Brett Greer

Mr

  • Room 0G.130 - School of Biological Sciences 19 Chlorine Gardens

    United Kingdom

Willing to speak to media

20012019
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Research Output 2001 2019

2019
Open Access
File
Zearalenone
Aflatoxin B1
Mycotoxins
Animals
T-2 Toxin
2018
9 Citations (Scopus)
Open Access
File
microcystin-LR
drinking water
human health
animal models
uptake mechanisms
2017
11 Citations (Scopus)
Open Access
File
Microcystins
Tilapia
Aquaculture
Fresh Water
Farms
2016
22 Citations (Scopus)

A validated UPLC–MS/MS method for the surveillance of ten aquatic biotoxins in European brackish and freshwater systems

Greer, B., McNamee, S. E., Boots, B., Cimarelli, L., Guillebault, D., Helmi, K., Marcheggiani, S., Panaiotov, S., Breitenbach, U., Akcaalan, R., Medlin, L. K., Kittler, K., Elliott, C. T. & Campbell, K., May 2016, In : Harmful Algae. 55, p. 31-40 10 p.

Research output: Contribution to journalArticle

microcystins
cylindrospermopsin
toxin
nodularin
microcystin-LR
14 Citations (Scopus)
Open Access
File
Alzheimer Disease
Brain
Brain Diseases
Neurodegenerative Diseases
Healthy Volunteers
2015

Chronic treatment with a stable obestatin analogue curbs insulin desensitisation in high fat fed mice

Cowan, E., Burch, K., Greer, B., McClune, D., Scantlebury, D., Grieve, D. & Green, B., Mar 2015.

Research output: Contribution to conferenceAbstract

2014
26 Citations (Scopus)
Planar waveguides
Microarrays
toxin
Screening
Water
15 Citations (Scopus)
Microcystins
Surface plasmon resonance
Assays
Screening
Antibodies
2013
14 Citations (Scopus)

Next generation planar waveguide detection of microcystins in freshwater and cyanobacterial extracts, utilising a novel lysis method for portable sample preparation and analysis

Devlin, S., Meneely, J. P., Greer, B., Greef, C., Lochhead, M. J. & Elliott, C. T., 26 Mar 2013, In : Analytica Chimica Acta. 769, p. 108-113 6 p.

Research output: Contribution to journalArticle

Open Access
File
Microcystins
Planar waveguides
lysis
sample preparation
Fresh Water
2011

A modified Tat peptide for selective intracellular delivery of macromolecules

Murphy, D. J., Walker, B., Greer, B., Harriott, P. & Martin, S. L., May 2011, In : Journal of Pharmacy and Pharmacology. 63, 5, p. 611-618 8 p.

Research output: Contribution to journalArticle

Plasminogen Activators
Urokinase-Type Plasminogen Activator
Peptides
Cell Line
Consensus Sequence
44 Citations (Scopus)
Virulence Factors
Pseudomonas aeruginosa
Virulence
Infection
Growth
2009
19 Citations (Scopus)

Inhibitor profiling of the Pseudomonas aeruginosa virulence factor LasB using N-alpha mercaptoamide template-based inhibitors

Cathcart, G., Gilmore, B., Greer, B., Harriott, P. & Walker, B., 01 Nov 2009, In : Bioorganic & Medicinal Chemistry Letters. 19, 21, p. 6230-6232 3 p.

Research output: Contribution to journalArticle

Virulence Factors
Pseudomonas aeruginosa
Amino Acids
Libraries
Dipeptides
2008
33 Citations (Scopus)

Antimicrobial activity of truncated alpha-defensin (human neutrophil peptide (HNP)-1) analogues without disulphide bridges.

Lundy, F., Nelson, J., Lockhart, D., Greer, B., Harriott, P. & Marley, J., Jan 2008, In : Molecular Immunology. 45 , 1, p. 190-193 4 p.

