• Room 03.019 - CEM

    United Kingdom

20082020

Research output per year

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Research Output

2020

Toxin-neutralizing antibodies elicited by naturally acquired cutaneous anthrax are elevated following severe disease and appear to target conformational epitopes

Dumas, E. K., Demiraslan, H., Ingram, R. J., Sparks, R. M., Muns, E., Zamora, A., Larabee, J., Garman, L., Ballard, J. D., Boons, G-J., James, J. A., Kayabas, U., Doganay, M. & Farris, A. D., 15 Apr 2020, In : PLoS ONE. 15, 4, 17 p., e0230782.

Research output: Contribution to journalArticle

Open Access
File
5 Downloads (Pure)
2019

A general protein O-glycosylation machinery conserved in Burkholderia species improves bacterial fitness and elicits glycan immunogenicity in humans

Mohamed, Y. F., Scott, N. E., Molinaro, A., Creuzenet, C., Ortega, X., Lertmemongkolchai, G., Tunney, M. M., Green, H., Jones, A. M., DeShazer, D., Currie, B. J., Foster, L. J., Ingram, R., De Castro, C. & Valvano, M. A., 26 Jul 2019, In : The Journal of biological chemistry.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
170 Downloads (Pure)

Control of Klebsiella pneumoniae infection in mice using dissolving microarray patches containing gentamicin

Rodgers, A. M., McCrudden, M. T. C., Courtenay, A. J., Kearney, M-C., Edwards, K. L., Ingram, R. J., Bengoechea, J. & Donnelly, R. F., 01 May 2019, In : Antimicrobial Agents and Chemotherapy. 63, 5, p. e02612-e02618 7 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
139 Downloads (Pure)

Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues

An, S-Q., Murtagh, J., Twomey, K. B., Gupta, M. K., O"Sullivan, T. P., Ingram, R., Valvano, M. A. & Tang, J., 27 May 2019, In : Nature Communications. NCOMMS-18-25986D.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
87 Downloads (Pure)
2018
Open Access
File
74 Downloads (Pure)
Open Access
File
7 Citations (Scopus)
253 Downloads (Pure)
Open Access
File
11 Citations (Scopus)
160 Downloads (Pure)

The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome

Humphries, F., Bergin, R., Jackson, R., Delagic, N., Wang, B., Yang, S., Dubois, A. V., Ingram, R. J. & Moynagh, P. N., 19 Apr 2018, In : Nature Communications. 9, 1, p. 1560 17 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
203 Downloads (Pure)
2017
Open Access
File
11 Citations (Scopus)
203 Downloads (Pure)

A Klebsiella pneumoniae antibiotic resistance mechanism that subdues host defences and promotes virulence

Kidd, T. J., Mills, G., Sá-Pessoa, J., Dumigan, A., Frank, C. G., Insua Romero, J. L., Ingram, R., Hobley, L. & Bengoechea, J. A., 15 Feb 2017, In : EMBO Molecular Medicine. 9, 2

Research output: Contribution to journalArticle

Open Access
File
42 Citations (Scopus)
327 Downloads (Pure)

Antibiotic capture by bacterial lipocalins uncovers an extracellular mechanism of intrinsic antibiotic resistance

El-Halfawy, O. M., Klett, J., Ingram, R. J., Loutet, S. A., Murphy, M. E. P., Martín-Santamaría, S. & Valvano, M. A., 14 Mar 2017, In : mBio. 8, 2

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
467 Downloads (Pure)

Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection

Ivin, M., Dumigan, A., de Vasconcelos, F. N., Ebner, F., Borroni, M., Kavirayani, A., Przybyszewska, K. N., Ingram, R. J., Lienenklaus, S., Kalinke, U., Stoiber, D., Bengoechea, J. A. & Kovarik, P., 07 Nov 2017, In : PLoS Pathogens. 13, 11, p. 1-29 e1006696.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
224 Downloads (Pure)

