• Room 06.012 - Ashby Tower

    United Kingdom

Accepting PhD Students

19962019
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Personal profile

Interests

Main interests are in computational methods in mechanics, biomechanics and mechanobiology with particular application to multi-scale mechanobiology (cells and tissues) and musculoskeletal biomechanics. 

Additionally, developing supporting technologies for the above research, such as mesh generation methods and stochastic modelling and risk assessment.

Expertise categories

Biomedical engineering, Materials technology, ICT Applications, Medicine, Health, Life sciences

Skills and competences

Biomechanics and mechanobiology, finite element analysis (including user customisation), agent-based models of cell behaviour (using lattice-based spatial representations), risk analysis (classical Monte Carlo and accelerated Monte Carlo methods using surrogate models), and constitutive modelling of material behaviour.

Particulars

Previously worked as a research fellow in Trinity College Dublin's Centre for Bioengineering (TCBE, http://www.tcd.ie/bioengineering) on a diverse range of projects including: patient-specific simulation of total hip replacement loosening; linking of patient-specific joint replacement simulation software with a health informatics electronic healthcare record, decision support, and work-flow management system; development and implementation of a simulation framework for mechanobiology research; and application of mechanobiology algorithms at both cell and tissue level to applications in orthopaedic and cardiovascular intervention.

Prior to working in Trinity College, worked as a research assistant in the Dept. of Mechanical Engineering in University College Dublin, and as a consultant engineer for a medical device campus spin-out company from University College Dublin's Bioengineering Research Centre.

Research Statement

To investigate cell and tissue mechanobiology through use of multi-scale modelling and physical measurement.  Specifically, to improve understanding of mechanisms by which mechanical force and deformation are transduced into cell signals and responses, based on analysis of mechanics and biochemistry at tissue, cell, and intracellular length and time-scales.

Ultimately, to translate this research to clinically relevant applications, e.g. in regenerative medicine, via collaboration with researchers in medicine and life sciences, biomaterials, and medical device engineering.

Research Themes

Cell and Tissue Mechanobiology

  • Computational modelling and investigation of cytoskeletal mechanics and interaction with intracellular biochemistry with the aim of understanding cellular response to mechanical stimuli (mechanotransduction).
  • Application of rule-based mechanotransduction algorithms to predicting response of cell populations to biomaterials and biomechanics inspired regenerative medicine strategies.
  • Modification of mechanotransduction algorithms to modelling macroscopic (organ level) response of tissues to medical devices or disease(e.g. bone resorption around joint replacements, osteoporosis, neointimal inflammation and restenosis around cardiovascular stents) .

Patient-Specific and Population-Based Implant Biomechanics

  • Modelling and simulation of long-term failure processes around orthopaedic implants (bone cement failure, implant-cement and implant-tissue interfacial failure, and bone remodelling).
  • Customisation and automation of simulations to enable prediction of patient-specific response to implants.
  • Incorporation of population variability into simulations of long-term failure processes using risk analysis strategies.

Teaching

Strength of Materials (MEE2001, MEE2015, MEE3055)

Bio-solid and Polymer Mechanics (MEE4048, MEE7020)

Other

Fingerprint Dive into the research topics where Alex Lennon is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Thigh Medicine & Life Sciences
Stents Engineering & Materials Science
Hip Medicine & Life Sciences
Bone cement Engineering & Materials Science
Arthroplasty Medicine & Life Sciences
Femur Medicine & Life Sciences
Hip Replacement Arthroplasties Medicine & Life Sciences
Cements Engineering & Materials Science

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2019

Research Output 1996 2019

1 Citation (Scopus)
Stents
Lactic acid
Processing
Constitutive models
Temperature

Multi-objective optimisation of material properties and strut geometry for poly(L-lactic acid) coronary stents using response surface methodology

Blair, R. W., Dunne, N. J., Lennon, A. B. & Menary, G. H., 26 Aug 2019, In : PLoS ONE. 14, 8, 21 p., e0218768.

Research output: Contribution to journalArticle

Open Access
File
polylactic acid
Stents
Struts
Multiobjective optimization
response surface methodology
1 Citation (Scopus)

Operative and radiographic acetabular component orientation in total hip replacement:Influence of pelvic orientation and surgical positioning technique

Rutherford, M., O'Connor, J. D., Gill, H. S., Hill, J., Beverland, D., Lennon, A. B. & Dunne, N. J., 09 Jan 2019, In : Medical Engineering and Physics.

Research output: Contribution to journalArticle

Open Access
File
Hip Replacement Arthroplasties
Ligaments
Orthopedics
Theaters
Regression analysis
3 Citations (Scopus)
Open Access
File
3D printers
Scaffolds
printing
Polymers
Powders

Effect of combined flexion and external rotation on measurements of the proximal femur from anteroposterior pelvic radiographs

O'Connor, J. D., Rutherford, M., Hill, J. C., Beverland, D. E., Dunne, N. J. & Lennon, A. B., 10 Apr 2018, In : Orthopaedics and Traumatology: Surgery and Research. 6 p.

Research output: Contribution to journalArticle

Open Access
File
Femur
Thigh
Neck
Hip Osteoarthritis
Hip Replacement Arthroplasties

Activities 2006 2014

  • 3 Participation in Festival/Exhibition
  • 1 Participation in conference
  • 1 Participation in workshop, seminar, course
  • 1 Editorial activity

North Belfast Area Learning Community STEM Careers Event

Alex Lennon (Participant)
22 Jan 2014

Activity: Participating in or organising an event typesParticipation in Festival/Exhibition

Careers event in Hunterhouse College

Alex Lennon (Participant)
26 Mar 2014

Activity: Participating in or organising an event typesParticipation in Festival/Exhibition

Sentinus GetSet Event

Alex Lennon (Participant)
06 Dec 2012

Activity: Participating in or organising an event typesParticipation in Festival/Exhibition

Bioengineering in Ireland 18

Alex Lennon (Member of the organising committee)
Oct 201128 Jan 2012

Activity: Participating in or organising an event typesParticipation in conference

Medical Engineering and Physics (Journal)

Alex Lennon (Guest editor)
2009

Activity: Publication peer-review and editorial work typesEditorial activity

Thesis

Pelvic Positioning and Acetabular Orientation in Total Hip Replacement

Author: Rutherford, M., 2019

Supervisor: Lennon, A. (Supervisor), Dunne, N. (Supervisor), Beverland, D. (Supervisor) & Hill, J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File