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Brian Walker

Professor

19942018

Research output per year

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Personal profile

Interests

Professor Walker was appointed in September 1998 to the Allen J. McClay Chair in Biomedicinal Chemistry to establish a Biomolecular Sciences programme within the School. His research interests are focused on the development and application of novel inhibitors for the identification and validation of protease targets of biomedical and pharmaceutical importance. This research is characterized by a fusion of biological chemistry and cell and molecular biology.

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Projects

R1708PMY: Modular synthetic approaches for the inhibition and assay of proteases

Walker, B.

01/08/2005 → 17/12/2019

Project: Research

R1293PMY: Protease-Tag Technology: Clinical Validation and Commercialisation

Martin, L. & Walker, B.

01/08/2012 → 01/08/2015

Project: Research

R1143PMY: Molecular and pharmacological validation of Cathepsin S as a novel target in cancer treatment

Scott, C., McCarthy, H. & Walker, B.

01/08/2009 → 22/03/2014

Project: Research

Research Output

A Bowman-Birk type chymotrypsin inhibitor peptide from the amphibian, Hylarana erythraea

Zhang, L., Chen, X., Wu, Y., Zhou, M., Ma, C., Xi, X., Chen, T., Walker, B., Shaw, C. & Wang, L., 11 Apr 2018, In : Scientific Reports. 8, 9 p., 5851.

Research output: Contribution to journal › Article

Open Access
File
    • 2 Citations (Scopus)
    170 Downloads (Pure)

    A Structural and Functional Analogue of a Bowman Birk-type Protease Inhibitor from Odorrana Schmackeri

    Wu, Y., Long, Q., Xu, Y., Guo, S., Chen, T., Wang, L., Zhou, M., Zhang, Y., Shaw, C. & Walker, B., Apr 2017, In : Bioscience Reports. 37, 2

    Research output: Contribution to journal › Article

    Open Access
    File
    • 8 Citations (Scopus)
    196 Downloads (Pure)

    Detection and inhibition of ENaC-activating proteases associated with airway dehydration in COPD

    Martin, L., Reihill, J., Douglas, L., Ferguson, T. & Walker, B., Sep 2017, In : European Respiratory Journal. 50, Suppl 61, PA4933.

    Research output: Contribution to journal › Meeting abstract

    • Neutrophil Elastase Activity is Associated with Exacerbations and Lung Function Decline in Bronchiectasis

    Chalmers, J. D., Moffitt, K. L., Suarez-Cuartin, G., Sibila, O., Finch, S., Furrie, E., Dicker, A., Wrobel, K., Elborn, J. S., Walker, B., Martin, S. L., Marshall, S. E., Huang, J. T-J. & Fardon, T. C., 15 May 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 10, p. 1384-1393

    Research output: Contribution to journal › Article

    Open Access
    File
    • 74 Citations (Scopus)
    361 Downloads (Pure)

    A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity

    Ferguson, T. E. G., Reihill, J. A., Walker, B., Hamilton, R. A. & Martin, S. L., 26 Jul 2016, In : PLoS ONE. 11, 7, 9 p., e0159868.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 3 Citations (Scopus)
    188 Downloads (Pure)