Projects per year
Personal profile
Research Statement
Krasnodembskaya’s research group works with Mesenchymal Stem Cells (MSC) with the particular focus on the MSC based cell therapy for Acute Respiratory Distress Syndrome (ARDS). ARDS constitutes a spectrum of severe acute respiratory failure and is leading cause of morbidity and mortality in critically ill. Our central goal is to understand how MSC work in the context of the injury microenvironment, how MSC modulate reparative capacities of the host cells and if we can enhance MSC therapeutic potential. We hope that this research will allow to develop better cell therapies as well as to identify new therapeutic targets for ARDS and sepsis. The current research projects are investigating effects of MSC on pulmonary macrophage polarisation, MSC modulation of distal lung endothelial and epithelial cell functions and more recently we became interested in therapeutic potential of MSC-derived extracellular vesicles as a potential cell-free therapy.
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Projects
- 6 Active
R1900CEM: Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for ARDS
Krasnodembskaya, A., McAuley, D. & O'Kane, C.
13/04/2018 → …
Project: Research
R2353CEM: Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST)
O'Kane, C., Krasnodembskaya, A. & McAuley, D.
25/01/2017 → …
Project: Research
R1675CEM: Validation and optimisation of mechanisms underpinning Mesenchymal Stromal Cells (MSC) efficacy in Acute Respiratory Distress Syndrome (ARDS) and sepsis through investigation of the effects of inflammatory microenvironment on MSC activation
Krasnodembskaya, A., McAuley, D. & O'Kane, C.
12/10/2016 → …
Project: Research
Research Output
Hypercapnic acidosis induces mitochondrial dysfunction and impairs the ability of mesenchymal stem cells to promote distal lung epithelial repair
Fergie, N., Todd, N., McClements, L., McAuley, D., O'Kane, C. & Krasnodembskaya, A., 16 Jan 2019, In : The FASEB Journal. 14 p.Research output: Contribution to journal › Article
Open Access
File
4
Citations
(Scopus)
144
Downloads
(Pure)
Intercellular Communication via Organelle Transfer in the Biology and Therapeutic Applications of Stem Cells
Murray, L. MA. & Krasnodembskaya, A. D., 01 Jan 2019, In : Stem Cells. 37, 1, p. 14-25Research output: Contribution to journal › Article
Open Access
File
11
Citations
(Scopus)
140
Downloads
(Pure)
Investigating the role of inflammasomes in tissue repair
Lau, M. F., Kelly, L., Krasnodembskaya, A., Fitzgerald, D., Ingram, R., O'Kane, C. & Dombrowski, Y., 2019.Research output: Contribution to conference › Poster
Mesenchymal stem cell‐derived extracellular vesicles for the treatment of acute respiratory distress syndrome: Concise Review
Abraham, A. & Krasnodembskaya, A., 24 Oct 2019, In : Stem Cells Transl Med.Research output: Contribution to journal › Article
Open Access
File
1
Citation
(Scopus)
47
Downloads
(Pure)
The Necrobiology of Mesenchymal Stromal Cells Affects Therapeutic Efficacy
Weiss, D. J., English, K., Krasnodembskaya, A., Isaza-Correa, J. M., Hawthorne, J. J. & Mahon, B. P., 04 Jun 2019, In : Frontiers in immunology. 10, 12 p., 1228.Research output: Contribution to journal › Article
Open Access
File
4
Citations
(Scopus)
94
Downloads
(Pure)
Prizes
BALR Young Investigator of the Year 2015 awarded to Dr Megan Jackson, PDRA in my group at the British Society winter meeting, 2015
Megan Jackson (Recipient) & Anna Krasnodembskaya (Recipient), Dec 2015
Prize: Prize (including medals and awards)
Best abstract ERS bursary
Yue Su (Recipient) & Anna Krasnodembskaya (Recipient), Feb 2020
Prize: Other distinction
Best basic science manuscript published in Thorax in 2012. Silver medal
Anna Krasnodembskaya (Recipient), May 2013
Prize: Prize (including medals and awards)
Best oral presentation award at the All Ireland Meeting of Intensive and Critical Care society (ICSI Joint Summer Meeting) was awarded to Ms Nicola Fergie, PhD student in my group
Nicola Fergie (Recipient) & Anna Krasnodembskaya (Recipient), Jun 2017
Prize: Prize (including medals and awards)
Best Poster Presentation Award
Johnatas Dutra Silva (Recipient) & Anna Krasnodembskaya (Recipient), Mar 2020
Prize: Other distinction
Activities
NI Science Festival
Anna Krasnodembskaya (Presenter)15 Feb 2020
Activity: Participating in or organising an event types › Participation in Festival/Exhibition
Critical Care (Journal)
Anna Krasnodembskaya (Peer reviewer)Feb 2020
Activity: Publication peer-review and editorial work types › Publication peer-review
Reasearch Experience Open Day
Anna Krasnodembskaya (Host)Jan 2020
Activity: Other activity types › Hosting a school group or open day
18th ERS Lung Science Conference 2020 (Metabolic alterations in lung aging and disease)
Anna Krasnodembskaya (Invited speaker)08 Mar 2020
Activity: Talk or presentation types › Invited or keynote talk at national or international conference
Press / Media
Stem Cells Portal 'Bringing Novel Therapies Closer to the Patient'
04/05/2018
1 Media contribution
Press/Media: Research
Thesis
Human Mesenchymal Stromal Cell Regulation of Pulmonary Macrophage Populations in the Acute Respiratory Distress Syndrome
Author: Morrison, T., 2017Supervisor: Krasnodembskaya, A. (Supervisor), Kissenpfennig, A. (Supervisor) & O'Kane, C. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
The role of lipid A in the virulence of ESKAPE pathogens
Author: Bartholomew, T., 2019Supervisor: Bengoechea, J. (Supervisor), McAuley, D. (Supervisor) & Krasnodembskaya, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy