School of Medicine, Dentistry and Biomedical Sciences

  • 97 Lisburn Road, Health Sciences Building

    BT9 7BL Belfast

    United Kingdom

Research Output 1973 2020

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Article
2019
4 Citations (Scopus)
56 Downloads (Pure)

Polygenic risk score as a determinant of risk of non-melanoma skin cancer in a European-descent renal transplant cohort

Stapleton, C. P., Birdwell, K. A., McKnight, A. J., Maxwell, A. P., Mark, P. B., Sanders, M. L., Chapman, F. A., van Setten, J., Phelan, P. J., Kennedy, C., Jardine, A., Traynor, J. P., Keating, B., Conlon, P. J. & Cavalleri, G. L., 01 Mar 2019, In : American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 19, 3, p. 801-810

Research output: Contribution to journalArticle

Open Access
File
Skin Neoplasms
Transplants
Kidney
Genome-Wide Association Study
Basal Cell Carcinoma
54 Citations (Scopus)
34 Downloads (Pure)

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

ABCTB Investigators, 03 Jan 2019, In : American Journal of Human Genetics. 104, 1, p. 21-34 14 p.

Research output: Contribution to journalArticle

Open Access
File
Breast Neoplasms
Estrogen Receptors
Prospective Studies
Single Nucleotide Polymorphism
Genome
1 Citation (Scopus)

Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia

Wellcome Trust Case Control Consortium 2 & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 01 Apr 2019, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 180, 3, p. 223-231

Research output: Contribution to journalArticle

Exome
Haplotypes
Genome-Wide Association Study
Schizophrenia
Population

Post-conflict area-based regeneration policy in deprived urban neighbourhoods

Mohan, G., Longo, A. & Kee, F., 14 Aug 2019, In : Regional Studies.

Research output: Contribution to journalArticle

regeneration
religious conflict
welfare economics
household income
economics

Posterior segment eye lesions: Prevalence and associations with ocular and systemic parameters: Results from the Gutenberg Health Study

Elbaz, H., Schulz, A., Ponto, K. A., Nickels, S., Pfeiffer, N., Mirshahi, A. & Peto, T., 18 Jul 2019, In : Graefe's Archive for Clinical and Experimental Ophthalmology. p. 1-9

Research output: Contribution to journalArticle

Posterior Eye Segment
Nevus
Optic Disk
Health
Intraocular Pressure

Post-streptococcal uveitis syndrome in a Caucasian population: a case series

Curragh, D. S., McAvoy, C. E., Rooney, M. & McLoone, E., 01 Mar 2019, In : Eye (Basingstoke). 33, 3, p. 380-384 5 p.

Research output: Contribution to journalArticle

Uveitis
Population
Pediatrics
Deoxyribonucleases
Case Management
86 Downloads (Pure)
Open Access
File
Macular Edema
Randomized Controlled Trials
Visual Acuity
Therapeutics
Injections
1 Citation (Scopus)
25 Downloads (Pure)

Precision Radiotherapy and Radiation Risk Assessment: How Do We Overcome Radiogenomic Diversity?

Fukunaga, H., Yokoya, A., Taki, Y., Butterworth, K. T. & Prise, K. M., 11 Apr 2019, In : The Tohoku Journal of Experimental Medicine. 247, 4, p. 223-235 13 p.

Research output: Contribution to journalArticle

Open Access
File
Radiotherapy
Risk assessment
Precision Medicine
Radiation Tolerance
Radiation
3 Citations (Scopus)
Radiotherapy
Radiation
Lung
Biological Phenomena
DNA Damage

Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics

Oesten, H., von Neubeck, C., Jakob, A., Enghardt, W., Krause, M., McMahon, S., Grassberger, C., Paganetti, H. & Luhr, A., 22 Apr 2019, In : Radiation Research.

Research output: Contribution to journalArticle

3 Citations (Scopus)
75 Downloads (Pure)
Open Access
File
Internet
Cluster Analysis
Motivation
Reward
Randomized Controlled Trials
106 Downloads (Pure)

Predicting poorer health outcomes in older community-dwelling patients with multimorbidity: prospective cohort study assessing the accuracy of different multimorbidity definitions

Sasseville, M., Smith, S. M., Freyne, L., McDowell, R., Boland, F., Fortin, M. & Wallace, E., 04 Jan 2019, In : BMJ Open. 9, 1, 8 p., e023919.

Research output: Contribution to journalArticle

Open Access
File
Independent Living
Comorbidity
Cohort Studies
Prospective Studies
Health
22 Downloads (Pure)

Predictors of an early death in patients diagnosed with colon cancer: a retrospective case-control study in the United Kingdom

Donnelly, C., Hart, N., McCrorie, A. D., Donnelly, M., Anderson, L., Ranaghan, L. & Gavin, A., 19 Jun 2019, In : BMJ Open. 9, 6, p. e026057 12 p., e026057.

Research output: Contribution to journalArticle

Open Access
File
Colonic Neoplasms
Case-Control Studies
United Kingdom
Social Isolation
Survival
98 Downloads (Pure)

Prescriber Variation in Relation to Prescribing Trends within the Preferred Drugs Initiative in Ireland (2012-2015): An Interrupted Time Series Study Using Latent Curve Models

McDowell, R. D., Bennett, K., Moriarty, F., Clarke, S., Barry, M. & Fahey, T., 09 Feb 2019, In : Medical Decision Making. 39, 3, p. 278-298

Research output: Contribution to journalArticle

Open Access
File
Ireland
Pharmaceutical Preparations
Guidelines
Drug Prescriptions
Proton Pump Inhibitors
1 Citation (Scopus)

Prevalence of Refractive Error, Presbyopia, and Spectacle Coverage in Bogotá, Colombia: A Rapid Assessment of Refractive Error

Casas Luque, L., Naidoo, K., Chan, V. F., Silva, J. C., Naduvilath, T. J., Peña, F., Mayorga, M. & Ramírez, L., 01 Aug 2019, In : Optometry and vision science : official publication of the American Academy of Optometry. 96, 8, p. 579-586 8 p.

Research output: Contribution to journalArticle

Presbyopia
Refractive Errors
Colombia
Vision Disorders
Confidence Intervals
24 Downloads (Pure)

Prevalence of self-reported mental disorders in pregnancy and associations with adverse neonatal outcomes: a population-based cross-sectional study

Mongan, D., Lynch, J., Hanna, D., Shannon, C., Hamilton, S., Potter, C., Gorman, C., McCambridge, O., Morrow, R. & Mulholland, C., 08 Nov 2019, In : BMC Pregnancy and Childbirth. 19, 1, p. 412

Research output: Contribution to journalArticle

Open Access
File
Mental Disorders
Cross-Sectional Studies
Pregnancy
Mothers
Northern Ireland
2 Citations (Scopus)
2 Downloads (Pure)

Problems sleeping with prostate cancer: exploring possible risk factors for sleep disturbance in a population-based sample of survivors

Maguire, R., Drummond, F. J., Hanly, P., Gavin, A. & Sharp, L., 09 Jan 2019, In : Supportive Care in Cancer.

Research output: Contribution to journalArticle

Open Access
File
Survivors
Prostatic Neoplasms
Sleep
Population
Sleep Initiation and Maintenance Disorders
Colorectal Neoplasms
Cohort Studies
Population
Confidence Intervals
Recurrence
7 Citations (Scopus)
43 Downloads (Pure)

Progress in cancer survival, mortality, and incidence in seven high-income countries 1995-2014 (ICBP SURVMARK-2): a population-based study

Arnold, M., Rutherford, M. J., Bardot, A., Ferlay, J., Andersson, T. M-L., Myklebust, T. Å., Tervonen, H., Thursfield, V., Ransom, D., Shack, L., Woods, R. R., Turner, D., Leonfellner, S., Ryan, S., Saint-Jacques, N., De, P., McClure, C., Ramanakumar, A. V., Stuart-Panko, H., Engholm, G. & 18 others, Walsh, P. M., Jackson, C., Vernon, S., Morgan, E., Gavin, A., Morrison, D. S., Huws, D. W., Porter, G., Butler, J., Bryant, H., Currow, D. C., Hiom, S., Parkin, D. M., Sasieni, P., Lambert, P. C., Møller, B., Soerjomataram, I. & Bray, F., 11 Sep 2019, In : Lancet Oncology.

Research output: Contribution to journalArticle

Open Access
File
Benchmarking
Survival
Mortality
Incidence
Population
1 Citation (Scopus)

Progression characteristics of ellipsoid zone loss in macular telangiectasia type 2.

Pauleikhoff, D., Bonelli, R., Dubis, A. M., Gunnemann, F., Rothaus, K., Issa, P. C., Heeren, T. FC., Peto, T., Clemons, T. E., Chew, E. Y., Bird, A. C., Sallo, F. B. & Study Group, M., 18 Oct 2019, In : Acta Ophthalmologica.

Research output: Contribution to journalArticle

Telangiectasis
Visual Acuity
Cohort Studies
Clinical Trials
Growth
2 Citations (Scopus)

Promising Artificial Intelligence-Machine Learning-Deep Learning Algorithms in Ophthalmology

Balyen, L. & Peto, T., 01 Jun 2019, In : Asia-Pacific Journal of Ophthalmology. 8, 3, p. 264-272

Research output: Contribution to journalArticle

Artificial Intelligence
Ophthalmology
Macular Degeneration
Diabetic Retinopathy
Glaucoma

Promoting co-production in the generation and use of research evidence to improve service provision in special care dentistry

Brocklehurst, P. R., Langley, J., Baker, S. R., McKenna, G., Smith, C. & Wassall, R., 12 Jul 2019, In : British Dental Journal. 227, p. 15-18 4 p.

Research output: Contribution to journalArticle

Dentistry
Delivery of Health Care
Research
82 Downloads (Pure)
Open Access
File
Vulnerable Populations
Exercise
Telephone
Social Support
Education
42 Downloads (Pure)

Prompting Medical Students to Self-Assess their Learning Needs during the Ageing and Health Module: A Mixed Methods Study

Kennedy, G., Rea, J. N. M. & Rea, I. M., 02 May 2019, In : Medical Education Online. 24, 1, 12 p., 1579558.

Research output: Contribution to journalArticle

Open Access
File
Medical Students
medical student
Learning
Visual Analog Scale
Students

PROTEIN-coding variants highlight the importance of lipolysis in adipocytes for body fat distribution

Kee, F., 18 Feb 2019, In : Nature Genetics. xx, xx, p. 452-469

Research output: Contribution to journalArticle

Body Fat Distribution
Lipolysis
Adipocytes
Type 2 Diabetes Mellitus
Genes
7 Citations (Scopus)
2 Downloads (Pure)

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body fat distribution

CHD Exome+ Consortium, 18 Feb 2019, In : Nature Genetics. xx, xx, p. xx xx.

Research output: Contribution to journalArticle

Body Fat Distribution
Homeostasis
Lipids
Fats
Genes
3 Citations (Scopus)
188 Downloads (Pure)

Protein Phosphatase 2A Reduces Cigarette Smoke-Induced Cathepsin S and Loss of Lung Function

Doherty, D. F., Nath, S., Poon, J., Foronjy, R. F., Ohlmeyer, M., Dabo, A. J., Salathe, M., Birrell, M., Belvisi, M., Baumlin, N., Kim, M. D., Weldon, S., Taggart, C. & Geraghty, P., 14 Jan 2019, In : American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Protein Phosphatase 2
Smoke
Tobacco Products
Chronic Obstructive Pulmonary Disease
2 Citations (Scopus)
88 Downloads (Pure)

Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia.

