Photo of Brian Walker

Brian Walker

Professor

19942018
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Interests

Professor Walker was appointed in September 1998 to the Allen J. McClay Chair in Biomedicinal Chemistry to establish a Biomolecular Sciences programme within the School. His research interests are focused on the development and application of novel inhibitors for the identification and validation of protease targets of biomedical and pharmaceutical importance. This research is characterized by a fusion of biological chemistry and cell and molecular biology.

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Anura Medicine & Life Sciences
Skin Chemical Compounds
Peptides Medicine & Life Sciences
Cloning Chemical Compounds
cathepsin S Medicine & Life Sciences
Amphibians Medicine & Life Sciences
Peptide Hydrolases Medicine & Life Sciences
Complementary DNA Medicine & Life Sciences

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Projects 2005 2015

R1708PMY: Modular synthetic approaches for the inhibition and assay of proteases

Walker, B.

01/08/2005 → 17/12/2019

Project: Research

R1293PMY: Protease-Tag Technology: Clinical Validation and Commercialisation

Martin, L. & Walker, B.

01/08/2012 → 01/08/2015

Project: Research

R1143PMY: Molecular and pharmacological validation of Cathepsin S as a novel target in cancer treatment

Scott, C., McCarthy, H. & Walker, B.

01/08/2009 → 22/03/2014

Project: Research

Research Output 1994 2018

2 Citations (Scopus)
147 Downloads (Pure)

A Bowman-Birk type chymotrypsin inhibitor peptide from the amphibian, Hylarana erythraea

Zhang, L., Chen, X., Wu, Y., Zhou, M., Ma, C., Xi, X., Chen, T., Walker, B., Shaw, C. & Wang, L., 11 Apr 2018, In : Scientific Reports. 8, 9 p., 5851.

Research output: Contribution to journal › Article

Open Access
File
Chymotrypsin
Peptides
Proteasome Endopeptidase Complex
Trypsin Inhibitors
Cloning
8 Citations (Scopus)
172 Downloads (Pure)

A Structural and Functional Analogue of a Bowman Birk-type Protease Inhibitor from Odorrana Schmackeri

Wu, Y., Long, Q., Xu, Y., Guo, S., Chen, T., Wang, L., Zhou, M., Zhang, Y., Shaw, C. & Walker, B., Apr 2017, In : Bioscience Reports. 37, 2

Research output: Contribution to journal › Article

Open Access
File
Tryptases
Protease Inhibitors
Anura
Trypsin
Skin

Detection and inhibition of ENaC-activating proteases associated with airway dehydration in COPD

Martin, L., Reihill, J., Douglas, L., Ferguson, T. & Walker, B., Sep 2017, In : European Respiratory Journal. 50, Suppl 61, PA4933.

Research output: Contribution to journal › Meeting abstract

Dehydration
Trypsin
Chronic Obstructive Pulmonary Disease
Peptide Hydrolases
Epithelial Cells
70 Citations (Scopus)
324 Downloads (Pure)

Neutrophil Elastase Activity is Associated with Exacerbations and Lung Function Decline in Bronchiectasis

Chalmers, J. D., Moffitt, K. L., Suarez-Cuartin, G., Sibila, O., Finch, S., Furrie, E., Dicker, A., Wrobel, K., Elborn, J. S., Walker, B., Martin, S. L., Marshall, S. E., Huang, J. T-J. & Fardon, T. C., 15 May 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 10, p. 1384-1393

Research output: Contribution to journal › Article

Open Access
File
Leukocyte Elastase
Bronchiectasis
Pancreatic Elastase
Sputum
Desmosine
3 Citations (Scopus)
158 Downloads (Pure)

A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity

Ferguson, T. E. G., Reihill, J. A., Walker, B., Hamilton, R. A. & Martin, S. L., 26 Jul 2016, In : PLoS ONE. 11, 7, 9 p., e0159868.

Research output: Contribution to journal › Article

Open Access
File
Furin
exotoxins
Cytotoxicity
Pseudomonas aeruginosa
trypsin