School of Medicine, Dentistry and Biomedical Sciences

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    BT9 7BL Belfast

    United Kingdom

Research Output 1973 2020

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2019

Intubation drug pack containing pre-filled syringes reduces the time to endotracheal intubation in a simulated paediatric emergency

Lawson, S., Flannigan, C., Green, C., Freeburn, L., Burns, A., McCann, J. & Bourke, T., 01 Mar 2019, In : BMJ Simulation and Technology Enhanced Learning.

Research output: Contribution to journalArticle

52 Downloads (Pure)

Investigating the clinical use of structured light plethysmography to assess lung function in children with neuromuscular disorders

Fleck, D., Curry, C., Donnan, K., Logue, O., Graham, K., Jackson, K., Keown, K., Winder, J., Shields, M. D. & Hughes, C. M., 26 Aug 2019, In : PLoS ONE. 14, 8, 19 p., e0221207.

Research output: Contribution to journalArticle

Open Access
File
Plethysmography
neuromuscular disorders
lung function
Light
Lung
1 Citation (Scopus)
62 Downloads (Pure)

Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol for a multicentre UK single arm phase II trial

Hall, A., Buckley, H. L., Flanagan, L., Gonzalez de Castro, D., Farnell, K., Moss, L., Gregory, R., Newbold, K., Du, Y., Flux, G. & Wadsley, J., 14 Jun 2019, In : BMC Cancer. 19, 10 p., 582.

Research output: Contribution to journalArticle

Open Access
File
Thyroid Neoplasms
Iodine
Therapeutics
Multicenter Studies
Disease-Free Survival
2 Citations (Scopus)
Longitudinal Studies
Prostatic Neoplasms
Psychology
Anxiety
Therapeutics
131 Downloads (Pure)

Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis

O'Leary, C., McGahon, M. K., Ashraf, S., McNaughten, J., Friedel, T., Cincolà, P., Barabas, P., Fernandez, J. A., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 01 Aug 2019, In : Investigative ophthalmology & visual science. 60, 10, p. 3297-3309

Research output: Contribution to journalArticle

Open Access
File
Endothelial Cells
Ligation
Retina
Retinal Neovascularization
Staining and Labeling
14 Citations (Scopus)
129 Downloads (Pure)

IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

Sheng, X., Nenseth, H. Z., Qu, S., Kuzu, O. F., Frahnow, T., Simon, L., Greene, S., Zeng, Q., Fazli, L., Rennie, P. S., Mills, I. G., Danielsen, H., Theis, F., Patterson, J. B., Jin, Y. & Saatcioglu, F., 24 Jan 2019, In : Nature Communications. 10, 12 p., 323.

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
cancer
Unfolded Protein Response
Chemical activation
Proteins
1 Citation (Scopus)
29 Downloads (Pure)

iRhom2 and TNF: Partners or enemies?

Badenes, M. & Adrain, C., 29 Oct 2019, In : Science Signaling. 12, 605, 2 p., eaaz0444.

Research output: Contribution to journalArticle

Open Access
File
Tumor Necrosis Factor Receptors
Metalloproteases
Liver Cirrhosis
Liver
Necrosis

Irradiation and dosimetry arrangement for a radiobiological experiment employing laser-accelerated protons

Polin, K., Doria, D., Romagnani, L., Chaudhary, P., Cirrone, G. A. P., Maiorino, C., Milluzzo, G., Petringa, G., Romano, F., Schettino, G., Scuderi, V., Prise, K. & Borghesi, M., 10 Oct 2019, In : Journal of Instrumentation. 14, 10, C10015.

Research output: Contribution to journalArticle

Irradiation
Dosimetry
dosimeters
Arrangement
Protons
43 Downloads (Pure)

Key factors associated with social distress after prostate cancer: Results from the United Kingdom Life after Prostate Cancer diagnosis study

Wright, P., Wilding, S., Watson, E., Downing, A., Selby, P., Hounsome, L., Wagland, R., Brewster, D. H., Huws, D., Butcher, H., Mottram, R., Kearney, T., Allen, M., Gavin, A. & Glaser, A. W., Jun 2019, In : Cancer epidemiology.

