• Room 02.059 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Dr Krasnodembskaya is open to PhD applications from motivated and enthusiastic students who is interested in Mesenchymal Stem Cells biology and therapeutic applications in lung diseases. Potential PhD projects on the following topics are available (the list is not exhaustive) :
Investigation of the role of MSC exosomal miRNAs in epithelial and endothelial repair in ARDS
The role of MSC mitochondrial transfer in lung regeneration
The role of apoptosis in MSC therapeutic effects in ARDS

20042024

Research activity per year

Personal profile

Research Statement

Our studies  are  focused on the development of    Mesenchymal Stem Cells (MSC) - based therapies for respiratory diseases, investigation of the mechanisms of action of MSCs and MSC extracellular vesicles   in the injured lung and the  role of lung-resident MSCs in lung repair and regeneration. Our central goal is to understand how MSC (and their EVs) work in the context of the injury microenvironment, how MSC modulate reparative capacities of the host cells and if we can enhance MSC therapeutic potential. We hope that this research will allow to develop better cell therapies as well as to  identify new therapeutic targets.

Given difficulties in  applying  the knowledge gained in animal models in a logical way to the human disease process, we have strong interest in physiologically relevant models of the human lung tissue such as organoids, lung-on-chip and decel-recel approach.  We have recently established  a novel organoid model of the distal lung based on primary human cells.

Ongoing work is investigating the ability of MSC-derived extracellular vesicles to alleviate lung injury through transfer of healthy mitochondria and miRNAs, and the role of endogenous lung MSCs in regulation of endothelial and epithelial cells using an organoid model of the distal lung.

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 14 - Life Below Water

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