• Room 01.022 - Clinical Science B Block 6 R.V.H. Site

    United Kingdom

Accepting PhD Students

Willing to speak to media

20042020
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Personal profile

Research Interests

Bioinformatics, Genetics, Epigenetics, Genomics, Transcriptomics, DNA Methylation, Kidney Disease, Rare Disease, Healthy Ageing, Chronic Diseases, Registries, Renal

Research Statement

Research is focused on genomic factors that influence human disease, in particular genetic-epigenetic-transcriptomic associations with kidney disease, diseases common in ageing populations, and rare diseases. We conduct studies on candidate genes, prioritised genetic regions, genome-wide and epigenome-wide screens, along with whole exome/genome sequencing with specific emphasis on MHC, telomere and mitochondrial influences.  Data is derived from individuals recruited as part of multi-centre collections and we participate in multiple mega-consortia projects, including developing and evaluating approaches for data integration from diverse sources.  We also launched an international renal genetics initiative, creating the first chromosome-based maps for renal disease and a contributor-driven database for genes and complex chromosome abnormalities consistently demonstrating renal involvement.

Our laboratories are well equipped for genetic studies, including scanners and next generation sequencing machines; we are a next generation sequencing development site.  This enables me to facilitate projects for many other teams looking at different diseases within and outside QUB.  Whole exome sequencing, whole genome sequencing, RNA-seq and ChIP-Seq for rare and complex disorders, plus bacterial whole genome sequencing are performed.  We are building the NICOLA (https://www.qub.ac.uk/sites/NICOLA/) bioresource, including multi-omic datasets with a focus on older individuals living in NI.  Whole genome sequencing of 1278 individuals for rare diseases is underway as part of the NI Genomic Medicine Centre with the complementary development of an online information hub and patient-centred pathways.  We hold several registries and are actively engaged in making maximal use of complex genomic information. 

Teaching

I have an extensive teaching commitment, having developed and co-ordinated six new modules, as well as several new postgraduate courses. Current teaching includes participating in standard setting, exam boards, progress reviews, postgraduate research boards and:

  • Mentoring, Personal and Professional Development Portfolios
  • MED1014: Genes, Molecules and Processes Foundations of Clinical Practice 1; I co-developed the genetic component of this module (three times) and Lecture
  • BMS2103: I co-developed the genetic component of this year 2 biomedical science module (Cell Biology and Clinical Genetics), which was brand new for 2017-2018, co-coordinate the module, and Lecture. Our BSc (Hons) in Biomedical Science Programme has been accredited by the Institute of Biomedical Science (IBMS) for a further five years to 2022.
  • MED1015: Systems, People and Populations Foundations of Clinical Practice 3; Lecture
  • MED1020: Concepts in People and Populations; Lecture
  • MED1021: Student Selected Component: Lecture
  • Preparation for Practice: Lecture
  • SCM7044/7025: Medical Statistics: Lecture
  • SCM7048: Genomics and Genetics: Designed, Module Coordinator and Lecture
  • SCM7052: Genomics, Cell Biology and Human Disease: Designed, Module Coordinator and Lecture
  • SCM8095: Genomics and Human Disease: Designed, Module Coordinator and Lecture.  This module has run across the MRes in Translational Medicine and MSc in Bioinformatics and Computational Biology, which has been shortlisted for the gradireland Higher Education Awards as Postgraduate Course of the Year in Computer Science & Technology  and Postgraduate Course of the Year in Science.
  • SCM8056: Postgraduate Research Induction, Minimising Plagiarism, Differentiation: Co-designed and Lecture
  • TPU3008: Integrated Pharmacology: Lecture

I am also the director of postgraduate education and training for the Centre of Public Health, QUB

Fingerprint Dive into the research topics where Amy Jayne McKnight is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 38 Similar Profiles
Diabetic Nephropathies Medicine & Life Sciences
Type 1 Diabetes Mellitus Medicine & Life Sciences
Single Nucleotide Polymorphism Medicine & Life Sciences
Genome-Wide Association Study Medicine & Life Sciences
Genes Medicine & Life Sciences
Rare Diseases Medicine & Life Sciences
Chronic Renal Insufficiency Medicine & Life Sciences
Kidney Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2008 2017

Selected Research Output 2004 2020

1 Citation (Scopus)

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen

SUMMIT Consortium, DCCT/EDIC Research Group, GENIE Consortium, Kretzler, M., Susztak, K., Colhoun, H. M., Krolewski, A. S., Paterson, A. D., Groop, P-H., Rich, S. S., Hirschhorn, J. N. & Florez, J. C., 30 Sep 2019, In : Journal of the American Society of Nephrology. 30, 10, p. 2000-2016 17 p.