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
Odds Ratio
Northern Ireland
Unemployment
Wales
116 Downloads (Pure)

Knowledge about iodine requirements during pregnancy and breastfeeding among pregnant women living in Northern Ireland

McMullan, P., Hunter, A., McCance, D., Woodside, J. & Mullan, K., 12 Mar 2019, In : BMC Nutrition . 5, 24

Research output: Contribution to journalArticle

Open Access
File
Northern Ireland
Breast Feeding
Iodine
Pregnant Women
Pregnancy

Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease

Brown, R., Paulsen, M., Schmidt, S., Schaterrny, J., Frank, A., Hirtz, S., Delaney, R., Doherty, D., Hagner, M., Taggart, C., Weldon, S. & Mall, M. A., 09 Sep 2019, In : American Journal of Respiratory Cell and Molecular Biology.

Research output: Contribution to journalArticle

Obstructive Lung Diseases
Pulmonary diseases
Interleukin-1 Receptors
Eosinophilia
Eosinophils

Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction – a subgroup analysis of the LeoPARDS randomised trial

Antcliffe, D. B., Santhakumaranb, S., Orme, R. M. L., Ward, J., Al-Beidh, F., O’Dea, K., Perkins, G. D., Singer, M., Mason, A. J., Cross, M., McAuley, D., Ashby, D. & Gordon, A., 19 Aug 2019, Intensive Care Medicine, 45, p. 1392–1400.

Research output: Contribution to specialist publicationArticle

Septic Shock
Sepsis
Organ Dysfunction Scores
Brain Natriuretic Peptide
Troponin I

Long-term impact of living with an obturator following a maxillectomy: A qualitative study

Semple, C. J., Rutherford, H., Killough, S., Moore, C. & McKenna, G., 13 Oct 2019, In : Journal of Dentistry.

Research output: Contribution to journalArticle

Prostheses and Implants
Interviews
Social Adjustment
Decision Support Techniques
Body Image
100 Downloads (Pure)

Long-term outcome of patients operated with pars plana vitrectomy for primary rhegmatogenous retinal detachment.

Peto, T., Poulsen, C. D., Green, A. & Grauslund, J., 29 Apr 2019, In : Ophthalmic Research.

Research output: Contribution to journalArticle

Open Access
File
Temazepam
Vitrectomy
Retinal Detachment
Silicone Oils
Visual Acuity
40 Downloads (Pure)

Loss of Diurnal Oscillatory Rhythms in Gut Microbiota Correlates with Changes in Circulating Metabolites in Type 2 Diabetic db/db Mice

Beli, E., Prabakaran, S., Krishnan, P., Evans-Molina, C. & Grant, M. B., 29 Sep 2019, In : Nutrients. 11, 10, 19 p., 2310.

Research output: Contribution to journalArticle

Open Access
File
Circadian Rhythm
intestinal microorganisms
circadian rhythm
metabolites
mice
10 Citations (Scopus)
94 Downloads (Pure)

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Felszeghy, S., Viiri, J., Paterno, J. J., Hyttinen, J. M. T., Koskela, A., Chen, M., Leinonen, H., Tanila, H., Kivinen, N., Koistinen, A., Toropainen, E., Amadio, M., Smedowski, A., Reinisalo, M., Winiarczyk, M., Mackiewicz, J., Mutikainen, M., Ruotsalainen, A. K., Kettunen, M., Jokivarsi, K. & 16 others, Sinha, D., Kinnunen, K., Petrovski, G., Blasiak, J., Bjørkøy, G., Koskelainen, A., Skottman, H., Urtti, A., Salminen, A., Kannan, R., Ferrington, D. A., Xu, H., Levonen, A. L., Tavi, P., Kauppinen, A. & Kaarniranta, K., 01 Jan 2019, In : Redox Biology. 20, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
File
Retinal Pigments
Retinal Pigment Epithelium
Macular Degeneration
Genes
Epithelial Cells
42 Downloads (Pure)

Loss of O-linked protein glycosylation in Burkholderia cenocepacia impairs biofilm formation, siderophore activity and alters transcriptional regulators

Oppy, C. C., Jebeli, L., Kuba, M., Oates, C. V., Strugnell, R., Edgington-Mitchell, L. E., Valvano, M., Hartland, E. L., Newton, H. J. & Scott, N. E., 14 Nov 2019, In : mSphere.

Research output: Contribution to journalArticle

Open Access
File
Burkholderia cenocepacia
Siderophores
Biofilms
Glycosylation
Proteomics
4 Citations (Scopus)

Lost in translation? Paradigm conflict at the primary-secondary care interface

Johnston, J. L. & Bennett, D., 01 Jan 2019, In : Medical Education. 53, 1, p. 56-63 8 p.

