• 97 Lisburn Road, Medical Biology Centre

    BT9 7BL Belfast

    United Kingdom

Research Output 1978 2020

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Article
2019
2 Citations (Scopus)

3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery

Economidou, S. N., Pere, C. P. P., Reid, A., Uddin, M. J., Windmill, J. F. C., Lamprou, D. & Douroumis, D., 22 Apr 2019, In : Materials Science and Engineering C: Materials for Biological Applications.

Research output: Contribution to journalArticle

Stereolithography
insulin
Insulin
delivery
lithography
Open Access
File
Plasma Gases
Acinetobacter baumannii
Biofilms
Biomass
Acinetobacter Infections

A Direct Compression Matrix Made from Xanthan Gum and Low Molecular Weight Chitosan Designed to Improve Compressibility in Controlled Release Tablets

Abu Fara, D., Dadou, S., Antonijevic, M., Chowdhry, B. Z. & Badwan, A. A., 12 Nov 2019, In : Pharmaceutics. 11, 11, 24 p., 603.

Research output: Contribution to journalArticle

Open Access
File
Chitosan
Tablets
Molecular Weight
Dyphylline
Polymers

A general protein O-glycosylation machinery conserved in Burkholderia species improves bacterial fitness and elicits glycan immunogenicity in humans

Mohamed, Y. F., Scott, N. E., Molinaro, A., Creuzenet, C., Ortega, X., Lertmemongkolchai, G., Tunney, M. M., Green, H., Jones, A. M., DeShazer, D., Currie, B. J., Foster, L. J., Ingram, R., De Castro, C. & Valvano, M. A., 26 Jul 2019, In : The Journal of biological chemistry.

Research output: Contribution to journalArticle

Open Access
File
Burkholderia
Glycosylation
Machinery
Polysaccharides
Burkholderia cenocepacia
Open Access
File
Bombesin
Smooth Muscle
Muscle
Rats
Skin

Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications

Hill, M., Twigg, M., Sheridan, E. A., Hardy, J. G., Elborn, J. S., Taggart, C. C., Scott, C. J. & Migaud, M. E., 02 Aug 2019, In : Pharmaceutics. 11, 8, 12 p., 379.

Research output: Contribution to journalArticle

Open Access
File
Tobramycin
Chitosan
Mucus
Drug Delivery Systems
Cystic Fibrosis

All-cause pneumonia in children after the introduction of pneumococcal vaccines in the United Kingdom: A population-based study.

Lau, W. C. Y., Bielicki, J., Tersigni, C., Saxena, S., Wong, I. C. K., Sharland, M. & Hsia, Y., 16 Apr 2019, In : Pharmacoepidemiology and Drug Safety.

Research output: Contribution to journalArticle

Open Access
File
Bradykinin
Anura
Smooth Muscle
Muscle
Skin
Open Access
File
Tarsiidae
Skin
Cells
Cell membranes
Microorganisms

A Novel Kunitzin-Like Trypsin Inhibitor Isolated from Defensive Skin Secretion of Odorrana versabilis

Dong, Y., Shi, D., Ying, Y., Xi, X., Chen, X., Wang, L., Zhou, M., Wu, Q., Ma, C. & Chen, T., 28 Jun 2019, In : Biomolecules. 9, 7, 14 p., 254.

Research output: Contribution to journalArticle

Open Access
File
Trypsin Inhibitors
Trypsin
Skin
Peptides
Bamboo
3 Citations (Scopus)
Methicillin Resistance
Methicillin
Cystic Fibrosis
Anura
Skin
1 Citation (Scopus)

A novel Pt(IV) mono azido mono triazolato complex evolves azidyl radicals following irradiation with visible light

Yao, K., Bertran, A., Morgan, J., Hare, S. M., Rees, N. H., Kenwright, A. M., Edkins, K., Bowen, A. M. & Farrer, N. J., 23 Apr 2019, In : Dalton transactions (Cambridge, England : 2003).

Research output: Contribution to journalArticle

Open Access
File
Guanosine Monophosphate
Nuclear magnetic resonance
Irradiation
Cycloaddition
X ray crystallography

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

Wilkinson, R., Burden, R., McDowell, S., McArt, D., McQuaid, S., Bingham, V., Williams, R., Cox, O., O'Connor, R., McCabe, N., Kennedy, R., Buckley, N. E. & Scott, C., 28 Jun 2019, In : Journal of Oncology.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Triple Negative Breast Neoplasms
Biomarkers
Neoplasms
DNA Repair
9 Citations (Scopus)

Antioxidant PLA Composites Containing Lignin for 3D Printing Applications: A Potential Material for Healthcare Applications

Dominguez Robles, J., Martin, N. K., Fong, M. L., Stewart, S. A., Irwin, N. J., Rial-Hermida, M. I., Donnelly, R. F. & Larraneta Landa, E., 04 Apr 2019, In : Pharmaceutics. 11, 4, 14 p., 165.

Research output: Contribution to journalArticle

Open Access
File
Lignin
Antioxidants
Delivery of Health Care
Curcumin
Castor Oil
Open Access
File
Polypharmacy
Medication Adherence
Primary Health Care
Pharmacies
Pharmacists

Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution

Cen, Y., Singh, W., Arkin, M., Moody, T. S., Huang, M., Zhou, J., Wu, Q. & Reetz, M. T., 19 Jul 2019, In : Nature Communications. 10, 10 p., 3198 .

Research output: Contribution to journalArticle

Open Access
File
cysteine
Lipase
Cysteine
enzymes
Antarctic regions
1 Citation (Scopus)

A spectroscopic and thermal investigation into the relationship between composition, secondary structure and physical characteristics of electrospun zein nanofibers

Wang, Y. H., Zhao, M., Barker, S. A., Belton, P. S. & Craig, D. Q. M., 01 May 2019, In : Materials Science and Engineering C. 98, p. 409-418 10 p.

Research output: Contribution to journalArticle

Zein
Nanofibers
fibers
Fibers
Chemical analysis
1 Citation (Scopus)
Cystic Fibrosis
Sputum
Biota
Microbiota
Logistic Models
Viscoelasticity
Carbohydrates
Polymers
Analysis of variance (ANOVA)
Pharmaceutical Preparations
Open Access
File
Vision Disorders
Pharmacists
Medicine
Pharmaceutical Services
Literature
Plasma Gases
Pseudomonas aeruginosa
Lipopolysaccharides
Gram-Negative Bacteria
Virulence
Size exclusion chromatography
Gel Chromatography
Fluorescence
Macular Degeneration
Intravitreal Injections
1 Citation (Scopus)

Bioevaluation of Ranatuerin-2Pb from the Frog Skin Secretion of Rana pipiens and Its Truncated Analogues

Zhou, X., Shi, D., Zhong, R., Ye, Z., Ma, C., Zhou, M., Xi, X., Wang, L., Chen, T. & Kwok, H. F., 25 Jun 2019, In : Biomolecules. 9, 6, 15 p., 249.

Research output: Contribution to journalArticle

Open Access
File
Rana pipiens
Anura
Skin
Peptides
Staphylococcus aureus
2 Citations (Scopus)

Biological Performance of Electrospun Polymer Fibres

Hall Barrientos, I. J., MacKenzie, G. R., Wilson, C. G., Lamprou, D. A. & Coats, P., 24 Jan 2019, In : Materials. 12, 3, 13 p., 363.

Research output: Contribution to journalArticle

Open Access
File
Scaffolds
Polymers
Collagen
Polycaprolactone
Cell adhesion

Boiling Licorice Produces Self-assembled Protein Nanoparticles: A Novel Source of Bioactive Nanomaterials

Zhou, J., Zhang, J., Gao, G., Wang, H., He, X., Chen, T., Ke, L., Rao, P. & Wang, Q., 24 Jul 2019, In : Journal of Agricultural and Food Chemistry.

Research output: Contribution to journalArticle

Glycyrrhiza
licorice
nanomaterials
Nanostructures
nanoparticles
Open Access
File
Memantine
Cholinesterase Inhibitors
Caregivers
Dementia
Practice Guidelines

Casein nanoparticles in combination with 2-hydroxypropyl-β-cyclodextrin improves the oral bioavailability of quercetin

Peñalva, R., Esparza, I., Morales-Gracia, J., González-Navarro, C. J., Larrañeta, E. & Irache, J. M., 30 Oct 2019, In : International Journal of Pharmaceutics. 570, 8 p., 118652.

Research output: Contribution to journalArticle

Quercetin
Caseins
Nanoparticles
Biological Availability
Flavonoids

Cell-Penetrating Peptides as a Tool for the Cellular Uptake of a Genetically Modified Nitroreductase for use in Directed Enzyme Prodrug Therapy

Anderson, S. D., Hobbs, R. J., Gwenin, V. V., Ball, P., Bennie, L. A., Coulter, J. A. & Gwenin, C. D., 01 Oct 2019, In : Journal of Functional Biomaterials. 10, 4

Research output: Contribution to journalArticle

Nitroreductases
Cell-Penetrating Peptides
Prodrugs
Peptides
Enzymes
1 Citation (Scopus)
Open Access
File
Transaminases
Salts
Enzymes
Haloferax volcanii
Biocatalysis

Cloning of a Novel Trypsin Inhibitor from the Traditional Chinese Medicine Decoction Pieces, Radix Trichosanthis

Sang, M., Ying, Y., Wu, Q., Ma, C., Xi, X., Zhou, M., Wang, L., Bininda-Emonds, O. & Chen, T., 01 Mar 2019, In : Analytical Biochemistry.

Research output: Contribution to journalArticle

Trypsin Inhibitors
Cloning
Chinese Traditional Medicine
Medicine
Organism Cloning
1 Citation (Scopus)

Community analysis and co-occurrence patterns in airway microbial communities during health and disease

Einarsson, G. G., Zhao, J., LiPuma, J. J., Downey, D. G., Tunney, M. M. & Elborn, J. S., 08 Jul 2019, In : ERJ Open. 5, 3, 11 p., 00128-2017.

Research output: Contribution to journalArticle

Open Access
File
Microbiota
Health
Bacteria
Chronic Disease
Burkholderia cepacia complex
Open Access
File
Zearalenone
Aflatoxin B1
Mycotoxins
Animals
T-2 Toxin

Composition of the airway bacterial community correlates with chest HRCT in adults with bronchiectasis

O'Neill, K., Einarsson, G., Rowan, S., McIlreavey, L., Lee, A., Lawson, J., Lynch, T., Horsley, A., Bradley, J., Elborn, J. & Tunney, M., 30 Jul 2019, In : Respirology.

Research output: Contribution to journalArticle

Bronchiectasis
Thorax
Tomography
rRNA Genes
Spirometry
2 Citations (Scopus)
Open Access
File
Klebsiella Infections
Klebsiella pneumoniae
Gentamicins
Bacterial Infections
Lymphoid Tissue
Female Contraceptive Devices
Plastics
Injections
Pharmaceutical Preparations
Polyurethanes

Deciduous DPSCs Ameliorate MPTP-Mediated Neurotoxicity, Sensorimotor Coordination and Olfactory Function in Parkinsonian Mice

Simon, C., Gan, Q. F., Kathivaloo, P., Mohamad, N. A., Dhamodharan, J., Krishnan, A., Sengodan, B., Palanimuthu, V. R., Marimuthu, K., Rajandas, H., Ravichandran, M. & Parimannan, S., 29 Jan 2019, In : International journal of molecular sciences. 20, 3, 13 p., 568.

Research output: Contribution to journalArticle

Open Access
File
Dental Pulp
Deciduous Tooth
stem cells
Stem cells
neurons

Defining the molecular evolution of extrauterine high grade serous carcinoma

Beirne, J. P., McArt, D. G., Roddy, A., McDermott, C., Ferris, J., Buckley, N. E., Coulter, P., McCabe, N., Eddie, S. L., Dunne, P. D., O'Reilly, P., Gilmore, A., Feeney, L., Ewing, D. L., Drapkin, R. I., Salto-Tellez, M., Kennedy, R. D., Harley, I. J. G., McCluggage, W. G. & Mullan, P. B., 04 Sep 2019, In : Gynecologic Oncology. 155, 2, p. 305-317 13 p.

Research output: Contribution to journalArticle

Molecular Evolution
Carcinoma
Fallopian Tubes
Carcinoma in Situ
Epithelium
1 Citation (Scopus)

Degradation kinetics of cold plasma-treated antibiotics and their antimicrobial activity

Sarangapani, C., Ziuzina, D., Behan, P., Boehm, D., Gilmore, B. F., Cullen, P. J. & Bourke, P., 08 Mar 2019, In : Scientific Reports. 9, 15 p., 3955.

Research output: Contribution to journalArticle

Open Access
File
Plasma Gases
Anti-Bacterial Agents
Ciprofloxacin
Waste Water
Ofloxacin
3 Citations (Scopus)

Design, Formulation, and Evaluation of Novel Dissolving Microarray Patches Containing Rilpivirine for Intravaginal Delivery

McCrudden, M., Larrañeta, E., Clark, A., Jarrahian, C., Rein-Weston, A., Creelman, B., Moyo, Y., Lachau-Durand, S., Niemeijer, N., Williams, P., McCarthy, H. O., Zehrung, D. & Donnelly, R. F., 06 Mar 2019, In : Advanced Healthcare Materials. 0, 0, p. 1801510 1 p.

