• Phone+44 (0)28 9097 6456, +44 (0)28 906 32546 / 906 32729, +44 (0)28 9097 2816
  • Emaila.stitt@qub.ac.uk
  • Room 02.061 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Pathogenic mechanisms in diabetic retinopathy and vasodegenerative diseases Mechanisms of vasopermeability Pathophysiological mechanisms underpinning retinal angiogenesis Vascular regeneration and the role of stem cells Cell therapy for occlusive diseases Metabolic plasticity and vascular disease

1990 …2020

Research output per year

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Research Output

2020

Claudin-5 Redistribution Induced by Inflammation Leads to Anti-VEGF Resistant Diabetic Macular Edema

Arima, M., Nakao, S., Yamaguchi, M., Feng, H., Fujii, Y., Shibata, K., Wada, I., Kaizu, Y., Ahmadieh, H., Ishibashi, T., Stitt, A. & Sonoda, K-H., 05 Mar 2020, In : Diabetes. 69, 3

Research output: Contribution to journalArticle

Ocular Regeneration - Where are We and What´s on the Horizon

Stitt, A. & Schrader, S., Mar 2020, In : Current eye research. 45, 3, p. 229

Research output: Contribution to journalArticle

2019

Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7

Pavlou, S., Augustine, J., Cunning, R., Harkin, K., Stitt, A. W., Xu, H. & Chen, M., 29 Apr 2019, In : International journal of molecular sciences. 20, 9, 12 p., 2101.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
94 Downloads (Pure)

CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation

Ashraf, S., Bell, S., O'Leary, C., Canning, P., Micu, I., Fernandez, J. A., O'Hare, M., Barabas, P., McCauley, H., Brazil, D. P., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 21 Mar 2019, In : JCI insight. 4, 6, 18 p., e122442.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
184 Downloads (Pure)

IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment

Augustine, J., Pavlou, S., Ali, I., Harkin, K., Ozaki, E., Campbell, M., Stitt, A. W., Xu, H. & Chen, M., 03 Dec 2019, In : Journal of neuroinflammation. 16, 15 p., 251.

Research output: Contribution to journalArticle

Open Access
File
31 Downloads (Pure)

Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina

Carroll, L. S., Uehara, H., Fang, D., Choi, S., Zhang, X., Singh, M., Sandhu, Z., Cummins, P. M., Curtis, T. M., Stitt, A. W., Archer, B. J. & Ambati, B. K., 03 Jun 2019, In : Investigative ophthalmology & visual science. 60, 7, p. 2494-2502 9 p.

Research output: Contribution to journalArticle

Open Access
File
88 Downloads (Pure)

Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis

O'Leary, C., McGahon, M. K., Ashraf, S., McNaughten, J., Friedel, T., Cincolà, P., Barabas, P., Fernandez, J. A., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 01 Aug 2019, In : Investigative ophthalmology & visual science. 60, 10, p. 3297-3309

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
155 Downloads (Pure)

NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes postischaemic revascularisation

O'Neill, K. M., Campbell, D. C., Edgar, K. S., Gill, E. K., Moez, A., McLoughlin, K. J., O'Neill, C. L., Dellett, M., Hargey, C. J., Abudalo, R. A., O'Hare, M., Doyle, P., Toh, T., Khoo, J., Wong, J., McCrudden, C. M., Meloni, M., Brunssen, C., Morawietz, H., Yoder, M. C. & 6 others, McDonald, D. M., Watson, C. J., Stitt, A. W., Margariti, A., Medina, R. J. & Grieve, D. J., 01 Apr 2019, In : Cardiovascular Research.

Research output: Contribution to journalArticle

Open Access
File
29 Downloads (Pure)

The Placental Growth Factor Pathway and its Potential Role in Macular Degenerative Disease

Cunningham, F., Van Bergen, T., Canning, P., Lengyel, I., Feyen, J. H. M. & Stitt, A. W., 04 May 2019, In : Current eye research. 44, 8, p. 813-822

Research output: Contribution to journalArticle

2 Citations (Scopus)

The RNA-binding protein QKI controls alternative splicing in vascular cells, producing an effective model for therapy

