Anna Krasnodembskaya

Phone+44 (0)28 9097 6386
Emaila.krasnodembskaya@qub.ac.uk

Room 02.059 - CEM
United Kingdom

Accepting PhD Students

PhD projects

Dr Krasnodembskaya is open to PhD applications from motivated and enthusiastic students who is interested in Mesenchymal Stem Cells biology and therapeutic applications in lung diseases. Potential PhD projects on the following topics are available (the list is not exhaustive) : Investigation of the role of MSC exosomal miRNAs in epithelial and endothelial repair in ARDS The role of MSC mitochondrial transfer in lung regeneration The role of apoptosis in MSC therapeutic effects in ARDS

Research output per year

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Personal profile

Research Statement

Krasnodembskaya’s research group works with Mesenchymal Stem Cells (MSC) with the particular focus on the MSC based cell therapy for Acute Respiratory Distress Syndrome (ARDS). ARDS constitutes a spectrum of severe acute respiratory failure and is leading cause of morbidity and mortality in critically ill. Our central goal is to understand how MSC work in the context of the injury microenvironment, how MSC modulate reparative capacities of the host cells and if we can enhance MSC therapeutic potential. We hope that this research will allow to develop better cell therapies as well as to identify new therapeutic targets for ARDS and sepsis. The current research projects are investigating effects of MSC on pulmonary macrophage polarisation, MSC modulation of distal lung endothelial and epithelial cell functions and more recently we became interested in therapeutic potential of MSC-derived extracellular vesicles as a potential cell-free therapy.

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Projects

6 Active

R1002CEM: "The role of extracellular vesicle miRNAs in Mesenchymal Stem Cells’ effects on macrophage modulation in ARDS”

Krasnodembskaya, A., McAuley, D., O'Kane, C. & Simpson, D.

10/01/2019 → …

Project: Research

R1896CEM: Investigating the antimicrobial efficacy of mesenchymal stromal cells as a novel potential therapy for Mycobacterial avium pulmonary infection

O'Kane, C., Krasnodembskaya, A., Schroeder, G. N. & Shaw, T.

14/05/2018 → …

Project: Research

R1900CEM: Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for ARDS

Krasnodembskaya, A., McAuley, D. & O'Kane, C.

13/04/2018 → …

Project: Research

R2353CEM: Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST)

O'Kane, C., Krasnodembskaya, A. & McAuley, D.

25/01/2017 → …

Project: Research

R1675CEM: Validation and optimisation of mechanisms underpinning Mesenchymal Stromal Cells (MSC) efficacy in Acute Respiratory Distress Syndrome (ARDS) and sepsis through investigation of the effects of inflammatory microenvironment on MSC activation

Krasnodembskaya, A., McAuley, D. & O'Kane, C.

12/10/2016 → …

Project: Research

Research Output

25 Article
16 Meeting abstract
1 Chapter
1 Poster
2 More
- 1 Comment/debate
- 1 Patent

Emerging Therapeutic Potential of Mesenchymal Stem/Stromal Cells in Preeclampsia

Suvakov, S., Richards, C., Nikolic, V., Simic, T. P., McGrath, K., Krasnodembskaya, A. & McClements, L., 14 Apr 2020, In : Current Hypertension Reports. 22, 37.

Research output: Contribution to journal › Article