Research output: Contribution to journalArticle

Open Access
File
Glomerular Basement Membrane
Genome-Wide Association Study
Diabetic Nephropathies
Collagen
Albuminuria
4 Citations (Scopus)

Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection

Steers, N. J., Li, Y., Drace, Z., D'Addario, J. A., Fischman, C., Liu, L., Xu, K., Na, Y-J., Neugut, Y. D., Zhang, J. Y., Sterken, R., Balderes, O., Bradbury, D., Ozturk, N., Ozay, F., Goswami, S., Mehl, K., Wold, J., Jelloul, F. Z., Rohanizadegan, M. & 25 othersGillies, C. E., Vasilescu, E-R. M., Vlad, G., Ko, Y-A., Mohan, S., Radhakrishnan, J., Cohen, D. J., Ratner, L. E., Scolari, F., Susztak, K., Sampson, M. G., Deaglio, S., Caliskan, Y., Barasch, J., Courtney, A. E., Maxwell, A. P., McKnight, A. J., Ionita-Laza, I., Bakker, S. J. L., Snieder, H., de Borst, M. H., D'Agati, V., Amoroso, A., Gharavi, A. G. & Kiryluk, K., 16 May 2019, In : New England Journal of Medicine. 380, 20, p. 1918-1928 11 p.

Research output: Contribution to journalArticle

Open Access
File
Allografts
Genotype
Tissue Donors
Kidney
Immunoglobulin G
2 Citations (Scopus)
Open Access
File
Adenocarcinoma
Area Under Curve
Genetic Testing
Genetic Predisposition to Disease
Body Mass Index

The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population

UK Ireland Renal Transplant Consortium, Stapleton, C. P., Heinzel, A., Guan, W., van der Most, P. J., van Setten, J., Lord, G. M., Keating, B. J., Israni, A. K., de Borst, M. H., Bakker, S. J. L., Snieder, H., Weale, M. E., Delaney, F., Hernandez-Fuentes, M. P., Reindl-Schwaighofer, R., Oberbauer, R., Jacobson, P. A., Mark, P. B., Chapman, F. A. & 15 othersPhelan, P. J., Sexton, D., Murray, S., Jardine, A., Traynor, J. P., McKnight, A. J., Maxwell, A. P., Smyth, L. J., Oetting, W. S., Matas, A. J., Mannon, R. B., Schladt, D. P., Iklé, D. N., Cavalleri, G. L. & Conlon, P. J., 27 Feb 2019, In : American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Research output: Contribution to journalArticle

Glomerular Filtration Rate
Transplants
Kidney
Population
Genome-Wide Association Study
1 Citation (Scopus)
Open Access
File
Kidney Diseases
Genetic Predisposition to Disease
Chronic Renal Insufficiency
Genome-Wide Association Study
Telomere
5 Citations (Scopus)

Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis

BIOS Consortium, 14 Apr 2019, In : Aging. 11, 7, p. 2045-2070

Research output: Contribution to journalArticle

Open Access
File
Epigenomics
Habits
Life Style
Cohort Studies
Biomarkers
Open Access
File
Metabolomics
Biomarkers
Chronic Renal Insufficiency
Proteomics
Metabolites
2 Citations (Scopus)
Open Access
File
Biomarkers
Chronic Renal Insufficiency
Kidney Diseases
Epigenomics
Creatinine
4 Citations (Scopus)

Novel risk genes identified in a genome-wide association study for coronary artery disease in patients with type 1 diabetes

