• Room 01.068 - Biological Sciences

    United Kingdom

20052019

Research output per year

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Research Output

2019

Altering the balance of Rho GTPase pathways in CLL determines CLL cell fate

Samir, Y., Rees-Unwin, K., Graham, C., Graham, R., Rahi, R., Adams, J. & Burthem, J., 27 Mar 2019, In : British Journal of Haematology. 185, S1, p. 171-172

Research output: Contribution to journalMeeting abstract

1 Citation (Scopus)

Diagnosis of epithelial ovarian cancer using a combined protein biomarker panel

Russell, M. R., Graham, C., D’Amato, A., Gentry-Maharaj, A., Ryan, A., Kalsi, J. K., Whetton, A. D., Menon, U., Jacobs, I. & Graham, R. L. J., 07 Aug 2019, In : British Journal of Cancer.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
130 Downloads (Pure)
2018

Phosphorylation of synaptic GTPase-activating protein (synGAP) by polo-like kinase (Plk2) alters the ratio of its GAP activity toward HRas, Rap1 and Rap2 GTPases.

Walkup IV, W. G., Sweredoski, M. J., Graham, R., Hess, S. & Kennedy, M. B., 10 Sep 2018, In : Biochemical and Biophysical Research Communications. 503, 3, p. 1599-1604

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
90 Downloads (Pure)

Quantitative Proteomic Studies in Mastocytosis

Graham, R., McMullen, A., Grayson, A., Lee, D., Dempsey-Hibbert, N., Ainley, C., Myers, B. & Graham, C., 16 Apr 2018, In : British Journal of Haematology. 181, S1, p. 58-59 2 p.

Research output: Contribution to journalMeeting abstract

3 Citations (Scopus)
2017

A combined biomarker panel shows improved sensitivity for the early detection of ovarian cancer allowing the identification of the most aggressive type II tumours

Russell, M. R., Graham, C., D'Amato, A., Gentry-Maharaj, A., Ryan, A., Kalsi, J. K., Ainley, C., Whetton, A. D., Menon, U., Jacobs, I. & Graham, R. L. J., 22 Aug 2017, In : British Journal of Cancer. 117, 5, p. 666-674 9 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
142 Downloads (Pure)

Cytoplasmic glycosylation of clathrin-mediated endocytosis signalling components alters the rate of iron uptake by placenta of mothers with type 2 diabetes

Palin, V., Russell, M., Graham, R., Aplin, J. & Westwood, M., 30 Aug 2017, In : Placenta. 57, p. 300-301 2 p., P2.26.

Research output: Contribution to journalMeeting abstract

2016

Early Detection Biomarkers and Risk Estimation Models for Ovarian Cancer

Russell, MR., D'Amato, A., Gentry-Maharaj, A., Ryan, A., Kalsi, J., Menon, U., Jacobs, I. & Graham, RLJ., 2016.

Research output: Contribution to conferencePaper

Novel risk models for early detection and screening of ovarian cancer

Russell, M. R., D'Amato, A., Graham, C., Crosbie, E. J., Gentry-Maharaj, A., Ryan, A., Kalsi, J. K., Fourkala, E. O., Dive, C., Walker, M., Whetton, A. D., Menon, U., Jacobs, I. & Graham, R. L. J., 26 Nov 2016, In : Oncotarget. 8, 1, p. 785-797

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
127 Downloads (Pure)

Protein Z: A putative novel biomarker for early detection of ovarian cancer

Russell, M. R., Walker, M. J., Williamson, A. J. K., Gentry-Maharaj, A., Ryan, A., Kalsi, J., Skates, S., D'Amato, A., Dive, C., Pernemalm, M., Humphryes, P. C., Fourkala, E-O., Whetton, A. D., Menon, U., Jacobs, I. & Graham, R. L. J., 15 Jun 2016, In : International Journal of Cancer. 138, 12, p. 2984-92

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
165 Downloads (Pure)
2015

Cell-specific proteomic analysis in Caenorhabditis elegans

Yuet, K. P., Doma, M. K., Ngo, J. T., Sweredoski, M. J., Graham, R. L. J., Moradian, A., Hess, S., Schuman, E. M., Sternberg, P. W. & Tirrell, D. A., 03 Mar 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 9, p. 2705-10 6 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Cytoplasmic glycosylation affects clathrin-mediated endocytosis and signalling in micronutrient and growth factor pathways during human placental development

Aplin, JD., Palin, V., Graham, R., Karolczak-Bayatti, M., Horn, J., Harris, LK. & Westwood, M., 2015.

Research output: Contribution to conferencePaper

Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases

Walkup, W. G., Washburn, L., Sweredoski, M. J., Carlisle, H. J., Graham, R. L., Hess, S. & Kennedy, M. B., 20 Feb 2015, In : The Journal of biological chemistry. 290, 8, p. 4908-27 20 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2014

Comprehensive proteomic profiling of outer membrane vesicles from Campylobacter jejuni

Jang, K-S., Sweredoski, M. J., Graham, R. L. J., Hess, S. & Clemons, W. M., 26 Feb 2014, In : Journal of proteomics. 98, p. 90-8

Research output: Contribution to journalArticle

37 Citations (Scopus)

F-box Protein FBXL16 Binds PP2A-B55α and Regulates Differentiation of Embryonic Stem Cells along the FLK1+ Lineage

Honarpour, N., Rose, C. M., Brumbaugh, J., Anderson, J., Graham, R. L. J., Sweredoski, M. J., Hess, S., Coon, J. J. & Deshaies, R. J., 01 Mar 2014, In : Molecular & cellular proteomics : MCP. 13, 3, p. 780-791 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
10 Downloads (Pure)

Identification of secreted bacterial proteins by noncanonical amino acid tagging

Mahdavi, A., Szychowski, J., Ngo, J. T., Sweredoski, M. J., Graham, R. L. J., Hess, S., Schneewind, O., Mazmanian, S. K. & Tirrell, D. A., 07 Jan 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 1, p. 433-438

Research output: Contribution to journalArticle

39 Citations (Scopus)

PROTEOMIC DISCOVERY OF CANDIDATE SERUM BIOMARKERS FOR EARLY DETECTION OF OVARIAN CANCER

Graham, R., Russell, M., Gentry-Maharaj, A., Ryan, A., Fourkala, E., Humphryes, P., Walker, M., Williamson, A., Menon, U. & Whetton, A., 2014, In : INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 24, 9, p. 1589 1 p.

Research output: Contribution to journalArticle

Semiquantitative analysis of clinical heat stress in Clostridium difficile strain 630 using a GeLC/MS workflow with emPAI quantitatio

Ternan, N. G., Jain, S., Graham, R. L. J. & McMullan, G., 24 Feb 2014, In : PLoS ONE. 9, 2, e88960.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
123 Downloads (Pure)
2013

Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins

Pierce, N. W., Lee, J. E., Liu, X., Sweredoski, M. J., Graham, R. L. J., Larimore, E. A., Rome, M., Zheng, N., Clurman, B. E., Hess, S., Shan, S. & Deshaies, R. J., 28 Mar 2013, In : Cell. 153, 1, p. 206-15 10 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)

Comprehensive profiling of N-linked glycosylation sites in HeLa cells using hydrazide enrichment

Malerod, H., Graham, R. L. J., Sweredoski, M. J. & Hess, S., 04 Jan 2013, In : Journal of Proteome Research. 12, 1, p. 248-59 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition

Kolawa, N., Sweredoski, M. J., Graham, R. L. J., Oania, R., Hess, S. & Deshaies, R. J., Oct 2013, In : Molecular & cellular proteomics : MCP. 12, 10, p. 2791-803 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

Eidahl, J. O., Crowe, B. L., North, J. A., McKee, C. J., Shkriabai, N., Feng, L., Plumb, M., Graham, R. L., Gorelick, R. J., Hess, S., Poirier, M. G., Foster, M. P. & Kvaratskhelia, M., 01 Apr 2013, In : Nucleic Acids Research. 41, 6, p. 3924-36 13 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)
2012

