• Room 04.036 - Medical Biology Centre

    United Kingdom

Accepting PhD Students

20012019

Research output per year

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Personal profile

Research Interests

I am a molecular cell biologist specialized in host-pathogen interactions. I successively worked on the molecular mechanisms underlying the interactions of several pathogens with host cells: HIV (PhD in Dr Dargemont’s laboratory, Institut Jacques Monod, Paris), pathogenic Escherichia coli and Legionella pneumophila (post-doc in Prof Frankel’s laboratory, Imperial College London) and rhinovirus (post-doc in Prof Johnston’s laboratory, Imperial College London).

In August 2016, I moved to Queen’s University Belfast to start my independent research supported by a research grant funded by the Medical Research Foundation (MRF) and Asthma UK. Rhinovirus infections are the main cause of the common cold and a major cause of exacerbation of chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD) or cystic fibrosis (CF), leading to an acute worsening of symptoms. However, there is currently no vaccine or antiviral treatment against rhinoviruses. In this context, my aim is to understand how rhinoviruses interact with host cells to replicate and in particular to identify host cell proteins essential for the replication of these viruses, which could be targeted by antiviral drugs. To investigate this, I use a range of molecular biology, cell biology, biochemistry and virology techniques.

If you are interested in learning more about my research, joining my group or collaborating with me, please email me: A.Mousnier@qub.ac.uk.

If you would like to support my research, you can make a gift through Queen's Foundation (http://www.qub.ac.uk/alumni/QueensUniversityofBelfastFoundation/). If you email me, I could give you more details about how to do it and how your gift would be used.

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Research Output

  • 25 Article
  • 1 Chapter (peer-reviewed)

Determination of In Vivo Interactomes of Dot/Icm Type IV Secretion System Effectors by Tandem Affinity Purification

So, E. C., Mousnier, A., Frankel, G. & Schroeder, G. N., 30 Jan 2019, Methods in Molecular Biology : Legionella . Springer, Vol. 1921. p. 289-303 15 p. (Methods in Molecular Biology ).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  • Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

    Mousnier, A., Bell, A. S., Swieboda, D. P., Morales-Sanfrutos, J., Pérez-Dorado, I., Brannigan, J. A., Newman, J., Ritzefeld, M., Hutton, J. A., Guedán, A., Asfor, A. S., Robinson, S. W., Hopkins-Navratilova, I., Wilkinson, A. J., Johnston, S. L., Leatherbarrow, R. J., Tuthill, T. J., Solari, R. & Tate, E. W., 14 May 2018, In : Nature chemistry. 10, 6, p. 599-606 8 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 24 Citations (Scopus)
    250 Downloads (Pure)

    Host lipidome analysis during rhinovirus replication in human bronchial epithelial cells identifies potential therapeutic targets

    Nguyen, A., Guedan, A., Mousnier, A., Swieboda, D., Zhang, Q., Horkai, D., Le Novere, N., Solari, R. & Wakelam, M. J. O., Sep 2018, In : Journal of Lipid Research. 59, 9, p. 1671-1684

    Research output: Contribution to journalArticle

    Open Access
    File
  • 9 Citations (Scopus)
    285 Downloads (Pure)

    Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication

    Guedán, A., Swieboda, D., Charles, M., Toussaint, M., Johnston, S. L., Asfor, A., Panjwani, A., Tuthill, T. J., Danahay, H. L., Raynham, T., Mousnier, A. & Solari, R., 01 May 2017, In : Journal of Virology. 91, 9, e00217-17 .

    Research output: Contribution to journalArticle

    Open Access
    File
  • 7 Citations (Scopus)
    220 Downloads (Pure)

    The Rab-binding profiles of bacterial virulence factors during infection

    So, E. C., Schroeder, G. N., Carson, D., Mattheis, C., Mousnier, A., Broncel, M., Tate, E. W. & Frankel, G., 11 Mar 2016, In : Journal of Biological Chemistry. 291, 11, p. 5832-5843 12 p.

    Research output: Contribution to journalArticle

  • 9 Citations (Scopus)

    Activities

    • 2 Invited talk

    Combating rhinoviruses by targeting the host

    Aurelie Mousnier (Invited speaker)

    07 May 2019

    Activity: Talk or presentation typesInvited talk