Caines, R., Cochrane, A., Kelaini, S., Gonzalez, M. V., Yang, C., Eleftheriadou, M., Moez, A., Stitt, A. W., Zeng, L., Grieve, D. J. & Margariti, A., 15 Aug 2019, In : Journal of Cell Science.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The role of placental growth factor (PlGF) and its receptor system in retinal vascular diseases

Van Bergen, T., Etienne, I., Cunningham, F., Moons, L., Schlingemann, R. O., Feyen, J. H. M. & Stitt, A. W., 01 Mar 2019, In : Progress in Retinal and Eye Research. 69, p. 116-136 21 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)
Open Access
1 Citation (Scopus)
2018

Characterization of a spontaneously immortalized murine Müller glial cell line QMMuC-1

Augustine, J., Pavlou, S., O'Hare, M., Harkin, K., Stitt, A., Curtis, T., Xu, H. & Chen, M., 01 Mar 2018, In : Investigative Opthalmology and Visual Science. 59, 3, p. 1666-1674

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
243 Downloads (Pure)

Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

Greenwood, J., Hammarlund-Udenaes, M., Jones, H. C., Stitt, A. W., Vandenbroucke, R. E., Romero, I. A., Campbell, M., Fricker, G., Brodin, B., Manninga, H., Gaillard, P. J., Schwaninger, M., Webster, C., Wicher, K. B. & Khrestchatisky, M., 12 Jan 2018, In : Fluids and barriers of the CNS. 15, 1, p. 3

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
176 Downloads (Pure)

Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling

Vilà-González, M., Kelaini, S., Magee, C., Caines, R., Campbell, D., Eleftheriadou, M., Cochrane, A., Drehmer, D., Tsifaki, M., O'Neill, K., Pedrini, E., Yang, C., Medina, R., McDonald, D., Simpson, D., Zampetaki, A., Zeng, L., Grieve, D., Lois, N., Stitt, A. W. & 1 others, Margariti, A., 17 Nov 2018, In : Stem Cells.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
231 Downloads (Pure)

Follistatin-Like 3 Enhances the Function of Endothelial Cells Derived from Pluripotent Stem Cells by Facilitating β-Catenin Nuclear Translocation Through Inhibition of Glycogen Synthase Kinase-3β Activity

Kelaini, S., Vilà-González, M., Caines, R., Campbell, D., Eleftheriadou, M., Tsifaki, M., Magee, C., Cochrane, A., O'Neill, K., Yang, C., Stitt, A. W., Zeng, L., Grieve, D. J. & Margariti, A., 01 Jul 2018, In : Stem Cells. 36, 7, p. 1033-1044

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
132 Downloads (Pure)

Interleukin-33 deficiency resulted in severe neuroretinal degeneration in retinal detachment

Chen, M., Augustine, J., Pavlou, S., Ali, I., Doyle, S. L., Stitt, A., Campbell, M. & Xu, H., May 2018.

Research output: Contribution to conferenceAbstract

Involvement of TRPV1 and TRPV4 Channels in Pathological Retinal Angiogenesis: Oral presentation

Curtis, T., O'leary, C., McGahon, M., Ashraf, S., McNaughten, J., Fernandez, J., Stitt, A. & McGeown, G., 2018, p. 150. 1 p.

Research output: Contribution to conferenceOther

NADPH oxidase 4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes postischemic revascularisation

O'Neill, K., Campbell, D., Edgar, K., Moez, A., McLoughlin, K., O'Neill, C., Dellett, M., Hargey, C., Abudalo, R., Gill, E., Doyle, P., Toh, T., Khoo, J., McCrudden, C., Brunssen, C., Morawietz, H., Yoder, M. C., Stitt, A., Margariti, A., Medina, R. & 1 others, Grieve, D., 03 Feb 2018.

Research output: Contribution to conferenceAbstract

Neurodegeneration in diabetic retinopathy: Does it really matter?

Simó, R., Stitt, A. W. & Gardner, T. W., 01 Sep 2018, In : Diabetologia. 61, 9, p. 1902-1912 11 p.