Avoiding pitfalls in proteomics sample preparation

Graham, R. L. J., Kalli, A., Smith, G. T., Sweredoski, M. J. & Hess, S., 01 Nov 2012, Biomacromolecular Mass Spectrometry: Tips from the Bench. Nova Science Publishers, Inc, p. 19-34 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Click chemistry facilitates formation of reporter ions and simplified synthesis of amine-reactive multiplexed isobaric tags for protein quantification

Sohn, C. H., Lee, J. E., Sweredoski, M. J., Graham, R. L. J., Smith, G. T., Hess, S., Czerwieniec, G., Loo, J. A., Deshaies, R. J. & Beauchamp, J. L., 08 Feb 2012, In : Journal of the American Chemical Society. 134, 5, p. 2672-80 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Designer reagents for mass spectrometry-based proteomics: clickable cross-linkers for elucidation of protein structures and interactions

Sohn, C. H., Agnew, H. D., Lee, J. E., Sweredoski, M. J., Graham, R. L. J., Smith, G. T., Hess, S., Czerwieniec, G., Loo, J. A., Heath, J. R., Deshaies, R. J. & Beauchamp, J. L., 20 Mar 2012, In : Analytical Chemistry. 84, 6, p. 2662-9 8 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Novel proteomic tools reveal essential roles of SRP and importance of proper membrane protein biogenesis

Zhang, D., Sweredoski, M. J., Graham, R. L. J., Hess, S. & Shan, S., Feb 2012, In : Molecular & cellular proteomics : MCP. 11, 2, p. M111.011585

Research output: Contribution to journalArticle

9 Citations (Scopus)

Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking

Haines, D. S., Lee, J. E., Beauparlant, S. L., Kyle, D. B., den Besten, W., Sweredoski, M. J., Graham, R. L. J., Hess, S. & Deshaies, R. J., Jun 2012, In : Molecular & cellular proteomics : MCP. 11, 6, p. M111.016444

Research output: Contribution to journalArticle

21 Citations (Scopus)
2011

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

Chan, N. C., Salazar, A. M., Pham, A. H., Sweredoski, M. J., Kolawa, N. J., Graham, R. L. J., Hess, S. & Chan, D. C., 01 May 2011, In : Human Molecular Genetics. 20, 9, p. 1726-37 12 p.

Research output: Contribution to journalArticle

558 Citations (Scopus)

LogViewer: a software tool to visualize quality control parameters to optimize proteomics experiments using Orbitrap and LTQ-FT mass spectrometers

Sweredoski, M. J., Smith, G. T., Kalli, A., Graham, R. L. J. & Hess, S., Dec 2011, In : Journal of biomolecular techniques : JBT. 22, 4, p. 122-6 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Proteomic analysis of LEDGF/p75 interactions with nuclear proteins

Graham, R. LJ., McKee, C. J., Sweredoski, M. J., Kvaratskhelia, M. & Hess, S., 2011.

Research output: Contribution to conferenceAbstract

Proteomics in the microbial sciences

Graham, C., McMullan, G. & Graham, R. L. J., 01 Jan 2011, In : Bioengineered Bugs. 2, 1, p. 1-14 14 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Quantitative proteomic analysis of the heat stress response in Clostridium difficile strain 630

Jain, S., Graham, C., Graham, R. L. J., McMullan, G. & Ternan, N. G., 02 Sep 2011, In : Journal of Proteome Research. 10, 9, p. 3880-3890 11 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Stable isotope labeling by amino acids in cell culture (SILAC) - an introduction for biologists

Graham, R. L. J., Sweredoski, M. J. & Hess, S., 23 Mar 2011, In : Current Proteomics. 8, 1, p. 2-16 15 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation

Lee, J. E., Sweredoski, M. J., Graham, R. L. J., Kolawa, N. J., Smith, G. T., Hess, S. & Deshaies, R. J., May 2011, In : Molecular & cellular proteomics : MCP. 10, 5, p. M110.006460

