• Room 04.036 - Medical Biology Centre

    United Kingdom

Accepting PhD Students

20012019

Research output per year

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Research Output

  • 25 Article
  • 1 Chapter (peer-reviewed)
2019

Determination of In Vivo Interactomes of Dot/Icm Type IV Secretion System Effectors by Tandem Affinity Purification

So, E. C., Mousnier, A., Frankel, G. & Schroeder, G. N., 30 Jan 2019, Methods in Molecular Biology : Legionella . Springer, Vol. 1921. p. 289-303 15 p. (Methods in Molecular Biology ).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2018

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

Mousnier, A., Bell, A. S., Swieboda, D. P., Morales-Sanfrutos, J., Pérez-Dorado, I., Brannigan, J. A., Newman, J., Ritzefeld, M., Hutton, J. A., Guedán, A., Asfor, A. S., Robinson, S. W., Hopkins-Navratilova, I., Wilkinson, A. J., Johnston, S. L., Leatherbarrow, R. J., Tuthill, T. J., Solari, R. & Tate, E. W., 14 May 2018, In : Nature chemistry. 10, 6, p. 599-606 8 p.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
245 Downloads (Pure)

Host lipidome analysis during rhinovirus replication in human bronchial epithelial cells identifies potential therapeutic targets

Nguyen, A., Guedan, A., Mousnier, A., Swieboda, D., Zhang, Q., Horkai, D., Le Novere, N., Solari, R. & Wakelam, M. J. O., Sep 2018, In : Journal of Lipid Research. 59, 9, p. 1671-1684

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
279 Downloads (Pure)
2017

Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication

Guedán, A., Swieboda, D., Charles, M., Toussaint, M., Johnston, S. L., Asfor, A., Panjwani, A., Tuthill, T. J., Danahay, H. L., Raynham, T., Mousnier, A. & Solari, R., 01 May 2017, In : Journal of Virology. 91, 9, e00217-17 .

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
213 Downloads (Pure)
2016

The Rab-binding profiles of bacterial virulence factors during infection

So, E. C., Schroeder, G. N., Carson, D., Mattheis, C., Mousnier, A., Broncel, M., Tate, E. W. & Frankel, G., 11 Mar 2016, In : Journal of Biological Chemistry. 291, 11, p. 5832-5843 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2014

A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases

Mousnier, A., Schroeder, G. N., Stoneham, C. A., So, E. C., Garnett, J. A., Yu, L., Matthews, S. J., Choudhary, J. S., Hartland, E. L. & Frankel, G., 12 Aug 2014, In : mBio. 5, 4, 10 p., e01148-14.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
194 Downloads (Pure)

Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion

Mousnier, A., Swieboda, D., Pinto, A., Guedán, A., Rogers, A. V., Walton, R., Johnston, S. L. & Solari, R., Oct 2014, In : Journal of Virology. 88, 20, p. 11671-85 15 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
221 Downloads (Pure)

Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists

Ajram, L., Begg, M., Slack, R., Cryan, J., Hall, D., Hodgson, S., Ford, A., Barnes, A., Swieboda, D., Mousnier, A. & Solari, R., 15 Apr 2014, In : European Journal of Pharmacology. 729, p. 75-85 11 p.

Research output: Contribution to journalArticle

Open Access
File
30 Citations (Scopus)
227 Downloads (Pure)

The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation

Young, J. C., Clements, A., Lang, A. E., Garnett, J. A., Munera, D., Arbeloa, A., Pearson, J., Hartland, E. L., Matthews, S. J., Mousnier, A., Barry, D. J., Way, M., Schlosser, A., Aktories, K. & Frankel, G., 2014, In : Nature Communications. 5, 10 p., 5887.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
227 Downloads (Pure)
2013

LtpD is a novel legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1

Harding, C. R., Mattheis, C., Mousnier, A., Oates, C. V., Hartland, E. L., Frankel, G. & Schroeder, G. N., Nov 2013, In : Infection and Immunity. 81, 11, p. 4261-4270 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Subcellular localization of legionella Dot/Icm effectors

Vogrin, A. J., Mousnier, A., Frankel, G. & Hartland, E. L., 2013, In : Methods in Molecular Biology . 954, p. 333-44 12 p.

Research output: Contribution to journalArticle

2012

EspZ of enteropathogenic and enterohemorrhagic Escherichia coli regulates type III secretion system protein translocation

Berger, C. N., Crepin, V. F., Baruch, K., Mousnier, A., Rosenshine, I. & Frankel, G., 2012, In : mBio. 3, 5

Research output: Contribution to journalArticle

24 Citations (Scopus)

Legionella pneumophila pathogenesis in the Galleria mellonella infection model

Harding, C. R., Schroeder, G. N., Reynolds, S., Kosta, A., Collins, J. W., Mousnier, A. & Frankel, G., Aug 2012, In : Infection and Immunity. 80, 8, p. 2780-2790 11 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Legionella pneumophila secretes a mitochondrial carrier protein during infection

Dolezal, P., Aili, M., Tong, J., Jiang, J-H., Marobbio, C. M. T., Marobbio, C. M., Lee, S. F., Schuelein, R., Belluzzo, S., Binova, E., Mousnier, A., Frankel, G., Giannuzzi, G., Palmieri, F., Gabriel, K., Naderer, T., Hartland, E. L. & Lithgow, T., Jan 2012, In : PLoS Pathogens. 8, 1, p. e1002459

Research output: Contribution to journalArticle

43 Citations (Scopus)
2010

Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo

Crepin, V. F., Girard, F., Schüller, S., Phillips, A. D., Mousnier, A. & Frankel, G., Jan 2010, In : Molecular Microbiology. 75, 2, p. 308-23 16 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Legionella pneumophila strain 130b possesses a unique combination of type IV secretion systems and novel Dot/Icm secretion system effector proteins

Schroeder, G. N., Petty, N. K., Mousnier, A., Harding, C. R., Vogrin, A. J., Wee, B., Fry, N. K., Harrison, T. G., Newton, H. J., Thomson, N. R., Beatson, S. A., Dougan, G., Hartland, E. L. & Frankel, G., Nov 2010, In : Journal of Bacteriology. 192, 22, p. 6001-6016 16 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection

Hemrajani, C., Berger, C. N., Robinson, K. S., Marchès, O., Mousnier, A. & Frankel, G., 16 Feb 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 7, p. 3129-34 6 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

The enteropathogenic Escherichia coli effector NleH inhibits apoptosis induced by Clostridium difficile toxin B

Robinson, K. S., Mousnier, A., Hemrajani, C., Fairweather, N., Berger, C. N. & Frankel, G., Jun 2010, In : Microbiology (Reading, England). 156, Pt 6, p. 1815-23 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2008

Cortactin recruitment by enterohemorrhagic Escherichia coli O157:H7 during infection in vitro and ex vivo

Mousnier, A., Whale, A. D., Schüller, S., Leong, J. M., Phillips, A. D. & Frankel, G., Oct 2008, In : Infection and Immunity. 76, 10, p. 4669-76 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Enteropathogenic Escherichia coli O125:H6 triggers attaching and effacing lesions on human intestinal biopsy specimens independently of Nck and TccP/TccP2

Bai, L., Schüller, S., Whale, A., Mousnier, A., Marches, O., Wang, L., Ooka, T., Heuschkel, R., Torrente, F., Kaper, J. B., Gomes, T. A. T., Xu, J., Phillips, A. D. & Frankel, G., Jan 2008, In : Infection and Immunity. 76, 1, p. 361-8 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut

Hemrajani, C., Marches, O., Wiles, S., Girard, F., Dennis, A., Dziva, F., Best, A., Phillips, A. D., Berger, C. N., Mousnier, A., Crepin, V. F., Kruidenier, L., Woodward, M. J., Stevens, M. P., La Ragione, R. M., MacDonald, T. T. & Frankel, G., Nov 2008, In : Infection and Immunity. 76, 11, p. 4804-13 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2007

von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step

Mousnier, A., Kubat, N., Massias-Simon, A., Ségéral, E., Rain, J-C., Benarous, R., Emiliani, S. & Dargemont, C., 21 Aug 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 34, p. 13615-20 6 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)
2005

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

Emiliani, S., Mousnier, A., Busschots, K., Maroun, M., Van Maele, B., Tempé, D., Vandekerckhove, L., Moisant, F., Ben-Slama, L., Witvrouw, M., Christ, F., Rain, J-C., Dargemont, C., Debyser, Z. & Benarous, R., 08 Jul 2005, In : The Journal of biological chemistry. 280, 27, p. 25517-23 7 p.

Research output: Contribution to journalArticle

196 Citations (Scopus)
2004

Nuclear import of HIV-1 integrase is inhibited in vitro by styrylquinoline derivatives

Mousnier, A., Leh, H., Mouscadet, J-F. & Dargemont, C., Oct 2004, In : Molecular Pharmacology. 66, 4, p. 783-8 6 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)
2002

Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1

Le Rouzic, E., Mousnier, A., Rustum, C., Stutz, F., Hallberg, E., Dargemont, C. & Benichou, S., 22 Nov 2002, In : The Journal of biological chemistry. 277, 47, p. 45091-8 8 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)
2001

Characterization of the nuclear import pathway for HIV-1 integrase

Depienne, C., Mousnier, A., Leh, H., Le Rouzic, E., Dormont, D., Benichou, S. & Dargemont, C., 25 May 2001, In : The Journal of biological chemistry. 276, 21, p. 18102-7 6 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)