Regulatory T cells promote myelin regeneration in the central nervous system

Dombrowski, Y., O'Hagan, T., Dittmer, M., Penalva, R., Mayoral, S. R., Bankhead, P., Fleville, S., Eleftheriadis, G., Zhao, C., Naughton, M., Hassan, R., Moffat, J., Falconer, J., Boyd, A., Hamilton, P., Allen, I. V., Kissenpfennig, A., Moynagh, P. N., Evergren, E., Perbal, B. & 5 others, Williams, A. C., Ingram, R. J., Chan, J. R., Franklin, R. J. M. & Fitzgerald, D. C., May 2017, In : Nature Neuroscience. 20, 5, p. 674–680 7 p.

Research output: Contribution to journalArticle

Open Access
File
111 Citations (Scopus)
568 Downloads (Pure)

The role of CCN3 in CNS myelination and remyelination

De La Vega Gallardo, N., Penalva, R., Evans, F., Naughton, M., Lin, Z., Perbal, B., Ingram, R. & Fitzgerald, D., 2017.

Research output: Contribution to conferencePoster

2016

A Secretory Leukocyte Protease Inhibitor Variant with Improved Activity against Lung Infection

Camper, N., Glasgow, A. M. A., Osbourn, M., Quinn, D. J., Small, D. M., McLean, D. T., Lundy, F. T., Elborn, J. S., McNally, P., Ingram, R. J., Weldon, S. & Taggart, C. C., May 2016, In : Mucosal immunology. 9, 3, p. 669-676

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
263 Downloads (Pure)

Breaking ground; year 2

Ingram, R. & Barnett-Vanes, A., 2016, (Accepted) How to complete a PhD in the medical and clinical sciences. Wiley-Blackwell

Research output: Chapter in Book/Report/Conference proceedingChapter

CD4+ T Cells Targeting Dominant and Cryptic Epitopes from Bacillus anthracis Lethal Factor

Ascough, S., Ingram, R. J., Chu, K. K. Y., Musson, J. A., Moore, S. J., Gallagher, T., Baillie, L., Williamson, E. D., Robinson, J. H., Maillere, B., Boyton, R. J. & Altmann, D. M., Jan 2016, In : Frontiers in Microbiology. 6, 12 p., 1506.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
204 Downloads (Pure)

Correction: Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation

De Majumdar, S., Yu, J., Fookes, M., McAteer, S. P., Llobet, E., Spence, S. F. S., Monaghan, A., Kissenpfennig, A., Ingram, R. J., Bengoechea, J., Gally, D. L., Fanning, S., Elborn, J. S. & Schneiders, T., 11 May 2016, In : PLoS Pathogens. 12, 5, p. e1005649

Research output: Contribution to journalArticle

Open Access
File
173 Downloads (Pure)
Open Access
File
21 Citations (Scopus)
283 Downloads (Pure)
2015
Open Access
File
45 Citations (Scopus)
350 Downloads (Pure)

Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation

De Majumdar, S., Yu, J., Fookes, M., McAteer, S. P., Llobet, E., Finn, S., Spence, S., Monahan, A., Kissenpfennig, A., Ingram, R. J., Bengoechea, J., Gally, D. L., Fanning, S., Elborn, J. S. & Schneiders, T., Jan 2015, In : PLoS Pathogens. 11, 1, 22 p., e1004627.

