Patrick G Johnston Centre for Cancer Research

2024

Entresto as a novel radioprotectant in a partial heart irradiation mouse model

Walls, G. M., Ghita, M., Karuna, N., Edgar, K., Brown, K. H., Queen, R., Watson, C. J. & Butterworth, K. T., 07 May 2024, In: Radiotherapy and Oncology. 194, Supplement 1, p. S5273-S5275 3 p., 2147.

Research output: Contribution to journal › Meeting abstract › peer-review

Novel mutations causing pachydermoperiostosis - hormonal and phenotypic alterations

Stelmachowska-Banaś, M., Barry, S., Angurala, I., Rice, T., Magid, K., Carreira, A., Rai, A., Evans, A., Bollington, M., Kaur, V., Alina, S. C., McGregor, A., Mandisodza, K., Sahoo, J., Gupta, R., Behera, K., Roy, A., Carr, I., Loughrey, P. & Dutta, P. & 1 others, Korbonits, M., 06 May 2024, In: Endocrine Abstracts. 99, 1 p., P513 .

Research output: Contribution to journal › Meeting abstract › peer-review

NOX4 NADPH oxidase signalling is a key determinant of angiogenic function of cord-blood endothelial colony-forming cells in hypoxia

Pun, S. H., O'Neill, K. M., Naderi-Meshkin, H., Malla, S., Botezatu, B., King, W., Dunne, P. D., Brazil, D. P., Watson, C. J. & Grieve, D. J., 26 Aug 2024, In: Medical Sciences Forum. 27, 1 (2), 1 p., 1.2.

Research output: Contribution to journal › Meeting abstract › peer-review

Poster abstract: A decade of abdominal paragangliomas in the Northern Ireland Regional Referral Centre

Loughrey, P. B., Cvasciuc, T., Rajendran, S., Mullan, K., Eatock, F., Hunter, S. J., Morrison, P. & Johnston, P., 16 Sept 2024, In: Endocrine Abstracts. 104, 1 p., P131.

Research output: Contribution to journal › Meeting abstract › peer-review

Poster abstract: Body weight in acromegaly - does it make any difference?

Kaniuka-Jakubowska, S., Higham, C., Davis, J., Kearney, T., Loughrey, P., Elamin, A., Flanagan, D., Kaszubowski, M., Ayuk, J., Orme, S. M. & Wass, J., 06 May 2024, In: Endocrine Abstracts. 99, 1 p., P515.

Research output: Contribution to journal › Meeting abstract › peer-review

Poster abstract: Treatment resistant cushing’s disease following standard and novel multi-modal therapy in the setting of a constitutional pathogenic MSH2 variant

Armstrong, T., Loughrey, B., Eatock, F. & Lindsay, J., 2024, In: Endocrine Abstracts. 1 p., P138.

Research output: Contribution to journal › Meeting abstract › peer-review

Poster abstract: Using transcriptomics to refine the subtypes of non-functioning pituitary neuroendocrine tumours

Upritchard, M., Loughrey, P. B., Craig, S., Cooke, S., Herron, B., Miskelly, J., McKnight, A. J. & James, J. A., 16 Sept 2024, In: Endocrine Abstracts. 104, 1 p., P156.

Research output: Contribution to journal › Meeting abstract › peer-review

2023

Comparing digital image analysis with a manual scoring approach for quantification of p63 and BRCA1 protein expression in oropharyngeal squamous cell carcinomas

Graham, L., Craig, S., McCombe, K., McQuaid, S., McDade, S. & James, J., 15 Sept 2023, In: Clinical Cancer Research. 29, 18_Supplement, PO-040.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

HPV detection in oropharyngeal squamous cell carcinoma: comparison of morphology and artificial intelligence

Craig, S., Gaborieau, V., Gault, R., McCombe, K., Moyes, A., Schache, A. G., Jones, T. M., Risk, J. M., Gunning, P., Brennan, P., James, J. & Abebi-Ardekani, B., 02 Sept 2023, In: Virchows Archiv. 483, p. S41 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

1 Citation (Scopus)

2022

Exploring the link between cancer policies and cancer survival: a comparison of seven countries

Nolte, E., Morris, M., Landon, S., McKee, M., Seguin, M., Butler, J. & Lawler, M., 25 Oct 2022, In: European Journal of Public Health. 32, Supplement_3

Research output: Contribution to journal › Meeting abstract › peer-review

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High throughput metabolism related drug screening identifies hypoxia inducible factor-1 alpha as a promising therapeutic target in proteasome inhibitor resistant multiple myeloma

Weir, P., Besse, L., Besse, A., Driessen, C., McMullin, M. F., Crawford, L. & Donaldson, D., 25 Aug 2022, In: Clinical Lymphoma, Myeloma and Leukemia. 22, Supplement, p. S99-S100 P-117.