Research output: Contribution to journalArticle

Open Access
File
Rilpivirine
Microarrays
Delivery of Health Care
Skin
Intramuscular Injections
Open Access
File
olanzapine
Solubility
Pharmaceutical Preparations
Propylene Glycol
Skin
Open Access
File
Cystic Fibrosis
Dimyristoylphosphatidylcholine
Derivatives
Peptides
Hydrophobicity
2 Citations (Scopus)

Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES

McBride, J. W., Malcolm, R. K., Dias, N., Cameron, D., Offord, R. E., Hartley, O., Kett, V. L., Devlin, B. & Boyd, P., 10 Jun 2019, In : International Journal of Pharmaceutics. 564, p. 207-213 7 p.

Research output: Contribution to journalArticle

Female Contraceptive Devices
Anti-Infective Agents
Pharmacokinetics
Silicone Elastomers
HIV

Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor

Miao, Y., Chen, G., Xi, X., Ma, C., Wang, L., Burrows, J. F., Duan, J., Zhou, M. & Chen, T., 14 Jul 2019, In : Biomolecules. 9, 7, 13 p., 280.

Research output: Contribution to journalArticle

Open Access
File
Protease Inhibitors
Peptides
Trypsin
Skin
Lysine

Dissolving Microneedles for Intradermal Vaccination against Shigellosis

Pastor, Y., Larrañeta, E., Erhard, Á., Quincooces, G., Peñuelas, I., Irache, J. M., Donnelly, R. & Gamazo, C., 24 Oct 2019, In : Vaccines. 7, 4

Research output: Contribution to journalArticle

Open Access
File
Bacillary Dysentery
Immunization
Vaccination
Skin
Antigens

DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen

Cole, G., Ali, A. A., McErlean, E., Mulholland, E. J., Short, A., McCrudden, C. M., McCaffrey, J., Robson, T., Kett, V. L., Coulter, J. A., Dunne, N. J., Donnelly, R. F. & McCarthy, H. O., 09 Jul 2019, In : Acta Biomaterialia.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Antigens
Stem cells
Nanoparticles
Tumors
3 Citations (Scopus)
Female Contraceptive Devices
Drug Stability
Appointments and Schedules
Lubricants
Phase III Clinical Trials
3 Citations (Scopus)

Effect of soil horizon stratigraphy on the microbial ecology of alpine paleosols

Young, J. M., Skvortsov, T., Kelleher, B. P., Mahaney, W. C., Somelar, P. & Allen, C. C. R., 20 Mar 2019, In : Science of the Total Environment. 657, p. 1183-1193

Research output: Contribution to journalArticle

Open Access
File
Stratigraphy
microbial ecology
Ecology
soil horizon
paleosol

Effects of Antibiotic Cycling Policy on Incidence of Healthcare-Associated MRSA and Clostridioides difficile Infection in Secondary Healthcare Settings

Conlon-Bingham, G. M., Aldeyab, M., Scott, M., Kearney, M. P., Farren, D., Gilmore, F. & McElnay, J., 01 Jan 2019, In : Emerging Infectious Disease journal. 25, 1, p. 52-62 11 p.

Research output: Contribution to journalArticle

Open Access
File
Methicillin-Resistant Staphylococcus aureus
Coinfection
Anti-Bacterial Agents
Delivery of Health Care
Amoxicillin-Potassium Clavulanate Combination

Effects of TAT-SOD at Acupoints on Essential Hypertension by Monitoring Meridians Electrical Potential

Guo, J., Xu, J., Chen, T., Xu, M., Liu, S., Zhang, C., Ke, L., Zhou, J., Wang, Q. & Rao, P-F., 15 Oct 2019, In : Chinese journal of integrative medicine. 7 p.

Research output: Contribution to journalArticle

Meridians
Acupuncture Points
Blood Pressure
Superoxides
Essential Hypertension
1 Citation (Scopus)

Elucidation of the Controlled-Release Behavior of Metoprolol Succinate from Directly Compressed Xanthan Gum/Chitosan Polymers: Computational and Experimental Studies

Dadou, S. M., El-Barghouthi, M. I., Antonijevic, M. D., Chowdhry, B. Z. & Badwan, A. A., 28 Mar 2019, In : ACS Biomaterials Science and Engineering.

Research output: Contribution to journalArticle

Xanthan gum
Metoprolol
Chitosan
Polymers
Tablets