Projects per year
Personal profile
Research Statement
Krasnodembskaya’s research group works with Mesenchymal Stem Cells (MSC) with the particular focus on the MSC based cell therapy for Acute Respiratory Distress Syndrome (ARDS). ARDS constitutes a spectrum of severe acute respiratory failure and is leading cause of morbidity and mortality in critically ill. Our central goal is to understand how MSC work in the context of the injury microenvironment, how MSC modulate reparative capacities of the host cells and if we can enhance MSC therapeutic potential. We hope that this research will allow to develop better cell therapies as well as to identify new therapeutic targets for ARDS and sepsis. The current research projects are investigating effects of MSC on pulmonary macrophage polarisation, MSC modulation of distal lung endothelial and epithelial cell functions and more recently we became interested in therapeutic potential of MSC-derived extracellular vesicles as a potential cell-free therapy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Network
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R2353CEM: Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST)
O'Kane, C., Krasnodembskaya, A. & McAuley, D.
25/01/2017 → …
Project: Research
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R1900CEM: Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for ARDS
Krasnodembskaya, A., McAuley, D. & O'Kane, C.
13/04/2018 → 30/09/2020
Project: Research
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R1675CEM: Validation and optimisation of mechanisms underpinning Mesenchymal Stromal Cells (MSC) efficacy in Acute Respiratory Distress Syndrome (ARDS) and sepsis through investigation of the effects of inflammatory microenvironment on MSC activation
Krasnodembskaya, A., McAuley, D. & O'Kane, C.
12/10/2016 → 28/02/2018
Project: Research
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Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis
Su, Y., Silva, J. D., Doherty, D., Simpson, D. A., Weiss, D. J., Rolandsson-Enes, S., McAuley, D. F., O'Kane, C. M., Brazil, D. P. & Krasnodembskaya, A. D., 10 Aug 2022, (Early online date) In: Thorax.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Novel Antibacterial Properties of the Human Dental Pulp Multipotent Mesenchymal Stromal Cell Secretome
Ravenscroft, H., El Karim, I., Krasnodembskaya, A. D., Gilmore, B., About, I. & Lundy, F. T., 06 Jun 2022, In: The American journal of pathology. 192, 6, p. 956-969Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Downloads (Pure) -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) , 2021, In: Autophagy. 17, 1, p. 1-382 382 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile151 Citations (Scopus)15 Downloads (Pure) -
Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells
Rolandsson Enes, S., Hampton, T. H., Barua, J., McKenna, D. H., Dos Santos, C., Amiel, E., Ashare, A., Liu, K. D., Krasnodembskaya, A. D., English, K., Stanton, B., Rocco, P., Matthay, M. A. & Weiss, D., 2021, In: European Respiratory Journal. 58, 2004149.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Downloads (Pure) -
Investigation of the MSC Paracrine Effects on Alveolar-Capillary Barrier Integrity in the In Vitro Models of ARDS
Silva, J. D. & Krasnodembskaya, A. D., 10 Mar 2021, In Vitro Models for Stem Cell Therapy. Stock, P. & Christ, B. (eds.). Springer, p. 63-81 19 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
Prizes
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1st place at WWIEM 3rd year PhD symposiun
Butler, David (Recipient) & Krasnodembskaya, Anna (Recipient), 21 Mar 2022
Prize: Prize (including medals and awards)
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2nd place in WWIEM symposium for 1st year PhD students
McClintock, Catherine (Recipient) & Krasnodembskaya, Anna (Recipient), Jun 2021
Prize: Prize (including medals and awards)
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2nd place in WWIEM symposium for 2nd year PhD students
McClintock, Catherine (Recipient) & Krasnodembskaya, Anna (Recipient), 10 May 2022
Prize: Prize (including medals and awards)
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3rd place at WWIEM symposium for 2nd year PhD students
Butler, David (Recipient) & Krasnodembskaya, Anna (Recipient), 2021
Prize: Prize (including medals and awards)
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BALR Young Investigator of the Year 2015 awarded to Dr Megan Jackson, PDRA in my group at the British Society winter meeting, 2015
Jackson, M. (Recipient) & Krasnodembskaya, Anna (Recipient), Dec 2015
Prize: Prize (including medals and awards)
Activities
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NI Science Festival
Anna Krasnodembskaya (Participant), Johnatas Dutra Silva (Participant), Declan Doherty (Participant), Catherine McClintock (Participant) & Dayene de Assis Fernandes Caldeira (Participant)
19 Feb 2022Activity: Participating in or organising an event types › Participation in Festival/Exhibition
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Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Lung Diseases, Vermont 2023
Anna Krasnodembskaya (Organiser)
2022 → 2023Activity: Participating in or organising an event types › Participation in conference
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ERS research seminar -Innovative 3D models for understanding mechanisms underlying lung diseases
Anna Krasnodembskaya (Session chair)
07 Apr 2022 → 08 Apr 2022Activity: Participating in or organising an event types › Participation in conference
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ISCT Scientific signature series (Pulmonary Series III)
Anna Krasnodembskaya (Contributor)
16 Jul 2021Activity: Participating in or organising an event types › Participation in conference
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Grant Reviewer
Anna Krasnodembskaya (Reviewer)
Jun 2021 → Jul 2021Activity: Consultancy types › Contribution to the work of national or international committees and working groups
Press / Media
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Stem Cells Portal 'Bringing Novel Therapies Closer to the Patient'
04/05/2018
1 Media contribution
Press/Media: Research
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UNDERSTANDING STEM CELLS AND THEIR IMPACT IN LUNG DISEASE
11/11/2015
1 Media contribution
Press/Media: Public Engagement Activities
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How stem cells can be used to treat lung disease
22/10/2015
1 item of Media coverage
Press/Media: Public Engagement Activities
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The DNA of Innovation Volume 5
20/10/2015
1 item of Media coverage
Press/Media: Public Engagement Activities
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European Respiratory Society International Congress 2014 Press Release
09/09/2014
1 Media contribution
Press/Media: Public Engagement Activities