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I have been actively researching inflammation and immunity in pulmonary diseases since my PhD with a Scholarship from the German Academic Exchange Service (DAAD). After a post-doctoral training at UC Davis (USA), I returned to Queen’s to develop my expertise in regulators of inflammation in chronic airway diseases such as Cystic Fibrosis (CF) and Asthma. My current work focuses on the role of the innate immunity in epithelial inflammation and its regulation. Our results in CF confirmed prolonged TLR4 signalling and persistent NF-kB activation associated with reduced lysosomal degradation and increased TLR4 recycling in CF. Subsequently I was the first to describe a dysregulation and lack of the NF-kB regulator A20 in CF, which was highly correlated to lung function in these patients. We also showed that pharmacological induction of A20 is anti-inflammatory, supporting the importance of A20 in NF-kB driven inflammation. Based on this proof of principle, my laboratory applied bioinformatics to predict drugs already licensed for use in humans to induce A20 as a potential therapeutic intervention for people with CF (Malcomson B et al. PNAS 2016). However, the blunted response of these repurposed drugs on A20 in chronic airway inflammation lead to the current investigations of potential A20 regulators. Additionally, based on the recent findings on A20 I am extending my research programme to potential drug development programmes with QUB. I am dedicated to develop an understanding and enthusiasm for research in under-graduate and post-graduate students. I am committed to inter-disciplinary research with a major focus on translational work to improve diagnosis or therapies for patients with chronic airway diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Li, J., Tong, L., Schock, B. C. & Ji, L-L., 01 Apr 2023, (Early online date) In: Molecular Neurobiology. 16 p.
Research output: Contribution to journal › Article › peer-review
Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organsWang, W., Bale, S., Wei, J., Yalavarthi, B., Bhattacharyya, D., Yan, J. J., Abdala-Valencia, H., Xu, D., Sun, H., Marangoni, R. G., Herzog, E., Berdnikovs, S., Miller, S. D., Sawalha, A. H., Tsou, P-S., Awaji, K., Yamashita, T., Sato, S., Asano, Y., Tiruppathi, C., & 4 others, 26 Oct 2022, In: Nature Communications. 13, 16 p., 6358.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile18 Downloads (Pure)
Mediators of systemic sclerosis-associated interstitial lung disease (SSc-ILD): systematic review and meta-analysesFields, A., Potel, K. N., Cabuhal, R., Aziri, B., Stewart, I. D. & Schock, B. C., 19 Oct 2022, (Early online date) In: Thorax. 9 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile10 Downloads (Pure)
Antimicrobial properties of phytohormone (gibberellins) against phytopathogens and clinical pathogensToner, P., Nelson, D., Rao, J. R., Ennis, M., Moore, J. & Schock, B., 21 Oct 2021, In: Access Microbiology.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile50 Downloads (Pure)
Microbial interaction: Prevotella spp. reduce P. aeruginosa induced inflammation in Cystic Fibrosis bronchial epithelial cellsBertelsen, A., Elborn, J. S. & Schock, B. C., 08 Jun 2021, (Early online date) In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 10 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile82 Downloads (Pure)
Liam Heaney (Participant), Ian Cadden (Participant), Michael Shields (Participant), Madeleine Ennis (Participant), Bettina Schock (Participant), Vanessa Brown (Participant), Michael Ryan (Participant), Dennis Carson (Participant) & Timothy Warke (Participant)
Impact: Health Impact, Quality of Life Impact