Amy Jayne McKnight

2024

A novel role for FERM domain-containing protein 3 (FRMD3) in CKD

Kennedy, C., Doyle, R., Gough, O., Mcevoy, C., Anallen, S. M., Hughes, M., Sheng, X., Crifo, B., Andrews, D., Gaffney, A., Rodriguez, J., Kennedy, S., Dillon, E., Crean, D., Zhang, W., Yi, Z., Nair, V., Susztak, K., Hirschhorn, J. & Florez, J. & 13 others, Groop, P.-H., Sandholm, N., Kretzler, M., Mckay, G. J., Mcknight, A. J., Maxwell, A. P., Matallanas, D., Dorman, A., Martin, F., Conlon, P. J., Sadlier, D. M., Brennan, E. & Godson, C., 16 Oct 2024, (Early online date) In: Kidney360.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

A systematic review of associations between the environment, DNA methylation, and cognition

Glover, S., Illyuk, J., Hill, C., McGuinness, B., McKnight, A. J. & Hunter, R., 16 Dec 2024, (Early online date) In: Environmental Epigenetics.

Research output: Contribution to journal › Article › peer-review

Open Access

Cohort profile: DNA methylation in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA) – recruitment and participant characteristics

Potter, C., Hill, C., Smyth, L. J., Neville, C., Scott, A., Kee, F., McGuinness, B. & McKnight, A., 13 Sept 2024, In: BMJ Open. 14, 9, 8 p., e085652.

Research output: Contribution to journal › Article › peer-review

Open Access

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13 Downloads (Pure)

Comparing the disease burden of rare and common diseases in the UK Biobank: Oral presentation

Hill, C., Crowe, A., Shah, S. & McKnight, A. J., 10 May 2024.

Research output: Contribution to conference › Other contribution to conference › peer-review

Donor genetic burden for cerebrovascular risk and kidney transplant outcome

Collins, K. E., Gilbert, E., Mauduit, V., Benson, K. A., Elhassan, E. A. E., O'Seaghdha, C., Hill, C., McKnight, A. J., Maxwell, A. P., van der Most, P. J., de Borst, M. H., Guan, W., Jacobson, P. A., Israni, A. K., Keating, B. J., Lord, G. M., Markkinen, S., Helanterä, I., Hyvärinen, K. & Partanen, J. & 4 others, Madden, S. F., Limou, S., Cavalleri, G. L. & Conlon, P. J., 29 May 2024, (Early online date) In: Journal of Nephrology.

Research output: Contribution to journal › Article › peer-review

Open Access

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2 Citations (Scopus)

9 Downloads (Pure)

Exploring accelerated ageing in diabetic kidney disease: Epigenetic clocks in UK-Ireland participants

Hill, C., Smyth, L. & McKnight, A. J., 17 May 2024.

Research output: Contribution to conference › Abstract › peer-review

Exploring the epigenome to identify biological links between the urban environment and neurodegenerative disease: an evidence review

Glover, S., Hill, C., McGuinness, B., McKnight, A. J. & Hunter, R. F., 15 Apr 2024, (Early online date) In: Cities and Health. 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

3 Citations (Scopus)

44 Downloads (Pure)

Genetic and epigenetic associations with post-transplant diabetes mellitus

Abdelrahman, Z., Maxwell, A. P. & McKnight, A. J., 17 Apr 2024, In: Genes. 15, 4, 20 p., 503.

Research output: Contribution to journal › Article › peer-review

Open Access

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17 Downloads (Pure)

Genetic variants affecting mitochondrial function provide further insights for kidney disease

Cañadas-Garre, M., Baños-Jaime, B., Maqueda, J., Smyth, L. J., Cappa, R., Skelly, R., Hill, C., Brennan, E. P., Doyle, R., Godson, C., Maxwell, A. P. & McKnight, A. J., 10 Jun 2024, In: BMC Genomics. 25, 20 p., 576.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

31 Downloads (Pure)

Integrated multiomic analyses: an approach to improve understanding of diabetic kidney disease

Hill, C., McKnight, A. J. & Smyth, L. J., 26 Oct 2024, (Early online date) In: Diabetic Medicine. 19 p., e15447.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

1 Citation (Scopus)

7 Downloads (Pure)

Integrating accelerometry, GPS, GIS and molecular data to investigate mechanistic pathways of the urban environmental exposome and cognitive outcomes in older adults: a longitudinal study protocol

Hunter, R. F., Cleland, C., Trott, M., O’Neill, S., Küçükali, H., Mullineaux, S., Kee, F., McKinley, J. M., Neville, C., O'Hara, L., Marr, C., McAlinden, M., Ellis, G., McKnight, A., Schipperijn, J., McHugh Power, J., Duong, T. & McGuinness, B., 10 Dec 2024, In: BMJ Open. 14, 12, 13 p., e085318.

