Projects per year
Personal profile
Research Interests
- AMR - development of plant-based antimicrobial alternatives
- Health and disease in humans and animals
- Food safety, quality and nutrition
- Rapid immunodiagnostic for chemical contaminants and biomarkers
Antimicrobial resistance (AMR) is a huge threat encompassing health and economic burdens in every region of the globe. Overuse or misuse of antibiotics can accelerate the natural evolution of microorganisms and the associated consequence has been further implicated by the lack of development of new antibiotics over the past 40 years. Responsible use of antibiotics and development of antibiotic alternatives are paramount in combatting AMR.
Traditional herbal medicine, sustained by near 7000 years of anecdotal theory and practice, still remains as major healthcare systems in many parts of the world and is very different from the mainstream of western medicine. My research interest in this area focuses on the development of plant-based phytochemicals as safer and sustainable alternative to therapeutic antibiotics for use in humans and animals. We have developed in-house expertise spanning from initial screening to isolation and identification of bio-compound, as well as toxicity evaluation and mode of action study to decipher the traditional knowledge of herbal remedy. We will collaborate with other research institution and industry (pharmaceutical, food and nutritional) to explore both therapeutic and health potential of botanicals as antimicrobial agents for tackling AMR, as nutraceuticals for promoting health and general well-being in humans, and as natural supplements for enhancing health and productivity of food animals.
My other research lies in the development of immunochemical and molecular methods utilising a range of biotechnological platforms including SPR biosensor and nanotechnology. I have participated and coordinated a series of EU Framework Programme projects (FP4-FP7) since 1998 and developed a range of commercial diagnostic kits for detection of small and large molecules such as antibiotic residues, chemicals proteins and biomarkers.
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Projects
R6313AFL: Development of a unique means of detecting and proving illegal administration of IBST
01/08/2008 → 31/05/2013
Project: Research
Research Output
Antibacterial, anti-inflammatory and peroxidasemediated cyclooxygenase-1 inhibitory properties of Fusarium solani extract
Ngwoke, K., Tochukwu, N., Chinechem, E., Nwankwo, V., Obi-Okafor, U., Izundu, C., Okoye, F. B. C., Esimone, C., Proksch, P. & Situ, C., 2019, In : Pharmaceutical Biology. 57, 1, p. 310-317Research output: Contribution to journal › Article
Open Access
File
Surface plasmon resonance biosensor for the determination of 3-methyl-quinoxaline-2-carboxylic acid, the marker residue of olaquindox, in swine tissues
Peng, D., Kavanagh, O., Gao, H., Zhang, X., Deng, S., Chen, D., Liu, Z., Xie, C., Yuan, Z. & Situ, C., Apr 2019, In : Food Chemistry.Research output: Contribution to journal › Article
Development of Monoclonal Antibodies and Indirect Competitive Enzyme-Linked Immunosorbent Assay Kits for the Detection of Clenbuterol and Salbutamol in the Tissues and Products of Food-Producing Animals
Peng, D., Zhang, L., Situ, C., Pan, Y., Tao, Y., Wang, Y. & Yuan, Z., 18 May 2017, In : Food Analytical Methods.Research output: Contribution to journal › Article
6
Citations
(Scopus)
Mechanisms of Antimicrobial Action of Cinnamon and Oregano Oils, Cinnamaldehyde, Carvacrol, 2,5-Dihydroxybenzaldehyde, and 2-Hydroxy-5-Methoxybenzaldehyde against Mycobacterium avium subsp. paratuberculosis (Map)
Nowotarska, S. W., Nowotarski, K., Grant, I., Elliott, C., Friedman, M. & Situ, C., 24 Aug 2017, In : Foods. 6, 72, p. 1-16Research output: Contribution to journal › Article
Open Access
File
Specific Monoclonal Antibody-Based Enzyme Immunoassay for Sensitive and Reliable Detection of Alternaria Mycotoxin Iso-Tenuazonic Acid in Food Products
Xiao, Z-L., Wang, Y-L., Shen, Y-D., Xu, Z-L., Dong, J-X., Wang, H., Situ, C., Wang, F., Yang, J-Y., Lei, H-T. & Sun, Y-M., 14 Sep 2017, In : Food Analytical Methods. 11, 3, p. 635-645 11 p.Research output: Contribution to journal › Article
Open Access
File
4
Citations
(Scopus)
133
Downloads
(Pure)
Prizes
Activities
Shanghai Institute of Meteria Medica
Chen Situ (Advisor)05 Dec 2019
Activity: Visiting an external institution types › Visiting an external academic institution
Global Food Security: Concerns, Research and Education
Chen Situ (Invited speaker)27 Nov 2019
Activity: Talk or presentation types › Public lecture/debate/seminar
Southern Medical University
Chen Situ (Advisor)28 Nov 2019
Activity: Visiting an external institution types › Visiting an external academic institution
South China Agricultural University
Chen Situ (Advisor)27 Nov 2019
Activity: Visiting an external institution types › Visiting an external academic institution
Thesis
Antimicrobial effects of naturally occurring compounds against microorganisms relevant to food safety
Author: Nowotarska, S. W., Apr 2010Supervisor: Situ, C. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Isolation and biological characterisation of plant-derived chemicals for antibacterial purposes in food animals and humans
Author: Ngwoke, K., Jul 2010Supervisor: Situ, C. (Supervisor) & Elliott, C. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File