Charmet, R., Duffy, S., Keshavarzi, S., Gyorgy, B., Marre, M., Rossing, P., McKnight, A., Maxwell, A., Ahluwalia, T. V. S., Paterson, A. D., Trégouët, D-A. & Hadjadj, S., 26 Apr 2018, In : Cardiovascular diabetology. p. 1-10

Research output: Contribution to journalArticle

Open Access
File
Genome-Wide Association Study
Type 1 Diabetes Mellitus
Coronary Artery Disease
Genes
Single Nucleotide Polymorphism
29 Citations (Scopus)

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

van Zuydam, N. R., Ahlqvist, E., Sandholm, N., Deshmukh, H., Rayner, N. W., Abdalla, M., Ladenvall, C., Ziemek, D., Fauman, E., Robertson, N. R., McKeigue, P. M., Valo, E., Forsblom, C., Harjutsalo, V., Perna, A., Rurali, E., Marcovecchio, M. L., Igo, R. P., Salem, R. M., Perico, N. & 31 othersLajer, M., Käräjämäki, A., Imamura, M., Kubo, M., Takahashi, A., Sim, X., Liu, J., van Dam, R. M., Jiang, G., Tam, C. H. T., Luk, A. O. Y., Lee, H. M., Lim, C. K. P., Szeto, C. C., So, W. Y., Chan, J. C. N., Ang, S. F., Dorajoo, R., Wang, L., Hua Clara, T. S., McKnight, A-J., Duffy, S., Pezzolesi, M. G., Consortium, G., Marre, M., Gyorgy, B., Hadjadj, S., Hiraki, L. T., Ahluwalia, T. S., Maxwell, A. P. & FINNDIANE Study centres, 29 Apr 2018, In : Diabetes. 67, 7, p. 1414-1427

Research output: Contribution to journalArticle

Open Access
File
Genome-Wide Association Study
Diabetic Nephropathies
Type 2 Diabetes Mellitus
Phenotype
Sample Size
511 Citations (Scopus)

New genetic loci link adipose and insulin biology to body fat distribution

Shungin, D., Winkler, T. W., Croteau-Chonka, D. C., Ferreira, T., Locke, A. E., Mägi, R., Strawbridge, R. J., Pers, T. H., Fischer, K., Justice, A. E., Workalemahu, T., Wu, J. M. W., Buchkovich, M. L., Heard-Costa, N. L., Roman, T. S., Drong, A. W., Song, C., Gustafsson, S., Day, F. R., Esko, T. & 31 othersFall, T., Kutalik, Z., Luan, J., Randall, J. C., Scherag, A., Vedantam, S., Wood, A. R., Chen, J., Fehrmann, R., Karjalainen, J., Kahali, B., Liu, C-T., Schmidt, E. M., Absher, D., Amin, N., Anderson, D., Beekman, M., Bragg-Gresham, J. L., Buyske, S., Demirkan, A., Ehret, G. B., Feitosa, M. F., Goel, A., Jackson, A. U., Johnson, T., Kleber, M. E., Kristiansson, K., Brennan, E. P., McKnight, A. J., Kee, F. & ADIPOGen Consortium, 12 Feb 2015, In : Nature. 518, 7538, p. 187-196 10 p.

Research output: Contribution to journalArticle

Body Fat Distribution
Genetic Loci
Waist-Hip Ratio
Waist Circumference
Hip
1445 Citations (Scopus)

Genetic studies of body mass index yield new insights for obesity biology

Locke, A. E., Kahali, B., Berndt, S. I., Justice, A. E., Pers, T. H., Day, F. R., Powell, C., Vedantam, S., Buchkovich, M. L., Yang, J., Croteau-Chonka, D. C., Esko, T., Fall, T., Ferreira, T., Gustafsson, S., Kutalik, Z., Luan, J., Mägi, R., Randall, J. C., Winkler, T. W. & 31 othersWood, A. R., Workalemahu, T., Faul, J. D., Smith, J. A., Hua Zhao, J., Zhao, W., Chen, J., Fehrmann, R., Hedman, Å. K., Karjalainen, J., Schmidt, E. M., Absher, D., Amin, N., Anderson, D., Beekman, M., Bolton, J. L., Bragg-Gresham, J. L., Buyske, S., Demirkan, A., Deng, G., Ehret, G. B., Feenstra, B., Feitosa, M. F., Fischer, K., Goel, A., Gong, J., Jackson, A. U., Kanoni, S., Brennan, E. P., McKnight, A. J. & LifeLines Cohort Study, 12 Feb 2015, In : Nature. 518, 7538, p. 197-206 10 p.