Research output: Contribution to journal › Meeting abstract › peer-review

New mechanistic and therapeutic insights into purified phospholipase A2 from Pseudechis australis snake venom - a novel anticancer agent for the treatment of precursor B-cell acute lymphoblastic leukaemia

Boncan, J., Hamilton, J., McCloskey, K. & Mills, K., 15 Nov 2022, In: Blood. 140, Supplement 1, p. 3120-3121

Research output: Contribution to journal › Meeting abstract › peer-review

Purified phospholipase A2 from Pseudechis australis snake venom - a novel anticancer agent for the treatment of precursor-B acute lymphoblastic leukaemia

Boncan, J., Brown, A., McCloskey, K. & Mills, K., 31 Mar 2022, In: British Journal of Haematology. 197, S1, BSH22-PO11.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

S130: NPM1 mutated AML: impact of co-mutational patterns - results of the European Harmony Alliance

Hernández-Sánchez, A., Villaverde-Ramiro, Á., Martínez Elicegui, J., González, T., Benner, A., Sträng, E., Castellani, G., Heckman, C. A., Versluis, J., Abáigar, M., Sobas, M., Azibeiro, R., Tur, L., Valk, P. J., Metzeler, K. H., Ayala, R., Dall’Olio, D., Tettero, J., Martínez-López, J. & Dombret, H. & 24 others, Pratcorona, M., Damm, F., Mills, K. I., Mayer, J., Thiede, C., Voso, M. T., Sanz, G. F., Calado, F., Döhner, K., Gaidzik, V. I., Heuser, M., Haferlach, T., Turki, A. T., Reinhardt, D., Villoria Medina, R., van Speybroeck, M., Schulze-Rath, R., Barbus, M., Butler, J. E., Hernández Rivas, J. M., Huntly, B. J., Ossenkoppele, G. J., Döhner, H. & Bullinger, L., 23 Jun 2022, In: HemaSphere. 6, p. 31-32 2 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

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Understanding batch variation within a cohort before digital pathology analysis of multiplex immunofluorescence in colorectal cancer

Carretero del Barrio, I., Viratham Pulsawatdi, A., McCombe, K., Bingham, V., James, J., Salto-Tellez, M. & Craig, S., 16 Aug 2022, In: Virchows Archiv. 481, p. s300 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

2021

Aerobic exercise an an adjuvant therapy in the management of metastatic castrate-resistant prostate cancer: A case study.

Brown, M., O’Connor, D., O'Sullivan, J., Jain, S. & Prue, G., 15 Jun 2021, In: Supportive Care in Cancer. 29, Suppl 1, p. S226 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

1 Citation (Scopus)

2020

Characterisation of the effect of novel anti-cancer components of Pseudechis australis and Crotalus vegrandis snake venom on acute lymphoblastic leukaemia cells

Boncan, J., McCloskey, K., Mills, K., Dobbin, S., Cobice, D. & McClean, S., 08 Dec 2020, In: British Journal of Pharmacology. 178, 2, p. 468-469 2 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Results of the ADRRAD Trial of pelvic IMRT plus radium-223 in men with mHSPC metastatic to bone

O'Sullivan, J., Turner, P. G., Jain, S., Grey, A., Biggart, S., Hounsell, A. R. & Cole, A., 20 Feb 2020, In: Journal of Clinical Oncology. 38, 6 suppl, p. 136 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

2019

Dysregulation of HUWE1 is associated with an increased mutational burden in Multiple Myeloma

Morgan, J., McAvera, R., Mills, K. & Crawford, L., 18 Oct 2019, In: Clinical Lymphoma, Myeloma and Leukemia. 19, Suppl 10, p. e71-e71

Research output: Contribution to journal › Meeting abstract › peer-review

Loss of TRIM33 in Multiple Myeloma correlates with increased genomic instability

McAvera, R., Morgan, J., Johnston, C., Mills, K. & Crawford, L., 18 Oct 2019, In: Clinical Lymphoma, Myeloma and Leukemia. 19, Suppl 10, p. e70-e71

Research output: Contribution to journal › Meeting abstract › peer-review

Targeting survivin to overcome cisplatin resistance in oesophageal adenocarcinoma

Douglas, R. V., Stevenson, L., Santos, R., Cairns, L., McCabe, N. H., Kennedy, R. D., Blayney, J. K. & Turkington, R. C., 26 May 2019, In: Journal of Clinical Oncology. 37, 15 Suppl, e15535.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

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Toxicity results from a novel phase I/II trial of VMAT radiotherapy to prostate and pelvic nodes plus six cycles of radium-223 in mCSPC metastatic to bone post ADT and docetaxel.

