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Personal profile

Research Interests

Research in my group aims to elucidate the mechanistic and biochemical pathways central to the process of microbial biofilm formation and to uncover novel targets for prevention of microbial biofilms particularly ‘druggable’ protease targets; spanning medicinal chemistry, microbiology, chemical biology, and synthetic chemistry directed toward antimicrobial and anti-biofilm applications. My main interests include the role of proteolytic enzymes as targets for small molecule inhibitor design to modulate the process of biofilm formation (lasB in P. aeruginosa biofilm formation) and virulence (ZapA, Proteus mirabilis UTI), development of novel approaches for biofilm control in chronic infections (synthesis of novel biocides, ionic liquids, ultrashort antimicrobial peptides and non-thermal plasma) and control of medical device associated infections. We have an active research interest in antibiotic biodiscovery from marine bacteria and achaea. Recently my group has developed a unique and exciting programme of halophile research, based on isolation of novel extreme halophiles from 250M year old halite evaporites from Kilroot Saltmine, N. Ireland.  This research has already yielded promising lead antimicrobial and quorum sensing inhibitory compounds, novel proteases and other enzymes relevant to API synthesis. In collaboration with the Centre for Plasma Physics, we are elucidating the mechanisms of action of Atmospheric Pressure, Non Thermal Plasma (APNTP) in biofilm control, with an aim to developing clinical applications of this exciting technology.

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Biofilms Medicine & Life Sciences
Plasma Gases Medicine & Life Sciences
Pseudomonas aeruginosa Medicine & Life Sciences
Bacteria Medicine & Life Sciences
Ionic Liquids Chemical Compounds
Proteus mirabilis Medicine & Life Sciences
Infection Medicine & Life Sciences
Anti-Bacterial Agents Medicine & Life Sciences

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Projects 2007 2018

Research Output 2001 2019

Open Access
File
Plasma Gases
Acinetobacter baumannii
Biofilms
Biomass
Acinetobacter Infections

A holistic study to understand the detoxification of mycotoxins in maize and impact on its molecular integrity using cold atmospheric plasma treatment

Wielogorska, E., Ahmed, Y., Meneely, J., Graham, W. G., Elliott, C. T. & Gilmore, B. F., 29 Jul 2019, In : Food Chemistry. 301, 8 p., 125281.

Research output: Contribution to journalArticle

Plasma Gases
Detoxification
Atmospheric Pressure
Mycotoxins
atmospheric pressure
Plasma Gases
Pseudomonas aeruginosa
Lipopolysaccharides
Gram-Negative Bacteria
Virulence

Bacteriophages against Proteus mirabilis Biofilms

Rice, C., Ganacias, C. J., Chai, Z., Flynn, P. B., Gilmore, B. F., Jones, B. V., Irwin, N., Kulakov, L. A. & Skvortsov, T., 20 Sep 2019. 1 p.

Research output: Contribution to conferencePoster

File
Proteus mirabilis
Biofilms
Ammonia
Bacteriophages
Urine

Bacteriophages for Biofilm Eradication

Rice, C., Skvortsov, T., Kumaresan, D., Flynn, P., Gilmore, B. & Kulakov, L., 20 Sep 2019.

Research output: Contribution to conferencePoster

File
Biofilms
Bacteriophages
Stenotrophomonas maltophilia
Proteus mirabilis
Anti-Infective Agents

Prizes

Plasma Gases
Biofilms
Infection Control
Microbiology
Pharmaceutical Preparations

Fellow, Higher Education Academy

Brendan Gilmore (Recipient), 2013

Prize: Other distinction

Fellow of the Linnean Society

Brendan Gilmore (Recipient), 15 Mar 2018

Prize: Fellowship awarded competitively

Fellow of the Royal Society of Chemistry

Brendan Gilmore (Recipient), 29 Jun 2016

Prize: Fellowship awarded competitively

Royal Pharmaceutical Society Science Award 2013

Brendan Gilmore (Recipient), 2013

Prize: Prize (including medals and awards)

Activities 2005 2018

NI Science Festival: Antibiotic Apocalypse: ‘Winning the War on AMR: Can we discover new antibiotics?’

Brendan Gilmore (Advisor)
21 Feb 2018

Activity: Talk or presentation typesPublic lecture/debate/seminar

Science Week 2018

Brendan Gilmore (Recipient)
Feb 2018

Activity: Other activity typesHosting a delegation or group

Non Thermal Plasmas – new frontiers in control of biofilm infections

Brendan Gilmore (Speaker)
26 Jul 201531 Jul 2015

Activity: Talk or presentation typesInvited talk

Phages 2015

Brendan Gilmore (Advisory board member)
01 Jan 201502 Sep 2015

Activity: Participating in or organising an event typesParticipation in conference

Thesis

Discovering bioactive compounds for bone growth: the osteogenicity of marine organism-derived extracts

Author: Carson, M. A., Mar 2018

Supervisor: Clarke, S. (Supervisor), Nelson, J. (Supervisor) & Gilmore, B. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Discovery of Novel Transaminases from Halophilic Microorganisms

Author: Kelly, S., Sep 2018

Supervisor: Gilmore, B. (Supervisor), Allen, C. (Supervisor) & Moody, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy