Brett Greer

Mr

  • Room 0G.130 - Biological Sciences

    United Kingdom

20012019

Research output per year

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Research Output

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A modified Tat peptide for selective intracellular delivery of macromolecules

Murphy, D. J., Walker, B., Greer, B., Harriott, P. & Martin, S. L., May 2011, In : Journal of Pharmacy and Pharmacology. 63, 5, p. 611-618 8 p.

Research output: Contribution to journalArticle

A novel, long-acting agonist of glucose-dependent insulinotropic polypeptide suitable for once-daily administration in type 2 diabetes

Irwin, N., Green, B., Mooney, M., Greer, B., Harriott, P., Bailey, C. J., Gault, V. A., O'Harte, F. P. M. & Flatt, P. R., Sep 2005, In : Journal of Pharmacology and Experimental Therapeutics. 314, 3, p. 1187-1194 8 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Antagonistic effects of two novel GIP analogs, (Hyp(3))GIP and (Hyp(3)) GIPLys(16)PAL, on the biological actions of GIP and longer-term effects in diabetic ob/ob mice

O'Harte, F. P. M., Hunter, K., Gault, V. A., Irwin, N., Green, B., Greer, B., Harriott, P., Bailey, C. J. & Flatt, P. R., Jun 2007, In : AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 292, 6, p. E1674-E1682 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Antimicrobial activity of truncated alpha-defensin (human neutrophil peptide (HNP)-1) analogues without disulphide bridges.

Lundy, F., Nelson, J., Lockhart, D., Greer, B., Harriott, P. & Marley, J., Jan 2008, In : Molecular Immunology. 45 , 1, p. 190-193 4 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.

Harriott, P., El-Agnaf, O. M., Paleologou, K. E., Greer, B., Abogrein, A. M., King, J. E., Salem, S. A., Fullwood, N. J., Benson, F. E., Hewitt, R., Ford, K. J., Martin, F. L., Cookson, M. R. & Allsop, D., Aug 2004, In : The FASEB Journal. 18 (11), 11, p. 1315-1317 3 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)

A validated UPLC–MS/MS method for the surveillance of ten aquatic biotoxins in European brackish and freshwater systems

Greer, B., McNamee, S. E., Boots, B., Cimarelli, L., Guillebault, D., Helmi, K., Marcheggiani, S., Panaiotov, S., Breitenbach, U., Akcaalan, R., Medlin, L. K., Kittler, K., Elliott, C. T. & Campbell, K., May 2016, In : Harmful Algae. 55, p. 31-40 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Characterisation and biological activity of Glu(3) amino acid substituted GIP receptor antagonists

Gault, V. A., Hunter, K., Irwin, N., Green, B., Greer, B., Harriott, P., O'Harte, F. P. M. & Flatt, P. R., 15 May 2007, In : Archives of Biochemistry and Biophysics. 461, 2, p. 263-274 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Characterisation and glucoregulatory actions of a novel acylated form of the (Pro(3))GIP receptor antagonist in type 2 diabetes

Gault, V. A., Hunter, K., Irwin, N., Greer, B., Green, B., Harriott, P., O'Harte, F. P. M. & Flatt, P. R., 01 Feb 2007, In : Biological Chemistry. 388, 2, p. 173-179 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3) GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-diabetes.

Flatt, P. R., Green, B., Harriott, P., Gault, V. A., Irwin, N., McCluskey, J. T., Greer, B., Bailey, C. J. & O'Harte, F. P. M., Aug 2005, In : Diabetes. 54(8), 8, p. 2436-2446 11 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid

Green, B. D., Gault, V. A., Flatt, P. R., Harriott, P., Greer, B. & O'Harte, F. P. M., 15 Aug 2004, In : Archives of Biochemistry and Biophysics. 428, 2, p. 136-143 8 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
Open Access
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42 Downloads (Pure)

Degradation, insulin secretion, and antihyperglycemic actions of two palmitate-derivitized N-terminal pyroglutamyl analogues of glucose-dependent insulinotropic polypeptide.

Flatt, P. R., Irwin, N., Gault, V. A., Green, B., Greer, B., Harriott, P., Bailey, C. J. & O'Harte, F. P. M., 24 Feb 2005, In : Journal of Medicinal Chemistry. 48(4), 4, p. 1244-1250 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala(8)-substituted GLP-1 analogues

Green, B., Gault, N., Mooney, M., Irwin, N., Harriott, P., Greer, B., Bailey, J., OHarte, F. P. M. & Flatt, P. R., 2004, In : Biological Chemistry. 385, p. 169-177 9 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
401 Downloads (Pure)
26 Citations (Scopus)

Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

Irwin, N., Gault, V. A., Green, B., Greer, B., McCluskey, J. T., Harriott, P., OHarte, F. P. M. & Flatt, P. R., Sep 2004, In : Biological Chemistry. 385, 9, p. 845-852 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
11 Citations (Scopus)
36 Citations (Scopus)

Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide

Irwin, N., Clarke, G. C., Green, B. D., Greer, B., Harriott, P., Gault, V. A., O'Harte, F. P. M. & Flatt, P. R., 14 Sep 2006, In : Biochemical Pharmacology. 72, 6, p. 719-728 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

GIP(Lys16PAL) and GIP(Lys37PAL): novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential.

Irwin, N., O'Hartet, F. P. M., Gault, V. A., Green, B., Greer, B., Harriott, P., Bailey, C. J. & Flatt, P. R., 09 Feb 2006, In : Journal of Medicinal Chemistry. 49, 3, p. 1047-1054 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Identification of the region of non-A beta component (NAC) of alzheimer's disease amyloid responsible for its aggregation and toxicity

Bodles, A. M., Guthrie, D. J. S., Greer, B. & Irvine, B., Jul 2001, In : Journal of Neurochemistry. 78(2), 2, p. 384-395 12 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Inhibition and fibril formation and toxicity of a fragment of alpha-synuclein by an N-methylated peptide analogue

Bodles, A. M., El-Agnaf, O. M. A., Greer, B., Guthrie, D. J. S. & Irvine, B., 08 Apr 2004, In : Neuroscience Letters. 359(1-2), 1-2, p. 89-93 5 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Inhibitor profiling of the Pseudomonas aeruginosa virulence factor LasB using N-alpha mercaptoamide template-based inhibitors

Cathcart, G., Gilmore, B., Greer, B., Harriott, P. & Walker, B., 01 Nov 2009, In : Bioorganic & Medicinal Chemistry Letters. 19, 21, p. 6230-6232 3 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Kinetic analysis of the cleavage of human protease-activated receptor-1/2/3 and 4 using quenched-fluorescent peptide substrates

Fox, M., Greer, B., Lawson, J., Healy, A. & Harriott, P., 2002, In : Protein and Peptide Letters. 9, 5, p. 387-393 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
37 Citations (Scopus)

Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu(9)-substituted analogues of glucagon-like peptide-1

Green, B., Gault, N., Irwin, N., Mooney, M., Bailey, J., Harriott, P., Greer, B., Flatt, P. R. & OHarte, F. P. M., 2003, In : Biological Chemistry. 384, p. 1543-1551 9 p.

Research output: Contribution to journalArticle

Next generation planar waveguide detection of microcystins in freshwater and cyanobacterial extracts, utilising a novel lysis method for portable sample preparation and analysis

Devlin, S., Meneely, J. P., Greer, B., Greef, C., Lochhead, M. J. & Elliott, C. T., 26 Mar 2013, In : Analytica Chimica Acta. 769, p. 108-113 6 p.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
277 Downloads (Pure)

Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo

Green, B., Gault, N., Mooney, M., Irwin, N., Bailey, J., Harriott, P., Greer, B., Flatt, P. R. & O'Harte, F. P. M., Dec 2003, In : Journal of Molecular Endocrinology. 31, 3, p. 529-540 12 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
44 Citations (Scopus)
46 Citations (Scopus)

N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity

Green, B., Mooney, M., Gault, N., Irwin, N., Bailey, J., Harriott, P., Greer, B., O'Harte, F. P. M. & Flatt, P. R., 2004, In : The Journal of endocrinology. 180, p. 379-388 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Oral Microcystin-LR Does Not Cause Hepatotoxicity in Pigs: Is the Risk of Microcystin-LR Overestimated?

Welten, R. D., Meneely, J. P., Chevallier, O. P., Kosek, V., Greer, B., Hajšlová, J. & Elliott, C. T., 02 Dec 2019, In : Exposure and Health. 18 p.

Research output: Contribution to journalArticle

Open Access
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31 Downloads (Pure)
16 Citations (Scopus)

Synthetic peptides interacting with the 67-kd laminin receptor can reduce retinal ischemia and inhibit hypoxia-induced retinal neovascularization.

Gebarowska, D., Stitt, A., Gardiner, T., Harriott, P., Greer, B. & Nelson, J., Jan 2002, In : American Journal of Pathology. 160(1), 1, p. 307-313 7 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.

Wilson, S., Greer, B., Hooper, J., Zijlstra, A., Walker, B., Quigley, J. P. & Hawthorne, S., 15 Jan 2005, In : Biochemical Journal. 388(3), 3, p. 967-972 6 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)
Open Access
File
11 Citations (Scopus)
127 Downloads (Pure)
Open Access
File
16 Citations (Scopus)
213 Downloads (Pure)