• Room 01.009 - CCRCB

    United Kingdom

Accepting PhD Students

PhD projects

Open to PhD applications in the fields of: - chromatin remodelers - epigenetics - cancer metastasis - proteomics - molecular cell biology - biochemistry

19982017

Research output per year

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Personal profile

Research Statement

Chromatin reprogramming and cancer metastasis.

Epithelial-to-Mesenchymal transition (EMT) is a reversible and dynamic process proposed to be co-opted by cancer cells during disease progression, metastasis and therapeutic recalcitrance. Control of the EMT program is orchestrated by a set of master regulators that form an integrated transcriptional network with extensive cross-regulation. Several studies have also suggested that EMT relies on the modulation of chromatin remodelers and epigenetic regulatory mechanisms which remain poorly understood. Modulation of chromatin structure are crucial for cell-type specific activation or repression of gene transcription.

We previously showed that chromatin reprogramming occurred during EMT while targeting a subset of EMT master regulators in oral cancer (Mohd-Sarip et al., 2017, Cell Reports). The hypothesis is that Nucleosome remodeling and histone deacetylase (NuRD) complex triggers dynamic epigenetic changes leading to EMT-MET in specific cancers.

To understand the dynamics of chromatin modifiers as a central mechanism underlying tumour development and progression; which is very often paired to the study of epigenetic properties where patterns vary from cancer cell-type to cell-type, it is pertinent to address the impact of chromatin during cancer metastasis. By taking an unbiased proteomics, epigenomics, state-of-the-art microscopy, chromatin-, molecular-, cell-biology and biochemistry-based approaches, novel partners and targets of the NuRD complex will be identified during cellular (de-)differentiation, with a focus on metastasis and EMT-MET.

Teaching

Year 3 BSc Biomedical Science_BMS3109_Clinical Biochemistry – Acid base regulation

Year 2 BSc Biomedical Science_Clinical Genetics - Chromatin remodelling and epigenetic modifiers as therapeutic targets

MRes (PGT) Translational Medicine_SCM8065_Cancer Biology – Epigenetics and Cancer

MSc (PGT) Cancer Medicine & Molecular Pathology of Cancer_SCM 8065/8121_Cancer Biology – Epigenetics and Cancer

Year 1 Medicine_SSC Genomic Impact in Medicine - Chromatin remodelling and epigenetic modifiers as therapeutic targets

Year 1 Medicine_SSC Mechanisms of Metastasis

 

Other

Eager to support and host fellowship applications for postdoc and PhD.

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Research Output

DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition in Oral Cancer Cells

Mohd-Sarip, A., Teeuwssen, M., Bot, A. G., De Herdt, M. J., Willems, S. M., Baatenburg de Jong, R. J., Looijenga, L. H. J., Zatreanu, D., Bezstarosti, K., van Riet, J., Oole, E., van Ijcken, W. F. J., van de Werken, H. J. G., Demmers, J. A., Fodde, R. & Verrijzer, C. P., 05 Jul 2017, In : Cell Reports. 20, 1, p. 61-75

Research output: Contribution to journalArticle

Open Access
File
  • 14 Citations (Scopus)
    268 Downloads (Pure)

    dRYBP counteracts chromatin-dependent activation and repression of transcription

    Fereres, S., Simón, R., Mohd-Sarip, A., Verrijzer, C. P. & Busturia, A., 21 Nov 2014, In : PLoS ONE. 9, 11, 17 p., e113255.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 10 Citations (Scopus)
    216 Downloads (Pure)

    Nucleotide Biosynthetic Enzyme GMP Synthase Is a TRIM21-Controlled Relay of p53 Stabilization

    Reddy, B. A., vanderKnaap, J. A., Bot, A. G. M., Mohd-Sarip, A., Dekkers, D. H. W., Timmermans, M. A., Martens, J. W. M., Demmers, J. A. & Verrijzer, C. P., 06 Feb 2014, In : Molecular Cell. 53, 3, p. 458-470 13 p.

    Research output: Contribution to journalArticle

  • 47 Citations (Scopus)

    Transcription-independent function of polycomb group protein PSC in cell cycle control

    Tielenius Kruythoff-Mohd Sarip, A., Lagarou, A., Doyen, C. M., Van Der Knaap, J. A., Aslan, Ü., Bezstarosti, K., Yassin, Y., Brock, H. W., Demmers, J. A. & Verrijzer, C. P., 11 May 2012, In : Science. 336, 6082, p. 744-747 4 p.

    Research output: Contribution to journalArticle

  • 22 Citations (Scopus)

    dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing

    Lagarou, A., Tielenius Kruythoff-Mohd Sarip, A., Moshkin, Y. M., Chalkley, G. E., Bezstarosti, K., Demmers, J. A. & Verrijzer, C. P., 15 Oct 2008, In : Genes and Development. 22, 20, p. 2799-2810 12 p.

    Research output: Contribution to journalArticle

  • 180 Citations (Scopus)

    Prizes

    Athena Award

    Tielenius Kruythoff-Mohd Sarip, Adone (Recipient), 2009

    Prize: Prize (including medals and awards)

  • Erasmus MC fellowship

    Tielenius Kruythoff-Mohd Sarip, Adone (Recipient), 2007

    Prize: Fellowship awarded competitively

  • VENI Fellowship

    Tielenius Kruythoff-Mohd Sarip, Adone (Recipient), 2007

    Prize: Fellowship awarded competitively

  • Activities

    • 1 Participation in workshop, seminar, course
    • 1 Hosting an academic visitor

    C. Peter Verrijzer

    Adone Tielenius Kruythoff-Mohd Sarip (Host)

    23 May 2019

    Activity: Hosting a visitor typesHosting an academic visitor

    Early Career Researchers Forum Inaugural

    Aidan Cole (Organiser), , Cristina Branco (Chair), , Seyed Mehdi Jafarnejad (Organiser), , Emma Allott (Organiser), , Stephen McMahon (Participant), , Karl Butterworth (Participant), , Emma Kerr (Participant), , Philip Dunne (Participant), , Adone Tielenius Kruythoff-Mohd Sarip (Participant), & Melissa LaBonte Wilson (Participant)

    25 Nov 2019

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course