Projects per year
Personal profile
Research Interests
- AMR - development of plant-based antimicrobial alternatives
- Health and disease in humans and animals
- Food safety, quality and nutrition
- Rapid immunodiagnostic for chemical contaminants and biomarkers
Antimicrobial resistance (AMR) is a huge threat encompassing health and economic burdens in every region of the globe. Overuse or misuse of antibiotics can accelerate the natural evolution of microorganisms and the associated consequence has been further implicated by the lack of development of new antibiotics over the past 40 years. Responsible use of antibiotics and development of antibiotic alternatives are paramount in combatting AMR.
Traditional herbal medicine, sustained by near 7000 years of anecdotal theory and practice, still remains as major healthcare systems in many parts of the world and is very different from the mainstream of western medicine. My research interest in this area focuses on the development of plant-based phytochemicals as safer and sustainable alternative to therapeutic antibiotics for use in humans and animals. We have developed in-house expertise spanning from initial screening to isolation and identification of bio-compound, as well as toxicity evaluation and mode of action study to decipher the traditional knowledge of herbal remedy. We will collaborate with other research institution and industry (pharmaceutical, food and nutritional) to explore both therapeutic and health potential of botanicals as antimicrobial agents for tackling AMR, as nutraceuticals for promoting health and general well-being in humans, and as natural supplements for enhancing health and productivity of food animals.
My other research lies in the development of immunochemical and molecular methods utilising a range of biotechnological platforms including SPR biosensor and nanotechnology. I have participated and coordinated a series of EU Framework Programme projects (FP4-FP7) since 1998 and developed a range of commercial diagnostic kits for detection of small and large molecules such as antibiotic residues, chemicals proteins and biomarkers.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Network
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R6313AFL: Development of a unique means of detecting and proving illegal administration of IBST
01/08/2008 → 31/05/2013
Project: Research
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The Effects of Agrimonia pilosa Ledeb, Anemone chinensis Bunge, and Smilax glabra Roxb on Broiler Performance, Nutrient Digestibility, and Gastrointestinal Tract Microorganisms
McMurray, R. L., Ball, M. E. E., Linton, M., Pinkerton, L., Kelly, C., Lester, J., Donaldson, C., Balta, I., Tunney, M. M., Corcionivoschi, N. & Situ, C., May 2022, In: ANIMALS. 12, 9, e1110.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Downloads (Pure) -
Antibacterial Activity of Four Plant Extracts Extracted from Traditional Chinese Medicinal Plants against Listeria monocytogenes, Escherichia coli, and Salmonella enterica subsp. enterica serovar Enteritidis
McMurray, R., Ball, E., Tunney, M., Corcionivoschi, N. & Situ, C., 26 Jun 2020, In: Microorganisms. 8, 962, 12 p., 962.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)130 Downloads (Pure) -
Antibacterial activity of traditional medicine
Situ, C., 27 Nov 2020, p. 29.Research output: Contribution to conference › Abstract › peer-review
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Poster abstract: The in vitro antibacterial effect of botanicals against Campylobacter jejuni, Listeria monocytogenes, Escherichia coli and Salmonella enterica
McMurray, R., Situ, C., Ball, E., Tunney, M. & Corcionivoschi, N., 31 Jan 2020, In: British Poultry Abstracts. 15, 1, p. 34-35Research output: Contribution to journal › Meeting abstract › peer-review
Open AccessFile18 Downloads (Pure) -
Antibacterial, anti-inflammatory and peroxidasemediated cyclooxygenase-1 inhibitory properties of Fusarium solani extract
Ngwoke, K., Tochukwu, N., Chinechem, E., Nwankwo, V., Obi-Okafor, U., Izundu, C., Okoye, F. B. C., Esimone, C., Proksch, P. & Situ, C., 2019, In: Pharmaceutical Biology. 57, 1, p. 310-317Research output: Contribution to journal › Article › peer-review
Open AccessFile134 Downloads (Pure)
Activities
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Antibacterial and multitarget properties of medicinal plants. The 19th Annual Congress of International Drug Discovery Science and Technology, May 11-13 2022, Tokyo, Japan
Chen Situ (Invited speaker)
11 May 2022Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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Antibacterial properties of botanicals and their potential as antibiotic alternatives in humans and animals. 3rd Global Webinar on Traditional and Alternative Medicine, July 16-18 2021
Chen Situ (Invited speaker)
2021Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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Antibacterial activity of traditional medicine. Global Webinar on Traditional and Alternative Medicine, November 27-29 2020
Chen Situ (Invited speaker)
27 Jul 2020 → 29 Jul 2020Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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Master Thesis and Viva (6 Candidates). College of Food Science, South China Agricultural University
Chen Situ (Examiner)
20 May 2020Activity: Examination types › PhD external examination
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Royal Society of Biology (External organisation)
Chen Situ (Member)
2020 → …Activity: Membership types › Membership of external research organisation