Research output: Contribution to journalArticle

Open Access
File
40 Citations (Scopus)
246 Downloads (Pure)

Natural cutaneous anthrax infection, but not vaccination, induces a CD4+ T cell response involving diverse cytokines

Ingram, R. J., Ascough, S., Reynolds, C. J., Metan, G., Doganay, M., Baillie, L., Williamson, D. E., Robinson, J. H., Maillere, B., Boyton, R. J. & Altmann, D. M., 26 Apr 2015, In : Cell & Bioscience . 5, 6 p., 20.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
176 Downloads (Pure)

Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome

Li, J. T., Melton, A. C., Su, G., Hamm, D. E., LaFemina, M., Howard, J., Fang, X., Bhat, S., Huynh, K-M., O'Kane, C., Ingram, R. J., Muir, R. R., McAuley, D. F., Matthay, M. A. & Sheppard, D., Jul 2015, In : Journal of Immunology. 195, 1, p. 87-95 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Whole genome protein microarrays for serum profiling of immunodominant antigens of Bacillus anthracis

Kempsell, K. E., Kidd, S. P., Lewandowski, K., Elmore, M. J., Charlton, S., Yeates, A., Cuthbertson, H., Cuthbertson, H., Hallis, B., Altmann, D. M., Rogers, M., Wattiau, P., Ingram, R. J., Brooks, T. & Vipond, R., 13 Aug 2015, In : Frontiers in Microbiology. 6, 16 p., 747.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
307 Downloads (Pure)
2014

Anthrax Lethal Factor as an Immune Target in Humans and Transgenic Mice and the Impact of HLA Polymorphism on CD4+ T Cell Immunity

Ascough, S., Ingram, R. J., Chu, K. K., Reynolds, C. J., Musson, J. A., Doganay, M., Metan, G., Ozkul, Y., Baillie, L., Sriskandan, S., Moore, S. J., Gallagher, T. B., Dyson, H., Williamson, E. D., Robinson, J. H., Maillere, B., Boyton, R. J. & Altmann, D. M., May 2014, In : PLoS Pathogens. 10, 5, 17 p., e1004085.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
209 Downloads (Pure)

Injectional anthrax infection due to heroin use induces strong immunological memory

Ascough, S., Ingram, R. J., Abarra, A., Holmes, A. J., Maillere, B., Altmann, D. M. & Boyton, R. J., Feb 2014, In : Journal of infection. 68, 2, p. 200-203 4 p.

Research output: Contribution to journalLetter

7 Citations (Scopus)

Keratinocyte Growth-Factor Promotes Epithelial Survival and Resolution in a Human Model of Lung Injury

Shyamsundar, M., McAuley, D. F., Ingram, R. J., Gibson, D. S., O'Kane, D., McKeown, S. T., Edwards, A., Taggart, C., Elborn, J. S., Calfee, C. S., Matthay, M. A. & O'Kane, C. M., 15 Jun 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 12, p. 1520-1529 10 p.

Research output: Contribution to journalArticle

Open Access
53 Citations (Scopus)
2013

CHARACTERISATION OF THE HUMAN ANTIBODY RESPONSE TO THE UK ANTHRAX VACCINE

Linley, E., Cuthbertson, H., Cooper, C., Dyson, H., Ingram, B., Osbourn, M. & Baillie, L., 2013.

Research output: Contribution to conferencePoster

Exposure to anthrax toxin alters human leucocyte expression of anthrax toxin receptor 1

Ingram, R. J., Harris, A., Ascough, S., Metan, G., Doganay, M., Ballie, L., Williamson, E. D., Dyson, H., Robinson, J. H., Sriskandan, S. & Altmann, D. M., Jul 2013, In : Clinical and experimental immunology. 173, 1, p. 84-91 8 p.

Research output: Contribution to journalArticle

File
7 Citations (Scopus)
214 Downloads (Pure)

Innate Lymphoid Cells Are The Predominant Producers of IL-17A In Acute Lung Injury

Muir, R., McAuley, D. & Ingram, B., 2013.

