Chen Situ

Phone+44 (0)28 9097 6546
Emailc.situ@qub.ac.uk

Room 0G.103 - Biological Sciences
United Kingdom

Accepting PhD Students

PhD projects

I am open to PhD applications in the fields of: ◦AMR - development of plant-based antimicrobial alternatives ◦Health and disease in humans and animals ◦Food safety, quality and nutrition ◦Rapid immunodiagnostic for chemical contaminants and biomarkers

Research output per year

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Personal profile

Research Interests

AMR - development of plant-based antimicrobial alternatives
Health and disease in humans and animals
Food safety, quality and nutrition
Rapid immunodiagnostic for chemical contaminants and biomarkers

Antimicrobial resistance (AMR) is a huge threat encompassing health and economic burdens in every region of the globe. Overuse or misuse of antibiotics can accelerate the natural evolution of microorganisms and the associated consequence has been further implicated by the lack of development of new antibiotics over the past 40 years. Responsible use of antibiotics and development of antibiotic alternatives are paramount in combatting AMR.

Traditional herbal medicine, sustained by near 7000 years of anecdotal theory and practice, still remains as major healthcare systems in many parts of the world and is very different from the mainstream of western medicine. My research interest in this area focuses on the development of plant-based phytochemicals as safer and sustainable alternative to therapeutic antibiotics for use in humans and animals. We have developed in-house expertise spanning from initial screening to isolation and identification of bio-compound, as well as toxicity evaluation and mode of action study to decipher the traditional knowledge of herbal remedy. We will collaborate with other research institution and industry (pharmaceutical, food and nutritional) to explore both therapeutic and health potential of botanicals as antimicrobial agents for tackling AMR, as nutraceuticals for promoting health and general well-being in humans, and as natural supplements for enhancing health and productivity of food animals.

My other research lies in the development of immunochemical and molecular methods utilising a range of biotechnological platforms including SPR biosensor and nanotechnology. I have participated and coordinated a series of EU Framework Programme projects (FP4-FP7) since 1998 and developed a range of commercial diagnostic kits for detection of small and large molecules such as antibiotic residues, chemicals proteins and biomarkers.

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Projects

1 Finished
1 Active

S2467BSC: KTP/ Lynn's Country Foods Limited

McEvoy, C. & Situ, C.

01/08/2019 → …

Project: ktp

R6313AFL: Development of a unique means of detecting and proving illegal administration of IBST

Situ, C.

01/08/2008 → 31/05/2013

Project: Research

Research Output

26 Article
15 Paper
13 Poster
2 Chapter
3 More
- 2 Other
- 1 Patent

Antibacterial, anti-inflammatory and peroxidasemediated cyclooxygenase-1 inhibitory properties of Fusarium solani extract

Ngwoke, K., Tochukwu, N., Chinechem, E., Nwankwo, V., Obi-Okafor, U., Izundu, C., Okoye, F. B. C., Esimone, C., Proksch, P. & Situ, C., 2019, In : Pharmaceutical Biology. 57, 1, p. 310-317

Research output: Contribution to journal › Article

Open Access

File

89 Downloads (Pure)

Surface plasmon resonance biosensor for the determination of 3-methyl-quinoxaline-2-carboxylic acid, the marker residue of olaquindox, in swine tissues

Peng, D., Kavanagh, O., Gao, H., Zhang, X., Deng, S., Chen, D., Liu, Z., Xie, C., Yuan, Z. & Situ, C., Apr 2019, In : Food Chemistry.

Research output: Contribution to journal › Article

Open Access

File

1 Citation (Scopus)

6 Downloads (Pure)

Development of Monoclonal Antibodies and Indirect Competitive Enzyme-Linked Immunosorbent Assay Kits for the Detection of Clenbuterol and Salbutamol in the Tissues and Products of Food-Producing Animals

Peng, D., Zhang, L., Situ, C., Pan, Y., Tao, Y., Wang, Y. & Yuan, Z., 18 May 2017, In : Food Analytical Methods.

Research output: Contribution to journal › Article

6 Citations (Scopus)

Mechanisms of Antimicrobial Action of Cinnamon and Oregano Oils, Cinnamaldehyde, Carvacrol, 2,5-Dihydroxybenzaldehyde, and 2-Hydroxy-5-Methoxybenzaldehyde against Mycobacterium avium subsp. paratuberculosis (Map)

Nowotarska, S. W., Nowotarski, K., Grant, I., Elliott, C., Friedman, M. & Situ, C., 24 Aug 2017, In : Foods. 6, 72, p. 1-16

Research output: Contribution to journal › Article

Open Access

File

379 Downloads (Pure)

Specific Monoclonal Antibody-Based Enzyme Immunoassay for Sensitive and Reliable Detection of Alternaria Mycotoxin Iso-Tenuazonic Acid in Food Products

Xiao, Z-L., Wang, Y-L., Shen, Y-D., Xu, Z-L., Dong, J-X., Wang, H., Situ, C., Wang, F., Yang, J-Y., Lei, H-T. & Sun, Y-M., 14 Sep 2017, In : Food Analytical Methods. 11, 3, p. 635-645 11 p.

Research output: Contribution to journal › Article

Open Access

File