Projects per year
Bioinformatics, Genetics, Epigenetics, Genomics, Transcriptomics, DNA Methylation, Kidney Disease, Rare Disease, Healthy Ageing, Chronic Diseases, Registries, Renal
Research is focused on genomic factors that influence human disease, in particular genetic-epigenetic-transcriptomic associations with kidney disease, diseases common in ageing populations, and rare diseases. We conduct studies on candidate genes, prioritised genetic regions, genome-wide and epigenome-wide screens, along with whole exome/genome sequencing with specific emphasis on MHC, telomere and mitochondrial influences. Data is derived from individuals recruited as part of multi-centre collections and we participate in multiple mega-consortia projects, including developing and evaluating approaches for data integration from diverse sources. We also launched an international renal genetics initiative, creating the first chromosome-based maps for renal disease and a contributor-driven database for genes and complex chromosome abnormalities consistently demonstrating renal involvement.
Our laboratories are well equipped for genetic studies, including scanners and next generation sequencing machines; we are a next generation sequencing development site. This enables me to facilitate projects for many other teams looking at different diseases within and outside QUB. Whole exome sequencing, whole genome sequencing, RNA-seq and ChIP-Seq for rare and complex disorders, plus bacterial whole genome sequencing are performed. We are building the NICOLA (https://www.qub.ac.uk/sites/NICOLA/) bioresource, including multi-omic datasets with a focus on older individuals living in NI. Whole genome sequencing of 1278 individuals for rare diseases is underway as part of the NI Genomic Medicine Centre with the complementary development of an online information hub and patient-centred pathways. We hold several registries and are actively engaged in making maximal use of complex genomic information.
I have an extensive teaching commitment, having developed and co-ordinated six new modules, as well as several new postgraduate courses. Current teaching includes participating in standard setting, exam boards, progress reviews, postgraduate research boards and:
- Mentoring, Personal and Professional Development Portfolios
- MED1014: Genes, Molecules and Processes Foundations of Clinical Practice 1; I co-developed the genetic component of this module (three times) and Lecture
- BMS2103: I co-developed the genetic component of this year 2 biomedical science module (Cell Biology and Clinical Genetics), which was brand new for 2017-2018, co-coordinate the module, and Lecture. Our BSc (Hons) in Biomedical Science Programme has been accredited by the Institute of Biomedical Science (IBMS) for a further five years to 2022.
- MED1015: Systems, People and Populations Foundations of Clinical Practice 3; Lecture
- MED1020: Concepts in People and Populations; Lecture
- MED1021: Student Selected Component: Lecture
- Preparation for Practice: Lecture
- SCM7044/7025: Medical Statistics: Lecture
- SCM7048: Genomics and Genetics: Designed, Module Coordinator and Lecture
- SCM7052: Genomics, Cell Biology and Human Disease: Designed, Module Coordinator and Lecture
- SCM8095: Genomics and Human Disease: Designed, Module Coordinator and Lecture. This module has run across the MRes in Translational Medicine and MSc in Bioinformatics and Computational Biology, which has been shortlisted for the gradireland Higher Education Awards as Postgraduate Course of the Year in Computer Science & Technology and Postgraduate Course of the Year in Science.
- SCM8056: Postgraduate Research Induction, Minimising Plagiarism, Differentiation: Co-designed and Lecture
- TPU3008: Integrated Pharmacology: Lecture
I am also the director of postgraduate education and training for the Centre of Public Health, QUB
Expertise related to UN SDGs
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
27/01/2016 → …
01/08/2008 → …
27/02/2014 → 31/10/2017
Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane CollagenSUMMIT Consortium, DCCT/EDIC Research Group, GENIE Consortium, Kretzler, M., Susztak, K., Colhoun, H. M., Krolewski, A. S., Paterson, A. D., Groop, P-H., Rich, S. S., Hirschhorn, J. N. & Florez, J. C., 30 Sep 2019, In: Journal of the American Society of Nephrology. 30, 10, p. 2000-2016 17 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile29 Citations (Scopus)459 Downloads (Pure)
& 25 others, , 16 May 2019, In: New England Journal of Medicine. 380, 20, p. 1918-1928 11 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile20 Citations (Scopus)7 Downloads (Pure)
Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk FactorsKunzmann, A., Cañadas-Garre, M., Thrift, A., McMenamin, U., Johnston, B., Cardwell, C., Anderson, L., Spence, A., Lagergren, J., Xie, S-H., Smyth, L., McKnight, A. & Coleman, H., 01 Jan 2019, In: Gastroenterology. 156, 1, p. 43-45
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile6 Citations (Scopus)157 Downloads (Pure)
The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant populationUK Ireland Renal Transplant Consortium, Stapleton, C. P., Heinzel, A., Guan, W., van der Most, P. J., van Setten, J., Lord, G. M., Keating, B. J., Israni, A. K., de Borst, M. H., Bakker, S. J. L., Snieder, H., Weale, M. E., Delaney, F., Hernandez-Fuentes, M. P., Reindl-Schwaighofer, R., Oberbauer, R., Jacobson, P. A., Mark, P. B., Chapman, F. A. & 15 others, , 27 Feb 2019, (Early online date) In: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
Research output: Contribution to journal › Article › peer-review
Genetic susceptibility to chronic kidney disease – some more pieces for the heritability puzzle: Genetic predisposition to kidney diseaseGarre, M. C., Anderson, K., Cappa, R., Skelly, R., Smyth, L., McKnight, A. J. & Maxwell, A. P., 31 May 2019, In: Frontiers in Genetics.
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile13 Citations (Scopus)83 Downloads (Pure)
McKnight, A. J. (Creator), Queen's University Belfast, Dec 2018
GEnetics of Nephropathy - an International Effort (GENIE) GWAS of Diabetic Nephropathy in the UK GoKinD and All-Ireland Cohorts
Amy Jayne McKnight (Member)2019 → …
Activity: Membership types › Membership of network
Amy Jayne McKnight (Invited speaker)02 Sep 2019 → 05 Sep 2019
Activity: Talk or presentation types › Invited or keynote talk at national or international conference
Amy Jayne McKnight (Invited speaker)21 Nov 2019
Activity: Talk or presentation types › Invited talk