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20082020

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2020

Toxin-neutralizing antibodies elicited by naturally acquired cutaneous anthrax are elevated following severe disease and appear to target conformational epitopes

Dumas, E. K., Demiraslan, H., Ingram, R. J., Sparks, R. M., Muns, E., Zamora, A., Larabee, J., Garman, L., Ballard, J. D., Boons, G-J., James, J. A., Kayabas, U., Doganay, M. & Farris, A. D., 15 Apr 2020, In : PLoS ONE. 15, 4, 17 p., e0230782.

Research output: Contribution to journalArticle

Open Access
File
4 Downloads (Pure)
2019

A general protein O-glycosylation machinery conserved in Burkholderia species improves bacterial fitness and elicits glycan immunogenicity in humans

Mohamed, Y. F., Scott, N. E., Molinaro, A., Creuzenet, C., Ortega, X., Lertmemongkolchai, G., Tunney, M. M., Green, H., Jones, A. M., DeShazer, D., Currie, B. J., Foster, L. J., Ingram, R., De Castro, C. & Valvano, M. A., 26 Jul 2019, In : The Journal of biological chemistry.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
170 Downloads (Pure)

Control of Klebsiella pneumoniae infection in mice using dissolving microarray patches containing gentamicin

Rodgers, A. M., McCrudden, M. T. C., Courtenay, A. J., Kearney, M-C., Edwards, K. L., Ingram, R. J., Bengoechea, J. & Donnelly, R. F., 01 May 2019, In : Antimicrobial Agents and Chemotherapy. 63, 5, p. e02612-e02618 7 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
139 Downloads (Pure)

Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues

An, S-Q., Murtagh, J., Twomey, K. B., Gupta, M. K., O"Sullivan, T. P., Ingram, R., Valvano, M. A. & Tang, J., 27 May 2019, In : Nature Communications. NCOMMS-18-25986D.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
87 Downloads (Pure)
2018
Open Access
File
74 Downloads (Pure)
Open Access
File
7 Citations (Scopus)
253 Downloads (Pure)
Open Access
File
11 Citations (Scopus)
158 Downloads (Pure)

The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome

Humphries, F., Bergin, R., Jackson, R., Delagic, N., Wang, B., Yang, S., Dubois, A. V., Ingram, R. J. & Moynagh, P. N., 19 Apr 2018, In : Nature Communications. 9, 1, p. 1560 17 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
203 Downloads (Pure)
2017
Open Access
File
11 Citations (Scopus)
203 Downloads (Pure)

A Klebsiella pneumoniae antibiotic resistance mechanism that subdues host defences and promotes virulence

Kidd, T. J., Mills, G., Sá-Pessoa, J., Dumigan, A., Frank, C. G., Insua Romero, J. L., Ingram, R., Hobley, L. & Bengoechea, J. A., 15 Feb 2017, In : EMBO Molecular Medicine. 9, 2

Research output: Contribution to journalArticle

Open Access
File
42 Citations (Scopus)
327 Downloads (Pure)

Antibiotic capture by bacterial lipocalins uncovers an extracellular mechanism of intrinsic antibiotic resistance

El-Halfawy, O. M., Klett, J., Ingram, R. J., Loutet, S. A., Murphy, M. E. P., Martín-Santamaría, S. & Valvano, M. A., 14 Mar 2017, In : mBio. 8, 2

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
467 Downloads (Pure)

Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection

Ivin, M., Dumigan, A., de Vasconcelos, F. N., Ebner, F., Borroni, M., Kavirayani, A., Przybyszewska, K. N., Ingram, R. J., Lienenklaus, S., Kalinke, U., Stoiber, D., Bengoechea, J. A. & Kovarik, P., 07 Nov 2017, In : PLoS Pathogens. 13, 11, p. 1-29 e1006696.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
223 Downloads (Pure)

Regulatory T cells promote myelin regeneration in the central nervous system

Dombrowski, Y., O'Hagan, T., Dittmer, M., Penalva, R., Mayoral, S. R., Bankhead, P., Fleville, S., Eleftheriadis, G., Zhao, C., Naughton, M., Hassan, R., Moffat, J., Falconer, J., Boyd, A., Hamilton, P., Allen, I. V., Kissenpfennig, A., Moynagh, P. N., Evergren, E., Perbal, B. & 5 others, Williams, A. C., Ingram, R. J., Chan, J. R., Franklin, R. J. M. & Fitzgerald, D. C., May 2017, In : Nature Neuroscience. 20, 5, p. 674–680 7 p.