Yang, M., Vesterlund, M., Siavelis, I., Moura-Castro, LH., Castor, A., Fioretos, T., Jafari, R., Lilljebjörn, H., Odom, DT., Olsson, L., Ravi, N., Woodward, EL., Harewood, L. & Paulsson, K., 03 Apr 2019, In : Nature Communications. 10, 15 p., 1519.

Research output: Contribution to journalArticle

Open Access
File
Pediatrics
Polyploidy
leukemias
Chromosomes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
46 Downloads (Pure)

Protocol for a scoping review of multi-omic analysis for rare diseases.

Kerr, K., McAneney, H. & McKnight, A., 05 May 2019, In : BMJ Open. 9, 4 p., e026278.

Research output: Contribution to journalArticle

Open Access
File
Rare Diseases
Research
Databases
Metabolomics
PubMed
18 Downloads (Pure)

Protocol for a systematic review and network meta-analysis of the management of new onset atrial fibrillation in critically unwell adult patients

Johnston, B. W., Hill, R., Duarte, R., Chean, C. S., McAuley, D. F., Blackwood, B., Pace, N. & Welters, I. D., 28 Oct 2019, In : Systematic Reviews. 8, 9 p., 242.

Research output: Contribution to journalArticle

Open Access
File
Atrial Fibrillation
Intensive Care Units
Registries
Network Meta-Analysis
MEDLINE
30 Downloads (Pure)

Protocolised non-invasive compared with invasive weaning from mechanical ventilation for adults in intensive care: the Breathe RCT

Perkins, G. D., Mistry, D., Lall, R., Gao-Smith, F., Snelson, C., Hart, N., Camporota, L., Varley, J., Carle, C., Paramasivam, E., Hoddell, B., de Paeztron, A., Dosanjh, S., Sampson, J., Blair, L., Couper, K., McAuley, D., Young, J. D., Walsh, T., Blackwood, B. & 7 others, Rose, L., Lamb, S. E., Dritsaki, M., Maredza, M., Khan, I., Petrou, S. & Gates, S., Sep 2019, In : Health Technology Assessment. 23, 48, 114 p.

Research output: Contribution to journalArticle

Open Access
File
Critical Care
Weaning
Artificial Respiration
Noninvasive Ventilation
Cost-Benefit Analysis

Protocolized versus non-protocolized weaning to reduce the duration of invasive mechanical weaning in neonates: a systematic review of all types of studies

Bol, B., van Zanten, H., Wielenga, J., vd Hoogen, A., Mansvelt, P., Blackwood, B. & Helder, O., 20 Jun 2019, In : Journal of Perinatal and Neonatal Nursing.

Research output: Contribution to journalArticle

Weaning
Artificial Respiration
Critical Illness
Neonatology
MEDLINE
3 Citations (Scopus)
Open Access
Caregivers
Confidence Intervals
Neoplasms
Quality of Life
Health Status

Putting Prostate Cancer Metabolism into the Right Context

Mills, I. G., Feb 2019, In : Urologic oncology. 2, 1, p. 37-38 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
31 Downloads (Pure)

Quality assurance guidance for scoring and reporting for pathologists and laboratories undertaking clinical trial work

on behalf of the UK National Cancer Research Institute (NCRI) Cellular-Molecular Pathology (CM-Path) clinical trials working group, 01 Apr 2019, In : Journal of Pathology: Clinical Research. 5, 2, p. 91-99 9 p.

Research output: Contribution to journalArticle

Open Access
File
Clinical Trials
Pathology
Calibration
Uncertainty
Outcome Assessment (Health Care)
5 Citations (Scopus)
56 Downloads (Pure)
Open Access
File
T-Cell Antigen Receptor
Computational Biology
T-Lymphocyte Gene Rearrangement
Quality Control
T-Cell Receptor Genes
109 Downloads (Pure)

Quality Indicators for Palliative Day Services: A modified Delphi study

McCorry, N. K., O'Connor, S., Leemans, K., Coast, J., Donnelly, M., Finucane, A., Jones, L., Kernohan, G., Perkins, P. & Dempster, M., 01 Feb 2019, In : Palliative Medicine. 33, 2, p. 197-205 9 p.

Research output: Contribution to journalArticle

Open Access
File
Delphi Technique
Quality Improvement
Quality of Health Care
Quality of Life
Research
28 Downloads (Pure)

Quality of life among symptomatic compared to PSA-detected prostate cancer survivors - Results from a UK wide patient-reported outcomes study

Donnelly, D. W., Vis, L. C., Kearney, T., Linda, S., Bennett, D., Wilding, S., Downing, A., Wright, P., Watson, E., Wagland, R., Cross, W. R., Mason, M. D., Siesling, S., van Manen, J. G., Glaser, A. W. & Gavin, A., 16 Oct 2019, In : BMC Cancer. 19, 9 p., 947.

Research output: Contribution to journalArticle

Open Access
File
Survivors
Prostatic Neoplasms
Quality of Life
Outcome Assessment (Health Care)
Demography
14 Citations (Scopus)
55 Downloads (Pure)

Quality of life in men living with advanced and localised prostate cancer in the UK a population-based study

Downing, A., Wright, P., Hounsome, L., Selby, P., Wilding, S., Watson, E., Wagland, R., Kind, P., Donnelly, D. W., Butcher, H., Catto, J. W. F., Cross, W., Mason, M., Sharp, L., Weller, D., Velikova, G., McCaughan, E., Mottram, R., Allen, M., Kearney, T. & 6 others, McSorley, O., Huws, D. W., Brewster, D. H., McNair, E., Gavin, A. & Glaser, A. W., 01 Mar 2019, In : Lancet Oncology. 20, 3, p. 436-447 12 p.

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
Quality of Life
Population
Androgens
Logistic Models
1 Downloads (Pure)

Radiation oncology : A clinical update from the north west cancer centre

Walls, G. M., Lyons, C., Jellett, L. J., Evans, R., Bedair, A., Brady, D., McLaughlin, L. M., Reilly, E., Reilly, A., McAleer, J. J. & Stewart, D. P., 01 May 2019, In : Ulster Medical Journal. 88, 2, p. 91-97 7 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
106 Downloads (Pure)

Radium-223 in asymptomatic patients with castration-resistant prostate cancer and bone metastases treated in an international early access program

Heidenreich, A., Gillessen, S., Heinrich, D., Keizman, D., O'Sullivan, J. M., Carles, J., Wirth, M., Miller, K., Reeves, J., Seger, M., Nilsson, S. & Saad, F., 07 Jan 2019, In : BMC Cancer. 19, 10 p., 12.

Research output: Contribution to journalArticle

Open Access
File
Radium
Bone Neoplasms
Castration
Prostatic Neoplasms
Neoplasm Metastasis
11 Citations (Scopus)
112 Downloads (Pure)

Randomized Phase II Study Evaluating Palbociclib in Addition to Letrozole as Neoadjuvant Therapy in Estrogen Receptor–Positive Early Breast Cancer: PALLET Trial

Johnston, S., Puhalla, S., Wheatley, D., Ring, A., Barry, P., Holcombe, C., Boileau, J. F., Provencher, L., Robidoux, A., Rimawi, M., McIntosh, S. A., Shalaby, I., Stein, R. C., Thirlwell, M., Dolling, D., Morden, J., Snowdon, C., Perry, S., Cornman, C., Batten, L. M. & 17 others, Jeffs, L. K., Dodson, A., Martins, V., Modi, A., Kent Osborne, C., Pogue-Geile, K. L., Cheang, M. C. U., Wolmark, N., Julian, T. B., Fisher, K., MacKenzie, M., Wilcox, M., Bartlett, C. H., Koehler, M., Dowsett, M., Bliss, J. M. & Jacobs, S. A., 20 Jan 2019, In : Journal of Clinical Oncology. 37, 3, p. 178-189 12 p.

Research output: Contribution to journalArticle

Open Access
File
letrozole
Neoadjuvant Therapy
Estrogens
Breast Neoplasms
Estrogen Receptors
48 Downloads (Pure)

Real-world insights into risk of developing cardiovascular disease following GnRH agonists versus antagonists for prostate cancer: a methodological protocol to a study using five European databases

George, G., Scailteux, L-M., Garmo, H., Balusson, F., Cardwell, C., Coster, G. D., Schutter, H. D., Kuiper, J. G., McMenamin, Ú., Verbeeck, J. & Van Hemelrijck, M., 18 Feb 2019, In : Fundamental & clinical pharmacology. 21 p.

Research output: Contribution to journalArticle

Open Access
File
Gonadotropin-Releasing Hormone
Prostatic Neoplasms
Cardiovascular Diseases
Databases
Hormone Antagonists
91 Downloads (Pure)

Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach

Craig, S., Anderson, L., Schache, A., Moran, M., Graham, L., Currie, K., Rooney, K., Robinson, M., Upile, N., Brooker, R., Mesri, M., Bingham, V., McQuaid, S., Jones, T., McCance, D., Salto-Tellez, M., McDade, S. & James, J., 20 Mar 2019, In : British Journal of Cancer.

Research output: Contribution to journalArticle

Open Access
File
Oropharyngeal Neoplasms
Guidelines
Squamous Cell Carcinoma
Survival
Immunohistochemistry
54 Downloads (Pure)

Regional Variations in Quality of Survival Among Men with Prostate Cancer Across the United Kingdom

Donnelly, D., Gavin, A., Downing, A., Hounsome, L., Kearney, T., McNair, E., Allan, D., Huws, D., Wright, P., Selby, P. J., Kind, P., Watson, E., Wagland, R., Wilding, S., Butcher, H., Mottram, R., Allen, M., McSorley, O., Linda, S., Mason, M. D. & 3 others, Cross, W. R., Catto, J. W. F. & Glaser, A. W., 01 Jul 2019, In : European Urology. 10 p.

Research output: Contribution to journalArticle

Open Access
File
Scotland
Prostatic Neoplasms
Northern Ireland
Survival
Wales

Regulators of A20 (TNFAIP3) - new drug-able targets in inflammation

Momtazi, G., Lambrecht, B. N., Naranjo, J. R. & Schock, B., 21 Feb 2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. L-00335-2018R1.

Research output: Contribution to journalArticle

Cystic Fibrosis
Chronic Obstructive Pulmonary Disease
Transcription Factors
Asthma
Inflammation
9 Citations (Scopus)
219 Downloads (Pure)

Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Non-Adherence in Severe Asthma

Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK), 15 Feb 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 4

Research output: Contribution to journalArticle

Open Access
File
Adrenal Cortex Hormones
Nitric Oxide
Asthma
Therapeutics
Technology

Repurposing of Cetuximab in antibody-directed chemotherapy-loaded nanoparticles in EGFR therapy-resistant pancreatic tumours

McDaid, W. J., Greene, M. K., Johnston, M. C., Pollheimer, E., Smyth, P., McLaughlin, K., Van Schaeybroeck, S., Straubinger, R. M., Longley, D. B. & Scott, C. J., 18 Oct 2019, In : Nanoscale. 13 p.

Research output: Contribution to journalArticle

Chemotherapy
Epidermal Growth Factor Receptor
Antibodies
Tumors
Nanoparticles
203 Downloads (Pure)

Resilience in medical doctors: a systematic review

McKinley, N., Karayanis, P. N., Convie, L., Clarke, M., Kirk, S. J. & Campbell, W. J., 29 Mar 2019, In : Postgraduate Medical Journal. 8 p., 136135.

Research output: Contribution to journalArticle

Open Access
File
Bibliographic Databases
Leisure Activities
PubMed
MEDLINE
Social Support