• Room 03.021 - Pharmacy & MCI

    United Kingdom

Accepting PhD Students

PhD projects

Open to PhD applications in the field of biofilm microbiology, antimicrobial discovery, bacterial protease biochemistry, host pathogen interactions, microbial biocatalysis.

20012020

Research output per year

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Personal profile

Research Interests

Research in my group aims to elucidate the mechanistic and biochemical pathways central to the process of microbial biofilm formation and to uncover novel targets for prevention of microbial biofilms particularly ‘druggable’ protease targets; spanning medicinal chemistry, microbiology, chemical biology, and synthetic chemistry directed toward antimicrobial and anti-biofilm applications. My main interests include the role of proteolytic enzymes as targets for small molecule inhibitor design to modulate the process of biofilm formation (lasB in P. aeruginosa biofilm formation) and virulence (ZapA, Proteus mirabilis UTI), development of novel approaches for biofilm control in chronic infections (synthesis of novel biocides, ionic liquids, ultrashort antimicrobial peptides and non-thermal plasma) and control of medical device associated infections. We have an active research interest in antibiotic biodiscovery from marine bacteria and achaea. Recently my group has developed a unique and exciting programme of halophile research, based on isolation of novel extreme halophiles from 250M year old halite evaporites from Kilroot Saltmine, N. Ireland.  This research has already yielded promising lead antimicrobial and quorum sensing inhibitory compounds, novel proteases and other enzymes relevant to API synthesis. In collaboration with the Centre for Plasma Physics, we are elucidating the mechanisms of action of Atmospheric Pressure, Non Thermal Plasma (APNTP) in biofilm control, with an aim to developing clinical applications of this exciting technology.

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Projects

Research Output

Open Access
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    Open Access
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    A holistic study to understand the detoxification of mycotoxins in maize and impact on its molecular integrity using cold atmospheric plasma treatment

    Wielogorska, E., Ahmed, Y., Meneely, J., Graham, W. G., Elliott, C. T. & Gilmore, B. F., 15 Dec 2019, In : Food Chemistry. 301, 8 p., 125281.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)
  • Bacteriophages against Proteus mirabilis Biofilms

    Rice, C., Ganacias, C. J., Chai, Z., Flynn, P. B., Gilmore, B. F., Jones, B. V., Irwin, N., Kulakov, L. A. & Skvortsov, T., 20 Sep 2019. 1 p.

    Research output: Contribution to conferencePoster

    File
  • Prizes

  • Annual Joint Norbrook Royal Society of Biology Lecture 2019

    Brendan Gilmore (Recipient), 20 Mar 2019

    Prize: Prize (including medals and awards)

  • Fellow, Higher Education Academy

    Brendan Gilmore (Recipient), 2013

    Prize: Other distinction

    Fellow of the Linnean Society

    Brendan Gilmore (Recipient), 15 Mar 2018

    Prize: Fellowship awarded competitively

    Fellow of the Royal Society of Chemistry

    Brendan Gilmore (Recipient), 29 Jun 2016

    Prize: Fellowship awarded competitively

    Activities

    Science vs. Microbes

    Johanne Barry (Invited speaker), Sara Cordeiro (Chair), Emma McAlister (Organiser), Ryan Donnelly (Invited speaker), Brendan Gilmore (Invited speaker), Aaron Brady (Invited speaker)
    20 Feb 2020

    Activity: Talk or presentation typesPublic lecture/debate/seminar

    Application of Cold Plasmas in the AgriFood Industry

    Brendan Gilmore (Advisor)
    05 Dec 2019

    Activity: Talk or presentation typesInvited talk

    ‘Antibiotic Resistance: Winning the War on AMR’

    Brendan Gilmore (Advisor)
    06 Mar 2019

    Activity: Talk or presentation typesPublic lecture/debate/seminar

    Non Thermal Plasma Exposure Enhances Antibiotic Sensitivity and Immune Response to Pathogenic Biofilms

    Brendan Gilmore (Advisor)
    10 Dec 201911 Dec 2019

    Activity: Talk or presentation typesInvited talk

    Thesis

    Development of versatile drug delivery strategies using PLGA nanoparticles

    Author: Fay, F., Jul 2010

    Supervisor: Scott, C. (Supervisor), Gilmore, B. (Supervisor) & McCarron, P. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Discovering bioactive compounds for bone growth: the osteogenicity of marine organism-derived extracts

    Author: Carson, M. A., Mar 2018

    Supervisor: Clarke, S. (Supervisor), Nelson, J. (Supervisor) & Gilmore, B. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Discovery of Novel Transaminases from Halophilic Microorganisms

    Author: Kelly, S., Sep 2018

    Supervisor: Gilmore, B. (Supervisor), Allen, C. (Supervisor) & Moody, T. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy