School of Medicine, Dentistry and Biomedical Sciences

  • 97 Lisburn Road, Health Sciences Building

    BT9 7BL Belfast

    United Kingdom

Research Output 1973 2020

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Review article
2017
5 Citations (Scopus)
138 Downloads (Pure)

Low-dose radiation-induced risk in spermatogenesis

Fukunaga, H., Butterworth, K. T., Yokoya, A., Ogawa, T. & Prise, K. M., 2017, In : International journal of radiation biology. 93, 12, p. 1291-1298 8 p.

Research output: Contribution to journalReview article

Open Access
File
Spermatogenesis
Radiation
Germ Cells
Fertility
Spermatozoa
9 Citations (Scopus)
84 Downloads (Pure)

Neutrophils as Components of Mucosal Homeostasis

Hall, C. H. T., Campbell, E. L. & Colgan, S. P., 01 Nov 2017, In : Cellular and Molecular Gastroenterology and Hepatology. 4, 3, p. 329-337 9 p.

Research output: Contribution to journalReview article

Open Access
File
Neutrophils
Homeostasis
Inflammation
Neutrophil Infiltration
Mucous Membrane
10 Citations (Scopus)

Personalised Medicine for Asthma and Chronic Obstructive Pulmonary Disease

Heaney, L. G. & McGarvey, L., Feb 2017, In : Respiration. 93, 3, p. 153-161 9 p.

Research output: Contribution to journalReview article

Precision Medicine
Chronic Obstructive Pulmonary Disease
Asthma
Biomarkers
Therapeutics
6 Citations (Scopus)
221 Downloads (Pure)

Phage Life Cycles Behind Bacterial Biodiversity

Olszak, T., Roszniowski, B., Latka, A., Valvano, M. A. & Drullis-Kawa, Z., 13 Apr 2017, In : Current medicinal chemistry. 24, 36, p. 3987-4001 15 p.

Research output: Contribution to journalReview article

Open Access
File
Biodiversity
Life Cycle Stages
Bacteriophages
Planets
Bacteria
1 Citation (Scopus)
239 Downloads (Pure)

Pharmacogenetic biomarkers of response in Crohn’s disease

Linares-Pineda, T., Canadas Garre, M. L., Sanchez-Pozo, A. & Calleja Hernandez, M. A., 20 Jun 2017, In : The pharmacogenomics journal. p. 1-13

Research output: Contribution to journalReview article

Open Access
File
Pharmacogenetics
Crohn Disease
Biomarkers
Interleukin-27
Interleukin-11
4 Citations (Scopus)

Pharmacological treatment for antipsychotic-related constipation

Every-Palmer, S., Newton-Howes, G. & Clarke, M. J., 24 Jan 2017, In : The Cochrane database of systematic reviews. 1, p. CD011128

Research output: Contribution to journalReview article

Constipation
Antipsychotic Agents
Pharmacology
Laxatives
Randomized Controlled Trials
7 Citations (Scopus)
108 Downloads (Pure)
Open Access
File
Biomarkers
RNA
Colorectal Neoplasms
Neoplasms
Paraffin
26 Citations (Scopus)
147 Downloads (Pure)

Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration

Kersten, E., Paun, C. C., Schellevis, R. L., Hoyng, C. B., Delcourt, C., Lengyel, I., Peto, T., Ueffing, M., Klaver, C. C. W., Dammeier, S., den Hollander, A. I. & de Jong, E. K., 15 May 2017, In : Survey of ophthalmology. 63

Research output: Contribution to journalReview article

Open Access
File
Macular Degeneration
Biomarkers
Lipid Metabolism
Oxidative Stress
Vitreous Body
39 Citations (Scopus)

Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges

MErCuRIC consortium, 04 Apr 2017, In : Nature reviews. Clinical oncology. 14, 9

Research output: Contribution to journalReview article

Hepatocyte Growth Factor
Biomarkers
Gastrointestinal Neoplasms
Neoplasms
Clinical Trials
220 Citations (Scopus)
70 Downloads (Pure)

The COMET Handbook: version 1.0

Williamson, P. R., Altman, D. G., Bagley, H., Barnes, K. L., Blazeby, J. M., Brookes, S. T., Clarke, M., Gargon, E., Gorst, S., Harman, N., Kirkham, J. J., McNair, A., Prinsen, C. A. C., Schmitt, J., Terwee, C. B. & Young, B., 20 Jun 2017, In : Trials. 18, Suppl 3, p. 280

Research output: Contribution to journalReview article

Open Access
File
Clinical Trials
Delivery of Health Care
Research
Decision Making
Public Health
19 Citations (Scopus)

The current and future role of biomarkers in type 2 cytokine-mediated asthma management

Pavord, I. D., Afzalnia, S., Menzies-Gow, A. & Heaney, L. G., Feb 2017, In : Clinical & Experimental Allergy. 47, 2, p. 148-160 13 p.

Research output: Contribution to journalReview article

Asthma
Biomarkers
Cytokines
Adrenal Cortex Hormones
Passive Immunization
44 Citations (Scopus)
156 Downloads (Pure)

The current evidence on statin use and prostate cancer prevention: are we there yet?

Alfaqih, M. A., Allott, E. H., Hamilton, R. J., Freeman, M. R. & Freedland, S. J., Feb 2017, In : Nature reviews. Urology. 14, 2, p. 107-119 13 p.

Research output: Contribution to journalReview article

Open Access
File
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Prostatic Neoplasms
Tertiary Prevention
Secondary Prevention
Neoplasms
1141 Downloads (Pure)

The Potential of Targeting DNA Repair Deficiency in Acute Myeloid Leukemia

Crean, C., Mills, K. I. & Savage, K. I., 28 Jul 2017, In : Journal of Cancer Therapy. 8, p. 691-698 8 p.

Research output: Contribution to journalReview article

Open Access
File
DNA Repair-Deficiency Disorders
Acute Myeloid Leukemia
DNA Repair
Leukocytes
Cell Count
2 Citations (Scopus)
267 Downloads (Pure)

The Role of Whey Acidic Protein Four-Disulfide-Core Proteins in Respiratory Health and Disease

Small, D. M., Doherty, D. F., Dougan, C. M., Weldon, S. & Taggart, C. C., 01 Apr 2017, In : Biological Chemistry. 398, 3, p. 425-440

Research output: Contribution to journalReview article

Open Access
File
Disulfides
Health
Elafin
Secretory Leukocyte Peptidase Inhibitor
Proteins
12 Citations (Scopus)
108 Downloads (Pure)

Tissue-based next generation sequencing: application in a universal healthcare system

Hynes, S. O., James, J. A., Maxwell, P. & Salto-Tellez, M., 28 Feb 2017, In : British Journal of Cancer. 116, 5, p. 553-560 8 p.

Research output: Contribution to journalReview article

Open Access
File
Delivery of Health Care
Precision Medicine
Neoplasms
Clinical Trials
Mutation
3 Citations (Scopus)
2756 Downloads (Pure)

Understanding Acid-Base Disorders

Maxwell, A., Hamilton, P. K., Connolly, G. M. & Morgan, N., 2017, In : The Ulster Medical Journal. 86, p. 161-166

Research output: Contribution to journalReview article

Open Access
File
Acids
Clinical Medicine
Medical Staff
Therapeutics
2016
10 Citations (Scopus)
97 Downloads (Pure)

Accessible Home Environments for People with Functional Limitations: A Systematic Review

Cho, H. Y., MacLachlan, M., Clarke, M. & Mannan, H., 17 Aug 2016, In : International Journal of Environmental Research and Public Health. 13, 8, 826.

Research output: Contribution to journalReview article

Open Access
File
Policy Making
Health
MEDLINE
Meta-Analysis
Decision Making
11 Citations (Scopus)

Asthma control and exacerbations: two different sides of the same coin. two different sides of the same coin

Heaney, L. G. & Brisk, R., Jan 2016, In : Current Opinon in Pulmonary Medicine. 22, 1, p. 32-37 6 p.

Research output: Contribution to journalReview article

Numismatics
Asthma
Biomarkers
Adrenal Cortex Hormones
Inflammation
26 Citations (Scopus)
91 Downloads (Pure)

Choosing Important Health Outcomes for Comparative Effectiveness Research: An Updated Review and Identification of Gaps

Gorst, S. L., Gargon, E., Clarke, M., Smith, V. & Williamson, P. R., 14 Dec 2016, In : PloS one. 11, 12, 14 p., e0168403.

