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Professor Walker was appointed in September 1998 to the Allen J. McClay Chair in Biomedicinal Chemistry to establish a Biomolecular Sciences programme within the School. His research interests are focused on the development and application of novel inhibitors for the identification and validation of protease targets of biomedical and pharmaceutical importance. This research is characterized by a fusion of biological chemistry and cell and molecular biology.
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Collaborations and top research areas from the last five years
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R5740PMY: The development of an Advanced Material for Protease Enzyme Capture
Martin, L. (PI) & Walker, B. (CoI)
01/08/2011 → …
Project: Research
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R3522PMY: The development and validation of novel companion diagnostics for oral anti-coagulants
Walker, B. (PI) & Martin, L. (CoI)
01/08/2012 → 30/01/2016
Project: Research
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R1293PMY: Protease-Tag Technology: Clinical Validation and Commercialisation
Martin, L. (PI) & Walker, B. (CoI)
01/08/2012 → 01/08/2015
Project: Research
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R2887PMY: Channel Activating Proteases (CAPS): molecular targets for correction of sodium channel dysfunction in airways disease
Martin, L. (PI), Elborn, S. (CoI) & Walker, B. (CoI)
01/08/2012 → 31/12/2015
Project: Research
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R4582PMY: Epithelial Sodium Channel (ENaC) and Channel Activating Proteases (CAPS):molecular targets for correction of sodium channel dysfunction ....
Martin, L. (PI) & Walker, B. (CoI)
01/08/2011 → 13/04/2012
Project: Research
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Novel inhibitors and activity-based probes targeting serine proteases
Ferguson, T. E. G., Reihill, J. A., Martin, S. L. & Walker, B., 28 Sept 2022, In: Frontiers in Chemistry. 10, 17 p., 1006618.Research output: Contribution to journal › Article › peer-review
Open AccessFile122 Downloads (Pure) -
Novel inhibitors and activity-based probes targeting trypsin-like serine proteases
Ferguson, T. E. G., Reihill, J. A., Martin, S. L. & Walker, B., 21 Apr 2022, In: Frontiers in Chemistry. 10, 17 p., 782608.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)195 Downloads (Pure) -
Proteases—from basic structure to function to drug design as targeted therapy
Kwok, H. F., Walker, B. & Shaw, C., 21 Nov 2022, In: Biology. 11, 11, 1680.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile1 Citation (Scopus)14 Downloads (Pure) -
A Bowman-Birk type chymotrypsin inhibitor peptide from the amphibian, Hylarana erythraea
Zhang, L., Chen, X., Wu, Y., Zhou, M., Ma, C., Xi, X., Chen, T., Walker, B., Shaw, C. & Wang, L., 11 Apr 2018, In: Scientific Reports. 8, 9 p., 5851.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)298 Downloads (Pure) -
A Structural and Functional Analogue of a Bowman Birk-type Protease Inhibitor from Odorrana Schmackeri
Wu, Y., Long, Q., Xu, Y., Guo, S., Chen, T., Wang, L., Zhou, M., Zhang, Y., Shaw, C. & Walker, B., Apr 2017, In: Bioscience Reports. 37, 2Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)311 Downloads (Pure)