Bernadette McGuinness

Dr

  • Room 03.019 - Clinical Science B

    United Kingdom

Accepting PhD Students

PhD projects

Dr McGuinness is open to wide ranging PhD applications from candidates with both a clinical and science background. Her fields of interest include: The role of inflammation in dementia The role of diet in cognitive decline Clinical trials in Alzheimer's disease and mild cognitive impairment Cognitive impairment in longitudinal studies Previous research experience is desirable.

20072019
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Research Output 2007 2019

2019
Open Access
Mouth Rehabilitation
Feeding Behavior
Nutritional Status
Habits
Control Groups
1 Citation (Scopus)
77 Downloads (Pure)

Cerebrospinal Fluid Spermidine, Glutamine and Putrescine Predict Postoperative Delirium Following Elective Orthopaedic Surgery

Pan, X., Cunningham, E. L., Passmore, A. P., McGuinness, B., McAuley, D. F., Beverland, D., O'Brien, S., Mawhinney, T., Schott, J. M., Zetterberg, H. & Green, B. D., 12 Mar 2019, In : Scientific Reports. 9, 1, 9 p., 4191.

Research output: Contribution to journalArticle

Open Access
File
Putrescine
Spermidine
Delirium
Glutamine
Orthopedics
4 Citations (Scopus)
38 Downloads (Pure)

Cohort profile: Design and methods in the eye and vision consortium of UK Biobank

UK Biobank Eye and Vision Consortium, 01 Feb 2019, In : BMJ Open. 9, 2, e025077.

Research output: Contribution to journalReview article

Open Access
File
Eye Diseases
Optical Coherence Tomography
Intraocular Pressure
Health
Multimodal Imaging
Ocular Tonometry
Patient Preference
Manometry
Intraocular Pressure
Glaucoma
2 Citations (Scopus)
134 Downloads (Pure)
Open Access
File
Alzheimer disease
Alzheimer Disease
inflammation
cognition
Cognition

Electrophysiological Signatures of Cognitive Impairment in Parkinson’s Disease – A Machine Learning Approach

Sweeney, A., Devereux, B., Ong, C., McKinley, J., Foy, J., Murphy, B., McGuinness, B. & Passmore, A., 02 Sep 2019.