Research output: Contribution to journal › Article › peer-review

Open Access

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22 Downloads (Pure)

Mitochondrial related variants associated with cardiovascular traits

Cañadas-Garre, M., Maqueda, J. J., Baños-Jaime, B., Hill, C., Skelly, R., Cappa, R., Brennan, E., Doyle, R., Godson, C., Maxwell, A. P. & McKnight, A. J., 27 Aug 2024, In: Frontiers in Physiology. 15, 17 p., 1395371.

Research output: Contribution to journal › Article › peer-review

Open Access

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13 Downloads (Pure)

Poster abstract: Using transcriptomics to refine the subtypes of non-functioning pituitary neuroendocrine tumours

Upritchard, M., Loughrey, P. B., Craig, S., Cooke, S., Herron, B., Miskelly, J., McKnight, A. J. & James, J. A., 16 Sept 2024, In: Endocrine Abstracts. 104, 1 p., P156.

Research output: Contribution to journal › Meeting abstract › peer-review

Stratification of glioma according to stemness scores in bulk and single cell transcriptomes

Abdelrahman, Z., McKnight, A. J., Abdelatty, A. & Wang, X., 24 Jan 2024.

Research output: Contribution to conference › Poster › peer-review

Stratification of glioma based on stemness scores in bulk and single-cell transcriptomes

Abdelrahman, Z., Abdelatty, A., Luo, J., McKnight, A. J. & Wang, X., Jun 2024, In: Computers in Biology and Medicine. 175, 15 p., 108304.

Research output: Contribution to journal › Article › peer-review

Open Access

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25 Downloads (Pure)

2023

A genome-wide association study identifies a possible role for cannabinoid signalling in the pathogenesis of diabetic kidney disease

Osman, W., Mousa, M., Albreiki, M., Baalfaqih, Z., Daggag, H., Hill, C., McKnight, A. J., Maxwell, A. P. & Al Safar, H., 22 Mar 2023, (Early online date) In: Scientific Reports. 13, 1, 11 p., 4661.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

67 Downloads (Pure)

Albuminuria-related genetic biomarkers: replication and predictive evaluation in individuals with and without diabetes from the UK Biobank

Cañadas-Garre, M., Kunzmann, A. T., Anderson, K., Brennan, E. P., Doyle, R., Patterson, C. C., Godson, C., Maxwell, A. P. & McKnight, A. J., 07 Jul 2023, In: International Journal of Molecular Sciences. 24, 13, 17 p., 11209.

Research output: Contribution to journal › Article › peer-review

Open Access

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2 Citations (Scopus)

35 Downloads (Pure)

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

VA Million Veteran Program & Global Lipids Genetics Consortium, 26 May 2023, (Early online date) In: Nature. 618, p. E19-E20

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Differential methylation in CD44 and SEC23A is associated with time preference in older individuals.

Northern Ireland COhort for the Longitudinal study of Ageing collaborative group, Apr 2023, In: Economics and Human Biology. 49

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

51 Downloads (Pure)

Differential methylation of telomere-related genes is associated with kidney disease in individuals with type 1 diabetes

Hill, C., Duffy, S., Kettyle, L. M., McGlynn, L., Sandholm, N., Salem, R. M., Thompson, A., Swan, E. J., Kilner, J., Rossing, P., Shiels, P. G., Lajer, M., Groop, P.-H., Maxwell, P., McKnight, A. J. & GENIE Consortium, O. B. O. T., May 2023, In: Genes. 14, 5, 28 p., 1029.

Research output: Contribution to journal › Article › peer-review

Open Access

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5 Citations (Scopus)

81 Downloads (Pure)

Ethics and genomics healthcare and research: building connections and sharing best practice: summary report

McKnight, A. J., 27 Jul 2023, Nuffield Council on Bioethics. 13 p.