Research output: Contribution to journalReview article

Open Access
File
32 Citations (Scopus)
278 Downloads (Pure)
Open Access
File
9 Citations (Scopus)
148 Downloads (Pure)

The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1β

Chambers, S. E. J., O'Neill, C. L., Guduric-Fuchs, J., McLoughlin, K. J., Liew, A., Egan, A. M., O'Brien, T., Stitt, A. W. & Medina, R. J., 09 Apr 2018, In : Stem Cells. p. 1-11

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
35 Downloads (Pure)

The Vasoreparative Potential of Endothelial Colony Forming Cells: A Journey Through Pre-clinical Studies

O'Neill, C., McLoughlin, K., Chambers, S., Guduric-Fuchs, J., Stitt, A. & Medina, R., 16 Oct 2018, In : Frontiers in Medicine. 5, 273, p. 1-9

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
149 Downloads (Pure)

Wedelolactone protects DNA-induced photoreceptor death

Harkin, K., Pavlou, S., Stitt, A., Xu, H. & Chen, M., 2018.

Research output: Contribution to conferenceAbstract

2017

Animal models of retinal vein occlusion

Khayat, M., Lois, N., Williams, M. & Stitt, A. W., 01 Dec 2017, In : Investigative Ophthalmology and Visual Science. 58, 14, p. 6175-6192 18 p.

Research output: Contribution to journalReview article

Open Access
File
3 Citations (Scopus)
194 Downloads (Pure)

Diabetic retinopathy: current understanding, mechanisms, and treatment strategies

Duh, E. J., Sun, J. K. & Stitt, A. W., 20 Jul 2017, In : Insight. 2, 14

Research output: Contribution to journalReview article

Open Access
117 Citations (Scopus)

Endothelial Progenitors: A Consensus Statement on Nomenclature

Medina, R. J., Barber, C. L., Sabatier, F., Dignat-George, F., Melero-Martin, J. M., Khosrotehrani, K., Ohneda, O., Randi, A. M., Chan, J. K. Y., Yamaguchi, T., Van Hinsbergh, V. W. M., Yoder, M. C. & Stitt, A. W., 10 Mar 2017, In : Stem cells translational medicine.

Research output: Contribution to journalArticle

Open Access
File
107 Citations (Scopus)
199 Downloads (Pure)

FUNCTIONAL HUMAN IPS-ECS FROM DIABETIC PATIENTS PROVIDE BASIS FOR IN VITRO MODEL OF DIABETIC RETINOPATHY

Vilà González, M., Kelaini, S., Drehmer, D., Harris, A., Lavery, N. J., Armstrong, D., Lois, N., Grieve, D., Stitt, A. & Margariti, A., 14 Jun 2017.

Research output: Contribution to conferenceAbstract

Open Access
File
11 Citations (Scopus)
210 Downloads (Pure)

Posterior drug delivery via periocular route: challenges and opportunities

Waite, D., Wang, Y., Jones, D., Stitt, A. & Thakur, R., 01 Jul 2017, In : Therapeutic Delivery. 8, 8, p. 685-699 15 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
203 Downloads (Pure)

QKI-6 INDUCES VASCULAR SMOOTH MUSCLE CELL DIFFERENTIATION THROUGH REGULATION OF THE HISTONE DEACETYLASE 7 MRNA SPLICING

Caines, R., Cochrane, A., Kelaini, S., Tsifaki, M., Vilà González, M., Grieve, D., Stitt, A. & Margariti, A., 14 Jun 2017.

Research output: Contribution to conferenceAbstract

Quaking is a Key Regulator of Endothelial Cell Differentiation, Neovascularization and Angiogenesis

Cochrane, A., Kelaini, S., Bojdo, J., Vilà-González, M., Drehmer, D., Caines, R., Magee, C., Eleftheriadou, M., Hu, Y., Grieve, D., Stitt, A., Zeng, L., Xu, Q. & Margariti, A., Apr 2017, In : Stem Cells. 35, 4, p. 952-966 15 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
278 Downloads (Pure)

The pathology associated with diabetic retinopathy

Lechner, J., O'Leary, O. E. & Stitt, A. W., Oct 2017, In : Vision Research. 139, p. 7-14

Research output: Contribution to journalArticle

29 Citations (Scopus)

THE RNA BINDING PROTEIN QUAKING IS A KEY REGULATOR OF ENDOTHELIAL CELL DIFFERENTIATION, NEOVASCULARIZATION AND ANGIOGENESIS THROUGH DIRECT BINDING OF THE 3’UTR OF STAT3

Kelaini, S., Cochrane, A., Margariti, A., Zeng, L., Hu, Y., Xiao, Q., Stitt, A., Grieve, D., Caines, R., Vilà González, M., Drehmer, D., Tsifaki, M., Eleftheriadou, M. & Bojdo, J., 14 Jun 2017.

