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Catherine Higgins

Dr

  • Room 03.013 - CCRCB

    United Kingdom

20092016
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  • 7 Similar Profiles
asparaginylendopeptidase Medicine & Life Sciences
Cystatin M Medicine & Life Sciences
Assays Chemical Compounds
Breast Neoplasms Medicine & Life Sciences
Melanoma Medicine & Life Sciences
Caspase 8 Medicine & Life Sciences
Death Domain Receptor Signaling Adaptor Proteins Medicine & Life Sciences
Bioactivity Chemical Compounds

Research Output 2009 2016

7 Citations (Scopus)
159 Downloads (Pure)

FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer

McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In : Molecular Cancer Therapeutics. p. 2432-2441 11 p.

Research output: Contribution to journal › Article

Open Access
File
Ionizing Radiation
Non-Small Cell Lung Carcinoma
Radiation
Caspase 8
Cell Death
6 Citations (Scopus)

Development of a potent and selective cell penetrant Legumain inhibitor

Ness, K. A., Eddie, S. L., Higgins, C. A., Templeman, A., D'Costa, Z., Gaddale, K. K. D., Bouzzaoui, S., Jordan, L., Janssen, D., Harrison, T., Burkamp, F., Young, A., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 01 Dec 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 23, p. 5642-5645

Research output: Contribution to journal › Letter

asparaginylendopeptidase
Assays
Cell Survival
Cells
Molecules
30 Citations (Scopus)

Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly

Majkut, J., Sgobba, M., Holohan, C., Crawford, N., Logan, A. E., Kerr, E., Higgins, C. A., Redmond, K. L., Riley, J. S., Stasik, I., Fennell, D. A., Van Schaeybroeck, S., Haider, S., Johnston, P. G., Haigh, D. & Longley, D. B., 28 Feb 2014, In : Nature Communications. 5, 3350.

Research output: Contribution to journal › Article

Death Domain Receptor Signaling Adaptor Proteins
effectors
Caspase 8
death
affinity
4 Citations (Scopus)

P3 SAR exploration of biphenyl carbamate based Legumain inhibitors

Higgins, C., Bouazzaoui, S., Gaddale Devanna, K., D'Costa, Z., Templeman, A., O'Rourke, M., Young, A., Scott, C., Harrison, T., Mullan, P. & Williams, R., 01 Jun 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 11, p. 2521-2524

Research output: Contribution to journal › Article

asparaginylendopeptidase
Carbamates
Enzymes
diphenyl
23 Citations (Scopus)
183 Downloads (Pure)

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.

D'Costa, Z. C., Higgins, C., Ong, C. W., Irwin, G. W., Boyle, D., McArt, D. G., McCloskey, K., Buckley, N. E., Crawford, N. T., Thiagarajan, L., Murray, J. T., Kennedy, R. D., Mulligan, K. A., Harkin, D. P., Waugh, D. J. J., Scott, C. J., Salto-Tellez, M., Williams, R. & Mullan, P. B., 08 Feb 2014, In : Oncotarget. 5, 6, p. 1609-1620 12 p.

Research output: Contribution to journal › Article

Open Access
File
asparaginylendopeptidase
Cystatin M
Breast Neoplasms
Neoplasms
Cathepsins