Research output: Contribution to journalArticle

alpha-Defensins
Disulfides
Defensins
Peptides
Therapeutic Uses
2007
11 Citations (Scopus)

Antagonistic effects of two novel GIP analogs, (Hyp(3))GIP and (Hyp(3)) GIPLys(16)PAL, on the biological actions of GIP and longer-term effects in diabetic ob/ob mice

O'Harte, F. P. M., Hunter, K., Gault, V. A., Irwin, N., Green, B., Greer, B., Harriott, P., Bailey, C. J. & Flatt, P. R., Jun 2007, In : AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 292, 6, p. E1674-E1682 9 p.

Research output: Contribution to journalArticle

Insulin
Glucose
Acylation
Fibroblasts
Medical problems
10 Citations (Scopus)

Characterisation and biological activity of Glu(3) amino acid substituted GIP receptor antagonists

Gault, V. A., Hunter, K., Irwin, N., Green, B., Greer, B., Harriott, P., O'Harte, F. P. M. & Flatt, P. R., 15 May 2007, In : Archives of Biochemistry and Biophysics. 461, 2, p. 263-274 12 p.

Research output: Contribution to journalArticle

Bioactivity
Amino Acids
Glucose
Peptides
gastric inhibitory polypeptide receptor
10 Citations (Scopus)

Characterisation and glucoregulatory actions of a novel acylated form of the (Pro(3))GIP receptor antagonist in type 2 diabetes

Gault, V. A., Hunter, K., Irwin, N., Greer, B., Green, B., Harriott, P., O'Harte, F. P. M. & Flatt, P. R., 01 Feb 2007, In : Biological Chemistry. 388, 2, p. 173-179 7 p.

Research output: Contribution to journalArticle

Medical problems
Type 2 Diabetes Mellitus
Insulin
Glucose
Palmitic Acid
2006
11 Citations (Scopus)
Glucagon-Like Peptide 1
Homeostasis
Insulin
Glucose
Peptides
33 Citations (Scopus)

Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide

Irwin, N., Clarke, G. C., Green, B. D., Greer, B., Harriott, P., Gault, V. A., O'Harte, F. P. M. & Flatt, P. R., 14 Sep 2006, In : Biochemical Pharmacology. 72, 6, p. 719-728 10 p.

Research output: Contribution to journalArticle

Hypoglycemic Agents
Glucose
Peptides
Insulin
Body Weight
34 Citations (Scopus)

GIP(Lys16PAL) and GIP(Lys37PAL): novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential.

Irwin, N., O'Hartet, F. P. M., Gault, V. A., Green, B., Greer, B., Harriott, P., Bailey, C. J. & Flatt, P. R., 09 Feb 2006, In : Journal of Medicinal Chemistry. 49, 3, p. 1047-1054 8 p.

Research output: Contribution to journalArticle

Hypoglycemic Agents
Glucose
Peptides
Insulin
Fatty Acids
44 Citations (Scopus)
2005
43 Citations (Scopus)

A novel, long-acting agonist of glucose-dependent insulinotropic polypeptide suitable for once-daily administration in type 2 diabetes

Irwin, N., Green, B., Mooney, M., Greer, B., Harriott, P., Bailey, C. J., Gault, V. A., O'Harte, F. P. M. & Flatt, P. R., Sep 2005, In : Journal of Pharmacology and Experimental Therapeutics. 314, 3, p. 1187-1194 8 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Glucose
Peptides
Insulin
Injections
128 Citations (Scopus)

Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3) GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-diabetes.

Flatt, P. R., Green, B., Harriott, P., Gault, V. A., Irwin, N., McCluskey, J. T., Greer, B., Bailey, C. J. & O'Harte, F. P. M., Aug 2005, In : Diabetes. 54(8), 8, p. 2436-2446 11 p.

Research output: Contribution to journalArticle

Gastric Inhibitory Polypeptide
Insulin Resistance
Obesity
Glucose
gastric inhibitory polypeptide receptor
31 Citations (Scopus)

Degradation, insulin secretion, and antihyperglycemic actions of two palmitate-derivitized N-terminal pyroglutamyl analogues of glucose-dependent insulinotropic polypeptide.