Research output: Contribution to conferenceAbstract

68 Citations (Scopus)
207 Downloads (Pure)

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Kunkle, B. W., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., Boland, A., Vronskaya, M., van der Lee, S. J., Amlie-Wolf, A., Bellenguez, C., Frizatti, A., Chouraki, V., Martin, E. R., Sleegers, K., Badarinarayan, N., Jakobsdottir, J., Hamilton-Nelson, K. L., Moreno-Grau, S., Olaso, R. & 448 others, Raybould, R., Chen, Y., Kuzma, A. B., Hiltunen, M., Morgan, T., Ahmad, S., Vardarajan, B. N., Epelbaum, J., Hoffmann, P., Boada, M., Beecham, G. W., Garnier, J. G., Harold, D., Fitzpatrick, A. L., Valladares, O., Moutet, M. L., Gerrish, A., Smith, A. V., Qu, L., Bacq, D., Denning, N., Jian, X., Zhao, Y., Del Zompo, M., Fox, N. C., Choi, S. H., Mateo, I., Hughes, J. T., Adams, H. H., Malamon, J., Sanchez-Garcia, F., Patel, Y., Brody, J. A., Dombroski, B. A., Naranjo, M. C. D., Daniilidou, M., Eiriksdottir, G., Mukherjee, S., Wallon, D., Uphill, J., Aspelund, T., Cantwell, L. B., Garzia, F., Galimberti, D., Hofer, E., Butkiewicz, M., Fin, B., Scarpini, E., Sarnowski, C., Bush, W. S., Meslage, S., Kornhuber, J., White, C. C., Song, Y., Barber, R. C., Engelborghs, S., Sordon, S., Voijnovic, D., Adams, P. M., Vandenberghe, R., Mayhaus, M., Cupples, L. A., Albert, M. S., De Deyn, P. P., Gu, W., Himali, J. J., Beekly, D., Squassina, A., Hartmann, A. M., Orellana, A., Blacker, D., Rodriguez-Rodriguez, E., Lovestone, S., Garcia, M. E., Doody, R. S., Munoz-Fernadez, C., Sussams, R., Lin, H., Fairchild, T. J., Benito, Y. A., Holmes, C., Karamujić-Čomić, H., Frosch, M. P., Thonberg, H., Maier, W., Roschupkin, G., Ghetti, B., Giedraitis, V., Kawalia, A., Li, S., Huebinger, R. M., Kilander, L., Moebus, S., Hernández, I., Kamboh, M. I., Brundin, R. M., Turton, J., Yang, Q., Katz, M. J., Concari, L., Lord, J., Beiser, A. S., Keene, C. D., Helisalmi, S., Kloszewska, I., Kukull, W. A., Koivisto, A. M., Lynch, A., Tarraga, L., Larson, E. B., Haapasalo, A., Lawlor, B., Mosley, T. H., Lipton, R. B., Solfrizzi, V., Gill, M., Longstreth, W. T., Montine, T. J., Frisardi, V., Diez-Fairen, M., Rivadeneira, F., Petersen, R. C., Deramecourt, V., Alvarez, I., Salani, F., Ciaramella, A., Boerwinkle, E., Reiman, E. M., Fievet, N., Rotter, J. I., Reisch, J. S., Hanon, O., Cupidi, C., Andre Uitterlinden, A. G., Royall, D. R., Dufouil, C., Maletta, R. G., de Rojas, I., Sano, M., Brice, A., Cecchetti, R., George-Hyslop, P. S., Ritchie, K., Tsolaki, M., Tsuang, D. W., Dubois, B., Craig, D., Wu, C. K., Soininen, H., Avramidou, D., Albin, R. L., Fratiglioni, L., Germanou, A., Apostolova, L. G., Keller, L., Koutroumani, M., Arnold, S. E., Panza, F., Gkatzima, O., Asthana, S., Hannequin, D., Whitehead, P., Atwood, C. S., Caffarra, P., Hampel, H., Quintela, I., Carracedo, Á., Lannfelt, L., Rubinsztein, D. C., Barnes, L. L., Pasquier, F., Frölich, L., Barral, S., McGuinness, B., Beach, T. G., Johnston, J. A., Becker, J. T., Passmore, P., Bigio, E. H., Schott, J. M., Bird, T. D., Warren, J. D., Boeve, B. F., Lupton, M. K., Bowen, J. D., Proitsi, P., Boxer, A., Powell, J. F., Burke, J. R., Kauwe, J. S. K., Burns, J. M., Mancuso, M., Buxbaum, J. D., Bonuccelli, U., Cairns, N. J., McQuillin, A., Cao, C., Livingston, G., Carlson, C. S., Bass, N. J., Carlsson, C. M., Hardy, J., Carney, R. M., Bras, J., Carrasquillo, M. M., Guerreiro, R., Allen, M., Chui, H. C., Fisher, E., Masullo, C., Crocco, E. A., DeCarli, C., Bisceglio, G., Dick, M., Ma, L., Duara, R., Graff-Radford, N. R., Evans, D. A., Hodges, A., Faber, K. M., Scherer, M., Fallon, K. B., Riemenschneider, M., Fardo, D. W., Heun, R., Farlow, M. R., Kölsch, H., Ferris, S., Leber, M., Foroud, T. M., Heuser, I., Galasko, D. R., Giegling, I., Gearing, M., Hüll, M., Geschwind, D. H., Gilbert, J. R., Morris, J. C., Green, R. C., Mayo, K., Growdon, J. H., Feulner, T., Hamilton, R. L., Harrell, L. E., Drichel, D., Honig, L. S., Cushion, T. D., Huentelman, M. J., Hollingworth, P., Hulette, C. M., Hyman, B. T., Marshall, R., Jarvik, G. P., Meggy, A., Abner, E., Menzies, G. E., Jin, L. W., Leonenko, G., Real, L. M., Jun, G. R., Baldwin, C. T., Grozeva, D., Karydas, A., Russo, G., Kaye, J. A., Kim, R., Jessen, F., Kowall, N. W., Vellas, B., Kramer, J. H., Vardy, E., LaFerla, F. M., Jöckel, K. H., Lah, J. J., Dichgans, M., Leverenz, J. B., Mann, D., Levey, A. I., Pickering-Brown, S., Lieberman, A. P., Klopp, N., Lunetta, K. L., Wichmann, H. E., Lyketsos, C. G., Morgan, K., Marson, D. C., Brown, K., Martiniuk, F., Medway, C., Mash, D. C., Nöthen, M. M., Masliah, E., Hooper, N. M., McCormick, W. C., Daniele, A., McCurry, S. M., Bayer, A., McDavid, A. N., Gallacher, J., McKee, A. C., van den Bussche, H., Mesulam, M., Brayne, C., Miller, B. L., Riedel-Heller, S., Miller, C. A., Miller, J. W., Al-Chalabi, A., Morris, J. C., Shaw, C. E., Myers, A. J., Wiltfang, J., O’Bryant, S., Olichney, J. M., Alvarez, V., Parisi, J. E., Singleton, A. B., Paulson, H. L., Collinge, J., Perry, W. R., Mead, S., Peskind, E., Cribbs, D. H., Rossor, M., Pierce, A., Ryan, N. S., Poon, W. W., Nacmias, B., Potter, H., Sorbi, S., Quinn, J. G., Sacchinelli, E., Raj, A., Spalletta, G., Raskind, M., Caltagirone, C., Bossù, P., Orfei, M. D., Reisberg, B., Clarke, R., Reitz, C., Smith, A. D., Ringman, J. M., Warden, D., Roberson, E. D., Wilcock, G., Rogaeva, E., Bruni, A. C., Rosen, H. J., Gallo, M., Rosenberg, R. N., Ben-Shlomo, Y., Sager, M. A., Mecocci, P., Saykin, A. J., Pastor, P., Cuccaro, M. L., Vance, J. M., Schneider, J. A., Schneider, L. S., Slifer, S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Swerdlow, R. H., Tang, M., Tanzi, R. E., Trojanowski, J. Q., Troncoso, J. C., Van Deerlin, V. M., Van Eldik, L. J., Vinters, H. V., Vonsattel, J. P., Weintraub, S., Welsh-Bohmer, K. A., Wilhelmsen, K. C., Williamson, J., Wingo, T. S., Woltjer, R. L., Wright, C. B., Yu, C. E., Yu, L., Saba, Y., Pilotto, A., Bullido, M. J., Peters, O., Crane, P. K., Bennett, D., Bosco, P., Coto, E., Boccardi, V., De Jager, P. L., Lleo, A., Warner, N., Lopez, O. L., Ingelsson, M., Deloukas, P., Cruchaga, C., Graff, C., Gwilliam, R., Fornage, M., Goate, A. M., Sanchez-Juan, P., Kehoe, P. G., Amin, N., Ertekin-Taner, N., Berr, C., Debette, S., Love, S., Launer, L. J., Younkin, S. G., Dartigues, J. F., Corcoran, C., Ikram, M. A., Dickson, D. W., Nicolas, G., Campion, D., Tschanz, J. A., Schmidt, H., Hakonarson, H., Clarimon, J., Munger, R., Schmidt, R., Farrer, L. A., Van Broeckhoven, C., C. O’Donovan, M., DeStefano, A. L., Jones, L., Haines, J. L., Deleuze, J. F., Owen, M. J., Gudnason, V., Mayeux, R., Escott-Price, V., Psaty, B. M., Ramirez, A., Wang, L. S., Ruiz, A., van Duijn, C. M., Holmans, P. A., Seshadri, S., Williams, J., Amouyel, P., Schellenberg, G. D., Lambert, J. C. & Pericak-Vance, M. A., 28 Feb 2019, In : Nature Genetics. 51, 3, p. 414-430 17 p.

