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Brian Walker

Professor

19942018

Research output per year

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Research Output

2018

A Bowman-Birk type chymotrypsin inhibitor peptide from the amphibian, Hylarana erythraea

Zhang, L., Chen, X., Wu, Y., Zhou, M., Ma, C., Xi, X., Chen, T., Walker, B., Shaw, C. & Wang, L., 11 Apr 2018, In : Scientific Reports. 8, 9 p., 5851.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
169 Downloads (Pure)
2017

A Structural and Functional Analogue of a Bowman Birk-type Protease Inhibitor from Odorrana Schmackeri

Wu, Y., Long, Q., Xu, Y., Guo, S., Chen, T., Wang, L., Zhou, M., Zhang, Y., Shaw, C. & Walker, B., Apr 2017, In : Bioscience Reports. 37, 2

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
196 Downloads (Pure)

Detection and inhibition of ENaC-activating proteases associated with airway dehydration in COPD

Martin, L., Reihill, J., Douglas, L., Ferguson, T. & Walker, B., Sep 2017, In : European Respiratory Journal. 50, Suppl 61, PA4933.

Research output: Contribution to journalMeeting abstract

Neutrophil Elastase Activity is Associated with Exacerbations and Lung Function Decline in Bronchiectasis

Chalmers, J. D., Moffitt, K. L., Suarez-Cuartin, G., Sibila, O., Finch, S., Furrie, E., Dicker, A., Wrobel, K., Elborn, J. S., Walker, B., Martin, S. L., Marshall, S. E., Huang, J. T-J. & Fardon, T. C., 15 May 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 10, p. 1384-1393

Research output: Contribution to journalArticle

Open Access
File
74 Citations (Scopus)
360 Downloads (Pure)
2016

A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity

Ferguson, T. E. G., Reihill, J. A., Walker, B., Hamilton, R. A. & Martin, S. L., 26 Jul 2016, In : PLoS ONE. 11, 7, 9 p., e0159868.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
187 Downloads (Pure)

DEVELOPMENT OF A PROTEASETAG® LATERAL FLOW DEVICE FOR DETECTION OF ACTIVE NEUTROPHIL ELASTASE IN THE CLINIC

McCafferty, D., Robb, C., Ferguson, T., Moffitt, K., Walker, B. & Martin, L., Oct 2016, In : Pediatric Pulmonology. 51, S45, p. 280 1 p.

Research output: Contribution to journalMeeting abstract

5 Citations (Scopus)

How specific are fluorogenic substrates designed to analyse active protease biomarkers of respiratory disease?

Robb, C., Ferguson, T., Moffitt, K., Downey, D., McCafferty, D., Ribeiro, D., Martin, L. & Walker, B., Dec 2016, In : Thorax. 71, Suppl 3, p. A79-A80 2 p.

Research output: Contribution to journalMeeting abstract

Inhibition of protease-ENaC signaling improves mucociliary function in cystic fibrosis airways

Reihill, J. A., Walker, B., Hamilton, R. A., Ferguson, T. E. G., Elborn, J. S., Stutts, M. J., Harvey, B. J., Saint-Criq, V., Hendrick, S. M. & Martin, S. L., Sep 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 6, p. 701-710 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

NE ULTRA – A NOVEL PROTEASETAG® FOR THE INHIBITION AND DETECTION OF NEUTROPHIL ELASTASE IN BIOLOGICAL SAMPLES

Ferguson, T., Robb, C., Moffitt, K., Martin, L., McCafferty, D. & Walker, B., Oct 2016, In : Pediatric Pulmonology. 51, S45, p. 281 1 p.

Research output: Contribution to journalMeeting abstract

2015

A novel inhibitor of channel activating proteases: Putting the CAP on ENaC

Reihill, J. A., Walker, B., Harvey, B., Stutts, J., Elborn, J. S. & Martin, S. L., Oct 2015, In : Pediatric Pulmonology. 50, Suppl 41, p. 229 1 p.

Research output: Contribution to journalMeeting abstract

A Novel Inhibitor of Channel Activating Proteases: Putting the Cap on ENAC

Reihill, J. A., Walker, B., Harvey, B., Stutts, J. & Elborn, J., Oct 2015, In : Pediatric Pulmonology. 50, S41, p. S229 1 p.

Research output: Contribution to journalMeeting abstract

Development of a Novel Assay for the Detection of Active Neutrophil Elastase in Patients with Chronic Obstructive Pulmonary Disease

Moffitt, KL., Martin, SL., Chalmers, J. & Walker, B., Dec 2015, In : Thorax. 70, Suppl 3, p. A126-A127

Research output: Contribution to journalMeeting abstract

Development of Novel Activity-Based Probes for the Detection of Serine Proteases

Ferguson, T., Walker, B. & Martin, S. L., 13 Apr 2015.

Research output: Contribution to conferencePoster

Inhibition of matrix metalloproteinases associated with chronic wounds

Robb, C., Walker, B. & Martin, L., 13 Apr 2015.

Research output: Contribution to conferencePaper

Utilisation of a novel ProteaseTag™ activity immunoassay for the specific measurement of neutrophil elastase in BAL from children with cystic fibrosis

Moffitt, K. L., McNally, P., Linnane, B., Walker, B. & Martin, S., Oct 2015, In : Pediatric Pulmonology. 50, Suppl 41, p. 266-267

Research output: Contribution to journalMeeting abstract

2014

Synergistic effects of proteasome inhibitor carfilzomib in combination with tyrosine kinase inhibitors in imatinib-sensitive and -resistant chronic myeloid leukemia models

Crawford, LJ., Chan, ET., Aujay, M., Holyoake, TL., Melo, JV., Jorgensen, HG., Suresh, S., Walker, B. & Irvine, AE., Mar 2014, In : ONCOGENESIS. 3, 2, 10 p., e90.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
170 Downloads (Pure)

Targeting trypsin-like proteases in cystic fibrosis airways

Reihill, J., Walker, B., Elborn, J. & Martin, L., 23 Oct 2014.

