• Room 01.023 - Biological Sciences

    United Kingdom

Accepting PhD Students

PhD projects

Membrane transporter biochemistry.

19962019

Research output per year

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Personal profile

Other

Grant reviewer for the Leverhulme Trust

Grant reviewer for the Medical Research Council

Grant reviewer for the Wellcome Trust

Grant reviewer for BBSRC

Reviewer for Applied and Environmental Microbiology

Research Statement

My research focuses on the structure, mechanism and physiological roles of integral membrane transporter proteins that function in multidrug efflux in bacterial pathogens and parasites that afflict both livestock and humans, as well as those that play important roles in nutrient uptake and herbicide resistance in plants. This research has important implications for both global food security and human health. Current emphasis is placed on inner membrane antiporters of the major facilitator superfamily (MFS) involved in multidrug resistance in Escherichia coli.

My laboratory utilises a comprehensive range of state-of-the-art techniques to answer important questions pertaining to the structure and mechanism of membrane transporters.  These include X-ray crystallography, fluorescence spectroscopy and transport assays using whole cells, inverted vesicles and purified protein reconstituted into proteoliposomes.

Teaching

BBC3034 Biomolecular Structure - Module Coordinator

CHM2009 Enzymology

BSC1009 Introductory Skills for Biosciences - Chemistry

GEN1005 Chemistry

BBC3031 Cell Signalling

BBC8046 Advanced Molecular Biology

BBC3025 Honours Project

BBC8001 MSc Research Project: BMSF/Biotechnology

 

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Projects

Research Output

Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography

Conlon, P., Eguaogie, O., Wilson, J., Sweet, J., Steinhoegl, J., Englert, K., Hancox, O., Law, C., Allman, S., Tucker, J. H. R., Hall, J. & Vyle, J., 11 Oct 2019, In : Chemical Science. 12 p., DOI: 10.1039/C9SC04098F.

Research output: Contribution to journalArticle

Open Access
File
  • 98 Downloads (Pure)

    Clamping down on drugs The Escherichia coli multidrug efflux protein MdtM

    Law, C. J. & Alegre, K. O., 27 Sep 2017, In : Research in Microbiology.

    Research output: Contribution to journalArticle

  • 3 Citations (Scopus)

    Recombinant vacuolar iron transporter family homologue PfVIT from human malaria-causing Plasmodium falciparum is a Fe2+/H+ exchanger

    Labarbuta, P., Duckett, K., Botting, C. H., Chahrour, O., Malone, J., Dalton, J. P. & Law, C. J., 15 Feb 2017, In : Nature Scientific Reports. 7, 42850.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 5 Citations (Scopus)
    219 Downloads (Pure)

    Insight into determinants of substrate binding and transport in a multidrug efflux protein

    Alegre, K. O., Paul, S., Labarbuta, P. & Law, C. J., 10 Mar 2016, In : Nature Scientific Reports. 6, 12 p., 22833.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 8 Citations (Scopus)
    228 Downloads (Pure)

    Synthesis of novel pyrophosphorothiolate-linked dinucleoside cap analogues in a ball mill

    Eguaogie, O., Cooke, L., Martin, P. M. L., Ravalico, F., Conway, L. P., Hodgson, D. R. W., Law, C. J. & Vyle, J. S., 2016, In : Organic and Biomolecular Chemistry. 14, 4, p. 1201–1205 5 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 12 Citations (Scopus)
    267 Downloads (Pure)

    Prizes

    EMBO Fellowship Award

    Law, Christopher (Recipient), 1997

    Prize: Fellowship awarded competitively

    ESF Travel Fellowship

    Law, Christopher (Recipient), 1996

    Prize: Fellowship awarded competitively

    Activities

    Edmund Kunji

    Christopher Law (Host)

    18 Sep 2018

    Activity: Hosting a visitor typesHosting an academic visitor

    Prof Richard Cogdell, FRS

    Christopher Law (Host)

    18 Apr 2018

    Activity: Hosting a visitor typesHosting an academic visitor

    Deutsche Forschungsgemeinschaft (German Research Foundation) (External organisation)

    Christopher Law (Reviewer)

    2018

    Activity: Membership typesMembership of peer review panel or committee

    Journal of Antimicrobial Chemotherapy (Journal)

    Christopher Law (Peer reviewer)

    2018

    Activity: Publication peer-review and editorial work typesPublication peer-review

    Iron homeostasis in malaria

    Christopher Law (Speaker)

    01 Sep 2017

    Activity: Talk or presentation typesInvited talk

    Thesis

    Purification and characterisation of the Escherichia coli multidrug efflux protein MdtM

    Author: Knipe, S., Dec 2013

    Supervisor: Law, C. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

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