Christopher Law

Senior Lecturer, School of Biological Sciences
Institute for Global Food Security

Phone+44 (0)28 9097 2071
Emailc.law@qub.ac.uk

Room 01.023 - Biological Sciences
United Kingdom

Accepting PhD Students

PhD projects

Membrane transporter biochemistry.

Research output per year

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Personal profile

Other

Grant reviewer for the Leverhulme Trust

Grant reviewer for the Medical Research Council

Grant reviewer for the Wellcome Trust

Grant reviewer for BBSRC

Reviewer for Applied and Environmental Microbiology

Research Statement

My research focuses on the structure, mechanism and physiological roles of integral membrane transporter proteins that function in multidrug efflux in bacterial pathogens and parasites that afflict both livestock and humans, as well as those that play important roles in nutrient uptake and herbicide resistance in plants. This research has important implications for both global food security and human health. Current emphasis is placed on inner membrane antiporters of the major facilitator superfamily (MFS) involved in multidrug resistance in Escherichia coli.

My laboratory utilises a comprehensive range of state-of-the-art techniques to answer important questions pertaining to the structure and mechanism of membrane transporters. These include X-ray crystallography, fluorescence spectroscopy and transport assays using whole cells, inverted vesicles and purified protein reconstituted into proteoliposomes.

Teaching

BBC3034 Biomolecular Structure - Module Coordinator

CHM2009 Enzymology

BSC1009 Introductory Skills for Biosciences - Chemistry

GEN1005 Chemistry

BBC3031 Cell Signalling

BBC8046 Advanced Molecular Biology

BBC3025 Honours Project

BBC8001 MSc Research Project: BMSF/Biotechnology

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Projects

1 Finished
1 Active

R1408BSC: Purification and characterisation of membrane transport proteins of pathogenic spirochaete bacteria

Law, C.

01/08/2011 → …

Project: Research

R1305BSC: BBSRC "Insight into antibiotic resistance of pathogenic bacteria via structural studies of multidrug transporter"

Law, C.

01/08/2012 → 31/08/2016

Project: Research

Research Output

33 Article
3 Chapter
2 Chapter (peer-reviewed)
1 Paper
2 More
- 1 Poster
- 1 Literature review

Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography

Conlon, P., Eguaogie, O., Wilson, J., Sweet, J., Steinhoegl, J., Englert, K., Hancox, O., Law, C., Allman, S., Tucker, J. H. R., Hall, J. & Vyle, J., 11 Oct 2019, In : Chemical Science. 12 p., DOI: 10.1039/C9SC04098F.

Research output: Contribution to journal › Article

Open Access

File

1 Citation (Scopus)

107 Downloads (Pure)

Clamping down on drugs The Escherichia coli multidrug efflux protein MdtM

Law, C. J. & Alegre, K. O., 27 Sep 2017, In : Research in Microbiology.

Research output: Contribution to journal › Article

3 Citations (Scopus)

Recombinant vacuolar iron transporter family homologue PfVIT from human malaria-causing Plasmodium falciparum is a Fe2+/H+ exchanger

Labarbuta, P., Duckett, K., Botting, C. H., Chahrour, O., Malone, J., Dalton, J. P. & Law, C. J., 15 Feb 2017, In : Nature Scientific Reports. 7, 42850.

Research output: Contribution to journal › Article

Open Access

File

7 Citations (Scopus)

230 Downloads (Pure)

Insight into determinants of substrate binding and transport in a multidrug efflux protein

Alegre, K. O., Paul, S., Labarbuta, P. & Law, C. J., 10 Mar 2016, In : Nature Scientific Reports. 6, 12 p., 22833.

Research output: Contribution to journal › Article

Open Access

File

8 Citations (Scopus)

244 Downloads (Pure)

Synthesis of novel pyrophosphorothiolate-linked dinucleoside cap analogues in a ball mill

Eguaogie, O., Cooke, L., Martin, P. M. L., Ravalico, F., Conway, L. P., Hodgson, D. R. W., Law, C. J. & Vyle, J. S., 2016, In : Organic and Biomolecular Chemistry. 14, 4, p. 1201–1205 5 p.

Research output: Contribution to journal › Article

Open Access

File