Research output: Contribution to journalArticle

Body Mass Index
Obesity
Adipogenesis
Genome-Wide Association Study
Adiposity
66 Citations (Scopus)
Chronic Renal Insufficiency
Methylation
DNA
DNA Methylation
Epigenomics
25 Citations (Scopus)

An Excess of Risk-Increasing Low-Frequency Variants Can Be a Signal of Polygenic Inheritance in Complex Diseases

Chan, Y., Lim, E. T., Sandholm, N., Wang, S. R., McKnight, A. J., Ripke, S., Daly, M. J., Neale, B. M., Salem, R. M. & Hirschhorn, J. N., 06 Mar 2014, In : The American Journal of Human Genetics. 94, 3, p. 437-452 16 p.

Research output: Contribution to journalArticle

Multifactorial Inheritance
Genome-Wide Association Study
Ulcerative Colitis
Crohn Disease
Chronic Kidney Failure
41 Citations (Scopus)

Genetics of New-Onset Diabetes after Transplantation

McCaughan, J. A., McKnight, A. J. & Maxwell, A. P., May 2014, In : Journal of the American Society of Nephrology. 25, 5, p. 1037-1049

Research output: Contribution to journalArticle

Transplantation
Single Nucleotide Polymorphism
Genome-Wide Association Study
Pathologic Processes
Kidney Transplantation
141 Citations (Scopus)

New susceptibility Loci associated with kidney disease in type 1 diabetes

Sandholm, N., Salem, R. M., McKnight, A. J., Brennan, E. P., Forsblom, C., Isakova, T., McKay, G. J., Williams, W. W., Sadlier, D. M., Mäkinen, V-P., Swan, E. J., Palmer, C., Boright, A. P., Ahlqvist, E., Deshmukh, H. A., Keller, B. J., Huang, H., Ahola, A. J., Fagerholm, E., Gordin, D. & 31 othersHarjutsalo, V., He, B., Heikkilä, O., Hietala, K., Kytö, J., Lahermo, P., Lehto, M., Lithovius, R., Osterholm, A-M., Parkkonen, M., Pitkäniemi, J., Rosengård-Bärlund, M., Saraheimo, M., Sarti, C., Söderlund, J., Soro-Paavonen, A., Syreeni, A., Thorn, L. M., Tikkanen, H., Tolonen, N., Tryggvason, K., Tuomilehto, J., Wadén, J., Gill, G. V., Prior, S., Guiducci, C., Mirel, D. B., Taylor, A., Savage, D. A., Maxwell, A. P. & DCCT/EDIC Research Group, Sep 2012, In : PLoS Genetics. 8, 9, p. e1002921 e1002921.

Research output: Contribution to journalArticle

Open Access
File
diabetic nephropathy
insulin-dependent diabetes mellitus
diabetes
Kidney Diseases
Diabetic Nephropathies
51 Citations (Scopus)

Donor ABCB1 Variant Associates with Increased Risk for Kidney Allograft Failure

Moore, J., McKnight, A. J., Döhler, B., Simmonds, M. J., Courtney, A. E., Brand, O. J., Briggs, D., Ball, S., Cockwell, P., Patterson, C. C., Maxwell, A. P., Gough, S. C. L., Opelz, G. & Borrows, R., 2012, In : Journal of the American Society of Nephrology. 23, 11, p. 1891-9 9 p.

Research output: Contribution to journalArticle

Renal Insufficiency
Allografts
Tissue Donors
Cytochrome P-450 CYP3A
Genotype
51 Citations (Scopus)

Association of Caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure

Moore, J., McKnight, A. J., Simmonds, M. J., Courtney, A. E., Hanvesakul, R., Brand, O. J., Briggs, D., Ball, S., Cockwell, P., Patterson, C., Maxwell, A., Gough, S. C. L. & Borrows, R., 07 Apr 2010, In : JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 303, 13, p. 1282-1287 6 p.

