Projects per year
Personal profile
Interests
Nanomedicine, Antibodies, Antibody-Drug Conjugates (ADCs), cathepsin proteases, cancer, inflammation, infection
Research Statement
Professor Chris Scott is Acting Director of the Centre for Cancer Research and Cell Biology at Queen’s University Belfast. Following a primary degree in Biochemistry he undertook a PhD and post doctoral training at Queen’s in molecular enzymology. In 2001, Chris was one of the founding members of QUB spinout company Fusion Antibodies Ltd., before returning to Queen’s in 2003 to take up an academic position. Chris is internationally renowned for his work in development of antibody and nanomedicine-based therapies for the treatment of cancer and other conditions. Work in his laboratory is funded by agencies such as Medical Research Council, HSCNI, and various industrial sources such as AstraZeneca and Immunocore. He also held a Royal Society Industrial Fellowship with GSK from 2012-15, and won the Vice Chancellor’s Prize for Innovation in 2015 with his group’s work on developing a novel nanomedicine for the treatment of sepsis and other inflammatory conditions. Chris is actively involved in nanomedicine across the UK and is a Trustee of the British Society of Nanomedicine.
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Projects
R1135CNR: Exploiting the cancer epigenome to develop a common cancer vaccine
McDade, S., Jafarnejad, S. M. & Scott, C.
10/01/2020 → …
Project: Research
R1846CNR: Development of intracellular VNARs as novel tools to dissect intracellular biological processes
20/12/2017 → …
Project: Research
Research Output
A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis
Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, In : EMBO Reports. e49254.Research output: Contribution to journal › Article
Open Access
File
4
Citations
(Scopus)
42
Downloads
(Pure)
FLIP(L): the pseudo‐caspase
Smyth, P., Sessler, T., Scott, C. & Longley, D., 24 Feb 2020, In : FEBS journal.Research output: Contribution to journal › Article
Open Access
File
pH-Responsive benzaldehyde-functionalized PEG-based polymeric nanoparticles for drug delivery: Effect of preparation method on morphology, dye encapsulation and attachment
Smyth, P., Gibson, T. J., Irvine, G., Black, G., Lavery, D., Semsarilar, M., Scott, C. J. & Themistou, E., 02 Jan 2020, In : European Polymer Journal. 124, 109471.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Refined construction of antibody-targeted nanoparticles leads to superior antigen binding and enhanced delivery of an entrapped payload to pancreatic cancer cells
Greene, M., Nogueira, J., Tracey, S., Richards, D., McDaid, W., Burrows, J., Campbell, K., Longley, D., Chudasama, V. & Scott, C., 14 May 2020, In : Nanoscale.Research output: Contribution to journal › Article
Open Access
File
Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications
Hill, M., Twigg, M., Sheridan, E. A., Hardy, J. G., Elborn, J. S., Taggart, C. C., Scott, C. J. & Migaud, M. E., 02 Aug 2019, In : Pharmaceutics. 11, 8, 12 p., 379.Research output: Contribution to journal › Article
Open Access
File
1
Citation
(Scopus)
89
Downloads
(Pure)
Activities
KTP/ Causeway Sensors Ltd - S2410CNR
Christopher Scott (Member), & James Burrows (Member)
01 Apr 2017 → 31 Mar 2020
Activity: Consultancy types › KTP & Consultancy in kind
British Society of Nanomedicine
Jonathan Coulter (Member of the organising committee), & Christopher Scott (Organiser)
10 Aug 2017 → 11 Aug 2017
Activity: Participating in or organising an event types › Participation in conference
Thesis
Development of Novel Antibody-Targeted Nanoparticle Strategies for Treatment of Pancreatic Cancer
Author: Johnston, M., Jul 2020Supervisor: Longley, D. (Supervisor) & Scott, C. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
Development of versatile drug delivery strategies using PLGA nanoparticles
Author: Fay, F., Jul 2010Supervisor: Scott, C. (Supervisor), Gilmore, B. (Supervisor) & McCarron, P. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
DNA Repair Deficincies as a Biomarker for Treatment Response in Acute Myeloid Leukaemia
Author: Crean, C., Jul 2020Supervisor: Mills, K. (Supervisor), Scott, C. (Supervisor) & Prise, K. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File