Research output: Book/Report › Other report

Open Access

Four missense genetic variants in CUBN are associated with higher levels of eGFR in non-diabetes but not in diabetes mellitus or its subtypes: a genetic association study in Europeans

Uglebjerg, N., Ahmadizar, F., Aly, D., Cañadas-Garre, M., Hill, C., Naber, A., Singh, S., Smyth, L., Tregouet, D.-A., Chaker, L., Ghanbari, M., Ahlqvist, E., Hadjadj, S., van Hoek, M., Kavousi, M., McKnight, A. J., Sijbrands, E., Simons, M., Rossing, P. & Ahluwalia, T. S., 28 Feb 2023, In: Frontiers in Endocrinology. 14, 1081741.

Research output: Contribution to journal › Article › peer-review

Open Access

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3 Citations (Scopus)

20 Downloads (Pure)

Harnessing genomic analysis to explore the role of telomeres in the pathogenesis and progression of diabetic kidney disease

Hill, C., Duffy, S., Coulter, T., Maxwell, A. P. & McKnight, A. J., 28 Feb 2023, In: Genes. 14, 3, 609.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

6 Citations (Scopus)

71 Downloads (Pure)

High prevalence of anxiety and depression in patients with rare diseases in the UK Biobank: exploring the impact of pain and physical wellbeing

Hill, C., Shah, S., Crowe, A. & McKnight, A. J., 12 Jun 2023.

Research output: Contribution to conference › Poster › peer-review

Longitudinal epigenome-wide analysis of kidney transplant recipients pretransplant and posttransplant

Smyth, L. J., Kerr, K. R., Kilner, J., McGill, Á. E., Maxwell, A. P. & McKnight, A. J., 01 Feb 2023, In: Kidney International Reports. 8, 2, p. 330-340 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

6 Citations (Scopus)

79 Downloads (Pure)

Perceptions and experiences of rare diseases among General Practitioners: An exploratory study in NI

McMullan, J., Crowe, A. L., McClenaghan, T., McAneney, H. & McKnight, A. J., 09 Jun 2023, In: Archives of Clinical and Medical Case Reports. 7, p. 248-256

Research output: Contribution to journal › Article › peer-review

Open Access

Rare Diseases Research Landscape project report

Bainbridge, K., Rare Disease Research Landscape Steering Group & McKnight, A. J., 21 Sept 2023, UK Medical Research Council. 84 p. (NIHR Open Research)

Research output: Book/Report › Commissioned report

Open Access

File

54 Downloads (Pure)

Stakeholder perceptions of complementary and integrative medicines from people living with rare diseases in Northern Ireland: a mixed methods study

Crowe, A. L., Kerr, K., McAneney, H., McMullan, J., Duffy, G. & McKnight, A. J., 05 Dec 2023, (Early online date) In: Complementary Medicine Research. 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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34 Downloads (Pure)

When should we offer antenatal sequencing for urinary tract malformations? A systematic review, cohort study and meta-analysis

Sonner, S., Reilly, K., Woolf, A. S., Chandler, N., Kilby, M. D., Maher, E. R., Flanagan, C., McKnight, A. J. & Mone, F., 06 Dec 2023, (Early online date) In: Prenatal Diagnosis. 44, 2, p. 187-195 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2 Citations (Scopus)

27 Downloads (Pure)

2022

A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events

Cappozzo, A., McCrory, C., Robinson, O., Freni Sterrantino, A., Sacerdote, C., Krogh, V., Panico, S., Tumino, R., Iacoviello, L., Ricceri, F., Sieri, S., Chiodini, P., McKay, G. J., McKnight, A. J., Kee, F., Young, I. S., McGuinness, B., Crimmins, E. M., Arpawong, T. E. & Kenny, R. A. & 6 others, O'Halloran, A., Polidoro, S., Solinas, G., Vineis, P., Ieva, F. & Fiorito, G., 29 Sept 2022, In: Clinical Epigenetics. 14, 121.