Research output: Contribution to journalArticle

Caveolin 1
Allografts
Fibrosis
Genotype
Transplants

Prizes

Albert Nelson Marquis Lifetime Achievement Award

Amy McKnight (Recipient), 2019

Prize: Prize (including medals and awards)

Industry
Excellence

Expert in diabetic nephropathy

Amy McKnight (Recipient), 30 Dec 2018

Prize: Prize (including medals and awards)

Leader in Diabetes Complications

Amy McKnight (Recipient), 07 Feb 2019

Prize: Prize (including medals and awards)

chronic illness
leader
academic achievement

Innovator in Diabetes

Amy McKnight (Recipient), 2010

Prize: Prize (including medals and awards)

Walls Bursary

Amy McKnight (Recipient), 2015

Prize: Prize (including medals and awards)

The AEG Raine Award

Amy McKnight (Recipient), 2012

Prize: Prize (including medals and awards)

Selected Activities 2010 2019

Faculty of Genomic Medicine (External organisation)

Amy Jayne McKnight (Member)
2019 → …

Activity: Membership typesMembership of network

Analytical challenges of harmonising and integrating diverse datasets / study types

Amy Jayne McKnight (Invited speaker)
02 Sep 201905 Sep 2019

Activity: Talk or presentation typesInvited or keynote talk at national or international conference

2019 UK Rare Disease Forum Conference

Amy Jayne McKnight (Session chair)
26 Oct 2019

Activity: Participating in or organising an event typesParticipation in conference

Complementing DNA sequence analysis with multi-omics for kidney disease

Amy Jayne McKnight (Invited speaker)
21 Nov 2019

Activity: Talk or presentation typesInvited talk

UKRI Population Research Resource Workshop

Amy Jayne McKnight (Advisor)
24 May 2019

Activity: Consultancy typesContribution to the work of national or international committees and working groups

Population Study Epigenetics and Genomics Working Group (External organisation)

Amy Jayne McKnight (Advisor)
01 Sep 2018 → …

Activity: Membership typesMembership of network

Multi-omic Advances for Chronic Kidney Disease

Amy Jayne McKnight (Invited speaker)
Nov 2018

Activity: Talk or presentation typesInvited or keynote talk at national or international conference

Diabetes and Renal Disease

Amy Jayne McKnight (Invited speaker)
01 Feb 2019

Activity: Talk or presentation typesInvited or keynote talk at national or international conference

NIA Biomarker Network Meeting

Amy Jayne McKnight (Participant)
2017 → …

Activity: Participating in or organising an event typesParticipation in conference

Applied genomic analyses for kidney disease

Amy Jayne McKnight (Advisor)
08 Aug 2017

Activity: Talk or presentation typesInvited talk

Diabetes UK (External organisation)

Amy Jayne McKnight (Member)
23 Jan 2017 → …

Activity: Membership typesMembership of peer review panel or committee

Improving diagnosis and personalising care: a beginner’s guide to WES and WGS

Amy Jayne McKnight (Speaker)
03 Mar 2015

Activity: Talk or presentation typesInvited talk

Webinar at Nature.com - Complementing the genome: epigenome wide studies to advance disease research

Amy Jayne McKnight (Presenter)
03 Dec 2014

Activity: Talk or presentation typesPublic lecture/debate/seminar

Northern Ireland Rare Disease Partnership (External organisation)

Amy Jayne McKnight (Member)
2012 → …

Activity: Membership typesMembership of public/government advisory/policy group or panel

Selected Press / Media

Rare disease plan and investment welcomed - Ards peninsula woman leads scheme

Amy McKnight

05/11/2015

1 media contribution

Press/Media: Public Engagement Activities

RariTea: raising awareness of issues and recent progress for rare diseases

Amy McKnight

21/02/201908/03/2019

2 media contributions

Press/Media: Public Engagement Activities