• Room 02.058 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Dr Margariti is open to wide-ranging PhD applications from candidates with a basic science or clinical background. Her fields of interest include: - Stem Cells - Diabetes - Cardiovascular biology - Vascular Diseases - Endothelial Dysfunction - RNA binding proteins - Epigenetics Previous research experience is desirable although not essential.

20062020

Research output per year

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Research Output

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Article
2020
1 Citation (Scopus)
2019

A histone deacetylase 7-derived peptide promotes vascular regeneration via facilitating 14-3-3γ phosphorylation

Yang, J., Moraga, A., Xu, J., Zhao, Y., Luo, P., Lao, K. H., Margariti, A., Zhao, Q., Ding, W., Wang, G., Zhang, M., Zheng, L., Zhang, Z., Hu, Y., Wang, W., Shen, L., Smith, A., Shah, A. M., Wang, Q. & Zeng, L., 13 Nov 2019, In : Stem Cells.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access
File
2 Citations (Scopus)
175 Downloads (Pure)

NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes postischaemic revascularisation

O'Neill, K. M., Campbell, D. C., Edgar, K. S., Gill, E. K., Moez, A., McLoughlin, K. J., O'Neill, C. L., Dellett, M., Hargey, C. J., Abudalo, R. A., O'Hare, M., Doyle, P., Toh, T., Khoo, J., Wong, J., McCrudden, C. M., Meloni, M., Brunssen, C., Morawietz, H., Yoder, M. C. & 6 others, McDonald, D. M., Watson, C. J., Stitt, A. W., Margariti, A., Medina, R. J. & Grieve, D. J., 01 Apr 2019, In : Cardiovascular Research.

Research output: Contribution to journalArticle

Open Access
File
29 Downloads (Pure)

The RNA-binding protein QKI controls alternative splicing in vascular cells, producing an effective model for therapy

Caines, R., Cochrane, A., Kelaini, S., Gonzalez, M. V., Yang, C., Eleftheriadou, M., Moez, A., Stitt, A. W., Zeng, L., Grieve, D. J. & Margariti, A., 15 Aug 2019, In : Journal of Cell Science.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018
Open Access
File
161 Downloads (Pure)

Direct Reprogramming to Vascular Cells: A Mini-Review

Tsifaki, M., Kelaini, S., Caines, R., Yacoub, A. & Margariti, A., 22 Aug 2018, In : Journal of Genetics and Cell Biology. p. 1-4

Research output: Contribution to journalArticle

Open Access
File
46 Downloads (Pure)

Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling

Vilà-González, M., Kelaini, S., Magee, C., Caines, R., Campbell, D., Eleftheriadou, M., Cochrane, A., Drehmer, D., Tsifaki, M., O'Neill, K., Pedrini, E., Yang, C., Medina, R., McDonald, D., Simpson, D., Zampetaki, A., Zeng, L., Grieve, D., Lois, N., Stitt, A. W. & 1 others, Margariti, A., 17 Nov 2018, In : Stem Cells.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
245 Downloads (Pure)

Follistatin-Like 3 Enhances the Function of Endothelial Cells Derived from Pluripotent Stem Cells by Facilitating β-Catenin Nuclear Translocation Through Inhibition of Glycogen Synthase Kinase-3β Activity

Kelaini, S., Vilà-González, M., Caines, R., Campbell, D., Eleftheriadou, M., Tsifaki, M., Magee, C., Cochrane, A., O'Neill, K., Yang, C., Stitt, A. W., Zeng, L., Grieve, D. J. & Margariti, A., 01 Jul 2018, In : Stem Cells. 36, 7, p. 1033-1044

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
138 Downloads (Pure)

RBPs Play Important Roles in Vascular Endothelial Dysfunction Under Diabetic Conditions

Yang, C., Kelaini, S., Caines, R. & Margariti, A., 20 Sep 2018, In : Frontiers in Physiology. 9, 1310, p. 1-11

Research output: Contribution to journalArticle

Open Access
File
195 Downloads (Pure)

Regenerating the Cardiovascular System Through Cell Reprogramming; Current Approaches and a Look Into the Future

Tsifaki, M., Kelaini, S., Caines, R., Yang, C. & Margariti, A., 20 Aug 2018, In : Frontiers in Cardiovascular Medicine . p. 1-12

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
183 Downloads (Pure)

The anti-psychotic drug pimozide is a novel chemotherapeutic for breast cancer

Dakir, E-H., Pickard, A., Srivastava, K., McCrudden, C. M., Gross, S. R., Lloyd, S., Zhang, S-D., Margariti, A., Morgan, R., Rudland, P. S. & El-Tanani, M., 09 Oct 2018, In : Oncotarget. 9, 79, p. 34889-34910 22 p.

