Projects per year
Personal profile
Research Interests
Research in my group aims to elucidate the mechanistic and biochemical pathways central to the process of microbial biofilm formation and to uncover novel targets for prevention of microbial biofilms particularly ‘druggable’ protease targets; spanning medicinal chemistry, microbiology, chemical biology, and synthetic chemistry directed toward antimicrobial and anti-biofilm applications. My main interests include the role of proteolytic enzymes as targets for small molecule inhibitor design to modulate the process of biofilm formation (lasB in P. aeruginosa biofilm formation) and virulence (ZapA, Proteus mirabilis UTI), development of novel approaches for biofilm control in chronic infections (synthesis of novel biocides, ionic liquids, ultrashort antimicrobial peptides and non-thermal plasma) and control of medical device associated infections. We have an active research interest in antibiotic biodiscovery from marine bacteria and achaea. Recently my group has developed a unique and exciting programme of halophile research, based on isolation of novel extreme halophiles from 250M year old halite evaporites from Kilroot Saltmine, N. Ireland. This research has already yielded promising lead antimicrobial and quorum sensing inhibitory compounds, novel proteases and other enzymes relevant to API synthesis. In collaboration with the Centre for Plasma Physics, we are elucidating the mechanisms of action of Atmospheric Pressure, Non Thermal Plasma (APNTP) in biofilm control, with an aim to developing clinical applications of this exciting technology.
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Biofilms
Medicine & Life Sciences
Plasma Gases
Medicine & Life Sciences
Pseudomonas aeruginosa
Medicine & Life Sciences
Bacteria
Medicine & Life Sciences
Ionic Liquids
Chemical Compounds
Proteus mirabilis
Medicine & Life Sciences
Infection
Medicine & Life Sciences
Anti-Bacterial Agents
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2007 2018
R1731PMY: EnvironSafe: Cold plasma innovations for food safety and sustainability
Gilmore, B., Elliott, C. & Graham, W.
15/02/2017 → …
Project: Research
R2907PMY: Development of a Portable Non Thermal Plasma Jet for Infection and Contamination Control
01/08/2012 → 16/11/2019
Project: Research
Plasma jets
Atmospheric pressure
Contamination
Hot Temperature
R1178PMY: Enabling phosphoros and peptide chemical biplogy using ionic liquids
Migaud, M., Gilmore, B., Hardacre, C., Prise, K., Scott, C. & Taggart, C.
01/08/2010 → …
Project: Research
R1418BSC: IKC in Synthetic Biology
Maggs, C., Allen, C., Gilmore, B., Grant, I., Hardacre, C., Migaud, M. & Timson, D. J.
08/05/2014 → 30/09/2018
Project: Research
Research Output 2001 2019
Acinetobacter baumannii biofilm biomass mediates tolerance to cold plasma
Flynn, P. B., Graham, W. G. & Gilmore, B. F., 13 Mar 2019, In : Letters in Applied Microbiology.Research output: Contribution to journal › Article
Open Access
File
Plasma Gases
Acinetobacter baumannii
Biofilms
Biomass
Acinetobacter Infections
A holistic study to understand the detoxification of mycotoxins in maize and impact on its molecular integrity using cold atmospheric plasma treatment
Wielogorska, E., Ahmed, Y., Meneely, J., Graham, W. G., Elliott, C. T. & Gilmore, B. F., 29 Jul 2019, In : Food Chemistry. 301, 8 p., 125281.Research output: Contribution to journal › Article
Plasma Gases
Detoxification
Atmospheric Pressure
Mycotoxins
atmospheric pressure
Atmospheric pressure non-thermal plasma exposure reduces Pseudomonas aeruginosa lipopolysaccharide toxicity in vitro and in vivo
Barakat, M. M., Dallal Bashi, Y. H., Carson, L., Graham, W. G., Gilmore, B. F. & Flynn, P. B., 01 Nov 2019, In : Microbial Pathogenesis. 136, 6 p., 103679.Research output: Contribution to journal › Article
Plasma Gases
Pseudomonas aeruginosa
Lipopolysaccharides
Gram-Negative Bacteria
Virulence
Bacteriophages against Proteus mirabilis Biofilms
Rice, C., Ganacias, C. J., Chai, Z., Flynn, P. B., Gilmore, B. F., Jones, B. V., Irwin, N., Kulakov, L. A. & Skvortsov, T., 20 Sep 2019. 1 p.Research output: Contribution to conference › Poster
File
Proteus mirabilis
Biofilms
Ammonia
Bacteriophages
Urine
Bacteriophages for Biofilm Eradication
Rice, C., Skvortsov, T., Kumaresan, D., Flynn, P., Gilmore, B. & Kulakov, L., 20 Sep 2019.Research output: Contribution to conference › Poster
File
Biofilms
Bacteriophages
Stenotrophomonas maltophilia
Proteus mirabilis
Anti-Infective Agents
Prizes
A Denver Russell Memorial Teleclass Lecture 2014 ‘Atmospheric pressure, non-thermal plasmas for biofilm and infection control’
Brendan Gilmore (Recipient), 08 Apr 2014
Prize: Prize (including medals and awards)
Plasma Gases
Biofilms
Infection Control
Microbiology
Pharmaceutical Preparations
Fellow of the Linnean Society
Brendan Gilmore (Recipient), 15 Mar 2018
Prize: Fellowship awarded competitively
Fellow of the Royal Society of Chemistry
Brendan Gilmore (Recipient), 29 Jun 2016
Prize: Fellowship awarded competitively
Royal Pharmaceutical Society Science Award 2013
Brendan Gilmore (Recipient), 2013
Prize: Prize (including medals and awards)
Activities 2005 2018
NI Science Festival: Antibiotic Apocalypse: ‘Winning the War on AMR: Can we discover new antibiotics?’
Brendan Gilmore (Advisor)21 Feb 2018
Activity: Talk or presentation types › Public lecture/debate/seminar
Science Week 2018
Brendan Gilmore (Recipient)Feb 2018
Activity: Other activity types › Hosting a delegation or group
Non Thermal Plasmas – new frontiers in control of biofilm infections
Brendan Gilmore (Speaker)26 Jul 2015 → 31 Jul 2015
Activity: Talk or presentation types › Invited talk
The Matrix Revisited: Understanding the Role of Extracellular Matrix Components In Biofilm Tolerance to Atmospheric Pressure Non-Thermal Plasma Exposure
Brendan Gilmore (Speaker)07 Jul 2015
Activity: Talk or presentation types › Invited talk
Phages 2015
Brendan Gilmore (Advisory board member)01 Jan 2015 → 02 Sep 2015
Activity: Participating in or organising an event types › Participation in conference
Thesis
Discovering bioactive compounds for bone growth: the osteogenicity of marine organism-derived extracts
Author: Carson, M. A., Mar 2018Supervisor: Clarke, S. (Supervisor), Nelson, J. (Supervisor) & Gilmore, B. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Discovery of Novel Transaminases from Halophilic Microorganisms
Author: Kelly, S., Sep 2018Supervisor: Gilmore, B. (Supervisor), Allen, C. (Supervisor) & Moody, T. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy