• Room 01.005 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Dr Watson is open to wide-ranging PhD applications from candidates with a basic science or clinical background. His fields of interest include; · Heart failure, Cardiomyopathy, Cardiac remodelling · Diabetes, Hypertension, Ischaemia · Biomarkers, Epigenetics, Fibrosis · Global Health

20042020
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Personal profile

Research Interests

My research is primarily focused on biomarkers, novel therapeutics and unravelling mechanisms of disease (epigenetics) in the areas of diabetes, cardiovascular disease, & global health.

For the last 10 years I have studied the cardiovascular system and the impact that cardiovascular risk factors such as diabetes, hypertension, and inflammation have on diabetic cardiomyopathy, cardiac fibrosis, and heart failure. This research is very translational and spans mechanistic work programmes (cardiac fibrosis, hypertrophy, and epigenetics) right through to clinical trials and health services research.  I am actively involved in cardio-proteomic and miRNA biomarker discovery programmes, pre-heart failure diagnostic and prognostic research for patient risk-stratification, and developing biomarker profiles for diabetic cardiomyopathy. I am also involved in developing novel therapeutic strategies for cardiac dysfunction, including pre-clinical and clinical studies.

My research also includes approaches to improve societal and global health challenges through the Global Health (gHealth) Research group that I have co-founded and co-direct (www.ghealthresearch.org). These research activities are focused on low & middle income countries, and include projects on healthcare strategies for the management of diabetes and cardiovascular disease, healthcare with smartphones, and the development of diagnostic biomarker approaches for detection of cardiomyopathy in settings where cardiac imaging facilities are not readily accessible. Our main collaborations at present are with clinicians, scientists and NGOs in sub-Saharan Africa.

Research Statement

Upon completion of my PhD at Queen’s University Belfast I joined University College Dublin (UCD) as a Newman Scholar in 2006 to develop a research programme on the prevention of heart failure, and subsequently acquired a post-doctoral research fellowship in collaboration with the Heartbeat Trust (www.heartbeat-trust.ie). Through the award of research grants, in 2013 I became an independent Principal Investigator and formed the Experimental & Clinical Cardiology group in UCD. In 2015, I took up an academic position within the School of Medicine, Dentistry and Biomedical Sciences at Queen's University Belfast where I am now a Lecturer with an established independent research programme focused on diabetes, cardiovascular disease, & global health.

Through my global health interests I co-founded the Global Health (gHealth) Research group (www.ghealthresearch.org) which is a multi-disciplinary and multi-organisational group of researchers seeking innovative methods of managing illness, particularly in low and middle income countries using emerging strategies of biomarker science, mHealth and health care system reform. As Research Director I am currently working on projects in Malawi, Uganda, Taiwan, Ireland & the US. Our most recent funding award to support these activities is from the Bill & Melinda Gates Foundation.

I am also the Translational Research coordinator for the charity Heartbeat Trust and a steering committee member for Northern Ireland Clinical Research Network for Diabetes. I am also actively participating in 3 on-going FP7 projects (FIBROTARGETS, HOMAGE, MEDIA), and involved in a number of innovation and commercialization activities around novel diagnostic biomarkers for heart failure and novel therapeutic strategies through application of drug repurposing.

To date, I have published 50 peer-reviewed papers, filed 3 patent applications, and as PI or co-I have secured grants totalling over £4M in research funding.

Fingerprint Dive into the research topics where Chris Watson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 13 Similar Profiles
Heart Failure Medicine & Life Sciences
Brain Natriuretic Peptide Medicine & Life Sciences
Natriuretic Peptides Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
Biomarkers Medicine & Life Sciences
Collagen Medicine & Life Sciences
DNA Methylation Medicine & Life Sciences
Fibrosis Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2004 2020

New-onset heart failure in the STOP-HF programme. Natriuretic peptide defines and tracks risk and enables earlier diagnosis of heart failure

McClelland, S., Zhou, S., O'Connell, E., Gallagher, J., Ryan, F., Watson, C. J., Ledwidge, M. & McDonald, K., 07 Jan 2020, In : European Journal of Heart Failure.

Research output: Contribution to journalArticle

2 Downloads (Pure)

Sacubitril-Valsartan in a routine community population: attention to volume status critical to achieving target dose

Pharithi, R. B., Ferre-Vallverdu, M., Maisel, A. S., O'Connell, E., Walshe, M., Sweeney, C., Barton, J., McDonald, K., O'Hare, D., Watson, C., Gallagher, J., Ledwidge, M. & McDonald, K., 05 Jan 2020, In : ESC Heart Failure.

Research output: Contribution to journalArticle

Open Access
File
Population
Heart Failure
Diuretics
Stroke Volume
LCZ 696
47 Downloads (Pure)

Artificial intelligence supported patient self-care in chronic heart failure: a paradigm shift from reactive to predictive, preventive and personalised care

Ski, C., Barret, M., Boyne, J., Brandts, J., Brunner-La Rocca, H. P., Maesschalck, L., De Wit, K., Dixon, L., Eurlings, C., Fitzsimons, D., Golubnitschaja, O., Hageman, A., Heemskerk, F., Hintzen, A., Helms, T. M., Hill, L., Hoesemakers, T., Marx, N., McDonald, K., Mertens, M. & 13 others, Muller-Wieland, D., Palant, A., Piesk, J., Pomazanskyi, A., Ramaekers, J., Ruff, P., Schutt, K., Shekhawat, Y., Thompson, D. R., Tsirkin, A., van der Mierden, K., Watson, C. & Zippel-Schultz, B., Dec 2019, In : EPMA Journal. 10, p. 445–464

Research output: Contribution to journalArticle

Open Access
File
Preventive Medicine
Artificial Intelligence
Self Care
Patient Care
Heart Failure
1 Citation (Scopus)
78 Downloads (Pure)

A systematic review of clinical prediction rules for the diagnosis of chronic heart failure

Gallagher, J., McCormack, D., Zhou, S., Ryan, F., Watson, C., McDonald, K. & Ledwidge, M. T., 10 Mar 2019, In : ESC Heart Failure.

Research output: Contribution to journalArticle

Open Access
File
Decision Support Techniques
Heart Failure
Area Under Curve
Brain Natriuretic Peptide
Checklist

Developing a disease management program for the improvement of heart failure outcomes: the do’s and the don’ts

Healy, L., Ledwidge, M., Gallagher, J., Watson, C. & McDonald, K., 08 Apr 2019, In : Expert Review of Cardiovascular Therapy. 17, 4, p. 267-273 7 p.

Research output: Contribution to journalReview article

Disease Management
Heart Failure
Heart Diseases
Guidelines
Benchmarking