Research output: Contribution to journalArticle

paradigm
medical practice
education
educational practice
educational policy
6 Downloads (Pure)
Open Access
File
Macular Degeneration
Low Birth Weight Infant
Health
Population
Birth Weight

Low-dose (0.01%) atropine eye-drops to reduce progression of myopia in children: a multicentre placebo-controlled randomised trial in the UK (CHAMP-UK) - study protocol

Azuara-Blanco, A., Logan, N., Strang, N., Saunders, K., Allen, P. M., Weir, R., Doherty, P., Adams, C., Gardner, E., Hogg, R., McFarland, M., Preston, J., Verghis, R., Loughman, J. J., Flitcroft, I., Mackey, D. A., Lee, S. S. Y., Hammond, C., Congdon, N. & Clarke, M., 25 Oct 2019, In : British Journal of Ophthalmology. 6 p., 314819.

Research output: Contribution to journalArticle

Ophthalmic Solutions
Myopia
Atropine
Randomized Controlled Trials
Placebos
2 Citations (Scopus)
55 Downloads (Pure)

Low Expression of miR-424-3p is Highly Correlated with Clinical Failure in Prostate Cancer

Richardsen, E., Andersen, S., Al-Saad, S., Rakaee, M., Nordby, Y., Pedersen, M. I., Ness, N., Ingebriktsen, L. M., Fassina, A., Taskén, K. A., Mills, I. G., Donnem, T., Bremnes, R. M. & Busund, L. T., 23 Jul 2019, In : Scientific Reports. 9, 1, p. 10662

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
MicroRNAs
Prostatectomy
Developed Countries
In Situ Hybridization

Machine learning for radiomics-based multi-modality and multi-parametric modeling

Wei, L., Osman, S., Hatt, M. & El Naqa, I., 13 Sep 2019, In : The Quarterly Journal of Nuclear Medicine and Molecular Imaging .

Research output: Contribution to journalArticle

Magnetic Resonance Imaging
Diagnostic Imaging
Software
Technology
Phenotype

MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinoma

Berggren, K. L., Restrepo Cruz, S., Hixon, M. D., Cowan, A. T., Keysar, S. B., Craig, S., James, J., Barry, M., Ozbun, M. A., Jimeno, A., McCance, D. J., Beswick, E. J. & Gan, G. N., 15 Aug 2019, In : Oncogene. 13 p.

Research output: Contribution to journalArticle

Radiation
Cytokines
Radiotherapy
Growth
Neoplasms
16 Citations (Scopus)
70 Downloads (Pure)

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

Coll, R. C., Hill, J. R., Day, C. J., Zamoshnikova, A., Boucher, D., Massey, N. L., Chitty, J. L., Fraser, J. A., Jennings, M. P., Robertson, A. A. B. & Schroder, K., 01 Jun 2019, In : Nature Chemical Biology. 15, p. 556–559

Research output: Contribution to journalArticle

Open Access
File
Inflammasomes
Hydrolysis
Adenosine Triphosphate
2 Downloads (Pure)

Mechanisms of physical activity behavior change in an incentive-based intervention: Mediation analysis

Murray, J. M., French, D. P., Kee, F., Gough, A., Tang, J. & Hunter, R. F., 27 Nov 2019, (Accepted) In : Health Psychology. HEA-2019-1641.

Research output: Contribution to journalArticle

Open Access
File
Motivation
Habits
Personal Autonomy
Structural Models
Self Efficacy

Mediating the relationship between loneliness and cognitive function: the role of depressive and anxiety symptoms

McHugh Power, J., Tang, J., Kenny, R. A., Lawlor, B. A. & Kee, F., 07 Apr 2019, In : Aging and Mental Health. 8 p.

Research output: Contribution to journalArticle

Loneliness
Cognition
Anxiety
Depression
Longitudinal Studies
8 Citations (Scopus)
53 Downloads (Pure)

Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium

EYE-RISK consortium, Mar 2019, In : Ophthalmology. 10 p.

