Projects per year
Personal profile
Research Statement
Our studies are focused on the development of Mesenchymal Stem Cells (MSC) - based therapies for respiratory diseases, investigation of the mechanisms of action of MSCs and MSC extracellular vesicles in the injured lung and the role of lung-resident MSCs in lung repair and regeneration. Our central goal is to understand how MSC (and their EVs) work in the context of the injury microenvironment, how MSC modulate reparative capacities of the host cells and if we can enhance MSC therapeutic potential. We hope that this research will allow to develop better cell therapies as well as to identify new therapeutic targets.
Given difficulties in applying the knowledge gained in animal models in a logical way to the human disease process, we have strong interest in physiologically relevant models of the human lung tissue such as organoids, lung-on-chip and decel-recel approach. We have recently established a novel organoid model of the distal lung based on primary human cells.
Ongoing work is investigating the ability of MSC-derived extracellular vesicles to alleviate lung injury through transfer of healthy mitochondria and miRNAs, and the role of endogenous lung MSCs in regulation of endothelial and epithelial cells using an organoid model of the distal lung.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R3564CEM: Tractable human distal lung organoid model as a new efficient tool to study mesenchymal-epithelial interactions in COPD
Krasnodembskaya, A. (PI) & Taggart, C. (CoI)
24/01/2024 → …
Project: Research
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R6663CEM: ALGORITM - Applying human lung tissue models to develop a personalised treatment for critically ill
Krasnodembskaya, A. (PI) & O'Kane, C. (CoI)
24/11/2020 → …
Project: Research
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R2353CEM: Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST)
O'Kane, C. (PI), Krasnodembskaya, A. (CoI) & McAuley, D. (CoI)
25/01/2017 → …
Project: Research
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R1002CEM: "The role of extracellular vesicle miRNAs in Mesenchymal Stem Cells’ effects on macrophage modulation in ARDS”
Krasnodembskaya, A. (PI), McAuley, D. (CoI), O'Kane, C. (CoI) & Simpson, D. (CoI)
10/01/2019 → 31/01/2023
Project: Research
Research output
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Human mesenchymal stromal cells inhibit Mycobacterium avium replication in clinically relevant models of lung infection
Shaw, T. D., Krasnodembskaya, A. D., Schroeder, G. N., Doherty, D. F., Silva, J. D., Tandel, S. M., Su, Y., Butler, D., Ingram, R. J. & O’Kane, C. M., Aug 2024, In: Thorax. 79, 8, p. 778-787Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)33 Downloads (Pure) -
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q.-L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. G., Mohanty, S., Möller, A., Nieuwland, R. & Ochiya, T. & 32 others, , Feb 2024, In: Journal of Extracellular Vesicles. 13, 2, 84 p., e12404.Research output: Contribution to journal › Article › peer-review
Open AccessFile545 Citations (Scopus)116 Downloads (Pure) -
Stem cells, cell therapies and bioengineering in lung biology and diseases 2023
Hynds, R. E., Magin, C. M., Ikonomou, L., Aschner, Y., Beers, M. F., Burgess, J. K., Heise, R. L., Hume, P. S., Krasnodembskaya, A. D., Mei, S. H. J., Misharin, A. V., Park, J.-A., Reynolds, S. D., Tschumperlin, D. J., Tanneberger, A. E., Vaidyanathan, S., Waters, C. M., Zettler, P. J., Weiss, D. J. & Ryan, A. L., Sept 2024, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 327, 3, p. L269-L414 14 p.Research output: Contribution to journal › Article › peer-review
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The MSC-EV-microRNAome: a perspective on therapeutic mechanisms of action in sepsis and ARDS
dos Santos, C. C., Lopes-Pacheco, M., English, K., Rolandsson Enes, S., Krasnodembskaya, A. & Rocco, P., 09 Jan 2024, In: Cells. 13, 2, 19 p., 122.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)46 Downloads (Pure) -
The role of extracellular vesicles and gap junctions in inter-cellular mitochondrial transfer
Caldeira, D. & Krasnodembskaya, A., 09 Aug 2024, Mitochondrial transplantation and transfer biology, methods, applications, and disease. Kubat, G. B., Ulger, O. & Gunaydin, S. (eds.). Elsevier Academic Press , p. 133-155 (Translational and Applied Bioenergetics).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
Prizes
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1st place at WWIEM 3rd year PhD symposiun
Butler, D. (Recipient) & Krasnodembskaya, A. (Recipient), 21 Mar 2022
Prize: Prize (including medals and awards)
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2nd place in WWIEM symposium for 1st year PhD students
McClintock, C. (Recipient) & Krasnodembskaya, A. (Recipient), Jun 2021
Prize: Prize (including medals and awards)
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2nd place in WWIEM symposium for 2nd year PhD students
McClintock, C. (Recipient) & Krasnodembskaya, A. (Recipient), 10 May 2022
Prize: Prize (including medals and awards)
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3rd place at WWIEM symposium for 2nd year PhD students
Butler, D. (Recipient) & Krasnodembskaya, A. (Recipient), 2021
Prize: Prize (including medals and awards)
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BALR Young Investigator of the Year 2015 awarded to Dr Megan Jackson, PDRA in my group at the British Thoracic Society winter meeting, 2015
Jackson, M. (Recipient) & Krasnodembskaya, A. (Recipient), Dec 2015
Prize: Prize (including medals and awards)
Activities
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European Respiratory Society International Congress 2024, Vienna, Austria
Krasnodembskaya, A. (Invited speaker)
07 Sept 2024Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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Cheng Chen
Krasnodembskaya, A. (Host)
09 Apr 2024 → 09 Jul 2024Activity: Hosting a visitor types › Hosting an academic visitor
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PhD Thesis "Enhancing the Immunomodulatory Efficacy of Allogeneic Mesenchymal Stromal Cells Through Pro-Inflammatory Cytokine Licensing"
Krasnodembskaya, A. (Examiner)
20 Mar 2024Activity: Examination types › PhD external examination
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Sigma Xi, The Scientific Research Honor Society (External organisation)
Krasnodembskaya, A. (Advisor)
Mar 2024 → …Activity: Membership types › Membership of network
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Xinpei Li
Krasnodembskaya, A. (Host)
17 Feb 2024 → 17 May 2024Activity: Hosting a visitor types › Hosting an academic visitor
Press/Media
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Stem Cells Portal 'Bringing Novel Therapies Closer to the Patient'
04/05/2018
1 Media contribution
Press/Media: Research
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UNDERSTANDING STEM CELLS AND THEIR IMPACT IN LUNG DISEASE
11/11/2015
1 Media contribution
Press/Media: Public Engagement Activities
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How stem cells can be used to treat lung disease
22/10/2015
1 item of Media coverage
Press/Media: Public Engagement Activities
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The DNA of Innovation Volume 5
20/10/2015
1 item of Media coverage
Press/Media: Public Engagement Activities
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European Respiratory Society International Congress 2014 Press Release
09/09/2014
1 Media contribution
Press/Media: Public Engagement Activities