Research output: Contribution to journalReview article

Open Access
File
Comparative Effectiveness Research
Health
Databases
Outcome Assessment (Health Care)
Delphi Technique
65 Citations (Scopus)
85 Downloads (Pure)

Choosing Important Health Outcomes for Comparative Effectiveness Research: An Updated Review and User Survey

Gorst, S. L., Gargon, E., Clarke, M., Blazeby, J. M., Altman, D. G. & Williamson, P. R., 19 Jan 2016, In : PloS one. 11, 1, 12 p., e0146444.

Research output: Contribution to journalReview article

Open Access
File
Comparative Effectiveness Research
Outcome Assessment (Health Care)
Health
Websites
clinical trials
41 Citations (Scopus)
222 Downloads (Pure)

Compression stockings for preventing deep vein thrombosis in airline passengers

Clarke, M. J., Broderick, C., Hopewell, S., Juszczak, E. & Eisinga, A., 14 Sep 2016, In : The Cochrane database of systematic reviews. 9, p. CD004002

Research output: Contribution to journalReview article

Open Access
File
Compression Stockings
Venous Thrombosis
Leg
Edema
Information Services
38 Citations (Scopus)
95 Downloads (Pure)

Core outcome sets and systematic reviews

Clarke, M. & Williamson, P. R., 20 Jan 2016, In : Systematic Reviews. 5, 11, p. 11 4 p.

Research output: Contribution to journalReview article

Open Access
File
Research
Delivery of Health Care
Health
81 Downloads (Pure)

Diagnosing dementia

Kane, J. PM., Richardson, S., Allan, L. & Thomas, A., 13 Feb 2016, In : British Journal of Hospital Medicine. 77, 2, p. C22, C24-5

Research output: Contribution to journalReview article

Open Access
File
11 Citations (Scopus)

Dual roles of DNA repair enzymes in RNA biology/post-transcriptional control

Vohhodina, J., Harkin, D. P. & Savage, K. I., Oct 2016, In : Wiley interdisciplinary reviews. RNA. 7, 5, p. 604-619

Research output: Contribution to journalReview article

DNA Repair Enzymes
DNA Repair
Repair
RNA
DNA
15 Citations (Scopus)
316 Downloads (Pure)

Fiducial Marker Guided Prostate Radiotherapy: A Review

O'Neill, A. GM., Jain, S., Hounsell, A. R. & O'Sullivan, J. M., 23 Sep 2016, In : British Journal of Radiology. 89

Research output: Contribution to journalReview article

Open Access
File
Fiducial Markers
Prostate
Radiotherapy
Image-Guided Radiotherapy
Anatomy
103 Citations (Scopus)
355 Downloads (Pure)

Gold nanoparticles for cancer radiotherapy: a review.

Haume, K., Rosa, S., Grellet, S., Śmiałek, M. A., Butterworth, K. T., V. Solov’yov, A., Prise, K. M., Golding, J. & Mason, N. J., 03 Nov 2016, In : Cancer Nanotechnology. 7, 8, 20 p.

Research output: Contribution to journalReview article

Open Access
File
Radiotherapy
Gold
Nanoparticles
radiation therapy
cancer
1 Citation (Scopus)
Cystic Fibrosis
Therapeutics
Comparative Effectiveness Research
Dry Powder Inhalers
Costs and Cost Analysis
31 Citations (Scopus)

Improving the relevance and consistency of outcomes in comparative effectiveness research

Tunis, S. R., Clarke, M., Gorst, S. L., Gargon, E., Blazeby, J. M., Altman, D. G. & Williamson, P. R., Mar 2016, In : Journal of comparative psychology (Washington, D.C. : 1983). 5, 2, p. 193-205 13 p.

Research output: Contribution to journalReview article

Patient Outcome Assessment
Comparative Effectiveness Research
Administrative Personnel
Health Care Costs
Clinical Trials
3 Citations (Scopus)
242 Downloads (Pure)

In patients with shortened dental arches do removable dental prostheses improve masticatory performance?

Moore, C. & McKenna, G., 16 Dec 2016, In : Evidence-based dentistry. 17, 4, 1 p.

Research output: Contribution to journalReview article

Open Access
File
Dental Prosthesis
Dental Arch
Mastication
Artificial Teeth
Library Science
23 Citations (Scopus)
198 Downloads (Pure)

IRS proteins and diabetic complications

Lavin, D. P., White, M. F. & Brazil, D. P., Nov 2016, In : Diabetologia. 59, 11, p. 2280-2291 12 p.

