Research Output per year
Fingerprint Dive into the research topics where Catherine Higgins is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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asparaginylendopeptidase
Medicine & Life Sciences
Cystatin M
Medicine & Life Sciences
Assays
Chemical Compounds
Breast Neoplasms
Medicine & Life Sciences
Melanoma
Medicine & Life Sciences
Caspase 8
Medicine & Life Sciences
Death Domain Receptor Signaling Adaptor Proteins
Medicine & Life Sciences
Bioactivity
Chemical Compounds
Network
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Research Output 2009 2016
FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer
McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In : Molecular Cancer Therapeutics. p. 2432-2441 11 p.Research output: Contribution to journal › Article
Open Access
File
Ionizing Radiation
Non-Small Cell Lung Carcinoma
Radiation
Caspase 8
Cell Death
Development of a potent and selective cell penetrant Legumain inhibitor
Ness, K. A., Eddie, S. L., Higgins, C. A., Templeman, A., D'Costa, Z., Gaddale, K. K. D., Bouzzaoui, S., Jordan, L., Janssen, D., Harrison, T., Burkamp, F., Young, A., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 01 Dec 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 23, p. 5642-5645Research output: Contribution to journal › Letter
asparaginylendopeptidase
Assays
Cell Survival
Cells
Molecules
Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly
Majkut, J., Sgobba, M., Holohan, C., Crawford, N., Logan, A. E., Kerr, E., Higgins, C. A., Redmond, K. L., Riley, J. S., Stasik, I., Fennell, D. A., Van Schaeybroeck, S., Haider, S., Johnston, P. G., Haigh, D. & Longley, D. B., 28 Feb 2014, In : Nature Communications. 5, 3350.Research output: Contribution to journal › Article
Death Domain Receptor Signaling Adaptor Proteins
effectors
Caspase 8
death
affinity
P3 SAR exploration of biphenyl carbamate based Legumain inhibitors
Higgins, C., Bouazzaoui, S., Gaddale Devanna, K., D'Costa, Z., Templeman, A., O'Rourke, M., Young, A., Scott, C., Harrison, T., Mullan, P. & Williams, R., 01 Jun 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 11, p. 2521-2524Research output: Contribution to journal › Article
asparaginylendopeptidase
Carbamates
Enzymes
diphenyl
TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.
D'Costa, Z. C., Higgins, C., Ong, C. W., Irwin, G. W., Boyle, D., McArt, D. G., McCloskey, K., Buckley, N. E., Crawford, N. T., Thiagarajan, L., Murray, J. T., Kennedy, R. D., Mulligan, K. A., Harkin, D. P., Waugh, D. J. J., Scott, C. J., Salto-Tellez, M., Williams, R. & Mullan, P. B., 08 Feb 2014, In : Oncotarget. 5, 6, p. 1609-1620 12 p.Research output: Contribution to journal › Article
Open Access
File
asparaginylendopeptidase
Cystatin M
Breast Neoplasms
Neoplasms
Cathepsins