Cole, A., O'Sullivan, J. & Jain, S., 01 Mar 2019, In: Journal of Clinical Oncology : official journal of the American Society of Clinical Oncology. p. 196 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

2018

A phase I dose escalation multi-centre study of crizotinib (MET inhibitor) combined with binimetinib (MEK inhibitor) in patients with advanced solid tumours

Wilson, R., Dass, P. H., Van Schaeybroeck, S., Elez, E., Quinton, A., Jones, R., Houlden, J., Collins, L., Roberts, C., Love, S., Lawler, M., Di Nicolantonio, F., Grayson, M., Bardelli, A., Laurent=puig, P., Maughan, T., Tabernero, J., Peeters, M., Middleton, M. & Rolfo, C., Nov 2018, In: European Journal of Cancer. 103, Suppl 1, p. e140-e141

Research output: Contribution to journal › Meeting abstract › peer-review

CHALLENGE-UK: A UK cohort of the colon health and lifelong exercise change study: A phase III randomised control trial.

Brown, M., Yates, T., Forde, C., Adams, R., Booth, C., Courneya, K., Donnelly, M., O'Callaghan, C., Russell, A., Storey, D., Thomas, A., Wilson, R. & Coyle, V., Nov 2018, In: Journal of Sports Sciences. 36, S1, p. 22

Research output: Contribution to journal › Meeting abstract › peer-review

Hypoxia gene expression defines a poor prognostic sub-group in oesophageal adenocarcinoma

Douglas, R. V., McKinney, C., Stevenson, L., Cairns, L., Kennedy, R. D., Blayney, J. K. & Turkington, R. C., 01 Oct 2018, In: Annals of oncology : official journal of the European Society for Medical Oncology. 29, Supplement 8, p. viii212 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

2017

Assessment of conditional survival probability in resected esophageal adenocarcinoma.

Graham, D. M., Bannon, F., Lloyd, M., Noble, F., Walker, R., Griffiths, E., Whiting, J., Nutzinger, B., Grehan, N., O'Neill, R., Skipworth, R., Mercer, S., Saunders, J., Parsons, S., Kennedy, R. D., Fitzgerald, R. C., Underwood, T. & Turkington, R., 30 May 2017, In: Journal of Clinical Oncology. 35, 15_suppl, p. 4030-4030 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Association of a DNA damage response deficiency (DDRD) assay with prognosis in resected esophageal and gastric adenocarcinoma

Turkington, R., Knight, L., Douglas, R., Blayney, J., Stevenson, L., McManus, D., McCavigan, A., Walker, S., Bornschein, J., McRae, S., Noble, F., Underwood, T., O'Neill, R., McQuaid, S., Arthur, K., James, J., Eatock, M., Harkin, D., Fitzgerald, R. C. & Kennedy, R., 01 May 2017, In: Journal of Clinical Oncology : official journal of the American Society of Clinical Oncology. 35, 15_suppl, p. 4026-4026 1 p., 4026.

Research output: Contribution to journal › Meeting abstract › peer-review

Conditional survival probability in patients with resected oesophageal adenocarcinoma receiving neoadjuvant chemotherapy

Turkington, R., Graham, D., Bannon, F., Noble, F., O'Neill, R., Blayney, J., Underwood, T., Kennedy, R. & Fitzgerald, R. C., 11 Oct 2017, In: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 27, supp6, p. vi222 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

Mammographic surveillance in family history patients: Do low cancer detection rates justify the high numbers of breast cancers detected?

Madden-McKee, C., Culleton, G., Hinds, G. & McIntosh, S., May 2017, In: European Journal of Surgical Oncology. 43, 5, p. S26-S27 2 p.

Research output: Contribution to journal › Meeting abstract › peer-review

PD-L1 Expression and Response to Neo-Adjuvant Chemotherapy in Esophageal Adenocarcinoma

Parkes, E., Blayney, J., mccarron, E., Douglas, R., Stevenson, L., McManus, D., McQuaid, S., Arthur, K., James, J., Salto-Tellez, M., Noble, F., Underwood, T., O'Neill, R., Fitzgerald, R. C., Kennedy, R. & Turkington, R., 01 May 2017, In: Journal of Clinical Oncology. 35, 15 supplement, p. 4023-4023 4023.