Research output: Contribution to journalArticle

Open Access
File
111 Citations (Scopus)
566 Downloads (Pure)
2016

A Secretory Leukocyte Protease Inhibitor Variant with Improved Activity against Lung Infection

Camper, N., Glasgow, A. M. A., Osbourn, M., Quinn, D. J., Small, D. M., McLean, D. T., Lundy, F. T., Elborn, J. S., McNally, P., Ingram, R. J., Weldon, S. & Taggart, C. C., May 2016, In : Mucosal immunology. 9, 3, p. 669-676

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
263 Downloads (Pure)

CD4+ T Cells Targeting Dominant and Cryptic Epitopes from Bacillus anthracis Lethal Factor

Ascough, S., Ingram, R. J., Chu, K. K. Y., Musson, J. A., Moore, S. J., Gallagher, T., Baillie, L., Williamson, E. D., Robinson, J. H., Maillere, B., Boyton, R. J. & Altmann, D. M., Jan 2016, In : Frontiers in Microbiology. 6, 12 p., 1506.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
204 Downloads (Pure)

Correction: Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation

De Majumdar, S., Yu, J., Fookes, M., McAteer, S. P., Llobet, E., Spence, S. F. S., Monaghan, A., Kissenpfennig, A., Ingram, R. J., Bengoechea, J., Gally, D. L., Fanning, S., Elborn, J. S. & Schneiders, T., 11 May 2016, In : PLoS Pathogens. 12, 5, p. e1005649

Research output: Contribution to journalArticle

Open Access
File
173 Downloads (Pure)
Open Access
File
21 Citations (Scopus)
283 Downloads (Pure)
2015
Open Access
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45 Citations (Scopus)
350 Downloads (Pure)

Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation

De Majumdar, S., Yu, J., Fookes, M., McAteer, S. P., Llobet, E., Finn, S., Spence, S., Monahan, A., Kissenpfennig, A., Ingram, R. J., Bengoechea, J., Gally, D. L., Fanning, S., Elborn, J. S. & Schneiders, T., Jan 2015, In : PLoS Pathogens. 11, 1, 22 p., e1004627.

Research output: Contribution to journalArticle

Open Access
File
40 Citations (Scopus)
245 Downloads (Pure)

Natural cutaneous anthrax infection, but not vaccination, induces a CD4+ T cell response involving diverse cytokines

Ingram, R. J., Ascough, S., Reynolds, C. J., Metan, G., Doganay, M., Baillie, L., Williamson, D. E., Robinson, J. H., Maillere, B., Boyton, R. J. & Altmann, D. M., 26 Apr 2015, In : Cell & Bioscience . 5, 6 p., 20.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
176 Downloads (Pure)

Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome

Li, J. T., Melton, A. C., Su, G., Hamm, D. E., LaFemina, M., Howard, J., Fang, X., Bhat, S., Huynh, K-M., O'Kane, C., Ingram, R. J., Muir, R. R., McAuley, D. F., Matthay, M. A. & Sheppard, D., Jul 2015, In : Journal of Immunology. 195, 1, p. 87-95 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Whole genome protein microarrays for serum profiling of immunodominant antigens of Bacillus anthracis

Kempsell, K. E., Kidd, S. P., Lewandowski, K., Elmore, M. J., Charlton, S., Yeates, A., Cuthbertson, H., Cuthbertson, H., Hallis, B., Altmann, D. M., Rogers, M., Wattiau, P., Ingram, R. J., Brooks, T. & Vipond, R., 13 Aug 2015, In : Frontiers in Microbiology. 6, 16 p., 747.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
307 Downloads (Pure)
2014

Anthrax Lethal Factor as an Immune Target in Humans and Transgenic Mice and the Impact of HLA Polymorphism on CD4+ T Cell Immunity

Ascough, S., Ingram, R. J., Chu, K. K., Reynolds, C. J., Musson, J. A., Doganay, M., Metan, G., Ozkul, Y., Baillie, L., Sriskandan, S., Moore, S. J., Gallagher, T. B., Dyson, H., Williamson, E. D., Robinson, J. H., Maillere, B., Boyton, R. J. & Altmann, D. M., May 2014, In : PLoS Pathogens. 10, 5, 17 p., e1004085.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
209 Downloads (Pure)

Keratinocyte Growth-Factor Promotes Epithelial Survival and Resolution in a Human Model of Lung Injury

Shyamsundar, M., McAuley, D. F., Ingram, R. J., Gibson, D. S., O'Kane, D., McKeown, S. T., Edwards, A., Taggart, C., Elborn, J. S., Calfee, C. S., Matthay, M. A. & O'Kane, C. M., 15 Jun 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 12, p. 1520-1529 10 p.