Research output: Contribution to journalReview article

Open Access
File
Diabetes Complications
Insulin
Type 2 Diabetes Mellitus
Proteins
1-Phosphatidylinositol 4-Kinase
1 Citation (Scopus)

Lost in translation: Review of identification bias, translation bias and research waste in dentistry

Layton, D. M. & Clarke, M., Jan 2016, In : Dental Materials. 32, 1, p. 26-33 8 p.

Research output: Contribution to journalReview article

Dentistry
Research
Bibliographic Databases
Tooth
Survival Analysis
8 Citations (Scopus)

MiRNA 34a: a therapeutic target for castration-resistant prostate cancer

Chalanqui, M. J., O'Doherty, M., Dunne, N. J. & McCarthy, H. O., 28 Mar 2016, In : Expert Opinion on Therapeutic Targets. 20, 9, p. 1075-1085 11 p.

Research output: Contribution to journalReview article

Castration
Prostatic Neoplasms
Bone
Bone and Bones
Therapeutics
34 Citations (Scopus)
110 Downloads (Pure)

Prognostic models in acute pulmonary embolism: a systematic review and meta-analysis

Elias, A., Mallett, S., Daoud-Elias, M., Poggi, J-N. & Clarke, M., 29 Apr 2016, In : BMJ Open. 6, 4, 28 p., e010324.

Research output: Contribution to journalReview article

Open Access
File
Pulmonary Embolism
Meta-Analysis
Literature
MEDLINE
Libraries
39 Downloads (Pure)

Questions and controversies in innate immune research: what is the physiological role of NLRP3?

Coll, RC., O’Neill, LAJ. & Schroder, K., 04 Apr 2016, In : Cell death discovery.

Research output: Contribution to journalReview article

Open Access
File

Systematic review and meta-analysis of the association between mumps during childhood and risk of type 1 diabetes mellitus

Saad, H. A., Patterson, C. C. & Cardwell, C. R., 01 Oct 2016, In : Journal of pediatric endocrinology & metabolism : JPEM. 29, 10, p. 1123-1128 6 p.

Research output: Contribution to journalReview article

Mumps
Type 1 Diabetes Mellitus
Meta-Analysis
Odds Ratio
Confidence Intervals
14 Citations (Scopus)
87 Downloads (Pure)

The European Cancer Patient's Bill of Rights, update and implementation 2016

European Cancer Concord (ECC), 01 Dec 2016, In : ESMO Open. 1, 6, e000127.

Research output: Contribution to journalReview article

Open Access
File
Patient Rights
Neoplasms
Practice Guidelines
Delivery of Health Care
Research
2015
59 Citations (Scopus)
316 Downloads (Pure)

Accuracy of LightCycler(®) SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis

Dark, P., Blackwood, B., Gates, S., McAuley, D., Perkins, G. D., McMullan, R., Wilson, C., Graham, D., Timms, K. & Warhurst, G., Jan 2015, In : Intensive Care Medicine. 41, 1, p. 21-33 13 p.

Research output: Contribution to journalReview article

Open Access
File
Meta-Analysis
Sepsis
Sensitivity and Specificity
Computer Systems
Routine Diagnostic Tests

Ageing and the immune system: focus on macrophages

Linehan, E. & Fitzgerald, D. C., 2015, In : European Journal of Microbiology and Immunology. 5, 1, p. 14-24 11 p.

Research output: Contribution to journalReview article

Immune System
Macrophages
Population
Toll-Like Receptors
Health
49 Citations (Scopus)

A review of recent advances in optical fibre sensors for in vivo dosimetry during radiotherapy

O'Keeffe, S., McCarthy, D., Woulfe, P., Grattan, M. W. D., Hounsell, A. R., Sporea, D., Mihai, L., Vata, I., Leen, G. & Lewis, E., 01 Jun 2015, In : British Journal of Radiology. 88, 1050, 20140702.

Research output: Contribution to journalReview article

Optical Fibers
Radiotherapy
Electromagnetic Phenomena
Brachytherapy
Needles
48 Citations (Scopus)

BRCA1, a 'complex' protein involved in the maintenance of genomic stability

Savage, K. I. & Harkin, D. P., Feb 2015, In : The FEBS Journal. 282, 4, p. 630-646 17 p.

Research output: Contribution to journalReview article

Genomic Instability
Tumors
Maintenance
Cell Cycle Checkpoints
DNA Repair
6 Citations (Scopus)
121 Downloads (Pure)

Genes and life-style factors in BELFAST nonagenarians: Nature, Nurture and Narrative

Rea, J. N. M., Carvalho, A., McNerlan, S. E., Alexander, H. D. & Rea, I. M., Oct 2015, In : Biogerontology. 16, 5, p. 587-97 11 p.