Research output: Contribution to journalArticle

Open Access
File
193 Downloads (Pure)
2017

Quaking is a Key Regulator of Endothelial Cell Differentiation, Neovascularization and Angiogenesis

Cochrane, A., Kelaini, S., Bojdo, J., Vilà-González, M., Drehmer, D., Caines, R., Magee, C., Eleftheriadou, M., Hu, Y., Grieve, D., Stitt, A., Zeng, L., Xu, Q. & Margariti, A., Apr 2017, In : Stem Cells. 35, 4, p. 952-966 15 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
292 Downloads (Pure)

Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration

Hong, X., Margariti, A., Le Bras, A., Jacquet, L., Kong, W., Hu, Y. & Xu, Q., 17 Jul 2017, In : Scientific Reports. 7, 1, p. 1-17 5590.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
174 Downloads (Pure)
2016

Reprogramming towards endothelial cells for vascular regeneration

Hong, X., Le Bras, A., Margariti, A. & Xu, Q., Sep 2016, In : Genes and Diseases. 3, 3, p. 186-197 14 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
191 Downloads (Pure)
2015

c-Kit+ progenitors generate vascular cells for tissue-engineered grafts through modulation of the Wnt/Klf4 pathway

Campagnolo, P., Tsai, T-N., Hong, X., Kirton, J. P., So, P-W., Margariti, A., Di Bernardini, E., Wong, M. M., Hu, Y., Stevens, M. M. & Xu, Q., Aug 2015, In : Biomaterials. 60, p. 53-61 9 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
205 Downloads (Pure)
Open Access

MicroRNA-199a induces differentiation of induced pluripotent stem cells into endothelial cells by targeting sirtuin 1

Li, Z., Margariti, A., Wu, Y., Yang, F., Hu, J., Zhang, L. & Chen, T., Sep 2015, In : Molecular Medicine Reports. 12, 3, p. 3711-3717

Research output: Contribution to journalArticle

12 Citations (Scopus)

MicroRNA-199b modulates vascular cell fate during iPS cell differentiation by targeting the notch ligand jagged1 and enhancing VEGF signaling

Chen, T., Margariti, A., Kelaini, S., Cochrane, A., Guha, S. T., Hu, Y., Stitt, A. W., Zhang, L. & Xu, Q., May 2015, In : Stem Cells. 33, 5, p. 1405-1418 19 p.

Research output: Contribution to journalArticle

Open Access
File
35 Citations (Scopus)
118 Downloads (Pure)

XBP 1-deficiency abrogates neointimal lesion of injured vessels via cross talk with the PDGF signaling

Zeng, L., Li, Y., Yang, J., Wang, G., Margariti, A., Xiao, Q., Zampetaki, A., Yin, X., Mayr, M., Mori, K., Wang, W., Hu, Y. & Xu, Q., 25 Oct 2015, In : Arteriosclerosis Thrombosis and Vascular Biology. 35, 10, p. 2134-2144 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2014

Direct reprogramming of adult cells: avoiding the pluripotent state

Kelaini, S., Cochrane, A. & Margariti, A., 15 Feb 2014, In : Stem cells and cloning : advances and applications. 7, p. 19-29 11 p.

Research output: Contribution to journalArticle

Open Access
File
51 Citations (Scopus)
404 Downloads (Pure)

Macrophages Control Vascular Stem/Progenitor Cell Plasticity Through Tumor Necrosis Factor-α-Mediated Nuclear Factor-κB Activation

Wong, M. M., Chen, Y., Margariti, A., Winkler, B., Campagnolo, P., Potter, C., Hu, Y. & Xu, Q., Mar 2014, In : Arteriosclerosis Thrombosis and Vascular Biology. 34, 3, p. 635-643 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Peripheral neuropathy may be a potential risk of cardiovascular disease in diabetes mellitus

Margariti, A., Dec 2014, In : Heart (British Cardiac Society). 100, 23, p. 1823-1824 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Unspliced X-box-binding Protein 1 (XBP1) Protects Endothelial Cells from Oxidative Stress through Interaction with Histone Deacetylase 3

Martin, D., Li, Y., Yang, J., Wang, G., Margariti, A., Jiang, Z., Yu, H., Zampetaki, A., Hu, Y., Xu, Q. & Zeng, L., 31 Oct 2014, In : Journal of Biological Chemistry. 289, 44, p. 30625-30634 10 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
200 Downloads (Pure)
2013

Adventitial stem cells in vein grafts display multilineage potential that contributes to neointimal formation

Chen, Y., Wong, M. M., Campagnolo, P., Simpson, R., Winkler, B., Margariti, A., Hu, Y. & Xu, Q., Aug 2013, In : Arteriosclerosis Thrombosis and Vascular Biology. 33, 8, p. 1844-51

Research output: Contribution to journalArticle

58 Citations (Scopus)

Dysfunction of Endothelial Progenitor Cells from Smokers and Chronic Obstructive Pulmonary Disease Patients Due to Increased DNA Damage and Senescence

Paschalaki, K. E., Starke, R. D., Hu, Y., Mercado, N., Margariti, A., Gorgoulis, V. G., Randi, A. M. & Barnes, P. J., Dec 2013, In : Stem Cells. 31, 12, p. 2813-2826 14 p.

Research output: Contribution to journalArticle

Open Access
File
88 Citations (Scopus)
212 Downloads (Pure)

Endothelial lineage differentiation from induced pluripotent stem cells is regulated by microRNA-21 and transforming growth factor beta2 (TGF-β2) pathways

Di Bernardini, E., Campagnolo, P., Margariti, A., Zampetaki, A., Karamariti, E., Hu, Y. & Xu, Q., 19 Dec 2013, In : The Journal of biological chemistry. 289, 6, p. 3383-3393 11 p.

Research output: Contribution to journalArticle

Open Access
File
50 Citations (Scopus)
198 Downloads (Pure)

Histone deacetylase 3 unconventional splicing mediates endothelial-to- mesenchymal transition through transforming growth factor β2

Zeng, L., Wang, G., Ummarino, D., Margariti, A., Xu, Q., Xiao, Q., Wang, W., Zhang, Z., Yin, X., Mayr, M., Cockerill, G., Li, J. Y., Chien, S., Hu, Y. & Xu, Q., 01 Nov 2013, In : Journal of Biological Chemistry. 288, 44, p. 31853-31866 14 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Sirolimus Stimulates Vascular Stem/Progenitor Cell Migration and Differentiation Into Smooth Muscle Cells via Epidermal Growth Factor Receptor/Extracellular Signal-Regulated Kinase/β-Catenin Signaling Pathway

Wong, M. M., Winkler, B., Karamariti, E., Wang, X., Yu, B., Simpson, R., Chen, T., Margariti, A. & Xu, Q., Oct 2013, In : Arteriosclerosis Thrombosis and Vascular Biology. 33, 10, p. 2397-2406

Research output: Contribution to journalArticle

32 Citations (Scopus)

Smooth Muscle Cells Differentiated from Reprogrammed Embryonic Lung Fibroblasts Through DKK3 Signalling are Potent for Tissue Engineering of Vascular Grafts

Karamariti, E., Margariti, A., Winker, B., Wang, X., Hong, X., Baban, D., Ragoussis, J., Huang, Y., Han, J-D. J., Wong, M. M., Sag, C. M., Shah, A. M., Hu, Y. & Xu, Q., 24 May 2013, In : Circulation Research. 112, 11, p. 1433-1443 11 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis

Zeng, L., Xiao, Q., Chen, M., Margariti, A., Martin, D., Ivetic, A., Xu, H., Mason, J., Wang, W., Cockerill, G., Mori, K., Yi-Shuan Li, J., Chien, S., Hu, Y. & Xu, Q., 2013, In : Circulation. 127, 16, p. 1712-1722 11 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation

Margariti, A., Li, H., Chen, T., Martin, D., Vizcay-Barrena, G., Alam, S., Karamariti, E., Xiao, Q., Zampetaki, A., Zhang, Z., Wang, W., Jiang, Z., Gao, C., Ma, B., Chen, Y-G., Cockerill, G., Hu, Y., Xu, Q. & Zeng, L., 11 Jan 2013, In : Journal of Biological Chemistry. 288, 2, p. 859-72 14 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)
2012

Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels

Margariti, A., Winkler, B., Karamariti, E., Zampetaki, A., Tsai, T., Baban, D., Ragoussis, J., Huang, Y., Han, J-D. J., Zeng, L., Hu, Y. & Xu, Q., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 34, p. 13793-8 6 p.

Research output: Contribution to journalArticle

160 Citations (Scopus)

Epigenetics in Vascular Disease - Therapeutic Potential of New Agents

Xu, S. S., Alam, S. & Margariti, A., 2012, In : Current vascular pharmacology.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2011

Chromobox protein homolog 3 is essential for stem cell differentiation to smooth muscles in vitro and in embryonic arteriogenesis

Xiao, Q., Wang, G., Yin, X., Luo, Z., Margariti, A., Zeng, L., Mayr, M., Ye, S., Xu, Q. & Margariti, A., 2011, In : Arteriosclerosis Thrombosis and Vascular Biology. 31, 8, p. 1842-52 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Galectin-9 protein expression in endothelial cells is positively regulated by histone deacetylase 3

Alam, S., Li, H., Margariti, A., Martin, D., Zampetaki, A., Habi, O., Cockerill, G., Hu, Y., Xu, Q. & Zeng, L., 2011, In : Journal of Biological Chemistry. 286, 51, p. 44211-7 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis

Zhou, B., Margariti, A., Zeng, L. & Xu, Q., 2011, In : Cardiovascular Research. 90, 3, p. 413-20 8 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation

Zhou, B., Margariti, A., Zeng, L., Habi, O., Xiao, Q., Martin, D., Wang, G., Hu, Y., Wang, X. & Xu, Q., 2011, In : Arteriosclerosis Thrombosis and Vascular Biology. 31, 11, p. 2676-84 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2010

Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow

Zampetaki, A., Zeng, L., Margariti, A., Xiao, Q., Li, H., Zhang, Z., Pepe, A. E., Wang, G., Habi, O., deFalco, E., Cockerill, G., Mason, J. C., Hu, Y. & Xu, Q., 2010, In : Circulation. 121, 1, p. 132-42 11 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin

Margariti, A., Zampetaki, A., Xiao, Q., Zhou, B., Karamariti, E., Martin, D., Yin, X., Mayr, M., Li, H., Zhang, Z., De Falco, E., Hu, Y., Cockerill, G., Xu, Q. & Zeng, L., 2010, In : Circulation Research. 106, 7, p. 1202-11 10 p., 2nd.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Protein kinase C{delta} deficiency accelerates neointimal lesions of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation

Bai, X., Margariti, A., Hu, Y., Sato, Y., Zeng, L., Ivetic, A., Habi, O., Mason, J. C., Wang, X. & Xu, Q., 2010, In : Arteriosclerosis Thrombosis and Vascular Biology. 30, 12, p. 2467-74 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Sp1-dependent activation of HDAC7 is required for platelet-derived growth factor-BB-induced smooth muscle cell differentiation from stem cells

Zhang, L., Jin, M., Margariti, A., Wang, G., Luo, Z., Zampetaki, A., Zeng, L., Ye, S., Zhu, J. & Xiao, Q., 2010, In : Journal of Biological Chemistry. 285, 49, p. 38463-72 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2009

Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2

Xiao, Q., Luo, Z., Pepe, A. E., Margariti, A., Zeng, L., Xu, Q. & Margariti, A., 2009, In : American journal of physiology. Cell physiology. 296, 4, p. C711-23

Research output: Contribution to journalArticle

136 Citations (Scopus)

Splicing of HDAC7 modulates the SRF-myocardin complex during stem-cell differentiation towards smooth muscle cells

Margariti, A., Xiao, Q., Zampetaki, A., Zhang, Z., Li, H., Martin, D., Hu, Y., Zeng, L. & Xu, Q., 2009, In : Journal of Cell Science. 122, Pt 4, p. 460-70 11 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

Zeng, L., Zampetaki, A., Margariti, A., Pepe, A. E., Alam, S., Martin, D., Xiao, Q., Wang, W., Jin, Z-G., Cockerill, G., Mori, K., Li, Y-S. J., Hu, Y., Chien, S. & Xu, Q., 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 20, p. 8326-31 6 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)
2007

Lacking cytokine production in ES cells and ES-cell-derived vascular cells stimulated by TNF-alpha is rescued by HDAC inhibitor trichostatin A

Zampetaki, A., Zeng, L., Xiao, Q., Margariti, A., Hu, Y., Xu, Q. & Margariti, A., 2007, In : American journal of physiology. Cell physiology. 293, 4, p. C1226-38

Research output: Contribution to journalArticle

16 Citations (Scopus)
2006

HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells

Zeng, L., Xiao, Q., Margariti, A., Zhang, Z., Zampetaki, A., Patel, S., Capogrossi, M. C., Hu, Y. & Xu, Q., 2006, In : The Journal of cell biology. 174, 7, p. 1059-69 11 p.

Research output: Contribution to journalArticle

187 Citations (Scopus)

Sca-1+ progenitors derived from embryonic stem cells differentiate into endothelial cells capable of vascular repair after arterial injury

Xiao, Q., Zeng, L., Zhang, Z., Margariti, A., Ali, Z. A., Channon, K. M., Xu, Q. & Hu, Y., 2006, In : Arteriosclerosis Thrombosis and Vascular Biology. 26, 10, p. 2244-51 8 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Stem cells, vascular smooth muscle cells and atherosclerosis

Margariti, A., Zeng, L. & Xu, Q., 2006, In : Histology and histopathology. 21, 9, p. 979-85 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)