Research output: Contribution to journalArticle

Open Access
File
Meta-Analysis
Immunity
Alzheimer Disease
Lipids
Serum Amyloid A Protein

Genome-wide DNA methylation analysis for type 1 diabetes

Smyth, L., Wooster, C., Kilner, J., Kee, F., Young, I., McGuinness, B., Maxwell, A., McKay, G., McKnight, A., GENIE Consortium & On behalf of NICOLA , 17 Jul 2019, (Accepted).

Research output: Contribution to conferenceAbstract

Recurrent neural networks
Geriatrics
Semantics
Data storage equipment
Deep neural networks
16 Downloads (Pure)
Open Access
File
Xanthophylls
Glomerular Filtration Rate
Kidney
Lutein
Tocopherols
123 Downloads (Pure)

Souvenaid in the management of mild cognitive impairment: An expert consensus opinion

Cummings, J., Passmore, P., McGuinness, B., Mok, V., Chen, C., Engelborghs, S., Woodward, M., Manzano, S., Garcia-Ribas, G., Cappa, S., Bertolucci, P. & Chu, L. W., 17 Aug 2019, In : Alzheimer's Research and Therapy. 11, 1, 73.

Research output: Contribution to journalReview article

Open Access
File
Expert Testimony
Consensus
Life Style
Early Diagnosis
Alzheimer Disease

The feasibility of mobile-EEG to profile cognitive impairment in Parkinson's disease and early-stage dementia

Sweeney, A., Devereux, B., Kearney, S., McKinley, J., Ong, C. W., Anderson, J., Murphy, B., McGuinness, B. & Passmore, A., 14 Apr 2019.

Research output: Contribution to conferenceAbstract

58 Downloads (Pure)
Open Access
File
Mouth Rehabilitation
systematic review
Nutrition
Nutritional Status
meta-analysis

The role of dry EEG in a memory clinic setting: a delayed recognition task

Toogood, A., Fitzpatrick, P., McCartney, B., Murphy, B., Jurek-Loughrey, A., Devereux, B. & McGuinness, B., 14 Jul 2019.

Research output: Contribution to conferenceAbstract

2 Citations (Scopus)
62 Downloads (Pure)

Vitamin E and Alzheimer’s disease: What do we know so far?

Browne, D., McGuinness, B., Woodside, J. V. & McKay, G. J., 18 Jul 2019, In : Clinical interventions in aging. 14, p. 1303-1317 15 p.

Research output: Contribution to journalReview article

Open Access
File
Vitamin E
Alzheimer Disease
Protein Isoforms
Tocotrienols
Tocopherols
Arsenic
alcohol
arsenic
Alcohols
Food
1 Citation (Scopus)

Automated quantification of retinal vessel morphometry in the UK biobank cohort

on behalf of the UK Biobank Eye and Vision Consortium, 12 Mar 2018, Proceedings of the 7th International Conference on Image Processing Theory, Tools and Applications (IPTA 2017). Institute of Electrical and Electronics Engineers Inc., 6 p. (International Conference on Image Processing Theory, Tools and Applications (IPTA): Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Retinal Vessels
Image analysis
Epidemiologic Studies
Topology
Processing
1 Citation (Scopus)
9 Downloads (Pure)
Open Access
File
Photography
Optical Coherence Tomography
Epiretinal Membrane
Color
Geographic Atrophy
1 Citation (Scopus)
51 Downloads (Pure)

CSF Beta-amyloid 1-42 Concentration Predicts Delirium Following Elective Arthroplasty Surgery in an Observational Cohort Study

Cunningham, E. L., McGuinness, B., McAuley, D. F., Toombs, J., Mawhinney, T., O'Brien, S., Beverland, D., Schott, J. M., Lunn, M. P., Zetterberg, H. & Passmore, A. P., 02 Feb 2018, In : Annals of Surgery.

Research output: Contribution to journalArticle

Open Access
File
Delirium
Arthroplasty
Observational Studies
Cerebrospinal Fluid
Cohort Studies
2 Citations (Scopus)
300 Downloads (Pure)

Effect of dietary interventions in mild cognitive impairment: a systematic review

McGrattan, A., McEvoy, C., McGuinness, B., McKinley, M. & Woodside, J., 09 Nov 2018, In : British Journal of Nutrition. 120, p. 1388 1405 p.