Research output: Contribution to journalArticle

Open Access
File
Mediterranean Diet
Macular Degeneration
Incidence
Proportional Hazards Models
Fabaceae
1 Citation (Scopus)
28 Downloads (Pure)
Open Access
File
Adult Respiratory Distress Syndrome
MicroRNAs
Mesenchymal Stromal Cells
Organelles
Mitochondria
5 Citations (Scopus)

Mesothelioma and thymic tumors Treatment challenges in (outside) a network setting

RARECAREnet Working Group & Gavin, A., Jan 2019, In : European Journal of Surgical Oncology. 45, 1, p. 75-80

Research output: Contribution to journalArticle

Thymus Neoplasms
Mesothelioma
Public Opinion
Translational Medical Research
Neoplasms
14 Downloads (Pure)

Methodology for the at-home collection of urine samples for prostate cancer detection

Webb, M., Manley, K., Olivan, M., Guldvik, I., Palczynska, M., Hurst, R., Connell, S. P., Mills, I. G., Brewer, D. S., Mills, R., Cooper, C. S. & Clark, J., 29 Nov 2019, In : BioTechniques.

Research output: Contribution to journalArticle

Open Access
File
Urine Specimen Collection
Prostatic Neoplasms
Genes
Urine
RNA

Methylation age as a correlate for allele burden, disease status and clinical response in myeloproliferative neoplasm patients treated with Vorinostat

McPherson, S., Greenfield, G., Andersen, C., Grinfeld, J., Hasselbalch, H., Nangalia, J., Mills, K. I. & McMullin, M. F., 26 Sep 2019, In : Experimental Hematology.

Research output: Contribution to journalArticle

Open Access
Methylation
Alleles
Essential Thrombocythemia
Neoplasms
Polycythemia Vera
1 Citation (Scopus)

Microplasma assisted synthesis of gold nanoparticle/graphene oxide nanocomposites and their potential application in SERS sensing

Sun, D., Tang, M., Zhang, L., Falzon, B. G., Padmanaban, D. B., Mariotti, D., Maguire, P., Xu, H., Chen, M. & Sun, D., 2019, In : Nanotechnology. 30, 11 p., 455603.

Research output: Contribution to journalArticle

Graphite
Gold
Oxides
Graphene
Raman scattering
7 Downloads (Pure)

miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA

Ray, J., Haughey, C., Hoey, C., Jeon, J., Murphy, R., Dura-Perez, L., McCabe, N., Downes, M., Jain, S., Boutros, P. C., Mills, I. G. & Liu, S. K., 23 Dec 2019, In : Cancer Letters.

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
Radiation
Radiotherapy
Retinoid X Receptor alpha
Recurrence
41 Downloads (Pure)

Mitochondria and chronic kidney disease: a molecular update

Skelly, R., Maxwell, A. & McKnight, A., 01 May 2019, In : SPG Biomed.

Research output: Contribution to journalArticle

Open Access
File
Chronic Renal Insufficiency
Mitochondria
Oxidative Phosphorylation
Mitochondrial DNA
Genes
10 Downloads (Pure)
Open Access
File
Northern Ireland
Lunch
Diet
Attitude to Health
Workplace
16 Citations (Scopus)
8 Downloads (Pure)
Open Access
File
Genome-Wide Association Study
Asthma
Alleles
Odds Ratio
Genome

Modifiable lifestyle and medical risk factors associated with myeloproliferative neoplasms

Duncombe, D., Anderson, L., James, G., de vocht, F., Fritschi, L., Mesa, R., Clarke, M. & McMullin, M., 18 Nov 2019, (Accepted) In : HemaSphere.

Research output: Contribution to journalArticle

Life Style
Confidence Intervals
Odds Ratio
Essential Thrombocythemia
Smoking
59 Downloads (Pure)

Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues

An, S-Q., Murtagh, J., Twomey, K. B., Gupta, M. K., O"Sullivan, T. P., Ingram, R., Valvano, M. A. & Tang, J., 27 May 2019, In : Nature Communications. NCOMMS-18-25986D.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
44 Downloads (Pure)

Molecular biomarkers and precision medicine in colorectal cancer: a systematic review of health economic analysis

Henderson, R., French, D., Sullivan, R., Maughan, T., Clarke, M. & Lawler, M., 21 May 2019, In : Oncotarget. 10, 36, p. 3408-3423 26 p.