Research output: Contribution to journal › Article › peer-review

Open Access

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14 Citations (Scopus)

50 Downloads (Pure)

A Formative Study of the Implementation of Whole Genome Sequencing in Northern Ireland

Kerr, K., McKenna, C., Heggarty, S., Bailie, C., McMullan, J., Crowe, A., Kilner, J., Donnelly, M., Boyle, S., Rea, G., Flanagan, C., McKee, S. & McKnight, A. J., 21 Jun 2022, In: Genes. 13, 7, 1104.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

155 Downloads (Pure)

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., Wenz, B., Clarke, S. L., Chesi, A., Wells, A., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K.-H. H., Ntalla, I., Hui, Q. & Klarin, D. & 31 others, Hilliard, A. T., Wang, Z., Xue, C., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Havulinna, A. S., Veturi, Y., Pacheco, J. A., Weir, D. R., Brown, M. R., Smyth, L. J., Cañadas-Garre, M., Li, X., Nelson, C. P., McKnight, A. J., Kee, F., Wilson, P., Brown, C. D. & Million Veterans Program, 04 Aug 2022, In: The American Journal of Human Genetics. 109, 8, p. 1366-1387 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

20 Citations (Scopus)

30 Downloads (Pure)

An investigation into DNA methylation patterns associated with risk preference in older individuals

Smyth, L. J., Cruise, S. M., Tang, J., Young, I., McGuinness, B., Kee, F., McKnight, A. J. & On behalf of NICOLA , 01 Oct 2022, In: Epigenetics. 17, 10, p. 1159-1172 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2 Citations (Scopus)

48 Downloads (Pure)

A saturated map of common genetic variants associated with human height

Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D., Graham, S. E., Mukamel, R. E., Spracklen, C. N., Yin, X., Chen, S.-H., Ferreira, T., Highland, H. H. & Ji, Y. & 31 others, Karaderi, T., Lin, K., Lüll, K., Malden, D. E., Medina-Gomez, C., Machado, M., Moore, A., Rüeger, S., Sim, X., Vrieze, S., Ahluwalia, T. S., Akiyama, M., Allison, M. A., Alvarez, M., Andersen, M. K., Ani, A., Appadurai, V., Arbeeva, L., Cai, H., Cañadas-Garre, M., Li, X., Nelson, C. P., Smyth, L. J., Sun, L., Wang, Z., Cole, J. W., Cooper, R. S., Kee, F., McKnight, A. J., Weir, D. R. & 23andMe Research Team, 12 Oct 2022, (Early online date) In: Nature.

Research output: Contribution to journal › Article › peer-review

Open Access

File

258 Citations (Scopus)

50 Downloads (Pure)

Carer reported experiences: supporting someone with a rare disease

McMullan, J., Crowe, A., Downes, K., McAneney, H. & McKnight, A. J., 01 May 2022, In: Health and Social Care in the Community. 30, p. 1097-1108

Research output: Contribution to journal › Article › peer-review

Open Access

File

12 Citations (Scopus)

146 Downloads (Pure)

Criteria to define rare diseases and orphan drugs: a systematic review protocol

Abozaid, G. M., Kerr, K., McKnight, A. & Al-Omar, H. A., 29 Jul 2022, In: BMJ Open. 12, 7, 5 p., e062126.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

18 Citations (Scopus)

122 Downloads (Pure)

DNA methylation at ten loci is a risk factor for kidney failure in individuals with type 1 diabetes and diabetic kidney disease

Syreeni, A., Dahlström, E. H., Smyth, L. J., Forsblom, C., Kilner, J., McKay, G. J., Maxwell, A. P., McKnight, A. J., Groop, P.-H. & Sandholm, N., 27 May 2022.

Research output: Contribution to conference › Abstract › peer-review

Open Access

File

26 Downloads (Pure)

DNA methylation is a risk factor for kidney failure in individuals with type 1 diabetes

Syreeni, A., Dahlström, E. H., Smyth, L. J., Gupta, Y., Forsblom, C., Kilner, J., McKay, G. J., Maxwell, A., McKnight, A., Groop, P.-H. & Sandholm, N., 30 Oct 2022, In: Diabetologia. 65, Supplement 1, p. S21 1 p., 38.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

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27 Downloads (Pure)

Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease

Smyth, L. J., Dahlström, E. H., Syreeni, A., Kerr, K., Kilner, J., Doyle, R., Brennan, E., Nair, V., Fermin, D., Nelson, R. G., Looker, H. C., Wooster, C., Andrews, D., Anderson, K., McKay, G. J., Cole, J. B., Salem, R. M., Conlon, P. J., Kretzler, M. & Hirschhorn, J. N. & 9 others, Sadlier, D., Godson, C., Florez, J. C., GENIE Consortium, Forsblom, C., Maxwell, A. P., Groop, P. H., Sandholm, N. & McKnight, A. J., 22 Dec 2022, In: Nature Communications. 13, 16 p., 7891.