Research output: Contribution to journalArticle

43 Citations (Scopus)
2010

Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen

O'Toole, P. W., Snelling, W. J., Canchaya, C., Forde, B. M., Hardie, K. R., Josenhans, C., Graham, R. L. J., McMullan, G., Parkhill, J., Belda, E. & Bentley, S. D., 10 Mar 2010, In : BMC Genomics. 11, 1, 164.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells

Raghavendra, N. K., Shkriabai, N., Graham, R. L., Hess, S., Kvaratskhelia, M. & Wu, L., 11 Aug 2010, In : Retrovirology. 7, p. 66

Research output: Contribution to journalArticle

28 Citations (Scopus)

Mass spectrometry in the elucidation of the glycoproteome of bacterial pathogens

Graham, R. L. J. & Hess, S., 24 Jun 2010, In : Current Proteomics. 7, 1, p. 57-81 25 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Proteomic analysis of the insoluble subproteome of Clostridium difficile strain 630

Jain, S., Graham, R. L. J., McMullan, G. & Ternan, N. G., Nov 2010, In : FEMS Microbiology Letters. 312, 2, p. 151-159 9 p.

Research output: Contribution to journalLetter

9 Citations (Scopus)
2008
7 Citations (Scopus)
2007

A semi-quantitative GeLC-MS analysis of temporal proteome expression in the emerging nosocomial pathogen Ochrobactrum anthropi

Graham, R. L. J., Sharma, M. K., Ternan, N. G., Weatherly, D. B., Tarleton, R. L. & McMullan, G., 13 Jun 2007, In : Genome Biology. 8, 6, R110.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Multidimensional analysis of the insoluble sub-proteome of Oceanobacillus iheyensis HTE831, an alkaliphilic and halotolerant deep-sea bacterium isolated from the Iheya ridge

Graham, R. L. J., Pollock, C. E., O'Loughlin, S. N., Ternan, N. G., Weatherly, D. B., Tarleton, R. L. & McMullan, G., Jan 2007, In : Proteomics. 7, 1, p. 82-91 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Proteomic analysis of conjunctival swab by mass spectrometry

McGilligan, V., Graham, JE., Moore, JE., McMullan, G., Graham, RLJ., Beirne, RO., DOWNES, SC. & MOORE, CBT., 2007, In : Acta Ophthalmologica Scandinavica. 85

Research output: Contribution to journalArticle

PROTEOMIC INVESTIGATION OF BIOFILM AND PLANKTONIC GROWTH OF CLINICALPSEUDOMONAS AERUGINOSA ISOLATES

Pattison, S., Graham, R., Deligianni, E., Moore, J., Elborn, S., McMullan, G. & Dooley, J., 2007, In : Pediatric Pulmonology. 42

Research output: Contribution to journalArticle

2006

A combined shotgun and multidimensional proteomic analysis of the insoluble subproteome of the obligate thermophile, Geobacillus thermoleovorans T80

Graham, R. L. J., O'Loughlin, S. N., Pollock, C. E., Ternan, N. G., Weatherly, D. B., Jackson, P. J., Tarleton, R. L. & McMullan, G., Sep 2006, In : Journal of Proteome Research. 5, 9, p. 2465-2473 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

A role for carbon catabolite repression in the metabolism of phosphonoacetate by Agromyces fucosus Vs2

O'Loughlin, S. N., Graham, R. L. J., McMullan, G. & Ternan, N. G., Aug 2006, In : FEMS Microbiology Letters. 261, 1, p. 133-140 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Multidimensional proteomic analysis of the soluble subproteome of the emerging nosocomial pathogen Ochrobactrum anthropi

Graham, R. L. J., Pollock, C. E., O'Loughlin, S. N., Ternan, N. G., Weatherly, D. B., Jackson, P. J., Tarleton, R. L. & McMullan, G., Nov 2006, In : Journal of Proteome Research. 5, 11, p. 3145-3153 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
14 Citations (Scopus)
2005
15 Citations (Scopus)