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20012019
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Research Output 2001 2019

  • 25 Article
  • 1 Chapter (peer-reviewed)
2019

Determination of In Vivo Interactomes of Dot/Icm Type IV Secretion System Effectors by Tandem Affinity Purification

So, E. C., Mousnier, A., Frankel, G. & Schroeder, G. N., 30 Jan 2019, Methods in Molecular Biology : Legionella . Springer, Vol. 1921. p. 289-303 15 p. (Methods in Molecular Biology ).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Legionella
His-His-His-His-His-His
Biotinylation
Ligases
Biotin
2018
15 Citations (Scopus)
205 Downloads (Pure)

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

Mousnier, A., Bell, A. S., Swieboda, D. P., Morales-Sanfrutos, J., Pérez-Dorado, I., Brannigan, J. A., Newman, J., Ritzefeld, M., Hutton, J. A., Guedán, A., Asfor, A. S., Robinson, S. W., Hopkins-Navratilova, I., Wilkinson, A. J., Johnston, S. L., Leatherbarrow, R. J., Tuthill, T. J., Solari, R. & Tate, E. W., 14 May 2018, In : Nature chemistry. 10, 6, p. 599-606 8 p.

Research output: Contribution to journalArticle

Open Access
File
Viruses
Pulmonary diseases
Pathogens
Cytotoxicity
Antiviral Agents
6 Citations (Scopus)
213 Downloads (Pure)

Host lipidome analysis during rhinovirus replication in human bronchial epithelial cells identifies potential therapeutic targets

Nguyen, A., Guedan, A., Mousnier, A., Swieboda, D., Zhang, Q., Horkai, D., Le Novere, N., Solari, R. & Wakelam, M. J. O., Sep 2018, In : Journal of Lipid Research. 59, 9, p. 1671-1684

Research output: Contribution to journalArticle

Open Access
File
Rhinovirus
Ceramidases
Epithelial Cells
Lipids
Fatty Acid Synthases
2017
5 Citations (Scopus)
171 Downloads (Pure)

Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication

Guedán, A., Swieboda, D., Charles, M., Toussaint, M., Johnston, S. L., Asfor, A., Panjwani, A., Tuthill, T. J., Danahay, H. L., Raynham, T., Mousnier, A. & Solari, R., 01 May 2017, In : Journal of Virology. 91, 9, e00217-17 .

Research output: Contribution to journalArticle

Open Access
File
Human rhinovirus
Rhinovirus
protein kinases
Protein Kinase Inhibitors
virus replication
2016
9 Citations (Scopus)

The Rab-binding profiles of bacterial virulence factors during infection

So, E. C., Schroeder, G. N., Carson, D., Mattheis, C., Mousnier, A., Broncel, M., Tate, E. W. & Frankel, G., 11 Mar 2016, In : Journal of Biological Chemistry. 291, 11, p. 5832-5843 12 p.

Research output: Contribution to journalArticle

rab GTP-Binding Proteins
His-His-His-His-His-His
Virulence Factors
Purification
Cell signaling
2014
22 Citations (Scopus)
160 Downloads (Pure)

A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases

Mousnier, A., Schroeder, G. N., Stoneham, C. A., So, E. C., Garnett, J. A., Yu, L., Matthews, S. J., Choudhary, J. S., Hartland, E. L. & Frankel, G., 12 Aug 2014, In : mBio. 5, 4, 10 p., e01148-14.

Research output: Contribution to journalArticle

Open Access
File
rab GTP-Binding Proteins
Legionella pneumophila
Legionella
Infection
His-His-His-His-His-His
12 Citations (Scopus)
211 Downloads (Pure)

Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion

Mousnier, A., Swieboda, D., Pinto, A., Guedán, A., Rogers, A. V., Walton, R., Johnston, S. L. & Solari, R., Oct 2014, In : Journal of Virology. 88, 20, p. 11671-85 15 p.

Research output: Contribution to journalArticle

Open Access
File
Human rhinovirus
Rhinovirus
protein secretion
Golgi Apparatus
Golgi apparatus
30 Citations (Scopus)
194 Downloads (Pure)

Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists

Ajram, L., Begg, M., Slack, R., Cryan, J., Hall, D., Hodgson, S., Ford, A., Barnes, A., Swieboda, D., Mousnier, A. & Solari, R., 15 Apr 2014, In : European Journal of Pharmacology. 729, p. 75-85 11 p.

