• Room 03.002 - CCRCB

    United Kingdom

Accepting PhD Students

20002020

Research output per year

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Personal profile

Interests

Nanomedicine, Antibodies, Antibody-Drug Conjugates (ADCs), cathepsin proteases, cancer, inflammation, infection

Research Statement

Professor Chris Scott is Acting Director of the Centre for Cancer Research and Cell Biology at Queen’s University Belfast.  Following a primary degree in Biochemistry he undertook a PhD and post doctoral training at Queen’s in molecular enzymology.  In 2001, Chris was one of the founding members of QUB spinout company Fusion Antibodies Ltd., before returning to Queen’s in 2003 to take up an academic position.  Chris is internationally renowned for his work in development of antibody and nanomedicine-based therapies for the treatment of cancer and other conditions.  Work in his laboratory is funded by agencies such as Medical Research Council, HSCNI, and various industrial sources such as AstraZeneca and Immunocore.  He also held a Royal Society Industrial Fellowship with GSK from 2012-15, and won the Vice Chancellor’s Prize for Innovation in 2015 with his group’s work on developing a novel nanomedicine for the treatment of sepsis and other inflammatory conditions. Chris is actively involved in nanomedicine across the UK and is a Trustee of the British Society of Nanomedicine.

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Projects

Research Output

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, In : EMBO Reports. e49254.

Research output: Contribution to journalArticle

Open Access
File
  • 4 Citations (Scopus)
    42 Downloads (Pure)

    FLIP(L): the pseudo‐caspase

    Smyth, P., Sessler, T., Scott, C. & Longley, D., 24 Feb 2020, In : FEBS journal.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 6 Downloads (Pure)
  • 1 Citation (Scopus)
    Open Access
    File
  • 5 Downloads (Pure)

    Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications

    Hill, M., Twigg, M., Sheridan, E. A., Hardy, J. G., Elborn, J. S., Taggart, C. C., Scott, C. J. & Migaud, M. E., 02 Aug 2019, In : Pharmaceutics. 11, 8, 12 p., 379.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 1 Citation (Scopus)
    89 Downloads (Pure)

    Activities

    • 1 Participation in conference
    • 1 KTP & Consultancy in kind

    KTP/ Causeway Sensors Ltd - S2410CNR

    Christopher Scott (Member), & James Burrows (Member)

    01 Apr 201731 Mar 2020

    Activity: Consultancy typesKTP & Consultancy in kind

    British Society of Nanomedicine

    Jonathan Coulter (Member of the organising committee), & Christopher Scott (Organiser)

    10 Aug 201711 Aug 2017

    Activity: Participating in or organising an event typesParticipation in conference

    Thesis

    Development of Novel Antibody-Targeted Nanoparticle Strategies for Treatment of Pancreatic Cancer

    Author: Johnston, M., Jul 2020

    Supervisor: Longley, D. (Supervisor) & Scott, C. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Development of versatile drug delivery strategies using PLGA nanoparticles

    Author: Fay, F., Jul 2010

    Supervisor: Scott, C. (Supervisor), Gilmore, B. (Supervisor) & McCarron, P. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    DNA Repair Deficincies as a Biomarker for Treatment Response in Acute Myeloid Leukaemia

    Author: Crean, C., Jul 2020

    Supervisor: Mills, K. (Supervisor), Scott, C. (Supervisor) & Prise, K. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File