• Room 02.059 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Dr Krasnodembskaya is open to PhD applications from motivated and enthusiastic students who is interested in Mesenchymal Stem Cells biology and therapeutic applications in lung diseases. Potential PhD projects on the following topics are available (the list is not exhaustive) : Investigation of the role of MSC exosomal miRNAs in epithelial and endothelial repair in ARDS The role of MSC mitochondrial transfer in lung regeneration The role of apoptosis in MSC therapeutic effects in ARDS

20042019

Research output per year

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Personal profile

Research Statement

Krasnodembskaya’s research group works with Mesenchymal Stem Cells (MSC) with the  particular focus  on the MSC based   cell therapy for Acute Respiratory Distress Syndrome (ARDS). ARDS constitutes a  spectrum of severe acute respiratory failure and is leading cause of morbidity and mortality in critically ill. Our central goal is to understand how MSC work in the context of the injury microenvironment, how MSC modulate reparative capacities of the host cells and if we can enhance MSC therapeutic potential. We hope that this research will allow to develop better cell therapies as well as to  identify new therapeutic targets for ARDS and sepsis. The current research projects are investigating effects of MSC on pulmonary macrophage polarisation, MSC modulation of distal lung endothelial and epithelial cell functions  and more recently we became interested in therapeutic potential of MSC-derived extracellular vesicles as a potential cell-free therapy.

 

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Projects

Research Output

Open Access
File
  • 4 Citations (Scopus)
    144 Downloads (Pure)

    Intercellular Communication via Organelle Transfer in the Biology and Therapeutic Applications of Stem Cells

    Murray, L. MA. & Krasnodembskaya, A. D., 01 Jan 2019, In : Stem Cells. 37, 1, p. 14-25

    Research output: Contribution to journalArticle

    Open Access
    File
  • 11 Citations (Scopus)
    140 Downloads (Pure)
    Open Access
    File
  • 1 Citation (Scopus)
    47 Downloads (Pure)

    The Necrobiology of Mesenchymal Stromal Cells Affects Therapeutic Efficacy

    Weiss, D. J., English, K., Krasnodembskaya, A., Isaza-Correa, J. M., Hawthorne, J. J. & Mahon, B. P., 04 Jun 2019, In : Frontiers in immunology. 10, 12 p., 1228.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 4 Citations (Scopus)
    94 Downloads (Pure)

    Prizes

  • Best abstract ERS bursary

    Yue Su (Recipient) & Anna Krasnodembskaya (Recipient), Feb 2020

    Prize: Other distinction

  • Best basic science manuscript published in Thorax in 2012. Silver medal

    Anna Krasnodembskaya (Recipient), May 2013

    Prize: Prize (including medals and awards)

  • Best Poster Presentation Award

    Johnatas Dutra Silva (Recipient) & Anna Krasnodembskaya (Recipient), Mar 2020

    Prize: Other distinction

    Activities

    Work experience

    Anna Krasnodembskaya (Host)
    Jan 2020 → …

    Activity: Other activity typesOther

    NI Science Festival

    Anna Krasnodembskaya (Presenter)
    15 Feb 2020

    Activity: Participating in or organising an event typesParticipation in Festival/Exhibition

    Critical Care (Journal)

    Anna Krasnodembskaya (Peer reviewer)
    Feb 2020

    Activity: Publication peer-review and editorial work typesPublication peer-review

    Reasearch Experience Open Day

    Anna Krasnodembskaya (Host)
    Jan 2020

    Activity: Other activity typesHosting a school group or open day

    18th ERS Lung Science Conference 2020 (Metabolic alterations in lung aging and disease)

    Anna Krasnodembskaya (Invited speaker)
    08 Mar 2020

    Activity: Talk or presentation typesInvited or keynote talk at national or international conference

    Press / Media

    Thesis

    Human Mesenchymal Stromal Cell Regulation of Pulmonary Macrophage Populations in the Acute Respiratory Distress Syndrome

    Author: Morrison, T., 2017

    Supervisor: Krasnodembskaya, A. (Supervisor), Kissenpfennig, A. (Supervisor) & O'Kane, C. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    The role of lipid A in the virulence of ESKAPE pathogens

    Author: Bartholomew, T., 2019

    Supervisor: Bengoechea, J. (Supervisor), McAuley, D. (Supervisor) & Krasnodembskaya, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy