• Room 0G.103 - Biological Sciences

    United Kingdom

Accepting PhD Students

PhD projects

I am open to PhD applications in the fields of: ◦AMR - development of plant-based antimicrobial alternatives ◦Health and disease in humans and animals ◦Food safety, quality and nutrition ◦Rapid immunodiagnostic for chemical contaminants and biomarkers

20022019

Research output per year

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Personal profile

Research Interests

  • AMR - development of plant-based antimicrobial alternatives
  • Health and disease in humans and animals
  • Food safety, quality and nutrition
  • Rapid immunodiagnostic for chemical contaminants and biomarkers

Antimicrobial resistance (AMR) is a huge threat encompassing health and economic burdens in every region of the globe. Overuse or misuse of antibiotics can accelerate the natural evolution of microorganisms and the associated consequence has been further implicated by the lack of development of new antibiotics over the past 40 years. Responsible use of antibiotics and development of antibiotic alternatives are paramount in combatting AMR.

Traditional herbal medicine, sustained by near 7000 years of anecdotal theory and practice, still remains as major healthcare systems in many parts of the world and is very different from the mainstream of western medicine. My research interest in this area focuses on the development of plant-based phytochemicals as safer and sustainable alternative to therapeutic antibiotics for use in humans and animals. We have developed in-house expertise spanning from initial screening to isolation and identification of bio-compound, as well as toxicity evaluation and mode of action study to decipher the traditional knowledge of herbal remedy. We will collaborate with other research institution and industry (pharmaceutical, food and nutritional) to explore both therapeutic and health potential of botanicals as antimicrobial agents for tackling AMR, as nutraceuticals for promoting health and general well-being in humans, and as natural supplements for enhancing health and productivity of food animals.

My other research lies in the development of immunochemical and molecular methods utilising a range of biotechnological platforms including SPR biosensor and nanotechnology. I have participated and coordinated a series of EU Framework Programme projects (FP4-FP7) since 1998 and developed a range of commercial diagnostic kits for detection of small and large molecules such as antibiotic residues, chemicals proteins and biomarkers.

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Projects

Research Output

Antibacterial, anti-inflammatory and peroxidasemediated cyclooxygenase-1 inhibitory properties of Fusarium solani extract

Ngwoke, K., Tochukwu, N., Chinechem, E., Nwankwo, V., Obi-Okafor, U., Izundu, C., Okoye, F. B. C., Esimone, C., Proksch, P. & Situ, C., 2019, In : Pharmaceutical Biology. 57, 1, p. 310-317

Research output: Contribution to journalArticle

Open Access
File
  • 79 Downloads (Pure)

    Surface plasmon resonance biosensor for the determination of 3-methyl-quinoxaline-2-carboxylic acid, the marker residue of olaquindox, in swine tissues

    Peng, D., Kavanagh, O., Gao, H., Zhang, X., Deng, S., Chen, D., Liu, Z., Xie, C., Yuan, Z. & Situ, C., Apr 2019, In : Food Chemistry.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 6 Citations (Scopus)
    Open Access
    File
  • 367 Downloads (Pure)

    Specific Monoclonal Antibody-Based Enzyme Immunoassay for Sensitive and Reliable Detection of Alternaria Mycotoxin Iso-Tenuazonic Acid in Food Products

    Xiao, Z-L., Wang, Y-L., Shen, Y-D., Xu, Z-L., Dong, J-X., Wang, H., Situ, C., Wang, F., Yang, J-Y., Lei, H-T. & Sun, Y-M., 14 Sep 2017, In : Food Analytical Methods. 11, 3, p. 635-645 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 4 Citations (Scopus)
    133 Downloads (Pure)

    Activities

    Shanghai Institute of Meteria Medica

    Chen Situ (Advisor)
    05 Dec 2019

    Activity: Visiting an external institution typesVisiting an external academic institution

    Global Food Security: Concerns, Research and Education

    Chen Situ (Invited speaker)
    27 Nov 2019

    Activity: Talk or presentation typesPublic lecture/debate/seminar

    Southern Medical University

    Chen Situ (Advisor)
    28 Nov 2019

    Activity: Visiting an external institution typesVisiting an external academic institution

    South China Agricultural University

    Chen Situ (Advisor)
    27 Nov 2019

    Activity: Visiting an external institution typesVisiting an external academic institution

    Guangzhou Medical University

    Chen Situ (Supervisor)
    29 Nov 2019

    Activity: Visiting an external institution typesVisiting an external academic institution

    Thesis

    Antimicrobial effects of naturally occurring compounds against microorganisms relevant to food safety

    Author: Nowotarska, S. W., Apr 2010

    Supervisor: Situ, C. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Isolation and biological characterisation of plant-derived chemicals for antibacterial purposes in food animals and humans

    Author: Ngwoke, K., Jul 2010

    Supervisor: Situ, C. (Supervisor) & Elliott, C. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File