• Room 01.027 - Sonic Arts Research Centre 4 Cloreen Park

    United Kingdom

Accepting PhD Students

20022019
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Personal profile

Research Interests

  • AMR - development of plant-based antimicrobial alternatives
  • Health and disease in humans and animals
  • Food safety, quality and nutrition
  • Rapid immunodiagnostic for chemical contaminants and biomarkers

Antimicrobial resistance (AMR) is a huge threat encompassing health and economic burdens in every region of the globe. Overuse or misuse of antibiotics can accelerate the natural evolution of microorganisms and the associated consequence has been further implicated by the lack of development of new antibiotics over the past 40 years. Responsible use of antibiotics and development of antibiotic alternatives are paramount in combatting AMR.

Traditional herbal medicine, sustained by near 7000 years of anecdotal theory and practice, still remains as major healthcare systems in many parts of the world and is very different from the mainstream of western medicine. My research interest in this area focuses on the development of plant-based phytochemicals as safer and sustainable alternative to therapeutic antibiotics for use in humans and animals. We have developed in-house expertise spanning from initial screening to isolation and identification of bio-compound, as well as toxicity evaluation and mode of action study to decipher the traditional knowledge of herbal remedy. We will collaborate with other research institution and industry (pharmaceutical, food and nutritional) to explore both therapeutic and health potential of botanicals as antimicrobial agents for tackling AMR, as nutraceuticals for promoting health and general well-being in humans, and as natural supplements for enhancing health and productivity of food animals.

My other research lies in the development of immunochemical and molecular methods utilising a range of biotechnological platforms including SPR biosensor and nanotechnology. I have participated and coordinated a series of EU Framework Programme projects (FP4-FP7) since 1998 and developed a range of commercial diagnostic kits for detection of small and large molecules such as antibiotic residues, chemicals proteins and biomarkers.

Fingerprint Dive into the research topics where Chen Situ is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Animals Chemical Compounds
Mycobacterium avium subsp. paratuberculosis Agriculture & Biology
Biomarkers Chemical Compounds
Biosensors Chemical Compounds
monoclonal antibodies Agriculture & Biology
Nandrolone Chemical Compounds
Tenuazonic Acid Chemical Compounds
carvacrol Agriculture & Biology

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2008 2013

Research Output 2002 2019

Antibacterial, anti-inflammatory and peroxidasemediated cyclooxygenase-1 inhibitory properties of Fusarium solani extract

Ngwoke, K., Tochukwu, N., Chinechem, E., Nwankwo, V., Obi-Okafor, U., Izundu, C., Okoye, F. B. C., Esimone, C., Proksch, P. & Situ, C., 2019, In : Pharmaceutical Biology. 57, 1, p. 310-317

Research output: Contribution to journalArticle

Open Access
File
Cyclooxygenase 1
Fusarium
Fungi
Anti-Inflammatory Agents
Soil

Surface plasmon resonance biosensor for the determination of 3-methyl-quinoxaline-2-carboxylic acid, the marker residue of olaquindox, in swine tissues

Peng, D., Kavanagh, O., Gao, H., Zhang, X., Deng, S., Chen, D., Liu, Z., Xie, C., Yuan, Z. & Situ, C., Apr 2019, In : Food Chemistry.

Research output: Contribution to journalArticle

olaquindox
quinoxalines
surface plasmon resonance
Surface Plasmon Resonance
biosensors
6 Citations (Scopus)
Clenbuterol
clenbuterol
Immunosorbents
Monoclonal antibodies
Albuterol
Open Access
File
cinnamon
adenosine triphosphate
oregano
Mycobacterium avium subsp. paratuberculosis
carvacrol
4 Citations (Scopus)

Specific Monoclonal Antibody-Based Enzyme Immunoassay for Sensitive and Reliable Detection of Alternaria Mycotoxin Iso-Tenuazonic Acid in Food Products

Xiao, Z-L., Wang, Y-L., Shen, Y-D., Xu, Z-L., Dong, J-X., Wang, H., Situ, C., Wang, F., Yang, J-Y., Lei, H-T. & Sun, Y-M., 14 Sep 2017, In : Food Analytical Methods. 11, 3, p. 635-645 11 p.

Research output: Contribution to journalArticle

Open Access
File
Tenuazonic Acid
tenuazonic acid
Alternaria
Monoclonal antibodies
Mycotoxins

Activities 2003 2019

Food Chemistry (Journal)

Chen Situ (Peer reviewer)
2019

Activity: Publication peer-review and editorial work typesPublication peer-review

PhD external examination

Chen Situ (Examiner)
Mar 2018 → …

Activity: Examination typesPhD external examination

International Conference on Nanoscience and Nanotechnology (IC2N)

Chen Situ (Presenter)
16 Jul 2017

Activity: Participating in or organising an event typesParticipation in conference

8th World Gene Convention 2017

Chen Situ (Invited speaker)
13 Nov 201715 Nov 2017

Activity: Talk or presentation typesInvited or keynote talk at national or international conference

UK-China AMR China Visit

Chen Situ (Presenter)
19 Nov 201725 Nov 2017

Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

Thesis

Antimicrobial effects of naturally occurring compounds against microorganisms relevant to food safety

Author: Nowotarska, S. W., Apr 2010

Supervisor: Situ, C. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File