Research output: Contribution to journalArticle

Open Access
File
Cognition
Diet
Folic Acid
Dementia
Alzheimer Disease
4 Citations (Scopus)
125 Downloads (Pure)

Evidence That Parietal Lobe Fatty Acids May Be More Profoundly Affected in Moderate Alzheimer’s Disease (AD) Pathology Than in Severe AD Pathology

Bin Nasaruddin, M., Pan, X., McGuinness, B., Passmore, A., Kehoe, P. G., Holscher, C., Graham, S. & Green, B., 26 Oct 2018, In : Metabolites. 8, 4

Research output: Contribution to journalArticle

Open Access
File
Parietal Lobe
Pathology
Alzheimer Disease
Fatty Acids
Lewy Bodies
39 Citations (Scopus)

Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

Tedja, M. S., Wojciechowski, R., Hysi, P. G., Eriksson, N., Furlotte, N. A., Verhoeven, V. J. M., Iglesias, A. I., Meester-Smoor, M. A., Tompson, S. W., Fan, Q., Khawaja, A. P., Cheng, C. Y., Höhn, R., Yamashiro, K., Wenocur, A., Grazal, C., Haller, T., Metspalu, A., Wedenoja, J., Jonas, J. B. & 30 others, Wang, Y. X., Xie, J., Mitchell, P., Foster, P. J., Klein, B. E. K., Klein, R., Paterson, A. D., Hosseini, S. M., Shah, R. L., Williams, C., Teo, Y. Y., Tham, Y. C., Gupta, P., Zhao, W., Shi, Y., Saw, W. Y., Chen, W., Evans, D. M., Wang, J. J., Wilson, C. H., Blows, P., Chakravarthy, U., Hogg, R. E., McGaughey, M., McGuinness, B., McKay, G. J., Paterson, E. N., Peto, T., Woodside, J. V. & Simpson, C. L., 01 Jun 2018, In : Nature Genetics. 50, 6, p. 834-848 15 p.

Research output: Contribution to journalArticle

Refractive Errors
Genome-Wide Association Study
Meta-Analysis
Light
Retina
5 Citations (Scopus)
246 Downloads (Pure)
Open Access
File
Meta-Analysis
Case-Control Studies
Alzheimer Disease
Antioxidants
Carotenoids
Open Access
1 Citation (Scopus)

The influence of TNF inhibitors on dementia incidence in patients with rheumatoid arthritis; an analysis from the BSRBR-RA

McGuinness, B., Holmes, C., Mirakhur, A., Kearsley-Fleet, L., Vieira, R., Watson, K. & Hyrich, K., 01 Mar 2018, In : International Journal of Geriatric Psychiatry. 33, 3, p. 556-558 3 p.

Research output: Contribution to journalArticle

2017
18 Citations (Scopus)
124 Downloads (Pure)

Metabolomic Profiling of Bile Acids in Clinical and Experimental Samples of Alzheimer's Disease

Pan, X., Elliott, C. T., McGuinness, B., Passmore, P., Kehoe, P. G., Hölscher, C., McClean, P. L., Graham, S. F. & Green, B. D., 17 Jun 2017, In : Metabolites. 7, 2, 12 p., 28.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Bile Acids and Salts
Alzheimer Disease
Brain
Taurocholic Acid
5 Citations (Scopus)

Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array

Barber, I. S., Braae, A., Clement, N., Patel, T., Guetta-Baranes, T., Brookes, K., Medway, C., Chappell, S., Guerreiro, R., Bras, J., Hernandez, D., Singleton, A. B., Hardy, J., Mann, D. M., Passmore, P., Craig, D., Johnston, J., McGuinness, B., Todd, S., Heun, R. & 16 others, Kölsch, H., Kehoe, P. G., Vardy, E. R. L. C., Hooper, N. M., Pickering-Brown, S., Snowden, J., Richardson, A., Jones, M., Neary, D., Harris, J., Lowe, J., Smith, A. D., Wilcock, G., Warden, D., Holmes, C. & Morgan, K., 01 Jan 2017, In : Neurobiology of Aging. 49, p. 215.e1-215.e8

Research output: Contribution to journalArticle

Parkinson Disease
Alzheimer Disease
Mutation
Genes
5 Citations (Scopus)
98 Downloads (Pure)
Open Access
File
Delirium
Apolipoproteins E
Arthroplasty
Observational Studies
Cohort Studies
1 Citation (Scopus)

Pisa syndrome due to donepezil: pharmacokinetic interactions to blame?