Research output: Contribution to journalArticle

Open Access
File
CCR4 Receptors
Chemokine Receptors
Chemotaxis
Allosteric Site
Ligands
21 Citations (Scopus)
193 Downloads (Pure)

The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation

Young, J. C., Clements, A., Lang, A. E., Garnett, J. A., Munera, D., Arbeloa, A., Pearson, J., Hartland, E. L., Matthews, S. J., Mousnier, A., Barry, D. J., Way, M., Schlosser, A., Aktories, K. & Frankel, G., 2014, In : Nature Communications. 5, 10 p., 5887.

Research output: Contribution to journalArticle

Open Access
File
effectors
Enteropathogenic Escherichia coli
adenosine diphosphate
phosphorylation
Phosphorylation
2013
23 Citations (Scopus)

LtpD is a novel legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1

Harding, C. R., Mattheis, C., Mousnier, A., Oates, C. V., Hartland, E. L., Frankel, G. & Schroeder, G. N., Nov 2013, In : Infection and Immunity. 81, 11, p. 4261-4270 10 p.

Research output: Contribution to journalArticle

Legionella pneumophila
Legionella
Phosphatidylinositols
Vacuoles
Sensilla

Subcellular localization of legionella Dot/Icm effectors

Vogrin, A. J., Mousnier, A., Frankel, G. & Hartland, E. L., 2013, In : Methods in Molecular Biology . 954, p. 333-44 12 p.

Research output: Contribution to journalArticle

Legionella
Proteins
Legionella pneumophila
Eukaryotic Cells
Protein Transport
2012
23 Citations (Scopus)

EspZ of enteropathogenic and enterohemorrhagic Escherichia coli regulates type III secretion system protein translocation

Berger, C. N., Crepin, V. F., Baruch, K., Mousnier, A., Rosenshine, I. & Frankel, G., 2012, In : mBio. 3, 5

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Enteropathogenic Escherichia coli
Protein Transport
Infection
Microbiological Attachment Sites
54 Citations (Scopus)

Legionella pneumophila pathogenesis in the Galleria mellonella infection model

Harding, C. R., Schroeder, G. N., Reynolds, S., Kosta, A., Collins, J. W., Mousnier, A. & Frankel, G., Aug 2012, In : Infection and Immunity. 80, 8, p. 2780-2790 11 p.

Research output: Contribution to journalArticle

Legionella pneumophila
Vacuoles
Infection
Larva
Legionnaires' Disease
43 Citations (Scopus)

Legionella pneumophila secretes a mitochondrial carrier protein during infection

Dolezal, P., Aili, M., Tong, J., Jiang, J-H., Marobbio, C. M. T., Marobbio, C. M., Lee, S. F., Schuelein, R., Belluzzo, S., Binova, E., Mousnier, A., Frankel, G., Giannuzzi, G., Palmieri, F., Gabriel, K., Naderer, T., Hartland, E. L. & Lithgow, T., Jan 2012, In : PLoS Pathogens. 8, 1, p. e1002459

Research output: Contribution to journalArticle

Legionella pneumophila
Mitochondrial Proteins
Carrier Proteins
Infection
Adenosine Triphosphate
2010
40 Citations (Scopus)

Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo

Crepin, V. F., Girard, F., Schüller, S., Phillips, A. D., Mousnier, A. & Frankel, G., Jan 2010, In : Molecular Microbiology. 75, 2, p. 308-23 16 p.

Research output: Contribution to journalArticle

Citrobacter rodentium
Polymerization
Wiskott-Aldrich Syndrome Protein
Actins
Enterohemorrhagic Escherichia coli
84 Citations (Scopus)

Legionella pneumophila strain 130b possesses a unique combination of type IV secretion systems and novel Dot/Icm secretion system effector proteins

Schroeder, G. N., Petty, N. K., Mousnier, A., Harding, C. R., Vogrin, A. J., Wee, B., Fry, N. K., Harrison, T. G., Newton, H. J., Thomson, N. R., Beatson, S. A., Dougan, G., Hartland, E. L. & Frankel, G., Nov 2010, In : Journal of Bacteriology. 192, 22, p. 6001-6016 16 p.

Research output: Contribution to journalArticle

Legionella pneumophila
Genome
Alveolar Macrophages
Paris
Multigene Family
93 Citations (Scopus)

NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection

Hemrajani, C., Berger, C. N., Robinson, K. S., Marchès, O., Mousnier, A. & Frankel, G., 16 Feb 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 7, p. 3129-34 6 p.

Research output: Contribution to journalArticle

Enteropathogenic Escherichia coli
Escherichia coli Infections
Citrobacter rodentium
Caspase 3
Apoptosis
21 Citations (Scopus)

The enteropathogenic Escherichia coli effector NleH inhibits apoptosis induced by Clostridium difficile toxin B

Robinson, K. S., Mousnier, A., Hemrajani, C., Fairweather, N., Berger, C. N. & Frankel, G., Jun 2010, In : Microbiology (Reading, England). 156, Pt 6, p. 1815-23 9 p.