Research output: Contribution to journalReview article

Open Access
File
Life Style
Genes
Personal Narratives
Behavioral Genetics
Social Behavior
67 Citations (Scopus)

Obesity and cancer: mechanistic insights from transdisciplinary studies

Allott, E. H. & Hursting, S. D., 01 Dec 2015, In : Endocrine-Related Cancer. 22, 6, p. R365-R386

Research output: Contribution to journalReview article

Open Access
Obesity
Neoplasms
Prostatic Neoplasms
Breast Neoplasms
Weight Loss
3 Citations (Scopus)

Optimising the management of bronchiolitis in infants

McNaughten, B. & Bourke, T. W., 31 Oct 2015, In : The Practitioner. 259, 1784, p. 13-5, 2

Research output: Contribution to journalReview article

Bronchiolitis
Work of Breathing
Tachypnea
Auscultation
Secondary Care
7 Citations (Scopus)
341 Downloads (Pure)
Open Access
File
Metal Nanoparticles
Prostatic Neoplasms
Radiotherapy
Image-Guided Radiotherapy
Neoplasms
47 Citations (Scopus)
696 Downloads (Pure)

Research in Progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

Heaney, L. G., Djukanovic, R., Woodcock, A., Walker, S., Matthews, J. G., Pavord, I. D., Bradding, P., Niven, R., Brightling, C. E., Chaudhuri, R., Arron, J. R., Choy, D. F., Cowan, D., Mansur, A., Menzies-Gow, A., Adcock, I., Chung, K. F., Corrigan, C., Coyle, P., Harrison, T. & 16 others, Johnston, S., Howarth, P., Lordan, J., Sabroe, I., Bigler, J., Smith, D., Catley, M., May, R., Pierre, L., Stevenson, C., Crater, G., Keane, F., Costello, R. W., Hudson, V., Supple, D. & Hardman, T., 23 Jul 2015, In : Thorax. 71, 2, p. 1587-189 3 p.

Research output: Contribution to journalReview article

Open Access
File
Biomedical Research
Asthma
Research
Drug Industry
Biomarkers

The human Nail apparatus - An update on anatomy, pathology and treatment

Loeser, C. R., Reid, L., Reeves, N., Sweeney, E. M. & Cotofana, S., 01 Jan 2015, In : Kosmetische Medizin. 36, 5, p. 184-191 8 p.

Research output: Contribution to journalReview article

Nails
Anatomy
Pathology
Therapeutics
Esthetics
44 Citations (Scopus)
334 Downloads (Pure)

The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung

Twigg, M. S., Brockbank, S., Lowry, P., FitzGerald, S. P., Taggart, C. & Weldon, S., 2015, In : Mediators of Inflammation. 2015, 293053.

Research output: Contribution to journalReview article

Open Access
File
Serine Proteases
Protease Inhibitors
Cystic Fibrosis
Neutrophils
Lung
5 Citations (Scopus)
676 Downloads (Pure)

The utility of animal models in developing immunosuppressive agents

McDaid, J., Scott, C. J., Kissenpfennig, A., Chen, H. & Martins, P. N., 15 Jul 2015, In : European Journal of Pharmacology. 759, p. 295-302 8 p.

Research output: Contribution to journalReview article

File
Immunosuppressive Agents
Animal Models
Autoimmune Diseases
Psychological Stress
Pharmaceutical Preparations
2014
14 Citations (Scopus)

Biological therapies in the acute respiratory distress syndrome

Boyle, A. J., McNamee, J. J. & McAuley, D. F., Jul 2014, In : Expert Opinion on Biological Therapy. 14, 7, p. 969-81

Research output: Contribution to journalReview article

Gene therapy
Biological Therapy
Adult Respiratory Distress Syndrome
Coagulation
Stem cells
31 Citations (Scopus)

Motion Management for Radical Radiotherapy in Non-small Cell Lung Cancer

Cole, A. J., Hanna, G. G., Jain, S. & O'Sullivan, J., Feb 2014, In : Clinical oncology (Royal College of Radiologists (Great Britain)). 26, 2, p. 67-80 14 p.

Research output: Contribution to journalReview article

Non-Small Cell Lung Carcinoma
Radiotherapy
Neoplasms
Image-Guided Radiotherapy
Lung