Pollock, D., Cunningham, E., McGuinness, B. & Passmore, A. P., 24 Jan 2017, In : Age and Ageing. 46, 3, p. 529-530 2 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Cholinesterase Inhibitors
Caregivers
donepezil
201 Citations (Scopus)

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

ARUK Consortium, 17 Jul 2017, In : Nature Genetics. 49, 9, p. 1373-1384

Research output: Contribution to journalArticle

Innate Immunity
Alzheimer Disease
Odds Ratio
Microglia
Genotype
12 Citations (Scopus)
130 Downloads (Pure)
Open Access
File
Carotenoids
Vitamin E
Case-Control Studies
Alzheimer Disease
Tocopherols
Life Style
Diet
Cognitive Dysfunction
2016
19 Citations (Scopus)
92 Downloads (Pure)

ABCA7 p.G215S as potential protective factor for Alzheimer's disease

Sassi, C., Nalls, M. A., Ridge, P. G., Gibbs, J. R., Ding, J., Lupton, M. K., Troakes, C., Lunnon, K., Al-Sarraj, S., Brown, K. S., Medway, C., Clement, N., Lord, J., Turton, J., Bras, J., Almeida, M. R., Passmore, P., Craig, D., Johnston, J., McGuinness, B. & 30 others, Todd, S., Heun, R., Kölsch, H., Kehoe, P. G., Vardy, E. R. L. C., Hooper, N. M., Mann, D. M., Pickering-Brown, S., Brown, K. S., Lowe, J., Morgan, K., Smith, A. D., Wilcock, G., Warden, D., Holmes, C., Holstege, H., Louwersheimer, E., van der Flier, W. M., Scheltens, P., Van Swieten, J. C., Santana, I., Oliveira, C., Morgan, K., Powell, J. F., Kauwe, J. S. K., Cruchaga, C., Goate, A. M., Singleton, A. B., Guerreiro, R. & Hardy, J., 01 Oct 2016, In : Neurobiology of Aging. 46, p. 235.e1-235.e9

Research output: Contribution to journalArticle

Open Access
File
Alzheimer Disease
Genome-Wide Association Study
Exome
Apolipoproteins E
Protective Factors
40 Citations (Scopus)
247 Downloads (Pure)

Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome

Pan, X., Bin Nasaruddin, M., Elliott, C. T., McGuinness, B., Passmore, A. P., Kehoe, P. G., Holscher, C., McClean, P. L., Graham, S. F. & Green, B. D., Feb 2016, In : Neurobiology of Aging. 38, p. 151-163 13 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolome
Alzheimer Disease
Pathology
Brain
Branched Chain Amino Acids
3 Citations (Scopus)
112 Downloads (Pure)

A randomised controlled trial of calcium channel blockade (CCB) with Amlodipine For the treatment oF subcortical ischaEmic vasCular demenTia (AFFECT): study protocol

Greenan, C., Murphy, L., Yu, L-M., Kehoe, P. G., Coulthard, E., Bath, P., Stewart, R., Jones, R., Corbett, A., Thomas, A., Connelly, P., Arrojo, F., Canning, R., Wallach, S., Henderson, C., McGuinness, B., O'Sullivan, M., Holmes, C., Knapp, M., Ballard, C. & 2 others, Passmore, P. & AFFECT Investigators, 18 Jul 2016, In : Trials. 17, 324, 12 p.

Research output: Contribution to journalArticle

Open Access
File
Amlodipine
Vascular Dementia
Calcium Channels
Randomized Controlled Trials
Therapeutics
23 Citations (Scopus)

Automated retinal image quality assessment on the UK Biobank dataset for epidemiological studies

UK Biobank Eye and Vision Consortium, 01 Apr 2016, In : Computers in Biology and Medicine. 71, p. 67-76 10 p.

