Projects per year
Personal profile
Research Interests
Research in my group aims to elucidate the mechanistic and biochemical pathways central to the process of microbial biofilm formation and to uncover novel targets for prevention of microbial biofilms particularly ‘druggable’ protease targets; spanning medicinal chemistry, microbiology, chemical biology, and synthetic chemistry directed toward antimicrobial and anti-biofilm applications. My main interests include the role of proteolytic enzymes as targets for small molecule inhibitor design to modulate the process of biofilm formation (lasB in P. aeruginosa biofilm formation) and virulence (ZapA, Proteus mirabilis UTI), development of novel approaches for biofilm control in chronic infections (synthesis of novel biocides, ionic liquids, ultrashort antimicrobial peptides and non-thermal plasma) and control of medical device associated infections. We have an active research interest in antibiotic biodiscovery from marine bacteria and achaea. Recently my group has developed a unique and exciting programme of halophile research, based on isolation of novel extreme halophiles from 250M year old halite evaporites from Kilroot Saltmine, N. Ireland. This research has already yielded promising lead antimicrobial and quorum sensing inhibitory compounds, novel proteases and other enzymes relevant to API synthesis. In collaboration with the Centre for Plasma Physics, we are elucidating the mechanisms of action of Atmospheric Pressure, Non Thermal Plasma (APNTP) in biofilm control, with an aim to developing clinical applications of this exciting technology.
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Projects
R1102CCE: 3D Printed Colourimetric Indicator Strip (3DCIS) for Non-Invasive, On-demand Chronic Wound Monitoring
Mills, A., Gilmore, B. & Stewart, D.
28/08/2019 → …
Project: Research
R1731PMY: EnvironSafe: Cold plasma innovations for food safety and sustainability
Gilmore, B., Elliott, C. & Graham, B.
15/02/2017 → …
Project: Research
R2907PMY: Development of a Portable Non Thermal Plasma Jet for Infection and Contamination Control
01/08/2012 → …
Project: Research
Research Output
3D printing of drug-loaded thermoplastic polyurethane meshes: A potential material for soft tissue reinforcement in vaginal surgery
Dominguez Robles, J., Mancinelli, C., Mancuso, E., Garcia-Romero, I., Gilmore, B., Casettari, L., Larrañeta, E. & Lamprou, D., 13 Jan 2020, In : Pharmaceutics. 12, 1, 15 p., 63.Research output: Contribution to journal › Article
Open Access
File
8
Citations
(Scopus)
79
Downloads
(Pure)
High-throughput toxicity screening of novel azepanium and 3-methylpiperidinium ionic liquids
Tether, A. L., Laverty, G., Puga, A. V., Seddon, K. R., Gilmore, B. F. & Kelly, S. A., 16 Jun 2020, In : RSC Advances. 10, 39, p. 22864-22870 7 p.Research output: Contribution to journal › Article
Open Access
File
Transaminases for industrial biocatalysis: novel enzyme discovery
Kelly, S. A., Mix, S., Moody, T. S. & Gilmore, B. F., 16 Apr 2020, In : Applied Microbiology and Biotechnology.Research output: Contribution to journal › Review article
Open Access
File
Acinetobacter baumannii biofilm biomass mediates tolerance to cold plasma
Flynn, P. B., Graham, W. G. & Gilmore, B. F., 13 Mar 2019, In : Letters in Applied Microbiology.Research output: Contribution to journal › Article
Open Access
File
A holistic study to understand the detoxification of mycotoxins in maize and impact on its molecular integrity using cold atmospheric plasma treatment
Wielogorska, E., Ahmed, Y., Meneely, J., Graham, W. G., Elliott, C. T. & Gilmore, B. F., 15 Dec 2019, In : Food Chemistry. 301, 8 p., 125281.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Prizes
A Denver Russell Memorial Teleclass Lecture 2014 ‘Atmospheric pressure, non-thermal plasmas for biofilm and infection control’
Gilmore, Brendan (Recipient), 08 Apr 2014
Prize: Prize (including medals and awards)
Annual Joint Norbrook Royal Society of Biology Lecture 2019
Gilmore, Brendan (Recipient), 20 Mar 2019
Prize: Prize (including medals and awards)
Fellow of the Linnean Society
Gilmore, Brendan (Recipient), 15 Mar 2018
Prize: Fellowship awarded competitively
Fellow of the Royal Society of Chemistry
Gilmore, Brendan (Recipient), 29 Jun 2016
Prize: Fellowship awarded competitively
Activities
Science vs. Microbes
Johanne Barry (Invited speaker), , Sara Cordeiro (Chair), , Emma McAlister (Organiser), , Ryan Donnelly (Invited speaker), , Brendan Gilmore (Invited speaker), & Aaron Brady (Invited speaker)
20 Feb 2020
Activity: Talk or presentation types › Public lecture/debate/seminar
AgriPlas: A Centre for Cold Plasmas in Agriculture
Brendan Gilmore (Advisor)
14 Jun 2019
Activity: Talk or presentation types › Public lecture/debate/seminar
PhD External Examiner
Brendan Gilmore (Examiner)
26 Mar 2019
Activity: Examination types › PhD external examination
Cold Plasma – An Answer to Antibiotic Resistance?
Brendan Gilmore (Advisor)
02 Jan 2019 → 04 Jan 2019
Activity: Talk or presentation types › Invited talk
Introduction to AgriPlas Centre at Queen's University Belfast: Plasmas in Agri-Food
Brendan Gilmore (Advisor)
28 Mar 2019
Activity: Talk or presentation types › Invited talk
Thesis
Development of versatile drug delivery strategies using PLGA nanoparticles
Author: Fay, F., Jul 2010Supervisor: Scott, C. (Supervisor), Gilmore, B. (Supervisor) & McCarron, P. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Discovering bioactive compounds for bone growth: the osteogenicity of marine organism-derived extracts
Author: Carson, M. A., Mar 2018Supervisor: Clarke, S. (Supervisor), Nelson, J. (Supervisor) & Gilmore, B. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Discovery of Novel Transaminases from Halophilic Microorganisms
Author: Kelly, S., Sep 2018Supervisor: Gilmore, B. (Supervisor), Allen, C. (Supervisor) & Moody, T. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy