• Room 02.059 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Dr Krasnodembskaya is open to PhD applications from motivated and enthusiastic students who is interested in Mesenchymal Stem Cells biology and therapeutic applications in lung diseases. Potential PhD projects on the following topics are available (the list is not exhaustive) : Investigation of the role of MSC exosomal miRNAs in epithelial and endothelial repair in ARDS The role of MSC mitochondrial transfer in lung regeneration The role of apoptosis in MSC therapeutic effects in ARDS

20042022

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Personal profile

Research Statement

Krasnodembskaya’s research group works with Mesenchymal Stem Cells (MSC) with the  particular focus  on the MSC based   cell therapy for Acute Respiratory Distress Syndrome (ARDS). ARDS constitutes a  spectrum of severe acute respiratory failure and is leading cause of morbidity and mortality in critically ill. Our central goal is to understand how MSC work in the context of the injury microenvironment, how MSC modulate reparative capacities of the host cells and if we can enhance MSC therapeutic potential. We hope that this research will allow to develop better cell therapies as well as to  identify new therapeutic targets for ARDS and sepsis. The current research projects are investigating effects of MSC on pulmonary macrophage polarisation, MSC modulation of distal lung endothelial and epithelial cell functions  and more recently we became interested in therapeutic potential of MSC-derived extracellular vesicles as a potential cell-free therapy.

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 14 - Life Below Water

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