Projects per year
Personal profile
Research Statement
Krasnodembskaya’s research group works with Mesenchymal Stem Cells (MSC) with the particular focus on the MSC based cell therapy for Acute Respiratory Distress Syndrome (ARDS). ARDS constitutes a spectrum of severe acute respiratory failure and is leading cause of morbidity and mortality in critically ill. Our central goal is to understand how MSC work in the context of the injury microenvironment, how MSC modulate reparative capacities of the host cells and if we can enhance MSC therapeutic potential. We hope that this research will allow to develop better cell therapies as well as to identify new therapeutic targets for ARDS and sepsis. The current research projects are investigating effects of MSC on pulmonary macrophage polarisation, MSC modulation of distal lung endothelial and epithelial cell functions and more recently we became interested in therapeutic potential of MSC-derived extracellular vesicles as a potential cell-free therapy.
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Projects
- 6 Active
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R1900CEM: Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for ARDS
Krasnodembskaya, A., McAuley, D. & O'Kane, C.
13/04/2018 → …
Project: Research
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R2353CEM: Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST)
O'Kane, C., Krasnodembskaya, A. & McAuley, D.
25/01/2017 → …
Project: Research
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R1675CEM: Validation and optimisation of mechanisms underpinning Mesenchymal Stromal Cells (MSC) efficacy in Acute Respiratory Distress Syndrome (ARDS) and sepsis through investigation of the effects of inflammatory microenvironment on MSC activation
Krasnodembskaya, A., McAuley, D. & O'Kane, C.
12/10/2016 → …
Project: Research
Research Output
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Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells.
Abreu, S., Hampton, T., Hoffman, E., Dearborne, J., Ashare, A., Sidhu, K., Mattheews, D., McKenna, D., Amiel, E., Barua, J., Krasnodembskaya, A., English, K., Mahon, B. P., Dos Santos, C., Cruz, F., Chambers, D., Liu, K. D., Matthay, M. A., Cramer, R., Stanton, B. & 4 others, , 09 Sep 2020, In : American Journal of Physiology - Lung Cellular and Molecular Physiology.Research output: Contribution to journal › Article › peer-review
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Emerging Therapeutic Potential of Mesenchymal Stem/Stromal Cells in Preeclampsia
Suvakov, S., Richards, C., Nikolic, V., Simic, T. P., McGrath, K., Krasnodembskaya, A. & McClements, L., 14 Apr 2020, In : Current Hypertension Reports. 22, 37.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
In reply
Krasnodembskaya, A., 22 Apr 2020, In : Stem cells translational medicine.Research output: Contribution to journal › Article
Open AccessFile -
MSC extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS
Silva, J. D., Su, Y., Calfee, C. S., Delucchi, K. L., Weiss, D., McAuley, D. F., O'Kane, C. & Krasnodembskaya, A. D., 17 Dec 2020, In : European Respiratory Journal. 57, 1Research output: Contribution to journal › Article › peer-review
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Role of A Novel Angiogenesis FKBPL-CD44 Pathway in Preeclampsia Risk Stratification and Mesenchymal Stem Cell Treatment
Todd, N., McNally, R., Alqudah, A., Jerotic, D., Suvakov, S., Obradovic, D., Hoch, D., Hombrebueno, J. R., Campos, G. L., Watson, C. J., Gojnic-Dugalic, M., Simic, T. P., Krasnodembskaya, A., Desoye, G., Eastwood, K-A., Hunter, A. J., Holmes, V. A., McCance, D. R., Young, I. S., Grieve, D. J. & 4 others, , 27 Nov 2020, In : The Journal of Clinical Endocrinology & Metabolism. 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Prizes
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BALR Young Investigator of the Year 2015 awarded to Dr Megan Jackson, PDRA in my group at the British Society winter meeting, 2015
Megan Jackson (Recipient) & Krasnodembskaya, Anna (Recipient), Dec 2015
Prize: Prize (including medals and awards)
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Best abstract ERS bursary
Su, Yue (Recipient) & Krasnodembskaya, Anna (Recipient), Feb 2020
Prize: Other distinction
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Best basic science manuscript published in Thorax in 2012. Silver medal
Krasnodembskaya, Anna (Recipient), May 2013
Prize: Prize (including medals and awards)
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Best oral presentation award at the All Ireland Meeting of Intensive and Critical Care society (ICSI Joint Summer Meeting) was awarded to Ms Nicola Fergie, PhD student in my group
Nicola Fergie (Recipient) & Krasnodembskaya, Anna (Recipient), Jun 2017
Prize: Prize (including medals and awards)
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Best Poster Presentation Award
Silva, Johnatas Dutra (Recipient) & Krasnodembskaya, Anna (Recipient), Mar 2020
Prize: Other distinction
Activities
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2020 Centre for Experimental Medicine Postdoctoral Research Symposium
Anna Krasnodembskaya (Organiser)
24 Jan 2020Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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7th International Forum on Stem Cells, 2020: IFSC Beijing, China
Anna Krasnodembskaya (Invited speaker)
18 Nov 2020Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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Reasearch Experience Open Day
Anna Krasnodembskaya (Host)
Jan 2020Activity: Other activity types › Hosting a school group or open day
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NI Science Festival
Anna Krasnodembskaya (Presenter)
15 Feb 2020Activity: Participating in or organising an event types › Participation in Festival/Exhibition
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PhD viva examination
Anna Krasnodembskaya (Examiner) & John Simpson (Examiner)
18 Sep 2020Activity: Examination types › Other examination
Press / Media
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Stem Cells Portal 'Bringing Novel Therapies Closer to the Patient'
04/05/2018
1 Media contribution
Press/Media: Research