Research output: Contribution to journal › Article › peer-review

Open Access

File

14 Citations (Scopus)

94 Downloads (Pure)

Exploring sex-specificities of the lymphoma genomic landscape in the UK Biobank

Hill, C., Muckian, M., Cañadas-Garre, M., McShane, C., Maxwell, A. P., Anderson, L. & McKnight, A. J., 16 Jun 2022, In: Irish Journal of Medical Science.

Research output: Contribution to journal › Meeting abstract

8 Downloads (Pure)

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease

Sandholm, N., Cole, J. B., Nair, V., Sheng, X., Liu, H., Ahlqvist, E., Van Zuydam, N., Dahlström, E. H., Fermin, D., Smyth, L., Salem, R. M., Forsblom, C., Valo, E., Harjutsalo, V., Brennan, E. P., McKay, G., Andrews, D., Doyle, R., Looker, H. & Nelson, R. & 11 others, Palmer, C., McKnight, A. J., Godson, C., Maxwell, P., Groop, L., McCarthy, M., Kretzler, M., Susztak, K., Hirschhorn, J. N., Florez, J. C. & Groop, P.-H., 28 Jun 2022, (Early online date) In: Diabetologia.

Research output: Contribution to journal › Article › peer-review

Open Access

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83 Downloads (Pure)

Harnessing the Full Potential of Multi-Omic Analyses to Advance the Study and Treatment of Chronic Kidney Disease

Hill, C., Avila-Palencia, I., Maxwell, A. P., Hunter, R. F. & McKnight, A. J., 27 Jun 2022, In: Frontiers in Nephrology . 2, 923068.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

5 Citations (Scopus)

114 Downloads (Pure)

Identification and validation of a novel pathogenic variant in GDF2 (BMP9) responsible for hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations

Balachandar, S., Graves, T. J., Shimonty, A., Kerr, K., Kilner, J., Xiao, S., Slade, R., Sroya, M., Alikian, M., Curetean, E., Thomas, E., McConnell, V., McKee, S., Boardman-Pretty, F., Devereau, A., Fowler, T. A., Caulfield, M. J., Alton, E. W., Ferguson, T. & Redhead, J. & 5 others, McKnight, A. J., Thomas, G. A., Research Consortium, G. E., Aldred, M. A. & Shovlin, C. L., Mar 2022, In: American Journal of Medical Genetics A. 188, 3, p. 959-964 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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34 Citations (Scopus)

77 Downloads (Pure)

Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., Clarke, S. L., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K.-H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z. & Xue, C. & 518 others, Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Havulinna, A. S., Veturi, Y., Pacheco, J. A., Rosenthal, E. A., Lingren, T., Feng, Q., Kullo, I. J., Narita, A., Takayama, J., Martin, H. C., Hunt, K. A., Trivedi, B., Haessler, J., Giulianini, F., Bradford, Y., Miller, J. E., Campbell, A., Lin, K., Millwood, I. Y., Rasheed, A., Hindy, G., Faul, J. D., Zhao, W., Weir, D. R., Turman, C., Huang, H., Graff, M., Choudhury, A., Sengupta, D., Mahajan, A., Brown, M. R., Zhang, W., Yu, K., Schmidt, E. M., Pandit, A., Gustafsson, S., Yin, X., Luan, J., Zhao, J.-H., Matsuda, F., Jang, H.-M., Yoon, K., Medina-Gomez, C., Pitsillides, A., Hottenga, J. J., Wood, A. R., Ji, Y., Gao, Z., Haworth, S., Yousri, N. A., Mitchell, R. E., Chai, J. F., Aadahl, M., Bjerregaard, A. A., Yao, J., Manichaikul, A., Hwu, C.-M., Hung, Y.-J., Warren, H. R., Ramirez, J., Bork-Jensen, J., Kårhus, L. L., Goel, A., Sabater-Lleal, M., Noordam, R., Mauro, P., Matteo, F., McDaid, A. F., Marques-Vidal, P., Wielscher, M., Trompet, S., Sattar, N., Møllehave, L. T., Munz, M., Zeng, L., Huang, J., Yang, B., Poveda, A., Kurbasic, A., Lamina, C., Forer, L., Scholz, M., Galesloot, T. E., Bradfield, J. P., Ruotsalainen, S. E., Daw, E., Zmuda, J. M., Mitchell, J. S., Fuchsberger, C., Christensen, H., Brody, J. A., Vazquez-Moreno, M., Feitosa, M. F., Wojczynski, M. K., Wang, Z., Preuss, M. H., Mangino, M., Christofidou, P., Verweij, N., Benjamins, J. W., Engmann, J., Tsao, N. L., Verma, A., Slieker, R. C., Lo, K. S., Zilhao, N. R., Le, P., Kleber, M. E., Delgado, G. E., Huo, S., Ikeda, D. D., Iha, H., Yang, J., Liu, J., Demirkan, A., Leonard, H. L., Marten, J., Frank, M., Schmidt, B., Smyth, L. J., Cañadas-Garre, M., Wang, C., Nakatochi, M., Wong, A., Hutri-Kähönen, N., Sim, X., Xia, R., Huerta-Chagoya, A., Fernandez-Lopez, J. C., Lyssenko, V., Nongmaithem, S. S., Bayyana, S., Stringham, H. M., Irvin, M. R., Oldmeadow, C., Kim, H.-N., Ryu, S., Timmers, P. R. H. J., Arbeeva, L., Dorajoo, R., Lange, L. A., Prasad, G., Lorés-Motta, L., Pauper, M., Long, J., Li, X., Theusch, E., Takeuchi, F., Spracklen, C. N., Loukola, A., Bollepalli, S., Warner, S. C., Wang, Y. X., Wei, W. B., Nutile, T., Ruggiero, D., Sung, Y. J., Chen, S., Liu, F., Yang, J., Kentistou, K. A., Banas, B., Nardone, G. G., Meidtner, K., Bielak, L. F., Smith, J. A., Hebbar, P., Farmaki, A.-E., Hofer, E., Lin, M., Concas, M. P., Vaccargiu, S., van der Most, P. J., Pitkänen, N., Cade, B. E., van der Laan, S. W., Chitrala, K. N., Weiss, S., Bentley, A. R., Doumatey, A. P., Adeyemo, A. A., Lee, J. Y., Petersen, E. R. B., Nielsen, A. A., Choi, H. S., Nethander, M., Freitag-Wolf, S., Southam, L., Rayner, N. W., Wang, C. A., Lin, S.-Y., Wang, J.-S., Couture, C., Lyytikäinen, L.-P., Nikus, K., Cuellar-Partida, G., Vestergaard, H., Hidalgo, B., Giannakopoulou, O., Cai, Q., Obura, M. O., van Setten, J., Li, X., Liang, J., Tang, H., Terzikhan, N., Shin, J. H., Jackson, R. D., Reiner, A. P., Martin, L. W., Chen, Z., Li, L., Kawaguchi, T., Thiery, J., Bis, J. C., Launer, L. J., Li, H., Nalls, M. A., Raitakari, O. T., Ichihara, S., Wild, S. H., Nelson, C. P., Campbell, H., Jäger, S., Nabika, T., Al-Mulla, F., Niinikoski, H., Braund, P. S., Kolcic, I., Kovacs, P., Giardoglou, T., Katsuya, T., de Kleijn, D., de Borst, G. J., Kim, E. K., Adams, H. H. H., Ikram, M. A., Zhu, X., Asselbergs, F. W., Kraaijeveld, A. O., Beulens, J. W. J., Shu, X.-O., Rallidis, L. S., Pedersen, O., Hansen, T., Mitchell, P., Hewitt, A. W., Kähönen, M., Pérusse, L., Bouchard, C., Tönjes, A., Chen, Y.-D. I., Pennell, C. E., Mori, T. A., Lieb, W., Franke, A., Ohlsson, C., Mellström, D., Cho, Y. S., Lee, H., Yuan, J.-M., Koh, W.-P., Rhee, S. Y., Woo, J.-T., Heid, I. M., Stark, K. J., Zimmermann, M. E., Völzke, H., Homuth, G., Evans, M. K., Zonderman, A. B., Polasek, O., Pasterkamp, G., Hoefer, I. E., Redline, S., Pahkala, K., Oldehinkel, A. J., Snieder, H., Biino, G., Schmidt, R., Schmidt, H., Bandinelli, S., Dedoussis, G., Thanaraj, T. A., Kardia, S. L. R., Peyser, P. A., Kato, N., Schulze, M. B., Girotto, G., Böger, C. A., Jung, B., Joshi, P. K., Bennett, D. A., De Jager, P. L., Lu, X., Mamakou, V., Brown, M., Caulfield, M. J., Munroe, P. B., Guo, X., Ciullo, M., Jonas, J. B., Samani, N. J., Kaprio, J., Pajukanta, P., Tusié-Luna, T., Aguilar-Salinas, C. A., Adair, L. S., Bechayda, S. A., de Silva, H. J., Wickremasinghe, A. R., Krauss, R. M., Wu, J.-Y., Zheng, W., Hollander, A. I., Bharadwaj, D., Correa, A., Wilson, J. G., Lind, L., Heng, C.-K., Nelson, A. E., Golightly, Y. M., Wilson, J. F., Penninx, B., Kim, H.-L., Attia, J., Scott, R. J., Rao, D. C., Arnett, D. K., Hunt, S. C., Walker, M., Koistinen, H. A., Chandak, G. R., Mercader, J. M., Costanzo, M. C., Jang, D., Burtt, N. P., Villalpando, C. G., Orozco, L., Fornage, M., Tai, E., van Dam, R. M., Lehtimäki, T., Chaturvedi, N., Yokota, M., Liu, J., Reilly, D. F., McKnight, A. J., Kee, F., Jöckel, K.-H., McCarthy, M. I., Palmer, C. N. A., Vitart, V., Hayward, C., Simonsick, E., van Duijn, C. M., Jin, Z.-B., Qu, J., Hishigaki, H., Lin, X., März, W., Gudnason, V., Tardif, J.-C., Lettre, G., Hart, L. M. '., Elders, P. J. M., Damrauer, S. M., Kumari, M., Kivimaki, M., van der Harst, P., Spector, T. D., Loos, R. J. F., Province, M. A., Parra, E. J., Cruz, M., Psaty, B. M., Brandslund, I., Pramstaller, P. P., Rotimi, C. N., Christensen, K., Ripatti, S., Widén, E., Hakonarson, H., Grant, S. F. A., Kiemeney, L. A. L. M., de Graaf, J., Loeffler, M., Kronenberg, F., Gu, D., Erdmann, J., Schunkert, H., Franks, P. W., Linneberg, A., Jukema, J. W., Khera, A. V., Männikkö, M., Jarvelin, M.-R., Kutalik, Z., Francesco, C., Mook-Kanamori, D. O., van Dijk, K. W., Watkins, H., Strachan, D. P., Grarup, N., Sever, P., Poulter, N., Chuang, L.-M., Rotter, J. I., Dantoft, T. M., Karpe, F., Neville, M. J., Timpson, N. J., Cheng, C.-Y., Wong, T.-Y., Khor, C. C., Li, H., Sabanayagam, C., Peters, A., Gieger, C., Hattersley, A. T., Pedersen, N. L., Magnusson, P. K. E., Boomsma, D. I., Willemsen, A. H. M., Cupples, L., van Meurs, J. B. J., Ghanbari, M., Gordon-Larsen, P., Huang, W., Kim, Y. J., Tabara, Y., Wareham, N. J., Langenberg, C., Zeggini, E., Kuusisto, J., Laakso, M., Ingelsson, E., Abecasis, G., Chambers, J. C., Kooner, J. S., de Vries, P. S., Morrison, A. C., Hazelhurst, S., Ramsay, M., North, K. E., Daviglus, M., Kraft, P., Martin, N. G., Whitfield, J. B., Abbas, S., Saleheen, D., Walters, R. G., Holmes, M. V., Black, C., Smith, B. H., Baras, A., Justice, A. E., Buring, J. E., Ridker, P. M., Chasman, D. I., Kooperberg, C., Tamiya, G., Yamamoto, M., van Heel, D. A., Trembath, R. C., Wei, W.-Q., Jarvik, G. P., Namjou, B., Hayes, M. G., Ritchie, M. D., Jousilahti, P., Salomaa, V., Hveem, K., Åsvold, B. O., Kubo, M., Kamatani, Y., Okada, Y., Murakami, Y., Kim, B.-J., Thorsteinsdottir, U., Stefansson, K., Zhang, J., Chen, Y., Ho, Y.-L., Lynch, J. A., Rader, D. J., Tsao, P. S., Chang, K.-M., Cho, K., O'Donnell, C. J., Gaziano, J. M., Wilson, P. W. F., Frayling, T. M., Hirschhorn, J. N., Kathiresan, S., Mohlke, K. L., Sun, Y. V., Morris, A. P., Boehnke, M., Natarajan, P., Deloukas, P., Willer, C. J., Assimes, T. L. & Peloso, G. M., 27 Dec 2022, In: Genome Biology. 23, 1, 268.