Flatt, P. R., Irwin, N., Gault, V. A., Green, B., Greer, B., Harriott, P., Bailey, C. J. & O'Harte, F. P. M., 24 Feb 2005, In : Journal of Medicinal Chemistry. 48(4), 4, p. 1244-1250 7 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.

Wilson, S., Greer, B., Hooper, J., Zijlstra, A., Walker, B., Quigley, J. P. & Hawthorne, S., 15 Jan 2005, In : Biochemical Journal. 388(3), 3, p. 967-972 6 p.

Research output: Contribution to journalArticle

2004
132 Citations (Scopus)

A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.

Harriott, P., El-Agnaf, O. M., Paleologou, K. E., Greer, B., Abogrein, A. M., King, J. E., Salem, S. A., Fullwood, N. J., Benson, F. E., Hewitt, R., Ford, K. J., Martin, F. L., Cookson, M. R. & Allsop, D., Aug 2004, In : The FASEB Journal. 18 (11), 11, p. 1315-1317 3 p.

Research output: Contribution to journalArticle

alpha-Synuclein
Parkinson disease
Parkinson Disease
Toxicity
Agglomeration
44 Citations (Scopus)

Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid

Green, B. D., Gault, V. A., Flatt, P. R., Harriott, P., Greer, B. & O'Harte, F. P. M., 15 Aug 2004, In : Archives of Biochemistry and Biophysics. 428, 2, p. 136-143 8 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Hypoglycemic Agents
Substitution reactions
Insulin
Glucose

Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala(8)-substituted GLP-1 analogues

Green, B., Gault, N., Mooney, M., Irwin, N., Harriott, P., Greer, B., Bailey, J., OHarte, F. P. M. & Flatt, P. R., 2004, In : Biological Chemistry. 385, p. 169-177 9 p.

Research output: Contribution to journalArticle

Palmitates
Insulin Receptor
Hypoglycemic Agents
Amides
Insulin
35 Citations (Scopus)

Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

Irwin, N., Gault, V. A., Green, B., Greer, B., McCluskey, J. T., Harriott, P., OHarte, F. P. M. & Flatt, P. R., Sep 2004, In : Biological Chemistry. 385, 9, p. 845-852 8 p.

Research output: Contribution to journalArticle

Insulin Receptor
Ablation
Homeostasis
Insulin
Glucose

Enzyme-Linked Intracellular Delivery of Macromolecules Utilising the TAT Peptide

Murphy, D., Martin, L., Greer, B., Gilmore, B., Harriott, P. & Walker, B., Sep 2004, p. 57-57. 1 p.

Research output: Contribution to conferencePaper

50 Citations (Scopus)

Inhibition and fibril formation and toxicity of a fragment of alpha-synuclein by an N-methylated peptide analogue

Bodles, A. M., El-Agnaf, O. M. A., Greer, B., Guthrie, D. J. S. & Irvine, B., 08 Apr 2004, In : Neuroscience Letters. 359(1-2), 1-2, p. 89-93 5 p.

Research output: Contribution to journalArticle

alpha-Synuclein
Peptides
Poisons
Amyloid
Neurodegenerative Diseases
37 Citations (Scopus)
Glucagon-Like Peptide 1
Incretins
glucagon-like peptide 1 (7-36)amide
exendin (9-39)
glucagon-like peptide-1 (9-36)-amide
39 Citations (Scopus)

N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity

Green, B., Mooney, M., Gault, N., Irwin, N., Bailey, J., Harriott, P., Greer, B., O'Harte, F. P. M. & Flatt, P. R., 2004, In : The Journal of endocrinology. 180, p. 379-388 10 p.

