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Personal profile

Research Interests

G protein-coupled receptors (GPCRs) represent the largest family of cell surface proteins. Agonist binding to GPCRs activates G proteins regulating many cellular effectors. Classically, G protein activation occurs at the plasma membrane and is rapidly terminated by β-arrestin recruitment to the activated GPCRs, promoting G protein uncoupling from receptor, GPCR internalisation and signalling arrest. 

However, recent studies revealed that upon internalisation, some GPCRs continue to activate G proteins from internal compartments leading to sustained production of second messengers far from the plasma membrane. This different spatiotemporal signalling profile allows distinct cellular functions from the ones occurring at the plasma membrane that can be exploited in the near future to design new pharmacological approaches. My research programme aims to tackle important questions underlying this novel signalling mode.

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Projects

Research Output

Emerging Role of Compartmentalized G Protein-Coupled Receptor Signaling in the Cardiovascular Field

Plouffe, B., Thomsen, A. R. B. & Irannejad, R., 05 Mar 2020, In : ACS Pharmacology & Translational Science.

Research output: Contribution to journalArticle

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    Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

    Luttrell, L. M., Wang, J., Plouffe, B., Smith, J. S., Yamani, L., Kaur, S., Jean-Charles, P. Y., Gauthier, C., Lee, M. H., Pani, B., Kim, J., Ahn, S., Rajagopal, S., Reiter, E., Bouvier, M., Shenoy, S. K., Laporte, S. A., Rockman, H. A. & Lefkowitz, R. J., 25 Sep 2018, In : Science Signaling. 11, 549, 23 p., eaat7650.

    Research output: Contribution to journalArticle

  • 28 Citations (Scopus)

    Translating biased signaling in the ghrelin receptor system into differential in vivo functions

    Mende, F., Hundahl, C., Plouffe, B., Skov, L. J., Sivertsen, B., Madsen, A. N., Lückmann, M., Diep, T. A., Offermanns, S., Frimurer, T. M., Bouvier, M. & Holst, B., 23 Oct 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 43, p. E10255-E10264

    Research output: Contribution to journalArticle

  • 7 Citations (Scopus)

    Type 2 diabetes–associated variants of the MT 2 melatonin receptor affect distinct modes of signaling

    Karamitri, A., Plouffe, B., Bonnefond, A., Chen, M., Gallion, J., Guillaume, J. L., Hegron, A., Boissel, M., Canouil, M., Langenberg, C., Wareham, N. J., Le Gouill, C., Lukasheva, V., Lichtarge, O., Froguel, P., Bouvier, M. & Jockers, R., 28 Aug 2018, In : Science Signaling. 11, 545, 14 p., eaan6622.

    Research output: Contribution to journalArticle

  • 13 Citations (Scopus)

    Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure

    Möller, D., Banerjee, A., Uzuneser, T. C., Skultety, M., Huth, T., Plouffe, B., Hübner, H., Alzheimer, C., Friedland, K., Müller, C. P., Bouvier, M. & Gmeiner, P., 13 Apr 2017, In : Journal of Medicinal Chemistry. 60, 7, p. 2908-2929 22 p.

    Research output: Contribution to journalArticle

  • 22 Citations (Scopus)

    Prizes

    Best Oral Presentation Award

    Bianca Plouffe (Recipient), 01 Sep 2004

    Prize: Prize (including medals and awards)

    Doctoral Fellowship Award

    Bianca Plouffe (Recipient), 01 Sep 2007

    Prize: Fellowship awarded competitively

    Étudiants-Chercheurs Etoiles Award

    Bianca Plouffe (Recipient), 01 Oct 2016

    Prize: Prize (including medals and awards)

    Excellence Scholarship

    Bianca Plouffe (Recipient), 01 Sep 2007

    Prize: Prize (including medals and awards)

    Graduate/Postdoctoral Travel Award

    Bianca Plouffe (Recipient), Apr 2008

    Prize: Prize (including medals and awards)

    Activities

    • 10 Oral presentation
    • 4 Invited talk

    Endosomal G protein signalling by US28 as a new target for glioblastoma multiforme

    Bianca Plouffe (Advisor)
    23 Oct 2019

    Activity: Talk or presentation typesOral presentation

    GPCR, G protein and ß-arrestin: three dancers dancing together in the endosome.

    Bianca Plouffe (Invited speaker)
    24 May 2018

    Activity: Talk or presentation typesInvited talk

    GPCR, G protein and ß-arrestin: three dancers dancing together in the endosome.

    Bianca Plouffe (Invited speaker)
    12 Jun 2018

    Activity: Talk or presentation typesInvited talk

    GPCR, G protein and ß-arrestin: three dancers dancing together in the endosome.

    Bianca Plouffe (Invited speaker)
    04 Jun 2018

    Activity: Talk or presentation typesInvited talk

    Human melatonin type 2 receptor structural insights revealed by natural variants.

    Bianca Plouffe (Speaker)
    26 May 2017

    Activity: Talk or presentation typesOral presentation