Research output: Contribution to journalArticle

Image quality
Epidemiologic Studies
Retinal Vessels
Uncertainty
Automation
9 Citations (Scopus)
117 Downloads (Pure)

Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer’s Disease

Sassi, C., Ridge, P. G., Nalls, M. A., Gibbs, R., Ding, J., Lupton, M. K., Troakes, C., Lunnon, K., Al-Sarraj, S., Brown, K. S., Medway, C., Lord, J., Turton, J., Morgan, K., Powell, J. F., Kauwe, J. S. K., Cruchaga, C., Bras, J., Goate, A. M., Singleton, A. B. & 18 others, Guerreiro, R., Hardy, J., Passmore, P., Craig, D., Johnston, J., McGuinness, B., Todd, S., Heun, R., Kölsch, H., Kehoe, P. G., Hooper, N. M., Vardy, E. R. L. C., Mann, D. M., Lowe, J., David Smith, A., Wilcock, G., Warden, D. & Holmes, C., 01 Jun 2016, In : PLoS ONE. 11, 6, e0150079.

Research output: Contribution to journalArticle

Open Access
File
Serum Amyloid A Protein
Amyloid beta-Protein Precursor
Staphylococcal Protein A
amyloid
Alzheimer disease
5 Citations (Scopus)
122 Downloads (Pure)
Open Access
File
Amyloid Precursor Protein Secretases
Longitudinal Studies
Dementia
Blood Platelets
Alzheimer Disease
7 Citations (Scopus)

Screening exons 16 and 17 of the amyloid precursor protein gene in sporadic early-onset Alzheimer's disease

Barber, I. S., Garc??a-C??rdenas, J. M., Sakdapanichkul, C., Deacon, C., Zapata Erazo, G., Guerreiro, R., Bras, J., Hernandez, D., Singleton, A. B., Guetta-Baranes, T., Braae, A., Clement, N., Patel, T., Brookes, K., Medway, C., Chappell, S., Mann, D. M., Passmore, P., Craig, D., Johnston, J. & 19 others, McGuinness, B., Todd, S., Heun, R., Kolsch, H., Kehoe, P. G., Vardy, E. R. L. C., Hooper, N. M., Pickering-Brown, S., Snowden, J., Richardson, A., Jones, M., Neary, D., Harris, J., Lowe, J., Smith, A. D., Wilcock, G., Warden, D., Holmes, C. & Morgan, K., 01 Mar 2016, Neurobiology of Aging. Elsevier Inc., p. 220.e1-220.e7 (Neurobiology of Aging; vol. 39).

Research output: Chapter in Book/Report/Conference proceedingChapter

Amyloid beta-Protein Precursor
Exons
Alzheimer Disease
Base Pairing
Genes
22 Citations (Scopus)

Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease.

Traylor, M., Adib-Samii, P., Harold, D., Alzheimer's Disease Neuroimaging Initiative, T. A. D. N., International Stroke Genetics Consortium (ISGC), UK Young Lacunar Stroke DNA resource, T. I. S. G. C., Dichgans, M., Williams, J., Lewis, C. M., Markus, H. S., METASTROKE, H. S., International Genomics of Alzheimer's Project (IGAP), investigators, A. T. METASTROKE. A. I. G. O. A. P. IGAP., Fornage, M., Holliday, E. G., Sharma, P., Bis, J. C., Psaty, B. M., Seshadri, S., Nalls, M. A., Devan, W. J., Boncoraglio, G. & 155 others, Malik, R., Mitchell, B. D., Kittner, S. J., Ikram, M. A., Clarke, R., Rosand, J., Meschia, J. F., Sudlow, C., Rothwell, P. M., Levi, C., Bevan, S., Kilarski, L. L., Walters, M., Thijs, V., Slowik, A., Lindgren, A., de Bakker, P. I. W., Lambert, J-C., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., Jun, G., DeStefano, A. L., Bis, J. C., Beecham, G. W., Grenier‐Boley, B., Russo, G., Thornton‐Wells, T. A., Jones, N., Smith, A. V., Chouraki, V., Thomas, C., Ikram, M. A., Zelenika, D., Vardarajan, B. N., Kamatani, Y., Lin, CF., Gerrish, A., Schmidt, H., Kunkle, B., Dunstan, M. L., Ruiz, A., Bihoreau, MT., Choi, S-H., Reitz, C., Pasquier, F., Hollingworth, P., Ramirez, A., Hanon, O., Fitzpatrick, A. L., Buxbaum, J. D., Campion, D., Crane, P. K., Baldwin, C., Becker, T., Gudnason, V., Cruchaga, C., Craig, D., Amin, N., Berr, C., Lopez, O. L., Jager, P. L. D., Deramecourt, V., Johnston, J. A., Evans, D., Lovestone, S., Letenneur, L., Morón, F. J., Rubinsztein, D. C., Eiriksdottir, G., Sleegers, K., Goate, A. M., Fiçvet, N., Huentelman, M. J., Gill, M., Brown, K. S., Kamboh, M. I., Keller, L., Barberger‐Gateau, P., McGuinness, B., Larson, E. B., Green, R., Myers, A. J., Dufouil, C., Todd, S., Wallon, D., Love, S., Rogaeva, E., Gallacher, J., George‐Hyslop, P. S., Clarimon, J., Lleo, A., Bayer, A. J., Tsuang, D. W., Yu, L., Tsolaki, M., Bossù, P., Spalletta, G., Proitsi, P., Collinge, J., Sorbi, S., Sanchez‐Garcia, F., Fox, N. C., Hardy, J., Naranjo, M. C. D., Bosco, P., Clarke, R., Brayne, C., Galimberti, D., Mancuso, M., Matthews, F. E., (EADI), E. A. D. I., (GERAD), G. A. E. R. I. A. D., (ADGC), A. D. G. C., (CHARGE), C. F. H. A. A. R. I. G. E., Moebus, S., Mecocci, P., Zompo, M. D., Maier, W., Hampel, H., Pilotto, A., Bullido, M., Panza, F., Caffarra, P., Nacmias, B., Gilbert, J. R., Mayhaus, M., Lannfelt, L., Hakonarson, H., Pichler, S., Carrasquillo, M. M., Ingelsson, M., Beekly, D., Alvarez, V., Zou, F., Valladares, O., Younkin, S. G., Coto, E., Hamilton‐Nelson, K. L., Gu, W., Razquin, C., Pastor, P., Mateo, I., Owen, M. J., Faber, K. M., Jonsson, P. V., Combarros, O., O'Donovan, M. C., Cantwell, L. B., Soininen, H., Blacker, D., Mead, S. & Mosley, T. H., 23 Feb 2016, Annals of neurology. Wiley-Blackwell, p. 739 1 p. (Annals of neurology; vol. 79).

Research output: Chapter in Book/Report/Conference proceedingChapter

Alzheimer Disease
Stroke
Genome-Wide Association Study
Single Nucleotide Polymorphism
Meta-Analysis
3 Citations (Scopus)
207 Downloads (Pure)
Open Access
File
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Dementia
Quality of Life
Blood Vessels
Polypharmacy
2015
288 Downloads (Pure)

Aspirin and anti-inflammatory drugs for the prevention of dementia

Jordan, F., McGuinness, B., Murphy, K., Passmore, P., Kelly, J. P. & Devane, D., 08 Jan 2015, In : Cochrane Database of Systematic Reviews. 2015, 1, p. 1-12

Research output: Contribution to journalArticle

Open Access
File
Non-Steroidal Anti-Inflammatory Agents
Primary Prevention
Secondary Prevention
Aspirin
Dementia
1 Citation (Scopus)

Blood type gene locus has no influence on ACE association with Alzheimer's disease

Braae, A., Medway, C., Carrasquillo, M., Younkin, S., Alzheimer's Research UK (ARUK) Consortium, Kehoe, P. G., Morgan, K., Passmore, P., Craig, D., Johnston, J. & McGuinness, B., 01 Apr 2015, In : Neurobiology of Aging. 36, 4, p. 1767.e1-1767.e2

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Alzheimer Disease
Genes
Genetic Predisposition to Disease
Blood Group Antigens
100 Citations (Scopus)

Convergent genetic and expression data implicate immunity in Alzheimer's disease

Jones, L., Lambert, J-C., Wang, L-S., Choi, S-H., Harold, D., Vedernikov, A., Escott-Price, V., Stone, T., Richards, A., Ibrahim-Verbaas, C. A., Naj, A. C., Sims, R., Gerrish, A., Craig, D., Johnston, J. A., McGuinness, B., Todd, S. & Passmore, P., Jun 2015, In : Alzheimers & dementia. 11, 6, p. 658-671 14 p.

Research output: Contribution to journalArticle