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20012019
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Personal profile

Research Interests

I am a molecular cell biologist specialized in host-pathogen interactions. I successively worked on the molecular mechanisms underlying the interactions of several pathogens with host cells: HIV (PhD in Dr Dargemont’s laboratory, Institut Jacques Monod, Paris), pathogenic Escherichia coli and Legionella pneumophila (post-doc in Prof Frankel’s laboratory, Imperial College London) and rhinovirus (post-doc in Prof Johnston’s laboratory, Imperial College London).

In August 2016, I moved to Queen’s University Belfast to start my independent research supported by a research grant funded by the Medical Research Foundation (MRF) and Asthma UK. Rhinovirus infections are the main cause of the common cold and a major cause of exacerbation of chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD) or cystic fibrosis (CF), leading to an acute worsening of symptoms. However, there is currently no vaccine or antiviral treatment against rhinoviruses. In this context, my aim is to understand how rhinoviruses interact with host cells to replicate and in particular to identify host cell proteins essential for the replication of these viruses, which could be targeted by antiviral drugs. To investigate this, I use a range of molecular biology, cell biology, biochemistry and virology techniques.

If you are interested in learning more about my research, joining my group or collaborating with me, please email me: A.Mousnier@qub.ac.uk.

If you would like to support my research, you can make a gift through Queen's Foundation (http://www.qub.ac.uk/alumni/QueensUniversityofBelfastFoundation/). If you email me, I could give you more details about how to do it and how your gift would be used.

Fingerprint Dive into the research topics where Aurelie Mousnier is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Legionella pneumophila Medicine & Life Sciences
Enteropathogenic Escherichia coli Medicine & Life Sciences
Enterohemorrhagic Escherichia coli Medicine & Life Sciences
Rhinovirus Medicine & Life Sciences
Integrases Medicine & Life Sciences
Infection Medicine & Life Sciences
Legionella Medicine & Life Sciences
Citrobacter rodentium Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2001 2019

  • 25 Article
  • 1 Chapter (peer-reviewed)

Determination of In Vivo Interactomes of Dot/Icm Type IV Secretion System Effectors by Tandem Affinity Purification

So, E. C., Mousnier, A., Frankel, G. & Schroeder, G. N., 30 Jan 2019, Methods in Molecular Biology : Legionella . Springer, Vol. 1921. p. 289-303 15 p. (Methods in Molecular Biology ).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Legionella
His-His-His-His-His-His
Biotinylation
Ligases
Biotin
14 Citations (Scopus)
190 Downloads (Pure)

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

Mousnier, A., Bell, A. S., Swieboda, D. P., Morales-Sanfrutos, J., Pérez-Dorado, I., Brannigan, J. A., Newman, J., Ritzefeld, M., Hutton, J. A., Guedán, A., Asfor, A. S., Robinson, S. W., Hopkins-Navratilova, I., Wilkinson, A. J., Johnston, S. L., Leatherbarrow, R. J., Tuthill, T. J., Solari, R. & Tate, E. W., 14 May 2018, In : Nature chemistry. 10, 6, p. 599-606 8 p.

Research output: Contribution to journalArticle

Open Access
File
Viruses
Pulmonary diseases
Pathogens
Cytotoxicity
Antiviral Agents
6 Citations (Scopus)
192 Downloads (Pure)

Host lipidome analysis during rhinovirus replication in human bronchial epithelial cells identifies potential therapeutic targets

Nguyen, A., Guedan, A., Mousnier, A., Swieboda, D., Zhang, Q., Horkai, D., Le Novere, N., Solari, R. & Wakelam, M. J. O., Sep 2018, In : Journal of Lipid Research. 59, 9, p. 1671-1684

Research output: Contribution to journalArticle

Open Access
File
Rhinovirus
Ceramidases
Epithelial Cells
Lipids
Fatty Acid Synthases
5 Citations (Scopus)
158 Downloads (Pure)

Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication

Guedán, A., Swieboda, D., Charles, M., Toussaint, M., Johnston, S. L., Asfor, A., Panjwani, A., Tuthill, T. J., Danahay, H. L., Raynham, T., Mousnier, A. & Solari, R., 01 May 2017, In : Journal of Virology. 91, 9, e00217-17 .

Research output: Contribution to journalArticle

Open Access
File
Human rhinovirus
Rhinovirus
protein kinases
Protein Kinase Inhibitors
virus replication
8 Citations (Scopus)

The Rab-binding profiles of bacterial virulence factors during infection

So, E. C., Schroeder, G. N., Carson, D., Mattheis, C., Mousnier, A., Broncel, M., Tate, E. W. & Frankel, G., 11 Mar 2016, In : Journal of Biological Chemistry. 291, 11, p. 5832-5843 12 p.

Research output: Contribution to journalArticle

rab GTP-Binding Proteins
His-His-His-His-His-His
Virulence Factors
Purification
Cell signaling