Research output: Contribution to conferenceAbstract

2016

Animal models of diabetic retinopathy

Chen, M. & Stitt, A., 2016, Animal models of ophthalmic diseases. Chan, C-C. (ed.). Springer, p. 67-83 Chapter 5. (Essentials in Ophthalmology).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

13 Citations (Scopus)

Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications

Kumar Vr, S., Darisipudi, M. N., Steiger, S., Devarapu, S. K., Tato, M., Kukarni, O. P., Mulay, S. R., Thomasova, D., Popper, B., Demleitner, J., Zuchtriegel, G., Reichel, C., Cohen, C. D., Lindenmeyer, M. T., Liapis, H., Moll, S., Reid, E., Stitt, A. W., Schott, B., Gruner, S. & 4 others, Haap, W., Ebeling, M., Hartmann, G. & Anders, H-J., Jun 2016, In : Journal of the American Society of Nephrology. 27, 6, p. 1635-1649 14 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Deletion of interleukin-33 (IL33) results in persistent Müller cell activation in retinal detachment

Pavlou, S., Augustine, J., Doyle, S., Stitt, A., Campbell, M., Xu, H. & Chen, M., May 2016.

Research output: Contribution to conferenceAbstract

Open Access
File
14 Citations (Scopus)
210 Downloads (Pure)

Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor

Hookham, M. B., Ali, I. H. A., O'Neill, C. L., Hackett, E., Lambe, M. H., Schmidt, T., Medina, R. J., Chamney, S., Rao, B., McLoone, E., Sweet, D., Stitt, A. W. & Brazil, D. P., 29 Nov 2016, In : Stem Cell Research & Therapy. 7, 173, 12 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
170 Downloads (Pure)

Inflammasome activation in the photoreceptor cells

Cunning, R., Pavlou, S., Stitt, A., Xu, H. & Chen, M., May 2016.

Research output: Contribution to conferenceAbstract

Lipoprotein-associated phospholipase A2 (Lp-PLA2) as a therapeutic target to prevent retinal vasopermeability during diabetes

Canning, P., Kenny, B-A., Prise, V., Glenn, J., Sarker, M. H., Hudson, N., Brandt, M., Lopez, F. J., Gale, D., Luthert, P. J., Adamson, P., Turowski, P. & Stitt, A. W., 28 Jun 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. 7213-7218 6 p.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
172 Downloads (Pure)

Mechanisms of Macular Edema and therapeutic approaches

Joussen, A., Stitt, A. & Lois, N., 01 Jul 2016, Ryan's Retina. Ryan, S., Peter, W., Schachat, A., Wilkinson, C. P., Hinton, D. & Sadda, S. R. (eds.). 6th ed. Saunders Elsevier Amsterdam, Atlanta, New York, London

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Myeloid Angiogenic Cells reparative function is impaired by Pentraxin 3

Medina, R., O'Neill, C., Guduric-Fuchs, J. & Stitt, A., 30 Oct 2016.

Research output: Contribution to conferencePoster

Phenotype-Based Discovery of 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol as a Novel Regulator of Ocular Angiogenesis

Reynolds, A. L., Alvarez, Y., Sasore, T., Waghorne, N., Butler, C. T., Kilty, C., Smith, A. J., McVicar, C., Wong, V. H. Y., Galvin, O., Merrigan, S., Osman, J., Grebnev, G., Sjölander, A., Stitt, A. W. & Kennedy, B. N., 01 Apr 2016, In : Journal of Biological Chemistry. 291, 14, p. 7242-7255 14 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The progress in understanding and treatment of diabetic retinopathy

Stitt, A. W., Curtis, T. M., Chen, M., Medina, R. J., McKay, G. J., Jenkins, A., Gardiner, T. A., Lyons, T. J., Hammes, H-P., Simó, R. & Lois, N., Mar 2016, In : Progress in Retinal and Eye Research. 51, p. 156-186

Research output: Contribution to journalArticle

196 Citations (Scopus)