Research output: Contribution to conferencePoster

Regulation of Foxp3+ Inducible Regulatory T Cell Stability by SOCS2

Knosp, C. A., Schiering, C., Spence, S., Carroll, H. P., Nel, H. J., Osbourn, M., Jackson, R., Lyubomska, O., Malissen, B., Ingram, R., Fitzgerald, D. C., Powrie, F., Fallon, P. G., Johnston, J. A. & Kissenpfennig, A., 01 Apr 2013, In : Journal of Immunology. 190, 7, p. 3235-3245 8 p.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)

Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response

Lowther, D. E., Chong, D. L., Ascough, S., Ettorre, A., Ingram, R. J., Boyton, R. J. & Altmann, D. M., Oct 2013, In : Acta Neuropathologica. 126, 4, p. 501-515

Research output: Contribution to journalArticle

25 Citations (Scopus)
2012

A novel approach to the development of a murine model of Cystic Fibrosis associated chronic pulmonary bacterial infection

Monahan, A., McGurnaghan, P., Elborn, S. & Ingram, B., Apr 2012.

Research output: Contribution to conferenceOther

Anthrax lethal toxin and the induction of CD4 T cell immunity

Ascough, S., Ingram, R. J. & Altmann, D. M., Oct 2012, In : Toxins. 4, 10, p. 878-99 22 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Comment on ‘Frequency of Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire

Ascough, S., Ingram, R. J., Metan, G., Maillere, B., Doganay, M., Ozkul, Y., Kim, L. U., Ballie, L., Moore, S., Huwar, T. B., Sriskandan, S. & Altmann, D. M., 01 Jun 2012, In : Journal of Immunology. 188, 11, p. 5205-5206 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Development of a murine model of cystic fibrosis associated chronic pulmonary bacterial infection

Monahan, A., McGurnaghan, P., Elborn, S. & Ingram, B., Jun 2012.

Research output: Contribution to conferenceOther

5 Citations (Scopus)

Foxp3+ Macrophages; do they exist?

Spence, S., Osbourn, M., Magorrian, S., Cross, M., McAuley, D., Kissenpfennig, A. & Ingram, B., 2012.

Research output: Contribution to conferencePoster

Foxp3+ macrophages do they exist?

Spence, S., Osbourn, M., Magorrian, S., Cross, M., McAuley, D., Kissenpfennig, A. & Ingram, B., 2012.

Research output: Contribution to conferencePoster

Open Access
File
89 Citations (Scopus)
370 Downloads (Pure)

Identification of immunodominant T cell epitopes from anthrax protective antigen for inclusion in a rationally designed sub-unit based vaccine

Ascough, S., Ingram, B., Musson, J. A., Doganay, M., Baillie, L., Williamson, E. D., Robinson, J. H., Maillere, B., Sriskandan, S. & Altmann, D. M., 2012.

Research output: Contribution to conferencePoster

It's in the genes! Human genetic diversity and the response to anthrax vaccines

Ingram, R. & Baillie, L., Jun 2012, In : Expert review of vaccines. 11, 6, p. 633-5 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The nature of innate and adaptive interleukin-17A responses in sham or bacterial inoculation

Chong, D. L. W., Ingram, R. J., Lowther, D. E., Muir, R., Sriskandan, S. & Altmann, D. M., Jul 2012, In : Immunology. 136, 3, p. 325-33 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The Role of Lymphocytes in Acute Lung Injury

Muir, R., Cross, M., O'Kane, C., Craig, T., Shyamsundar, M., McAuley, D. & Ingram, B., 2012.

Research output: Contribution to conferenceOther

2011

Protein Microarrays for Characterisation of the Bacillus anthracis ‘infectome’

Kidd, S., Kempsell, K., Ingram, B., Watteau, P., Altmann, D. M., Elmore, M., Charlton, S., Hallis, B. & Vipond, R., 2011.

Research output: Contribution to conferencePoster

2010

Analysis of the CD4+ T cell response to Anthrax lethal Factor

Ascough, S., Ingram, B., Chu, K., Doganay, M., Williamson, E. D., Baillie, L., Robinson, J. H., Sriskandan, S. & Altmann, D. M., 2010.

Research output: Contribution to conferenceOther