Projects per year
Personal profile
Interests
Main interests are in computational methods in mechanics, biomechanics and mechanobiology with particular application to multi-scale mechanobiology (cells and tissues) and musculoskeletal biomechanics.
Additionally, developing supporting technologies for the above research, such as mesh generation methods and stochastic modelling and risk assessment.
Expertise categories
Biomedical engineering, Materials technology, ICT Applications, Medicine, Health, Life sciences
Skills and competences
Biomechanics and mechanobiology, finite element analysis (including user customisation), agent-based models of cell behaviour (using lattice-based spatial representations), risk analysis (classical Monte Carlo and accelerated Monte Carlo methods using surrogate models), and constitutive modelling of material behaviour.
Particulars
Previously worked as a research fellow in Trinity College Dublin's Centre for Bioengineering (TCBE, http://www.tcd.ie/bioengineering) on a diverse range of projects including: patient-specific simulation of total hip replacement loosening; linking of patient-specific joint replacement simulation software with a health informatics electronic healthcare record, decision support, and work-flow management system; development and implementation of a simulation framework for mechanobiology research; and application of mechanobiology algorithms at both cell and tissue level to applications in orthopaedic and cardiovascular intervention.
Prior to working in Trinity College, worked as a research assistant in the Dept. of Mechanical Engineering in University College Dublin, and as a consultant engineer for a medical device campus spin-out company from University College Dublin's Bioengineering Research Centre.
Research Statement
To investigate cell and tissue mechanobiology through use of multi-scale modelling and physical measurement. Specifically, to improve understanding of mechanisms by which mechanical force and deformation are transduced into cell signals and responses, based on analysis of mechanics and biochemistry at tissue, cell, and intracellular length and time-scales.
Ultimately, to translate this research to clinically relevant applications, e.g. in regenerative medicine, via collaboration with researchers in medicine and life sciences, biomaterials, and medical device engineering.
Research Themes
Cell and Tissue Mechanobiology
- Computational modelling and investigation of cytoskeletal mechanics and interaction with intracellular biochemistry with the aim of understanding cellular response to mechanical stimuli (mechanotransduction).
- Application of rule-based mechanotransduction algorithms to predicting response of cell populations to biomaterials and biomechanics inspired regenerative medicine strategies.
- Modification of mechanotransduction algorithms to modelling macroscopic (organ level) response of tissues to medical devices or disease(e.g. bone resorption around joint replacements, osteoporosis, neointimal inflammation and restenosis around cardiovascular stents) .
Patient-Specific and Population-Based Implant Biomechanics
- Modelling and simulation of long-term failure processes around orthopaedic implants (bone cement failure, implant-cement and implant-tissue interfacial failure, and bone remodelling).
- Customisation and automation of simulations to enable prediction of patient-specific response to implants.
- Incorporation of population variability into simulations of long-term failure processes using risk analysis strategies.
Teaching
Strength of Materials (MEE2001, MEE2015, MEE3055)
Bio-solid and Polymer Mechanics (MEE4048, MEE7020)
Other
Researcher ID: http://www.researcherid.com/rid/A-1133-2010
LinkedIn: http://uk.linkedin.com/in/alexlennon
CORDIS Partner Search Profile: http://cordis.europa.eu/partners/user/alexlennon
_connect (UK research and innovation network) profile: http://connect.innovateuk.org/web/alex.lennon/summary
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R6595MEE: European Training Network to Develop Improved Bioresorbable Materials for Orthopaedic and Vascular Implant Applications
Lennon, A. (PI), Buchanan, F. (CoI), Malinov, S. (CoI) & Menary, G. (CoI)
18/07/2018 → …
Project: Research
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S2651MAS: Fusion/ Atlantic Prosthetics Orthotic Services Ltd
Lennon, A. (PI)
07/03/2018 → 31/10/2019
Project: ktp
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Employing synchrotron X-ray scattering and microscopy to explore microstructural mysteries in bioresorbable vascular scaffolds
Cameron, J., Luccio, T. D., Barr, J., Rocher, L., Kim, E., Menary, G. H., Lennon, A. B. & Kornfield, J. A., 15 Jan 2025, In: Acta Biomaterialia. 192, p. 175-188 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Estimation of passive drag in swimming via experimental and computational means
Haskins, A., McCabe, C., Keating, R., Lennon, A. & Chandar, D., 15 Jul 2024, In: European Journal of Computational Mechanics. 33, 3, p. 255-294 40 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile59 Downloads (Pure) -
Facilitating patient-specific joint restoration in total-hip arthroplasty
Denton, O., Dunne, N., Hill, J., Beverland, D. & Lennon, A., 27 Jan 2024.Research output: Contribution to conference › Abstract
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Idealised processing history of bioresorbable vascular scaffolds – the future of testing?
Barr, J., Menary, G. & Lennon, A., 27 Jan 2024.Research output: Contribution to conference › Abstract
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The biomechanics of a physically impaired individual from early medieval Ranelagh, Ireland
White, J., Murphy, E. & Lennon, A., 28 Oct 2024, (Accepted) In: Bioarchaeology International.Research output: Contribution to journal › Article › peer-review
Prizes
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NovaUCD Campus Company Development Programme Awards (runner-up)
Lennon, A. (Recipient), 18 Nov 2004
Prize: Prize (including medals and awards)
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Student scholarship, Combined Meeting of Bioengineering in Ireland (Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland) and The Ulster Biomedical Engineering Society
Lennon, A. (Recipient), 1998
Prize: Prize (including medals and awards)
Activities
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Post Operative Total Hip Arthroplasty Mechanics: An Integrated Musculoskeletal-Continuum Mechanics Approach
Lennon, A. (Examiner)
2020Activity: Examination types › PhD external examination
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Computational testing of patient-specific gait features and pelvic motion effects on the risk of edge contact in total hip replacements.
Lennon, A. (Examiner)
02 Jul 2019Activity: Examination types › PhD external examination
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EPSRC Healthcare Technologies Investigator Led Prioritisation Panel (Event)
Lennon, A. (Member)
30 Jan 2018 → 31 Jan 2018Activity: Membership types › Membership of peer review panel or committee
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Osteoarthritis and Cartilage (Journal)
Lennon, A. (Peer reviewer)
2018Activity: Publication peer-review and editorial work types › Publication peer-review