Research output: Contribution to journal › Meeting abstract › peer-review

2016

Abstract OT3-02-07: Neo-DDRD: A biomarker-driven neoadjuvant feasibility study in breast cancer

McIntosh, S., Parkes, E., James, C., Lioe, T., Lowry, K., Keating, K., Khambata-Ford, S. & Kennedy, R., 15 Feb 2016, In: Cancer Research. 76, 4 Supplement, OT3-02-07.

Research output: Contribution to journal › Meeting abstract › peer-review

An exploration of men’s experiences of undergoing active surveillance for favourable-risk prostate cancer: a mixed methods study protocol

Ruane-McAteer, E., O'Sullivan, J., Porter, S. & Prue, G., Mar 2016, In: Psycho-oncology. 25, S1, p. 16-17 2 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

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3 Citations (Scopus)

218 Downloads (Pure)

Breast cancer outcomes following predictive BRCA testing in Northern Ireland

Hinds, G., Irwin, G., McFaul, L., Stewart, R., Morton, L., Savage, K. I., Morrison, P. J. & McIntosh, S. A., Jun 2016, In: Current Oncology. 23, 3, p. e298 P043.

Research output: Contribution to journal › Meeting abstract › peer-review

7 Citations (Scopus)

Chemoprevention in BRCA1 Mutation Carriers—A Proof-of-Concept Study

Campbell, A., Savage, K., McIntosh, S. & Harkin, D., May 2016, In: Current Oncology. 23, 3, p. e290 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Identification of potentially pathogenic variants in candidate breast and ovarian cancer susceptibility genes in BRCAX patients

Savage, A. L., Chenevix-Trench, G., Jun Li, J., McDade, S. S., Morrison, P. J., McIntosh, S. A., Harkin, D. P. & Savage, K. I., Jun 2016, In: Current Oncology. 23, 3, p. e308 1 p., P089.

Research output: Contribution to journal › Meeting abstract › peer-review

Loss of Function Cohesin Complex Gene Mutations Create Neomorphic Cell States Advantageous to Oncogeneisis

Smith, J., Savage, K., Thompson, A. & Mills, K., 22 Oct 2016, In: Blood. 128, p. 1564-1565 2 p.

Research output: Contribution to journal › Meeting abstract › peer-review

MErCuRIC1: A phase 1a study of MEK1/2 inhibitor PD-0325901 with cMET inhibitor crizotinib in patients with advanced solid tumours

Wilson, R., Middleton, M., Houlden, J., Van Schaeybroeck, S., Rolfo, C., Elez, E., Taieb, J., Andre, T., Bardelli, A., Laurent=puig, P., Tabernero, J., Peeters, M., Maughan, T., Roberts, C., Love, S., Lawler, M., Salto-Tellez, M., Grayson, M., Popovici, V. & Di Nicolantonio, F., 08 Oct 2016, In: Annals of Oncology.

Research output: Contribution to journal › Meeting abstract › peer-review

Preclinical radiotherapy technology, dosimetry and treatment planning

Butterworth, K., Ghita, M., McGarry, C. K., Jain, S., Hanna, G. G., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., Apr 2016, In: Radiotherapy and Oncology. 119, Supplement 1 , p. S238-S239 2 p.

Research output: Contribution to journal › Meeting abstract › peer-review

SPORT high-risk trial: A randomised feasibility study evaluating stereotactic prostate radiotherapy in high-risk localised prostate cancer with or without elective nodal irradiation

Lyons, C., McGarry, C., Hounsell, A., Hynds, S., Prise, K., O'Sullivan, J. & Jain, S., 01 Nov 2016, In: European Journal of Surgical Oncology. 42, 11, p. S235 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

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The Utility of Post-Chemotherapy PET Scans in Resectable Oesophageal Adenocarcinoma

Turkington, R., McManus, D., David, C., Napier, E., Kennedy, A., Carey, D., Clements, B., Harrison, C., Purcell, C., Eatock, M. & Kennedy, R., 22 Sept 2016, In: British Journal of Surgery.

Research output: Contribution to journal › Meeting abstract › peer-review

Vorinostat Does Not Improve Outcome in Patients with Acute Myeloid Leukemia and High Risk Myelodysplasia Treated with Azacitidine: Results of the UK Trials Acceleration Programme Ravva Trial

Craddock, C., Houlton, A. E., Ferguson, P., Raghavan, M., Fox, S., Dudley, L., Quek, L. S., Cavenagh, J. D., Dennis, M., Wheatley, K., Vyas, P., McMullin, M. F., Pillai, S. P., Kelly, R., Siddique, S., Wheatley, K. & Vyas, P., 30 Nov 2016, In: Blood. 128, 22, p. 1065

Research output: Contribution to journal › Meeting abstract › peer-review

We can cure, but can we care? Favourable-risk disease ≠ favourable psychological wellbeing in men recently diagnosed with PCa: Baseline findings from a prospective, longitudinal study

Ruane-McAteer, E., O'Sullivan, J. M., Porter, S. & Prue, G., 14 Oct 2016, In: Psycho-oncology. p. 190 1 p., 25.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

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2015

Cabozantinib attenuates CXCL8-driven macrophage dependent migration and invasion of PTEN-deficient prostate cancer cells

Neisen, J. L., McCabe, N., Kennedy, R. D. & Waugh, D. J., 01 Jan 2015, In: Cancer Research. 75, 1 Suppl, A49.

Research output: Contribution to journal › Meeting abstract › peer-review

Cautionary tale of active surveillance in intermediate-risk patients: Overall and cause-specific survival in the Sunnybrook experience

Musunuru, H. B., Klotz, L., Vespirini, D., Zhang, L., Mamedov, A., Sethukavalan, P., Jethava, V., Yamamoto, T., Jain, S. & Loblaw, D. A., 01 Mar 2015, In: Journal of Clinical Oncology. 33, 7 Suppl, 163.

Research output: Contribution to journal › Meeting abstract › peer-review

Comparison of active surveillance with other treatment options for low-risk prostate cancer

Musunuru, H. B., Morton, G., Klotz, L., Vespirini, D., Cheung, P., Chung, H. T., Zhang, L., Mamedov, A., Sethukavalan, P., Jethava, V., D'Alimonte, L., Deabreu, A., Jain, S., Yamamoto, T. & Loblaw, D. A., 01 Mar 2015, In: Journal of Clinical Oncology. 33, 7 Suppl, 178.

Research output: Contribution to journal › Meeting abstract › peer-review

ID: 263 Loss of IL-6/Stat3 signalling drives metastatic prostate cancer in mice and men

Pencik, J., Schlederer, M., Gruber, W., Unger, C., Walker, S., Chalaris, A., Marie, I., Hassler, M. R., Javaheri, T., Aksov, O., Blayney, J., Mazal, P., Grebien, F., Egger, G., Poli, V., Eferl, R., Kennedy, R., Fend, F., Scharpf, M. & Braun, M. & 14 others, Perner, S., Levy, D. E., Malcolm, T., Turner, S., Haitel, A., Susani, M., Moazzami, A., Rose-John, S., Aberger, F., Merkel, O., Morrigi, R., Culig, Z., Dolznig, H. & Kenner, L., Nov 2015, In: Cytokine. 76, 1, p. 112 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

MErCuRIC1: A Phase I study of MEK1/2 inhibitor PD-0325901 with cMET inhibitor crizotinib in RASMT and RASWT (with aberrant c-MET) metastatic colorectal cancer (mCRC) patients.

Van Schaeybroeck, S., Rolfo, C., Elez, E., Kelly, S., Houlden, J., Collins, L., Love, S., Andre, T., lawler, M., Di Nicolantonio, F., Grayson, M., Popovici, V., Bardelli, A., Laurent=puig, P., Salto-Tellez, M., Maughan, T., Tabernero, J., Peeters, M., Wilson, R. & Middleton, M., 2015, In: Journal of Clinical Oncology. 33, (suppl; abstr TPS3632)

Research output: Contribution to journal › Meeting abstract › peer-review

Modulation of mutated cohesin complex gene expression in acute myeloid leukaemia cell lines

Smith, J. S., Liberante, F. G., Thompson, A. & Mills, K. I., 19 Apr 2015, In: British Journal of Haematology. 169, Supplement s1, p. 87

Research output: Contribution to journal › Meeting abstract › peer-review

Molecular Classification of the invasive front in colorectal cancer

McArt, D., Dunne, P., Kay, E., O'Grady, A., Barrett, H., Arthur, K., Longley, D., Hamilton, P. W., Waugh, D. J., Lawler, M., Johnston, P. G., Salto-Tellez, M. & Van Schaeybroeck, S., 20 May 2015, In: Journal of Clinical Oncology. 33, Suppl 15, 3573.

Research output: Contribution to journal › Meeting abstract › peer-review

Patrick G Johnston Centre for Cancer Research

Research output

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