• Room 01.009 - PGJCCR

    United Kingdom

Accepting PhD Students

PhD projects

Open to PhD applications in the fields of: - chromatin remodelers - epigenetics - cancer metastasis - proteomics - molecular cell biology - biochemistry

19982021

Research activity per year

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Personal profile

Research Statement

Chromatin reprogramming and cancer metastasis.

Epithelial-to-Mesenchymal transition (EMT) is a reversible and dynamic process proposed to be co-opted by cancer cells during disease progression, metastasis and therapeutic recalcitrance. Control of the EMT program is orchestrated by a set of master regulators that form an integrated transcriptional network with extensive cross-regulation. Several studies have also suggested that EMT relies on the modulation of chromatin remodelers and epigenetic regulatory mechanisms which remain poorly understood. Modulation of chromatin structure are crucial for cell-type specific activation or repression of gene transcription.

We previously showed that chromatin reprogramming occurred during EMT while targeting a subset of EMT master regulators in oral cancer (Mohd-Sarip et al., 2017, Cell Reports). The hypothesis is that Nucleosome remodeling and histone deacetylase (NuRD) complex triggers dynamic epigenetic changes leading to EMT-MET in specific cancers.

To understand the dynamics of chromatin modifiers as a central mechanism underlying tumour development and progression; which is very often paired to the study of epigenetic properties where patterns vary from cancer cell-type to cell-type, it is pertinent to address the impact of chromatin during cancer metastasis. By taking an unbiased proteomics, epigenomics, state-of-the-art microscopy, chromatin-, molecular-, cell-biology and biochemistry-based approaches, novel partners and targets of the NuRD complex will be identified during cellular (de-)differentiation, with a focus on metastasis and EMT-MET.

Teaching

Year 3 BSc Biomedical Science_BMS3109_Clinical Biochemistry – Acid base regulation

Year 2 BSc Biomedical Science_Clinical Genetics - Chromatin remodelling and epigenetic modifiers as therapeutic targets

MRes (PGT) Translational Medicine_SCM8065_Cancer Biology – Epigenetics and Cancer

MSc (PGT) Cancer Medicine & Molecular Pathology of Cancer_SCM 8065/8121_Cancer Biology – Epigenetics and Cancer

Year 1 Medicine_SSC Genomic Impact in Medicine - Chromatin remodelling and epigenetic modifiers as therapeutic targets

Year 1 Medicine_SSC Mechanisms of Metastasis

 

Other

Eager to support and host fellowship applications for postdoc and PhD.

Expertise related to UN Sustainable Devlopment Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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