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Professor Walker was appointed in September 1998 to the Allen J. McClay Chair in Biomedicinal Chemistry to establish a Biomolecular Sciences programme within the School. His research interests are focused on the development and application of novel inhibitors for the identification and validation of protease targets of biomedical and pharmaceutical importance. This research is characterized by a fusion of biological chemistry and cell and molecular biology.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R4582PMY: Epithelial Sodium Channel (ENaC) and Channel Activating Proteases (CAPS):molecular targets for correction of sodium channel dysfunction ....
Martin, L. (PI) & Walker, B. (CoI)
01/08/2011 → …
Project: Research
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R5740PMY: The development of an Advanced Material for Protease Enzyme Capture
Martin, L. (PI) & Walker, B. (CoI)
01/08/2011 → …
Project: Research
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R2634PMY: Channel activating proteases (CAPS): identification of novel targets for correcting sodium channel dysfunction in CF
Martin, L. (PI), Elborn, S. (CoI) & Walker, B. (CoI)
01/08/2009 → …
Project: Research
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R1708PMY: Modular synthetic approaches for the inhibition and assay of proteases
Walker, B. (PI)
01/08/2005 → …
Project: Research
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R3522PMY: The development and validation of novel companion diagnostics for oral anti-coagulants
Walker, B. (PI) & Martin, L. (CoI)
01/08/2012 → 30/01/2016
Project: Research
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Novel inhibitors and activity-based probes targeting serine proteases
Ferguson, T. E. G., Reihill, J. A., Martin, S. L. & Walker, B., 28 Sept 2022, In: Frontiers in Chemistry. 10, 17 p., 1006618.Research output: Contribution to journal › Article › peer-review
Open AccessFile109 Downloads (Pure) -
Novel inhibitors and activity-based probes targeting trypsin-like serine proteases
Ferguson, T. E. G., Reihill, J. A., Martin, S. L. & Walker, B., 21 Apr 2022, In: Frontiers in Chemistry. 10, 17 p., 782608.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)112 Downloads (Pure) -
Proteases—from basic structure to function to drug design as targeted therapy
Kwok, H. F., Walker, B. & Shaw, C., 21 Nov 2022, In: Biology. 11, 11, 1680.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile1 Citation (Scopus)3 Downloads (Pure) -
A Bowman-Birk type chymotrypsin inhibitor peptide from the amphibian, Hylarana erythraea
Zhang, L., Chen, X., Wu, Y., Zhou, M., Ma, C., Xi, X., Chen, T., Walker, B., Shaw, C. & Wang, L., 11 Apr 2018, In: Scientific Reports. 8, 9 p., 5851.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)286 Downloads (Pure) -
A Structural and Functional Analogue of a Bowman Birk-type Protease Inhibitor from Odorrana Schmackeri
Wu, Y., Long, Q., Xu, Y., Guo, S., Chen, T., Wang, L., Zhou, M., Zhang, Y., Shaw, C. & Walker, B., Apr 2017, In: Bioscience Reports. 37, 2Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)306 Downloads (Pure)