Projects per year
Personal profile
Research Statement
Krasnodembskaya’s research group works with Mesenchymal Stem Cells (MSC) with the particular focus on the MSC based cell therapy for Acute Respiratory Distress Syndrome (ARDS). ARDS constitutes a spectrum of severe acute respiratory failure and is leading cause of morbidity and mortality in critically ill. Our central goal is to understand how MSC work in the context of the injury microenvironment, how MSC modulate reparative capacities of the host cells and if we can enhance MSC therapeutic potential. We hope that this research will allow to develop better cell therapies as well as to identify new therapeutic targets for ARDS and sepsis. The current research projects are investigating effects of MSC on pulmonary macrophage polarisation, MSC modulation of distal lung endothelial and epithelial cell functions and more recently we became interested in therapeutic potential of MSC-derived extracellular vesicles as a potential cell-free therapy.
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- 21 Similar Profiles
Mesenchymal Stromal Cells
Medicine & Life Sciences
Adult Respiratory Distress Syndrome
Medicine & Life Sciences
Lung
Medicine & Life Sciences
Stem Cells
Medicine & Life Sciences
Cell- and Tissue-Based Therapy
Medicine & Life Sciences
Pneumonia
Medicine & Life Sciences
Nanotubes
Medicine & Life Sciences
Macrophages
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2014 2019
- 6 Active
R1900CEM: Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for ARDS
Krasnodembskaya, A., McAuley, D. & O'Kane, C.
13/04/2018 → …
Project: Research
R2353CEM: Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST)
O'Kane, C., Krasnodembskaya, A. & McAuley, D.
25/01/2017 → …
Project: Research
R1675CEM: Validation and optimisation of mechanisms underpinning Mesenchymal Stromal Cells (MSC) efficacy in Acute Respiratory Distress Syndrome (ARDS) and sepsis through investigation of the effects of inflammatory microenvironment on MSC activation
Krasnodembskaya, A., McAuley, D. & O'Kane, C.
12/10/2016 → …
Project: Research
Research Output 2004 2019
Hypercapnic acidosis induces mitochondrial dysfunction and impairs the ability of mesenchymal stem cells to promote distal lung epithelial repair
Fergie, N., Todd, N., McClements, L., McAuley, D., O'Kane, C. & Krasnodembskaya, A., 16 Jan 2019, In : The FASEB Journal. 14 p.Research output: Contribution to journal › Article
Open Access
File
Acidosis
Stem cells
Mesenchymal Stromal Cells
Repair
Lung
Intercellular Communication via Organelle Transfer in the Biology and Therapeutic Applications of Stem Cells
Murray, L. MA. & Krasnodembskaya, A. D., 01 Jan 2019, In : Stem Cells. 37, 1, p. 14-25Research output: Contribution to journal › Article
Open Access
File
Organelles
Stem Cells
Therapeutics
Nanotubes
Cell- and Tissue-Based Therapy
Investigating the role of inflammasomes in tissue repair
Lau, M. F., Kelly, L., Krasnodembskaya, A., Fitzgerald, D., Ingram, R., O'Kane, C. & Dombrowski, Y., 2019.Research output: Contribution to conference › Poster
Mesenchymal stem cell‐derived extracellular vesicles for the treatment of acute respiratory distress syndrome: Concise Review
Abraham, A. & Krasnodembskaya, A., 24 Oct 2019, In : Stem Cells Transl Med.Research output: Contribution to journal › Article
Open Access
File
Adult Respiratory Distress Syndrome
Mesenchymal Stromal Cells
MicroRNAs
Organelles
Mitochondria
The Necrobiology of Mesenchymal Stromal Cells Affects Therapeutic Efficacy
Weiss, D. J., English, K., Krasnodembskaya, A., Isaza-Correa, J. M., Hawthorne, J. J. & Mahon, B. P., 04 Jun 2019, In : Frontiers in immunology. 10, 12 p., 1228.Research output: Contribution to journal › Article
Open Access
File
Mesenchymal Stromal Cells
Cell- and Tissue-Based Therapy
Autophagy
Therapeutics
Action Potentials
Prizes
BALR Young Investigator of the Year 2015 awarded to Dr Megan Jackson, PDRA in my group at the British Society winter meeting, 2015
Megan Jackson (Recipient) & Anna Krasnodembskaya (Recipient), Dec 2015
Prize: Prize (including medals and awards)
Group
Society
Best basic science manuscript published in Thorax in 2012. Silver medal
Anna Krasnodembskaya (Recipient), May 2013
Prize: Prize (including medals and awards)
Numismatics
Manuscripts
Silver
Lung Diseases
Thorax
Best oral presentation award at the All Ireland Meeting of Intensive and Critical Care society (ICSI Joint Summer Meeting) was awarded to Ms Nicola Fergie, PhD student in my group
Nicola Fergie (Recipient) & Anna Krasnodembskaya (Recipient), Jun 2017
Prize: Prize (including medals and awards)
Ireland
Group
student
Society
British Lung Foundation, ERS 2014 Travel Award
Anna Krasnodembskaya (Recipient), 2014
Prize: Other distinction
Certificate of Acknowledgement of outstanding scientific contributions as a visiting scientist 2009-2012 (University of California San Francisco)
Anna Krasnodembskaya (Recipient), Dec 2012
Prize: Other distinction
Activities 2011 2019
Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Lung Diseases
Anna Krasnodembskaya (Organiser)15 Jul 2019 → 18 Jul 2019
Activity: Participating in or organising an event types › Participation in conference
Stem Cells Transl Med (Journal)
Anna Krasnodembskaya (Peer reviewer)15 Apr 2019
Activity: Publication peer-review and editorial work types › Publication peer-review
Molecular therapy : the journal of the American Society of Gene Therapy (Journal)
Anna Krasnodembskaya (Peer reviewer)02 Jan 2019
Activity: Publication peer-review and editorial work types › Publication peer-review
Thorax (Journal)
Anna Krasnodembskaya (Peer reviewer)Jun 2019
Activity: Publication peer-review and editorial work types › Publication peer-review
Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Lung Diseases
Anna Krasnodembskaya (Session chair)15 Jul 2019 → 18 Jul 2019
Activity: Participating in or organising an event types › Participation in conference
Press / Media
Stem Cells Portal 'Bringing Novel Therapies Closer to the Patient'
04/05/2018
1 media contribution
Press/Media: Research
Thesis
Human Mesenchymal Stromal Cell Regulation of Pulmonary Macrophage Populations in the Acute Respiratory Distress Syndrome
Author: Morrison, T., 2017Supervisor: Krasnodembskaya, A. (Supervisor), Kissenpfennig, A. (Supervisor) & O'Kane, C. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
The role of lipid A in the virulence of ESKAPE pathogens
Author: Bartholomew, T., 2019Supervisor: Bengoechea, J. (Supervisor), McAuley, D. (Supervisor) & Krasnodembskaya, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy