• Room 06.012 - Ashby Tower

    United Kingdom

Accepting PhD Students

PhD projects

Open to PhD applications in the fields of biomechanics/biomaterials for surgical planning, medical device design/evaluation, and/or fundamental mechanobiology of cells/tissues. Individuals interested in working with Dr Lennon are welcome to contact him to discuss ideas and/or possible collaborations.

19962019

Research output per year

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Personal profile

Interests

Main interests are in computational methods in mechanics, biomechanics and mechanobiology with particular application to multi-scale mechanobiology (cells and tissues) and musculoskeletal biomechanics. 

Additionally, developing supporting technologies for the above research, such as mesh generation methods and stochastic modelling and risk assessment.

Expertise categories

Biomedical engineering, Materials technology, ICT Applications, Medicine, Health, Life sciences

Skills and competences

Biomechanics and mechanobiology, finite element analysis (including user customisation), agent-based models of cell behaviour (using lattice-based spatial representations), risk analysis (classical Monte Carlo and accelerated Monte Carlo methods using surrogate models), and constitutive modelling of material behaviour.

Particulars

Previously worked as a research fellow in Trinity College Dublin's Centre for Bioengineering (TCBE, http://www.tcd.ie/bioengineering) on a diverse range of projects including: patient-specific simulation of total hip replacement loosening; linking of patient-specific joint replacement simulation software with a health informatics electronic healthcare record, decision support, and work-flow management system; development and implementation of a simulation framework for mechanobiology research; and application of mechanobiology algorithms at both cell and tissue level to applications in orthopaedic and cardiovascular intervention.

Prior to working in Trinity College, worked as a research assistant in the Dept. of Mechanical Engineering in University College Dublin, and as a consultant engineer for a medical device campus spin-out company from University College Dublin's Bioengineering Research Centre.

Research Statement

To investigate cell and tissue mechanobiology through use of multi-scale modelling and physical measurement.  Specifically, to improve understanding of mechanisms by which mechanical force and deformation are transduced into cell signals and responses, based on analysis of mechanics and biochemistry at tissue, cell, and intracellular length and time-scales.

Ultimately, to translate this research to clinically relevant applications, e.g. in regenerative medicine, via collaboration with researchers in medicine and life sciences, biomaterials, and medical device engineering.

Research Themes

Cell and Tissue Mechanobiology

  • Computational modelling and investigation of cytoskeletal mechanics and interaction with intracellular biochemistry with the aim of understanding cellular response to mechanical stimuli (mechanotransduction).
  • Application of rule-based mechanotransduction algorithms to predicting response of cell populations to biomaterials and biomechanics inspired regenerative medicine strategies.
  • Modification of mechanotransduction algorithms to modelling macroscopic (organ level) response of tissues to medical devices or disease(e.g. bone resorption around joint replacements, osteoporosis, neointimal inflammation and restenosis around cardiovascular stents) .

Patient-Specific and Population-Based Implant Biomechanics

  • Modelling and simulation of long-term failure processes around orthopaedic implants (bone cement failure, implant-cement and implant-tissue interfacial failure, and bone remodelling).
  • Customisation and automation of simulations to enable prediction of patient-specific response to implants.
  • Incorporation of population variability into simulations of long-term failure processes using risk analysis strategies.

Teaching

Strength of Materials (MEE2001, MEE2015, MEE3055)

Bio-solid and Polymer Mechanics (MEE4048, MEE7020)

Other

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Projects

Research Output

  • 1 Citation (Scopus)

    Multi-objective optimisation of material properties and strut geometry for poly(L-lactic acid) coronary stents using response surface methodology

    Blair, R. W., Dunne, N. J., Lennon, A. B. & Menary, G. H., 26 Aug 2019, In : PLoS ONE. 14, 8, 21 p., e0218768.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 74 Downloads (Pure)

    Operative and radiographic acetabular component orientation in total hip replacement:Influence of pelvic orientation and surgical positioning technique

    Rutherford, M., O'Connor, J. D., Gill, H. S., Hill, J., Beverland, D., Lennon, A. B. & Dunne, N. J., 09 Jan 2019, In : Medical Engineering and Physics.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 1 Citation (Scopus)
    47 Downloads (Pure)
    Open Access
    File
  • 4 Citations (Scopus)
    87 Downloads (Pure)

    Effect of combined flexion and external rotation on measurements of the proximal femur from anteroposterior pelvic radiographs

    O'Connor, J. D., Rutherford, M., Hill, J. C., Beverland, D. E., Dunne, N. J. & Lennon, A. B., 10 Apr 2018, In : Orthopaedics and Traumatology: Surgery and Research. 6 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 133 Downloads (Pure)

    Activities

    UKRI Grant Reviewer

    Alex Lennon (Reviewer)
    2019

    Activity: Other activity typesOther

    EPSRC Healthcare Technologies Investigator Led Prioritisation Panel (Event)

    Alex Lennon (Member)
    30 Jan 201831 Jan 2018

    Activity: Membership typesMembership of peer review panel or committee

    Thesis

    A combined experimental and computational framework to optimise processing and design of poly(L-lactic acid) bioresorbable stents

    Author: Blair, R., Dec 2019

    Supervisor: Menary, G. (Supervisor), Lennon, A. (Supervisor) & Dunne, N. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Pelvic Positioning and Acetabular Orientation in Total Hip Replacement

    Author: Rutherford, M., 2019

    Supervisor: Lennon, A. (Supervisor), Dunne, N. (Supervisor), Beverland, D. (Supervisor) & Hill, J. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File