20042019
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Personal profile

Research Statement

Krasnodembskaya’s research group works with Mesenchymal Stem Cells (MSC) with the  particular focus  on the MSC based   cell therapy for Acute Respiratory Distress Syndrome (ARDS). ARDS constitutes a  spectrum of severe acute respiratory failure and is leading cause of morbidity and mortality in critically ill. Our central goal is to understand how MSC work in the context of the injury microenvironment, how MSC modulate reparative capacities of the host cells and if we can enhance MSC therapeutic potential. We hope that this research will allow to develop better cell therapies as well as to  identify new therapeutic targets for ARDS and sepsis. The current research projects are investigating effects of MSC on pulmonary macrophage polarisation, MSC modulation of distal lung endothelial and epithelial cell functions  and more recently we became interested in therapeutic potential of MSC-derived extracellular vesicles as a potential cell-free therapy.

 

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  • 21 Similar Profiles
Mesenchymal Stromal Cells Medicine & Life Sciences
Adult Respiratory Distress Syndrome Medicine & Life Sciences
Lung Medicine & Life Sciences
Stem Cells Medicine & Life Sciences
Cell- and Tissue-Based Therapy Medicine & Life Sciences
Pneumonia Medicine & Life Sciences
Nanotubes Medicine & Life Sciences
Macrophages Medicine & Life Sciences

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Projects 2014 2019

Research Output 2004 2019

2 Citations (Scopus)
Open Access
File
Acidosis
Stem cells
Mesenchymal Stromal Cells
Repair
Lung
6 Citations (Scopus)

Intercellular Communication via Organelle Transfer in the Biology and Therapeutic Applications of Stem Cells

Murray, L. MA. & Krasnodembskaya, A. D., 01 Jan 2019, In : Stem Cells. 37, 1, p. 14-25

Research output: Contribution to journalArticle

Open Access
File
Organelles
Stem Cells
Therapeutics
Nanotubes
Cell- and Tissue-Based Therapy
Open Access
File
Adult Respiratory Distress Syndrome
Mesenchymal Stromal Cells
MicroRNAs
Organelles
Mitochondria
1 Citation (Scopus)

The Necrobiology of Mesenchymal Stromal Cells Affects Therapeutic Efficacy

Weiss, D. J., English, K., Krasnodembskaya, A., Isaza-Correa, J. M., Hawthorne, J. J. & Mahon, B. P., 04 Jun 2019, In : Frontiers in immunology. 10, 12 p., 1228.

Research output: Contribution to journalArticle

Open Access
File
Mesenchymal Stromal Cells
Cell- and Tissue-Based Therapy
Autophagy
Therapeutics
Action Potentials

Activities 2011 2019

Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Lung Diseases

Anna Krasnodembskaya (Organiser)
15 Jul 201918 Jul 2019

Activity: Participating in or organising an event typesParticipation in conference

Stem Cells Transl Med (Journal)

Anna Krasnodembskaya (Peer reviewer)
15 Apr 2019

Activity: Publication peer-review and editorial work typesPublication peer-review

Molecular therapy : the journal of the American Society of Gene Therapy (Journal)

Anna Krasnodembskaya (Peer reviewer)
02 Jan 2019

Activity: Publication peer-review and editorial work typesPublication peer-review

Thorax (Journal)

Anna Krasnodembskaya (Peer reviewer)
Jun 2019

Activity: Publication peer-review and editorial work typesPublication peer-review

Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Lung Diseases

Anna Krasnodembskaya (Session chair)
15 Jul 201918 Jul 2019

Activity: Participating in or organising an event typesParticipation in conference

Press / Media

Thesis

Human Mesenchymal Stromal Cell Regulation of Pulmonary Macrophage Populations in the Acute Respiratory Distress Syndrome

Author: Morrison, T., 2017

Supervisor: Krasnodembskaya, A. (Supervisor), Kissenpfennig, A. (Supervisor) & O'Kane, C. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

The role of lipid A in the virulence of ESKAPE pathogens

Author: Bartholomew, T., 2019

Supervisor: Bengoechea, J. (Supervisor), McAuley, D. (Supervisor) & Krasnodembskaya, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy