• Room 03.019 - CEM

    United Kingdom

20082019

Research output per year

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Personal profile

Research Statement

The overarching aim of my research is to understand the lymphocytic response to bacterial infections, in order to facilitate rational vaccine design. I have a particular interest in the interface between innate and adaptive lymphocytic cell responses.  We use a combination of approaches to elucidate the lymphocytic responses to bacterial infection, including in vitro models and analysis of clinical samples, but the greatest area of expertise within my lab is the use of in vivo murine bacterial infection models.  There are a number of ongoing projects within the lab, these include;

(i) The induction of innate immunological memory against bacterial infection.

(ii) Identification of bacterial (Pseudomonas and Anthrax) antigens that elicit a memory T cell response and may therefore represent novel vaccine candidates

(iii) Defining the role of T cells in driving and resolving inflammation (Streptococcus and Pseudomonas)

(iv) The rational design and optimisation of pre-clinical models to test novel antimicrobials and investigate host-pathogen interactions. 

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Projects

Research Output

Natural Exposure to Cutaneous Anthrax Gives Long-Lasting T Cell Immunity Encompassing Infection-Specific Epitopes

Ingram, R., Metan, G., Maillere, B., Doganay, M., Ozkul, Y., Kim, L. U., Baillie, L., Dyson, H., Williamson, E. D., Chu, K. K., Ascough, S., Moore, S., Huwar, T. B., Robinson, J. H., Sriskandan, S. & Altmann, D. M., 01 Apr 2010, In : Journal of Immunology. 184, 7, p. 3814-3821 8 p.

Research output: Contribution to journalArticle

  • 26 Citations (Scopus)

    Anthrax Lethal Factor as an Immune Target in Humans and Transgenic Mice and the Impact of HLA Polymorphism on CD4+ T Cell Immunity

    Ascough, S., Ingram, R. J., Chu, K. K., Reynolds, C. J., Musson, J. A., Doganay, M., Metan, G., Ozkul, Y., Baillie, L., Sriskandan, S., Moore, S. J., Gallagher, T. B., Dyson, H., Williamson, E. D., Robinson, J. H., Maillere, B., Boyton, R. J. & Altmann, D. M., May 2014, In : PLoS Pathogens. 10, 5, 17 p., e1004085.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 13 Citations (Scopus)
    196 Downloads (Pure)
    Open Access
    File
  • 84 Citations (Scopus)
    354 Downloads (Pure)

    Keratinocyte Growth-Factor Promotes Epithelial Survival and Resolution in a Human Model of Lung Injury

    Shyamsundar, M., McAuley, D. F., Ingram, R. J., Gibson, D. S., O'Kane, D., McKeown, S. T., Edwards, A., Taggart, C., Elborn, J. S., Calfee, C. S., Matthay, M. A. & O'Kane, C. M., 15 Jun 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 12, p. 1520-1529 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 51 Citations (Scopus)

    A general protein O-glycosylation machinery conserved in Burkholderia species improves bacterial fitness and elicits glycan immunogenicity in humans

    Mohamed, Y. F., Scott, N. E., Molinaro, A., Creuzenet, C., Ortega, X., Lertmemongkolchai, G., Tunney, M. M., Green, H., Jones, A. M., DeShazer, D., Currie, B. J., Foster, L. J., Ingram, R., De Castro, C. & Valvano, M. A., 26 Jul 2019, In : The Journal of biological chemistry.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 1 Citation (Scopus)
    127 Downloads (Pure)

    Prizes

    Immunology Research Prize

    Beckie Ingram (Recipient), 01 Aug 2015

    Prize: Prize (including medals and awards)

    New Investigator Award

    Beckie Ingram (Recipient), 01 Aug 2011

    Prize: Prize (including medals and awards)

    Poster Prize

    Beckie Ingram (Recipient), 2012

    Prize: Prize (including medals and awards)

  • Prize - Best Poster

    Beckie Ingram (Recipient), 20 Mar 2015

    Prize: Prize (including medals and awards)

    Activities

    Invited talk - Innate lymphoid cell memory

    Beckie Ingram (Speaker)
    18 Feb 2016

    Activity: Talk or presentation typesInvited talk

    Invited talk - The yin and yang of innate lymphoid cells

    Beckie Ingram (Speaker)
    09 Feb 2016

    Activity: Talk or presentation typesInvited talk

    Anthrax Workshop, National Centre for Disease Control and Public Health

    Beckie Ingram (Invited speaker)
    2015

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

    Journal of visualized experiments : JoVE (Journal)

    Beckie Ingram (Peer reviewer)
    2015 → …

    Activity: Publication peer-review and editorial work typesPublication peer-review

    Infection and Immunity (Journal)

    Beckie Ingram (Peer reviewer)
    2015 → …

    Activity: Publication peer-review and editorial work typesEditorial activity