Projects per year
Personal profile
Other
Grant reviewer for the Leverhulme Trust
Grant reviewer for the Medical Research Council
Grant reviewer for the Wellcome Trust
Grant reviewer for BBSRC
Reviewer for Applied and Environmental Microbiology
Research Statement
My research focuses on the structure, mechanism and physiological roles of integral membrane transporter proteins that function in multidrug efflux in bacterial pathogens and parasites that afflict both livestock and humans, as well as those that play important roles in nutrient uptake and herbicide resistance in plants. This research has important implications for both global food security and human health. Current emphasis is placed on inner membrane antiporters of the major facilitator superfamily (MFS) involved in multidrug resistance in Escherichia coli.
My laboratory utilises a comprehensive range of state-of-the-art techniques to answer important questions pertaining to the structure and mechanism of membrane transporters. These include X-ray crystallography, fluorescence spectroscopy and transport assays using whole cells, inverted vesicles and purified protein reconstituted into proteoliposomes.
Teaching
BBC3034 Biomolecular Structure - Module Coordinator
CHM2009 Enzymology
BSC1009 Introductory Skills for Biosciences - Chemistry
GEN1005 Chemistry
BBC3031 Cell Signalling
BBC8046 Advanced Molecular Biology
BBC3025 Honours Project
BBC8001 MSc Research Project: BMSF/Biotechnology
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Projects
R1408BSC: Purification and characterisation of membrane transport proteins of pathogenic spirochaete bacteria
01/08/2011 → …
Project: Research
R1305BSC: BBSRC "Insight into antibiotic resistance of pathogenic bacteria via structural studies of multidrug transporter"
01/08/2012 → 31/08/2016
Project: Research
Research Output
Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography
Conlon, P., Eguaogie, O., Wilson, J., Sweet, J., Steinhoegl, J., Englert, K., Hancox, O., Law, C., Allman, S., Tucker, J. H. R., Hall, J. & Vyle, J., 11 Oct 2019, In : Chemical Science. 12 p., DOI: 10.1039/C9SC04098F.Research output: Contribution to journal › Article
Open Access
File
Clamping down on drugs The Escherichia coli multidrug efflux protein MdtM
Law, C. J. & Alegre, K. O., 27 Sep 2017, In : Research in Microbiology.Research output: Contribution to journal › Article
3
Citations
(Scopus)
Recombinant vacuolar iron transporter family homologue PfVIT from human malaria-causing Plasmodium falciparum is a Fe2+/H+ exchanger
Labarbuta, P., Duckett, K., Botting, C. H., Chahrour, O., Malone, J., Dalton, J. P. & Law, C. J., 15 Feb 2017, In : Nature Scientific Reports. 7, 42850.Research output: Contribution to journal › Article
Open Access
File
5
Citations
(Scopus)
219
Downloads
(Pure)
Insight into determinants of substrate binding and transport in a multidrug efflux protein
Alegre, K. O., Paul, S., Labarbuta, P. & Law, C. J., 10 Mar 2016, In : Nature Scientific Reports. 6, 12 p., 22833.Research output: Contribution to journal › Article
Open Access
File
8
Citations
(Scopus)
228
Downloads
(Pure)
Synthesis of novel pyrophosphorothiolate-linked dinucleoside cap analogues in a ball mill
Eguaogie, O., Cooke, L., Martin, P. M. L., Ravalico, F., Conway, L. P., Hodgson, D. R. W., Law, C. J. & Vyle, J. S., 2016, In : Organic and Biomolecular Chemistry. 14, 4, p. 1201–1205 5 p.Research output: Contribution to journal › Article
Open Access
File
12
Citations
(Scopus)
267
Downloads
(Pure)
Prizes
Activities
Edmund Kunji
Christopher Law (Host)
18 Sep 2018
Activity: Hosting a visitor types › Hosting an academic visitor
Prof Richard Cogdell, FRS
Christopher Law (Host)
18 Apr 2018
Activity: Hosting a visitor types › Hosting an academic visitor
Deutsche Forschungsgemeinschaft (German Research Foundation) (External organisation)
Christopher Law (Reviewer)
2018
Activity: Membership types › Membership of peer review panel or committee
Journal of Antimicrobial Chemotherapy (Journal)
Christopher Law (Peer reviewer)
2018
Activity: Publication peer-review and editorial work types › Publication peer-review
Iron homeostasis in malaria
Christopher Law (Speaker)
01 Sep 2017
Activity: Talk or presentation types › Invited talk
Thesis
Purification and characterisation of the Escherichia coli multidrug efflux protein MdtM
Author: Knipe, S., Dec 2013Supervisor: Law, C. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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