Research output: Contribution to journalArticle

Enteropathogenic Escherichia coli
Apoptosis
Mitochondrial Swelling
Pseudomembranous Enterocolitis
Guanine Nucleotide Exchange Factors
2008
9 Citations (Scopus)

Cortactin recruitment by enterohemorrhagic Escherichia coli O157:H7 during infection in vitro and ex vivo

Mousnier, A., Whale, A. D., Schüller, S., Leong, J. M., Phillips, A. D. & Frankel, G., Oct 2008, In : Infection and Immunity. 76, 10, p. 4669-76 8 p.

Research output: Contribution to journalArticle

Cortactin
Enterohemorrhagic Escherichia coli
Escherichia coli O157
Infection
Polymerization
27 Citations (Scopus)

Enteropathogenic Escherichia coli O125:H6 triggers attaching and effacing lesions on human intestinal biopsy specimens independently of Nck and TccP/TccP2

Bai, L., Schüller, S., Whale, A., Mousnier, A., Marches, O., Wang, L., Ooka, T., Heuschkel, R., Torrente, F., Kaper, J. B., Gomes, T. A. T., Xu, J., Phillips, A. D. & Frankel, G., Jan 2008, In : Infection and Immunity. 76, 1, p. 361-8 8 p.

Research output: Contribution to journalArticle

Enteropathogenic Escherichia coli
Enterohemorrhagic Escherichia coli
Biopsy
Polymerization
Neuronal Wiskott-Aldrich Syndrome Protein
27 Citations (Scopus)

Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut

Hemrajani, C., Marches, O., Wiles, S., Girard, F., Dennis, A., Dziva, F., Best, A., Phillips, A. D., Berger, C. N., Mousnier, A., Crepin, V. F., Kruidenier, L., Woodward, M. J., Stevens, M. P., La Ragione, R. M., MacDonald, T. T. & Frankel, G., Nov 2008, In : Infection and Immunity. 76, 11, p. 4804-13 10 p.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Sheep
Escherichia coli O157
NF-kappa B
Coinfection
2007
59 Citations (Scopus)

von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step

Mousnier, A., Kubat, N., Massias-Simon, A., Ségéral, E., Rain, J-C., Benarous, R., Emiliani, S. & Dargemont, C., 21 Aug 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 34, p. 13615-20 6 p.

Research output: Contribution to journalArticle

Integrases
Carrier Proteins
Gene Expression
Proteasome Endopeptidase Complex
Ligases
2005
194 Citations (Scopus)

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

Emiliani, S., Mousnier, A., Busschots, K., Maroun, M., Van Maele, B., Tempé, D., Vandekerckhove, L., Moisant, F., Ben-Slama, L., Witvrouw, M., Christ, F., Rain, J-C., Dargemont, C., Debyser, Z. & Benarous, R., 08 Jul 2005, In : The Journal of biological chemistry. 280, 27, p. 25517-23 7 p.

Research output: Contribution to journalArticle

Integrases
Chromosomes
HIV-1
Mutagenesis
Viruses
2004
50 Citations (Scopus)

Nuclear import of HIV-1 integrase is inhibited in vitro by styrylquinoline derivatives

Mousnier, A., Leh, H., Mouscadet, J-F. & Dargemont, C., Oct 2004, In : Molecular Pharmacology. 66, 4, p. 783-8 6 p.

Research output: Contribution to journalArticle

Integrases
Cell Nucleus Active Transport
Antiviral Agents
DNA
Viral Genome
2002
92 Citations (Scopus)

Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1

Le Rouzic, E., Mousnier, A., Rustum, C., Stutz, F., Hallberg, E., Dargemont, C. & Benichou, S., 22 Nov 2002, In : The Journal of biological chemistry. 277, 47, p. 45091-8 8 p.

Research output: Contribution to journalArticle

Nuclear Pore Complex Proteins
Nuclear Envelope
HIV-1
Viral DNA
Nuclear Pore
2001
65 Citations (Scopus)

Characterization of the nuclear import pathway for HIV-1 integrase

Depienne, C., Mousnier, A., Leh, H., Le Rouzic, E., Dormont, D., Benichou, S. & Dargemont, C., 25 May 2001, In : The Journal of biological chemistry. 276, 21, p. 18102-7 6 p.

Research output: Contribution to journalArticle

Integrases
Cell Nucleus Active Transport
Nuclear Pore
Guanosine Triphosphate
Viruses