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Catherine Higgins

Dr

  • Room 03.013 - CCRCB

    United Kingdom

20092020

Research output per year

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Research Output

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, In : EMBO Reports. e49254.

Research output: Contribution to journal › Article

Open Access
File
    • 27 Downloads (Pure)

    FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer

    McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In : Molecular Cancer Therapeutics. p. 2432-2441 11 p.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 8 Citations (Scopus)
    188 Downloads (Pure)

    Development of a potent and selective cell penetrant Legumain inhibitor

    Ness, K. A., Eddie, S. L., Higgins, C. A., Templeman, A., D'Costa, Z., Gaddale, K. K. D., Bouzzaoui, S., Jordan, L., Janssen, D., Harrison, T., Burkamp, F., Young, A., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 01 Dec 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 23, p. 5642-5645

    Research output: Contribution to journal › Article

    • 6 Citations (Scopus)

    Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly

    Majkut, J., Sgobba, M., Holohan, C., Crawford, N., Logan, A. E., Kerr, E., Higgins, C. A., Redmond, K. L., Riley, J. S., Stasik, I., Fennell, D. A., Van Schaeybroeck, S., Haider, S., Johnston, P. G., Haigh, D. & Longley, D. B., 28 Feb 2014, In : Nature Communications. 5, 3350.

    Research output: Contribution to journal › Article

    • 31 Citations (Scopus)

    P3 SAR exploration of biphenyl carbamate based Legumain inhibitors

    Higgins, C., Bouazzaoui, S., Gaddale Devanna, K., D'Costa, Z., Templeman, A., O'Rourke, M., Young, A., Scott, C., Harrison, T., Mullan, P. & Williams, R., 01 Jun 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 11, p. 2521-2524

    Research output: Contribution to journal › Article

    • 4 Citations (Scopus)