Research output: Contribution to journalArticle

Open Access
File
Molecular Medicine
Precision Medicine
Colorectal Neoplasms
irinotecan
Biomarkers
7 Downloads (Pure)

Monte Carlo radiative transfer for the nebular phase of Type Ia supernovae

Shingles, L. J., Sim, S. A., Kromer, M., Maguire, K., Bulla, M., Collins, C., Ballance, C. P., Michel, A. S., Ramsbottom, C. A., Roepke, F. K., Seitenzahl, I. R. & Tyndall, N. B., 31 Dec 2019, In : Monthly Notices of the Royal Astronomical Society.

Research output: Contribution to journalArticle

Open Access
File
radiative transfer
settling
supernovae
ionization
explosions
14 Citations (Scopus)
61 Downloads (Pure)

More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

Gomez-Valero, L., Rusniok, C., Carson, D., Mondino, S., Pérez-Cobas, A. E., Rolando, M., Pasricha, S., Reuter, S., Demirtas, J., Crumbach, J., Descorps-Declere, S., Hartland, E. L., Jarraud, S., Dougan, G., Schroeder, G. N., Frankel, G. & Buchrieser, C., 18 Jan 2019, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journalArticle

Open Access
File
Legionella
Genome
rab GTP-Binding Proteins
Legionella pneumophila
Proteins

Mothers' well-being, parenting attitudes, and home environment: Cumulative risk and parity in early motherhood

Hickey, G., McGilloway, S., Leckey, Y., Furlong, M., Leavy, S., Stokes, A., O'Connor, S., Bywater, T. & Donnelly, M., 01 Jul 2019, In : Child: Care, Health and Development. 45, 4, p. 523-530 8 p.

Research output: Contribution to journalArticle

Parenting
Parity
Mothers
Parents
Vulnerable Populations
4 Downloads (Pure)

Multifaceted intervention to Reduce Antimicrobial Prescribing in Care Homes: A process evaluation of a UK-based non-randomised feasibility study

Potter, R., Campbell, A., Ellard, D. R., Shaw, C., Gardner, E., Agus, A., O'Reilly, D., Underwood, M., Loeb, M., Stafford, B., Tunney, M. & Hughes, C., 21 Nov 2019, In : BMJ Open. 9, 11, e032185.

Research output: Contribution to journalArticle

Open Access
File
Feasibility Studies
Home Care Services
Decision Making
General Practitioners
Northern Ireland
56 Downloads (Pure)

National action plans to tackle NCDs: role of stakeholder network analysis

Hunter, R., Wickramasinghe, K., Erguder, T., Bolat, A., Ari, H. O., Yilidirim, H. H., Ursu, P., Robinson, G., Breda, J., Mikkelsen, B., Connolly, P., Clarke, M. & Kee, F., 20 May 2019, In : BMJ. 365, 1871, 4 p.

Research output: Contribution to journalArticle

Open Access
File
80 Downloads (Pure)
Open Access
File
HDL Lipoproteins
HDL Cholesterol
Cholesterol
Republic of Korea
Population
1 Citation (Scopus)

No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study

Dong, J., Gharahkhani, P., Chow, W-H., Gammon, M. D., Liu, G., Caldas, C., Wu, A. H., Ye, W., Onstad, L., Anderson, L., Bernstein, L. & Pharoah, P., 01 Feb 2019, In : Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Research output: Contribution to journalArticle

Barrett Esophagus
Random Allocation
Vitamin D
Adenocarcinoma
Single Nucleotide Polymorphism
11 Downloads (Pure)

No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cells

Dutton, L. R., O'Neill, C. L., Medina, R. J. & Brazil, D. P., 29 Nov 2019, In : The Journal of biological chemistry. 294, 48, p. 18041-18045 5 p.

Research output: Contribution to journalArticle

Open Access
File
Vascular Endothelial Growth Factor Receptor-2
Endothelial cells
Endothelial Cells
Chemical activation
Bone Morphogenetic Proteins
4 Citations (Scopus)
28 Downloads (Pure)

Novel Hydrogel-Forming Microneedle Array for Intradermal Vaccination in Mice Using Ovalbumin as a Model Protein Antigen

Courtenay, A. J., Rodgers, A. M., McCrudden, M. T. C., McCarthy, H. O. & Donnelly, R. F., 07 Jan 2019, In : Molecular Pharmaceutics. 16, 1, p. 118-127 10 p.

Research output: Contribution to journalArticle

Open Access
File
Hydrogel
Ovalbumin
Vaccination
Antigens
Vaccines