Christopher Law

Dr

  • Room 01.023 - Biological Sciences

    United Kingdom

Accepting PhD Students

PhD projects

Membrane transporter biochemistry.

19962019
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Personal profile

Other

Grant reviewer for the Leverhulme Trust

Grant reviewer for the Medical Research Council

Grant reviewer for the Wellcome Trust

Grant reviewer for BBSRC

Reviewer for Applied and Environmental Microbiology

Research Statement

My research focuses on the structure, mechanism and physiological roles of integral membrane transporter proteins that function in multidrug efflux in bacterial pathogens and parasites that afflict both livestock and humans, as well as those that play important roles in nutrient uptake and herbicide resistance in plants. This research has important implications for both global food security and human health. Current emphasis is placed on inner membrane antiporters of the major facilitator superfamily (MFS) involved in multidrug resistance in Escherichia coli.

My laboratory utilises a comprehensive range of state-of-the-art techniques to answer important questions pertaining to the structure and mechanism of membrane transporters.  These include X-ray crystallography, fluorescence spectroscopy and transport assays using whole cells, inverted vesicles and purified protein reconstituted into proteoliposomes.

Teaching

BBC3034 Biomolecular Structure - Module Coordinator

CHM2009 Enzymology

BSC1009 Introductory Skills for Biosciences - Chemistry

GEN1005 Chemistry

BBC3031 Cell Signalling

BBC8046 Advanced Molecular Biology

BBC3025 Honours Project

BBC8001 MSc Research Project: BMSF/Biotechnology

 

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  • 2 Similar Profiles
Escherichia coli Medicine & Life Sciences
Multiple Drug Resistance Medicine & Life Sciences
Antiporters Medicine & Life Sciences
Membrane Transport Proteins Medicine & Life Sciences
triclabendazole Medicine & Life Sciences
Proteins Medicine & Life Sciences
Phosphates Medicine & Life Sciences
Active Biological Transport Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2011 2016

Research Output 1996 2019

51 Downloads (Pure)

Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography

Conlon, P., Eguaogie, O., Wilson, J., Sweet, J., Steinhoegl, J., Englert, K., Hancox, O., Law, C., Allman, S., Tucker, J. H. R., Hall, J. & Vyle, J., 11 Oct 2019, In : Chemical Science. 12 p., DOI: 10.1039/C9SC04098F.

Research output: Contribution to journalArticle

Open Access
File
X ray crystallography
Dimers
Organophosphonates
Oligodeoxyribonucleotides
DNA
3 Citations (Scopus)

Clamping down on drugs The Escherichia coli multidrug efflux protein MdtM

Law, C. J. & Alegre, K. O., 27 Sep 2017, In : Research in Microbiology.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Constriction
Escherichia coli
Membrane Transport Proteins
Active Biological Transport
5 Citations (Scopus)
179 Downloads (Pure)

Recombinant vacuolar iron transporter family homologue PfVIT from human malaria-causing Plasmodium falciparum is a Fe2+/H+ exchanger

Labarbuta, P., Duckett, K., Botting, C. H., Chahrour, O., Malone, J., Dalton, J. P. & Law, C. J., 15 Feb 2017, In : Nature Scientific Reports. 7, 42850.

Research output: Contribution to journalArticle

Open Access
File
Falciparum Malaria
Iron
Membrane Proteins
Plasmodium
Plasmodium falciparum
7 Citations (Scopus)
178 Downloads (Pure)

Insight into determinants of substrate binding and transport in a multidrug efflux protein

Alegre, K. O., Paul, S., Labarbuta, P. & Law, C. J., 10 Mar 2016, In : Nature Scientific Reports. 6, 12 p., 22833.

Research output: Contribution to journalArticle

Open Access
File
Multiple Drug Resistance
Amino Acids
Proteins
Membrane Transport Proteins
Escherichia coli Proteins
10 Citations (Scopus)
222 Downloads (Pure)

Synthesis of novel pyrophosphorothiolate-linked dinucleoside cap analogues in a ball mill

Eguaogie, O., Cooke, L., Martin, P. M. L., Ravalico, F., Conway, L. P., Hodgson, D. R. W., Law, C. J. & Vyle, J. S., 2016, In : Organic and Biomolecular Chemistry. 14, 4, p. 1201–1205 5 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphites
Grinding (comminution)
Ball mills
disulfides
grinding

Prizes

EMBO Fellowship Award

Christopher Law (Recipient), 1997

Prize: Fellowship awarded competitively

ESF Travel Fellowship

Christopher Law (Recipient), 1996

Prize: Fellowship awarded competitively

Activities 1997 2018

Prof Richard Cogdell, FRS

Christopher Law (Host)
18 Apr 2018

Activity: Hosting a visitor typesHosting an academic visitor

Journal of Antimicrobial Chemotherapy (Journal)

Christopher Law (Peer reviewer)
2018

Activity: Publication peer-review and editorial work typesPublication peer-review

Edmund Kunji

Christopher Law (Host)
18 Sep 2018

Activity: Hosting a visitor typesHosting an academic visitor

Deutsche Forschungsgemeinschaft (German Research Foundation) (External organisation)

Christopher Law (Reviewer)
2018

Activity: Membership typesMembership of peer review panel or committee

Applied Microbiology and Biotechnology (Journal)

Christopher Law (Peer reviewer)
2017

Activity: Publication peer-review and editorial work typesPublication peer-review