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Needs of informal caregivers of people with a rare disease: a rapid review of the literature

Mcmullan, J., Lohfeld, L. & McKnight, A. J., 12 Dec 2022, In: BMJ Open. 12, 12, 7 p., e063263.

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Prevalence and risk factors for age-related macular degeneration in a population-based cohort study of older adults in Northern Ireland using multimodal imaging: NICOLA Study

Hogg, R. E., Wright, D. M., Quinn, N. B., Muldrew, K. A., Hamill, B., Smyth, L., McKnight, A. J., Woodside, J., Tully, M. A., Cruise, S., McGuinness, B., Young, I. S., Kee, F., Peto, T. & Chakravarthy, U., 10 Oct 2022, (Early online date) In: British Journal of Ophthalmology. 7 p.

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The role of epigenetic clocks in explaining educational inequalities in mortality: a multi-cohort study and meta-analysis

Fiorito, G., Pedron, S., Ochoa-Rosales, C., McCrory, C., Polidoro, S., Zhang, Y., Dugué, P.-A., Ratliff, S., Zhao, W. N., McKay, G. J., Costa, G., Solinas, M. G., Mullan Harris, K., Tumino, R., Grioni, S., Ricceri, F., Panico, S., Brenner, H., Schwettmann, L. & Waldenberger, M. & 17 others, Matias-Garcia, P. R., Peters, A., Hodge, A., Giles, G. G., Schmitz, L. L., Levine, M., Smith, J. A., Liu, Y., Kee, F., Young, I. S., McGuinness, B., McKnight, A. J., van Meurs, J., Voortman, T., Kenny, R. A., Vineis, P. & Carmeli, C., 01 Sept 2022, In: The journals of gerontology. Series A, Biological sciences and medical sciences. 77, 9, p. 1750–1759

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2021

Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study

Smyth, L., Kilner, J., Nair, V., Liu, H., Brennan, E. P., Kerr, K., Sandholm, N., Cole, J. B., Dahlström, E., Syreeni, A., Salem, R. M., Nelson, R., Looker, H., Wooster, C., Anderson, K., McKay, G., Kee, F., Young, I., Andrews, D. & Forsblom, C. & 8 others, Hirschhorn, J. N., Godson, C., Groop, P.-H., Maxwell, P., Susztak, K., Kretzler, M., Florez, J. C. & McKnight, A. J., 01 May 2021, In: Clinical Epigenetics.

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Biochemical biomarkers

Cañadas-Garre, M., Smyth, L., Neville, C., Vijayakumar, A., Kee, F., Woodside, J. & McKnight, A. J., 15 Jun 2021, Objective measures of health and wellbeing of older adults in Northern Ireland: the NICOLA Study Wave 1. Kee, F., Neville, C., McGuinness, B. & Hogg, R. (eds.). Queen's University Belfast, p. 103-127

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Criteria to define rare diseases and orphan drugs: systematic review

Abozaid, G., Kerr, K., McKnight, A. & Alomar, H., 13 Aug 2021, PROSPERO.

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Amy Jayne McKnight

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