Research output: Contribution to journalArticle

Dipeptidyl Peptidase 4
Glucagon-Like Peptide 1
Hypoglycemic Agents
Inhibitory Concentration 50
glucagon-like peptide 1 (7-36)amide
2003

Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu(9)-substituted analogues of glucagon-like peptide-1

Green, B., Gault, N., Irwin, N., Mooney, M., Bailey, J., Harriott, P., Greer, B., Flatt, P. R. & OHarte, F. P. M., 2003, In : Biological Chemistry. 384, p. 1543-1551 9 p.

Research output: Contribution to journalArticle

Cyclic AMP Receptors
Glucagon-Like Peptide 1
Hypoglycemic Agents
Insulin
Dipeptidyl Peptidase 4
28 Citations (Scopus)

Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo

Green, B., Gault, N., Mooney, M., Irwin, N., Bailey, J., Harriott, P., Greer, B., Flatt, P. R. & O'Harte, F. P. M., Dec 2003, In : Journal of Molecular Endocrinology. 31, 3, p. 529-540 12 p.

Research output: Contribution to journalArticle

Dipeptidyl Peptidase 4
Glucagon-Like Peptide 1
Glucose
Insulin
glucagon-like peptide 1 (7-36)amide
2002

Antidiabetic potential of four novel analogues of glucose-dependent insulinotropic polypeptide demonstrated in an animal model of Type 2 diabetes

Mooney, M., Gault, N., Flatt, P. R., Harriott, P., Greer, B., Bailey, C. J. & O'Harte, F. P. M., 2002, In : Diabetologia. 45, p. A178-A178 1 p.

Research output: Contribution to journalMeeting abstract

34 Citations (Scopus)
Medical problems
Hypoglycemic Agents
Obesity
Insulin
Glucose
5 Citations (Scopus)

Kinetic analysis of the cleavage of human protease-activated receptor-1/2/3 and 4 using quenched-fluorescent peptide substrates

Fox, M., Greer, B., Lawson, J., Healy, A. & Harriott, P., 2002, In : Protein and Peptide Letters. 9, 5, p. 387-393 7 p.

Research output: Contribution to journalArticle

Proteinase-Activated Receptors
PAR-2 Receptor
PAR-1 Receptor
Peptide Receptors
Thrombin

Novel N-Fmoc and N-palmitate analogues of glucose-dependent insullinotropic polypeptide exhibit DPP IV resistance, increased insulin-releasing activity and antidiabetic action.

Flatt, P. R., Gault, N., Harriott, P., Greer, B., Mooney, M., Bailey, C. J. & O'Harte, F. P. M., Sep 2002, In : Diabetologia. 45, p. A177-A177 1 p.

Research output: Contribution to journalMeeting abstract

N-terminally modified analogues of glucose-dependent insulinotropic polypeptide exhibit improved insulinotropic activity and antihyperglycaemic potential compared with glucagon-like peptide-1 counterparts

Gault, V. A., Green, B., Greer, B., Harriott, P., Flatt, P. R. & O'Harte, F. P. M., 2002, In : Diabetologia. 45, S2, p. A177 1 p.

Research output: Contribution to journalMeeting abstract

32 Citations (Scopus)

Synthetic peptides interacting with the 67-kd laminin receptor can reduce retinal ischemia and inhibit hypoxia-induced retinal neovascularization.

Gebarowska, D., Stitt, A., Gardiner, T., Harriott, P., Greer, B. & Nelson, J., Jan 2002, In : American Journal of Pathology. 160(1), 1, p. 307-313 7 p.

Research output: Contribution to journalArticle

Laminin Receptors
Retinal Neovascularization
Ischemia
Peptides
Retina
2001
101 Citations (Scopus)

Identification of the region of non-A beta component (NAC) of alzheimer's disease amyloid responsible for its aggregation and toxicity

Bodles, A. M., Guthrie, D. J. S., Greer, B. & Irvine, B., Jul 2001, In : Journal of Neurochemistry. 78(2), 2, p. 384-395 12 p.

Research output: Contribution to journalArticle

Synucleins
Amyloid
Toxicity
Alzheimer Disease
Agglomeration