Research output: Contribution to conferencePaper

2013

Cathepsin S from both tumour and tumour-associated cells promote cancer growth and neovascularisation

Small, D. M., Burden, R. E., Jaworski, J., Hegarty, S. M., Spence, S., Burrows, J. F., McFarlane, C., Kissenpfennig, A., McCarthy, H. O., Johnston, J. A., Walker, B. & Scott, C. J., Nov 2013, In : International Journal of Cancer. 133, 9, p. 2102-2112 11 p.

Research output: Contribution to journalArticle

Open Access
File
48 Citations (Scopus)
283 Downloads (Pure)

Design and efficacy of peptide mimetics of LL-37

Irwin, C., Yu, Y., Walker, B. & Lundy, F., 2013, In : Journal of Dental Research.

Research output: Contribution to journalMeeting abstract

Evaluating the antifungal activity of a novel truncated antimicrobial peptide

Lukes, L., Luo, Y., Yu, Y., Walker, B. & Lundy, F., 2013, In : Journal of Dental Research.

Research output: Contribution to journalMeeting abstract

4 Citations (Scopus)

The inhibition of matrix metalloproteinases associated with inflammatory disease

Robb, C., Martin, L. & Walker, B., 15 Apr 2013, (Unpublished).

Research output: Contribution to conferencePaper

2012
44 Citations (Scopus)

Chymotrypsin-like serine proteinases are involved in the maintenance of cell viability

Moffitt, K. L., Walker, B. & Martin, S. L., Dec 2012, In : Biochimie. 94, 12, p. 2582-2589 8 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
207 Downloads (Pure)
4 Citations (Scopus)
40 Downloads (Pure)
15 Citations (Scopus)

Mapping biological to clinical phenotypes during the development (21 days) and resolution (21 days) of experimental gingivitis

Scott, A. E., Milward, M., Linden, G., Matthew, J. B., Carlile, M. J., Lundy, F., Naeeni, M. A., Martin, L., Walker, B., Kinane, D., Brock, G. R. & Chapple, I. L. C., Feb 2012, In : Journal of Clinical Periodontology. 39, 2, p. 123-131 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2011

A modified Tat peptide for selective intracellular delivery of macromolecules

Murphy, D. J., Walker, B., Greer, B., Harriott, P. & Martin, S. L., May 2011, In : Journal of Pharmacy and Pharmacology. 63, 5, p. 611-618 8 p.

Research output: Contribution to journalArticle

A Novel Bacterial Protease-triggered Polymeric Antimicrobial Release System

Chen, W., Walker, B., Gorman, S. & Gilmore, B., Jul 2011, p. 103.

Research output: Contribution to conferencePoster

Comprehensive Inhibitor Profiling Of The Proteus Mirabilis Metalloprotease Virulence Factor Zapa (Mirabilysin)

Carson, L., Cathcart, G., Scott, C., Hollenberg, M. D., Walker, B., Ceri, H. & Gilmore, B., Aug 2011, In : Biochimie. 93, 10, p. 1824-1827 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
46 Citations (Scopus)

Proteasome inhibitors in cancer therapy

Crawford, L., Walker, B. & Irvine, A., Jun 2011, In : Journal of Cell Communication and Signaling. 5, 2, p. 101-110 10 p.

Research output: Contribution to journalArticle

180 Citations (Scopus)

Synthesis and biological evaluation of antioxidant peptides as putative treatment for Alzheimer's disease

Tegazzini, D., Martin, L. & Walker, B., Jun 2011, p. 490.

Research output: Contribution to conferencePaper

2010

From sentencing to execution--the processes of apoptosis.

Moffitt, K., Martin, L. & Walker, B., May 2010, In : Journal of Pharmacy and Pharmacology. 62(5), 5, p. 547-562 16 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Inhibition of Pseudomonas elastase, LasB, attenuates biofilm formation and increases antimicrobial susceptibility in vitro

Gilmore, B., Cathcart, G. & Walker, B., Oct 2010, p. 1385-1386. 2 p.

Research output: Contribution to conferencePaper

47 Citations (Scopus)

Methods for measuring proteasome activity: Current limitations and future developments

Liggett, A., Crawford, L., Walker, B., Morris, T. & Irvine, A., Nov 2010, In : Leukemia research. 34, 11, p. 1403-1409 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Proteases implicated in apoptosis: old and new.

Moffitt, K., Martin, L. & Walker, B., May 2010, In : Journal of Pharmacy and Pharmacology. 62(5), 5, p. 563-576 14 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The effects of bacterial stimulation on prostasin levels within the cystic fibrosis lung

Moffitt, K., Einarsson, G., Walker, B., Elborn, J. & Martin, L., Jun 2010, p. S18-S18. 1 p.

Research output: Contribution to conferencePaper

1 Citation (Scopus)

The Role of Functional Amyloid in Bacterial Biofilm Formation and Antimicrobial Susceptibility

Currie, K., Gorman, S., Walker, B. & Gilmore, B., Oct 2010, p. 1392-1393. 2 p.

Research output: Contribution to conferencePaper

2009
8 Citations (Scopus)