Projects per year
Personal profile
Research Statement
Krasnodembskaya’s research group works with Mesenchymal Stem Cells (MSC) and MSC derived extracellular vesicles (EVs) with the particular focus on the MSC based cell therapy for acute and chronic lung diseases. Our central goal is to understand how MSC (and their EVs) work in the context of the injury microenvironment, how MSC modulate reparative capacities of the host cells and if we can enhance MSC therapeutic potential. We hope that this research will allow to develop better cell therapies as well as to identify new therapeutic targets. The current research projects are investigating effects of MSC EVs on pulmonary macrophage polarisation and MSC EV modulation of distal lung endothelial and epithelial cell functions. Given difficulties in appling the knowledge gained in animal models in a logical way to the human disease process, we have strong interest in physiologically relevant models of the human lung tissue such as organoids, lung-on-chip and decel-recel approach. In our work we actively use a novel organoid model of the distal lung based on primary human cells (established by us) and a model of ex vivo cultured lung slices.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R2353CEM: Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST)
O'Kane, C., Krasnodembskaya, A. & McAuley, D.
25/01/2017 → …
Project: Research
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R1900CEM: Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for ARDS
Krasnodembskaya, A., McAuley, D. & O'Kane, C.
13/04/2018 → 30/09/2020
Project: Research
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R1675CEM: Validation and optimisation of mechanisms underpinning Mesenchymal Stromal Cells (MSC) efficacy in Acute Respiratory Distress Syndrome (ARDS) and sepsis through investigation of the effects of inflammatory microenvironment on MSC activation
Krasnodembskaya, A., McAuley, D. & O'Kane, C.
12/10/2016 → 28/02/2018
Project: Research
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Nebulised mesenchymal stem cell derived extracellular vesicles ameliorate E. coli induced pneumonia in a rodent model
Gonzalez, H., McCarthy, S., Masterson, C., Byrnes, D., Sallent, I., Horan, E., Elliman, S. J., Vella, G., Mello, A. P., Silva, J. D., Krasnodembskaya, A. D., MacLoughlin, R., Laffey, J. G. & O'Toole, D., 06 Jun 2023, In: Stem Cell Research & Therapy. 14, 151.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Repair of acute respiratory distress syndrome in COVID-19 by stromal cells (REALIST-COVID Trial): A multicentre, randomised, controlled trial
Gorman, E. A., Rynne, J., Gardiner, H. J., Rostron, A. J., Bannard-Smith, J., Bentley, A. M., Brealey, D., Campbell, C., Curley, G., Clarke, M., Dushianthan, A., Hopkins, P., Jackson, C., Kefela, K., Krasnodembskaya, A., Laffey, J. G., McDowell, C., McFarland, M., McFerran, J., McGuigan, P., & 12 others , 08 May 2023, (Early online date) In: American Journal of Respiratory and Critical Care Medicine.Research output: Contribution to journal › Article › peer-review
Open Access -
The role of lung resident mesenchymal stromal cells in the pathogenesis and repair of chronic lung disease
Doherty, D. F., Roets, L. & Krasnodembskaya, A. D., May 2023, In: Stem Cells. 41, 5, p. 431–443 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
Biomarkers of mitochondrial dysfunction in acute respiratory distress syndrome: A systematic review and meta-analysis
McClintock, C. R., Mulholland, N. & Krasnodembskaya, A. D., 14 Dec 2022, In: Frontiers in Medicine. 9, 20 p., 1011819.Research output: Contribution to journal › Review article › peer-review
Open AccessFile17 Downloads (Pure) -
Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis
Su, Y., Silva, J. D., Doherty, D., Simpson, D. A., Weiss, D. J., Rolandsson-Enes, S., McAuley, D. F., O'Kane, C. M., Brazil, D. P. & Krasnodembskaya, A. D., 10 Aug 2022, (Early online date) In: Thorax.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Downloads (Pure)
Prizes
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1st place at WWIEM 3rd year PhD symposiun
Butler, David (Recipient) & Krasnodembskaya, Anna (Recipient), 21 Mar 2022
Prize: Prize (including medals and awards)
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2nd place in WWIEM symposium for 1st year PhD students
McClintock, Catherine (Recipient) & Krasnodembskaya, Anna (Recipient), Jun 2021
Prize: Prize (including medals and awards)
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2nd place in WWIEM symposium for 2nd year PhD students
McClintock, Catherine (Recipient) & Krasnodembskaya, Anna (Recipient), 10 May 2022
Prize: Prize (including medals and awards)
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3rd place at WWIEM symposium for 2nd year PhD students
Butler, David (Recipient) & Krasnodembskaya, Anna (Recipient), 2021
Prize: Prize (including medals and awards)
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BALR Young Investigator of the Year 2015 awarded to Dr Megan Jackson, PDRA in my group at the British Thoracic Society winter meeting, 2015
Jackson, Megan (Recipient) & Krasnodembskaya, Anna (Recipient), Dec 2015
Prize: Prize (including medals and awards)
Activities
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European Respiratory Society International Congress, 2023, Milan
Anna Krasnodembskaya (Chair)
12 Sep 2023Activity: Participating in or organising an event types › Participation in conference
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European Respiratory Society International Congress, 2023, Milan
Anna Krasnodembskaya (Chair)
10 Sep 2023Activity: Participating in or organising an event types › Participation in conference
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European Respiratory Society International Congress, 2023, Milan
Anna Krasnodembskaya (Invited speaker)
09 Sep 2023 → 13 Sep 2023Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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6th International ARDS Conference
Anna Krasnodembskaya (Invited speaker)
19 Jun 2023 → 22 Jun 2023Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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TERMIS-EU 2023, ManchesterEuropean Chapter of Tissue Engineering and Regerative Medicine International Society Conference 2023
Anna Krasnodembskaya (Speaker)
28 Mar 2023 → 31 Mar 2023Activity: Participating in or organising an event types › Participation in conference
Press/Media
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Stem Cells Portal 'Bringing Novel Therapies Closer to the Patient'
04/05/2018
1 Media contribution
Press/Media: Research
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UNDERSTANDING STEM CELLS AND THEIR IMPACT IN LUNG DISEASE
11/11/2015
1 Media contribution
Press/Media: Public Engagement Activities
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How stem cells can be used to treat lung disease
22/10/2015
1 item of Media coverage
Press/Media: Public Engagement Activities
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The DNA of Innovation Volume 5
20/10/2015
1 item of Media coverage
Press/Media: Public Engagement Activities
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European Respiratory Society International Congress 2014 Press Release
09/09/2014
1 Media contribution
Press/Media: Public Engagement Activities