnie, M., Savage, K., Wilson, R., Ladner, R. & LaBonte Wilson, M., 13 Nov 2018.

  Research output: Contribution to conference › Poster › peer-review

• Inhibition of dUTPase represents a novel therapeutic strategy in triple negative breast cancer.

  Ladner, R., Davison, C., Knowlson, C., Savage, K., Mulligan, K., Wilson, P. & Johnston, P., 2018.

  Research output: Contribution to conference › Poster › peer-review

• Molecular biomarkers and precision medicine in colorectal cancer: Value for Money?

  Henderson, R., Clarke, M., French, D., Lawler, M., Sullivan, R. & Maughan, T., 12 Sept 2018.

  Research output: Contribution to conference › Poster

  • Biological Marker 100%
  • Personalized Medicine 100%
  • Colorectal Cancer 100%
  • Health 100%
  • Accuracy 100%

• Radio-resistance of PTEN-deficient prostate tumours is enhanced by treatment-induced chemokine signalling and is associated with biochemical recurrence and development of metastasis.

  Armstrong, C., Coulter, J., Ong, C. W., Maxwell, P., Butterworth, K., Oksana, L., Berlingeri, S., LaBonte Wilson, M., Walker, S., O'Sullivan, J., Salto-Tellez, M., Jain, S., Mills, I., Illidge, T., Kennedy, R., Prise, K. & Waugh, D., 01 Aug 2018.

  Research output: Contribution to conference › Poster › peer-review

• Therapy-induced hypoxia attenuates response to enzalutamide and promotes resistance in pre-clinical models of prostate cancer

  LaBonte Wilson, M., 22 Aug 2018.

  Research output: Contribution to conference › Poster › peer-review

  • Combination Therapy 100%
  • Hypoxia 100%
  • Prostate Cancer 100%
  • Enzalutamide 100%
  • Prostate 100%

• Tumor-infiltrating lymphocytes and CD4/FOXP3 ratios reliably predict survival using digital image analysis

  Craig, S., Bankhead, P., Bingham, V., McQuaid, S., Tumelty, M., McDade, S., Salto-Tellez, M. & James, J., Jul 2018.

  Research output: Contribution to conference › Poster › peer-review
• 2017

  Adolescent males and their knowledge of HPV and HPV vaccination worldwide: a systematic review’

  Prue, G., Shapiro, G., Maybin, R., Santin, O. & Lawler, M., 2017.

  Research output: Contribution to conference › Poster › peer-review

• Enhanced radio-sensitivity of PTEN-deficient prostate tumours mediated by inhibition of intrinsic and treatment-potentiated CXC-chemokine signaling

  Armstrong, C., Coulter, J., Ong, C. W., Maxwell, P., LaBonte Wilson, M., Butterworth, K., Lyubomska, O., Berlingeri, S., Gallagher, R., Walker, S., O'Sullivan, J., Mills, I., Salto-Tellez, M., Illidge, T., Bristow, R. G., Kennedy, R., Prise, K. & Waugh, D., 2017.

  Research output: Contribution to conference › Poster › peer-review

• Enzalutamide-induced hypoxia attenuates response and promotes resistance in pre-clinical models of prostate cancer.

  Maxwell, P., McKechnie, M., Armstrong, C., Ong, C. W., Waugh, D. & LaBonte Wilson, M., 2017.

  Research output: Contribution to conference › Poster › peer-review

• Expanding the potential for epigenetic targeting therapies in prostate cancer: HDAC inhibition sensitises to radiotherapy

  Manley, J., Maxwell, P., Longley, D., Waugh, D. & LaBonte Wilson, M., 2017.

  Research output: Contribution to conference › Poster › peer-review