Research output: Contribution to journalArticle

Open Access
53 Citations (Scopus)
2013

Exposure to anthrax toxin alters human leucocyte expression of anthrax toxin receptor 1

Ingram, R. J., Harris, A., Ascough, S., Metan, G., Doganay, M., Ballie, L., Williamson, E. D., Dyson, H., Robinson, J. H., Sriskandan, S. & Altmann, D. M., Jul 2013, In : Clinical and experimental immunology. 173, 1, p. 84-91 8 p.

Research output: Contribution to journalArticle

File
7 Citations (Scopus)
213 Downloads (Pure)

Regulation of Foxp3+ Inducible Regulatory T Cell Stability by SOCS2

Knosp, C. A., Schiering, C., Spence, S., Carroll, H. P., Nel, H. J., Osbourn, M., Jackson, R., Lyubomska, O., Malissen, B., Ingram, R., Fitzgerald, D. C., Powrie, F., Fallon, P. G., Johnston, J. A. & Kissenpfennig, A., 01 Apr 2013, In : Journal of Immunology. 190, 7, p. 3235-3245 8 p.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)

Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response

Lowther, D. E., Chong, D. L., Ascough, S., Ettorre, A., Ingram, R. J., Boyton, R. J. & Altmann, D. M., Oct 2013, In : Acta Neuropathologica. 126, 4, p. 501-515

Research output: Contribution to journalArticle

25 Citations (Scopus)
2012

Anthrax lethal toxin and the induction of CD4 T cell immunity

Ascough, S., Ingram, R. J. & Altmann, D. M., Oct 2012, In : Toxins. 4, 10, p. 878-99 22 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Comment on ‘Frequency of Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire

Ascough, S., Ingram, R. J., Metan, G., Maillere, B., Doganay, M., Ozkul, Y., Kim, L. U., Ballie, L., Moore, S., Huwar, T. B., Sriskandan, S. & Altmann, D. M., 01 Jun 2012, In : Journal of Immunology. 188, 11, p. 5205-5206 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access
File
89 Citations (Scopus)
370 Downloads (Pure)

It's in the genes! Human genetic diversity and the response to anthrax vaccines

Ingram, R. & Baillie, L., Jun 2012, In : Expert review of vaccines. 11, 6, p. 633-5 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The nature of innate and adaptive interleukin-17A responses in sham or bacterial inoculation

Chong, D. L. W., Ingram, R. J., Lowther, D. E., Muir, R., Sriskandan, S. & Altmann, D. M., Jul 2012, In : Immunology. 136, 3, p. 325-33 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2010

An anthrax subunit vaccine candidate based on protective regions of Bacillus anthracis protective antigen and lethal factor

Baillie, L. W., Huwar, T. B., Moore, S., Mellado-Sanchez, G., Rodriguez, L., Neeson, B. N., Flick-Smith, H. C., Jenner, D. C., Atkins, H. S., Ingram, R. J., Altmann, D. M., Nataro, J. P. & Pasetti, M. F., Sep 2010, In : Vaccine. 28, 41, p. 6740-8 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Natural Exposure to Cutaneous Anthrax Gives Long-Lasting T Cell Immunity Encompassing Infection-Specific Epitopes

Ingram, R., Metan, G., Maillere, B., Doganay, M., Ozkul, Y., Kim, L. U., Baillie, L., Dyson, H., Williamson, E. D., Chu, K. K., Ascough, S., Moore, S., Huwar, T. B., Robinson, J. H., Sriskandan, S. & Altmann, D. M., 01 Apr 2010, In : Journal of Immunology. 184, 7, p. 3814-3821 8 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Repertoire of HLA-DR1-restricted CD4 T cell responses to capsular Caf1 antigen of Y. pestis HLA-transgenic mice

Musson, J. A., Ingram, R., Durand, G., Ascough, S., Waters, E. L., Hartley, M. G., Robson, T., Maillere, B., Williamson, E. D., Sriskandan, S., Altmann, D. & Robinson, J. H., Oct 2010, In : Infection and Immunity. 78 (10), 10, p. 4356-4362 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)