Projects per year
Personal profile
Interests
Nanomedicine, Antibodies, Antibody-Drug Conjugates (ADCs), cathepsin proteases, cancer, inflammation, infection
Research Statement
Professor Chris Scott is Director of the Patrick G Johnston Centre for Cancer Research. Following a primary degree in Biochemistry he undertook a PhD and post doctoral training at Queen’s in molecular enzymology. In 2001, Chris was one of the founding members of QUB spinout company Fusion Antibodies Ltd., before returning to Queen’s in 2003 to take up an academic position. Chris is internationally renowned for his work in development of antibody and nanomedicine-based therapies for the treatment of cancer and other conditions. Work in his laboratory is funded by agencies such as Medical Research Council, US-Ireland, and various industrial sources such as AstraZeneca and Immunocore. He also held a Royal Society Industrial Fellowship with GSK from 2012-15, and won the Vice Chancellor’s Prize for Innovation in 2015 with his group’s work on developing a novel nanomedicine for the treatment of sepsis and other inflammatory conditions. Chris is a member of the Medical Research Council Developmental Pathway Funding Scheme Panel.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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R1589CNR: Dissecting the role of macrophage-derived cysteine cathepsin S in lung adenocarcinoma
Small, D., Kerr, E., Scott, C. & Williams, R.
06/12/2021 → …
Project: Research
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R1135CNR: Exploiting the cancer epigenome to develop a common cancer vaccine
McDade, S., Jafarnejad, S. M. & Scott, C.
10/01/2020 → …
Project: Research
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Cathepsin S (CTSS) activity in health and disease - A treasure trove of untapped clinical potential
Smyth, P., Sasiwachirangkul, J., Williams, R. & Scott, C. J., Dec 2022, In: Molecular Aspects of Medicine. 88, 101106.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Downloads (Pure) -
Lysosomal cysteine proteases are mediators of cell death in macrophages following exposure to amorphous silica nanoparticles
Ishaq, F., Sereesongsaeng, N., Johnston, M. C., Scott, C. J. & Burden, R. E., 01 Apr 2022, In: Chemico-biological interactions. 356, 109882.Research output: Contribution to journal › Article › peer-review
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USP17 is required for peripheral trafficking of lysosomes
Lin, J., McCann, A., Sereesongsaeng, N., Burden, J., Alsa'd, A. A. M., Burden, R., Micu, I., Williams, R., Van Schaeybroeck, S., Evergren, E., Mullan, P., Scott, C. & Burrows, J., 26 Jan 2022, In: EMBO Reports.Research output: Contribution to journal › Article › peer-review
Open AccessFile99 Downloads (Pure) -
Antibody therapy in pancreatic cancer: mAb-ye we're onto something?
Boland, A. J., O'Kane, A. A., Buick, R., Longley, D. B. & Scott, C. J., Aug 2021, In: Biochimica et Biophysica Acta - Reviews on Cancer. 1876, 1, 20 p., 188557.Research output: Contribution to journal › Article › peer-review
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Developing a series of inhaled reversible peptide inhibitors against Cathepsin S
Suleiman, H., Taggart, C., Scott, C. & Williams, R., 25 Feb 2021, Winter School (Medicine, Dentistry and Biomedical Sciences) Meeting 2021: Proteinases and their Inhibitors.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Activities
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Robert STRAUBINGER
Christopher Scott (Host)
Jan 2022 → Jul 2022Activity: Hosting a visitor types › Hosting an academic visitor
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CSO and scientific co-founder
Christopher Scott (Advisor)
Jan 2022Activity: Consultancy types › KTP & Consultancy in kind
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Medical Research Council (External organisation)
Christopher Scott (Advisor)
Jan 2022Activity: Membership types › Membership of peer review panel or committee
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AilseVax Ltd
Christopher Scott (Advisor)
Dec 2021Activity: Consultancy types › KTP & Consultancy in kind
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Medical Research Council (External organisation)
Christopher Scott (Advisor)
2021Activity: Membership types › Membership of peer review panel or committee