• Room 03.002 - CCRCB

    United Kingdom

Accepting PhD Students

20002020
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Research Output 2000 2020

2020
11 Downloads (Pure)

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, In : EMBO Reports. e49254.

Research output: Contribution to journalArticle

Open Access
File
Death Domain Receptor Signaling Adaptor Proteins
CASP8 and FADD-Like Apoptosis Regulating Protein
Apoptosis
Caspase 8
Death Domain Receptors
Drug delivery
Encapsulation
Polyethylene glycols
attachment
delivery
2019
1 Citation (Scopus)
63 Downloads (Pure)

Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications

Hill, M., Twigg, M., Sheridan, E. A., Hardy, J. G., Elborn, J. S., Taggart, C. C., Scott, C. J. & Migaud, M. E., 02 Aug 2019, In : Pharmaceutics. 11, 8, 12 p., 379.

Research output: Contribution to journalArticle

Open Access
File
Tobramycin
Chitosan
Mucus
Drug Delivery Systems
Cystic Fibrosis
66 Downloads (Pure)

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

Wilkinson, R., Burden, R., McDowell, S., McArt, D., McQuaid, S., Bingham, V., Williams, R., Cox, O., O'Connor, R., McCabe, N., Kennedy, R., Buckley, N. E. & Scott, C., 28 Jun 2019, In : Journal of Oncology.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Triple Negative Breast Neoplasms
Biomarkers
Neoplasms
DNA Repair

Identification and SAR exploration of a novel series of Legumain inhibitors

Eddie, S. L., Gregson, A., Graham, E., Burton, S., Harrison, T., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 15 Jun 2019, In : Bioorganic & Medicinal Chemistry Letters. 29, 12, p. 1546-1548 3 p.

Research output: Contribution to journalArticle

asparaginylendopeptidase
Dipeptides
Molecules
Research
Experiments
2 Citations (Scopus)
55 Downloads (Pure)

Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

Nogueira, J. C. F., Greene, M. K., Richards, D. A., Furby, A. O., Steven, J., Porter, A., Barelle, C., Scott, C. J. & Chudasama, V., 27 Jun 2019, In : Chemical Communications. 55, 53, p. 7671-7674

Research output: Contribution to journalArticle

Open Access
File
glycolic acid
Nanoconjugates
Antigen Receptors
Lactic acid
Antigens
1 Citation (Scopus)

Repurposing of Cetuximab in antibody-directed chemotherapy-loaded nanoparticles in EGFR therapy-resistant pancreatic tumours

McDaid, W. J., Greene, M. K., Johnston, M. C., Pollheimer, E., Smyth, P., McLaughlin, K., Van Schaeybroeck, S., Straubinger, R. M., Longley, D. B. & Scott, C. J., 18 Oct 2019, In : Nanoscale. 13 p.

Research output: Contribution to journalArticle

Chemotherapy
Epidermal Growth Factor Receptor
Antibodies
Tumors
Nanoparticles
1 Citation (Scopus)

Star polymers with acid-labile diacetal-based cores synthesized by aqueous RAFT polymerization for intracellular DNA delivery

Gibson, T. J., Smyth, P., Semsarilar, M., McCann, A. P., McDaid, W. J., Johnston, M. C., Scott, C. J. & Themistou, E., 05 Jul 2019, In : Polymer Chemistry. 11, 2, p. 344-357 14 p.

Research output: Contribution to journalArticle

Polymerization
Stars
Polymers
DNA
Acids
2 Citations (Scopus)

Targeting of Cathepsin S Reduces Cystic Fibrosis-like Lung Disease

Small, D. M., Brown, R. R., Doherty, D. F., Abladey, A., Zhou- Suckow, Z., Delaney, R. J., Kerrigan, L., Dougan, C. M., Borensztajn, K. S., Holsinger, L., Booth, R., Scott, C. J., Lopez Campos, G., Elborn, J. S., Mall, M. A., Weldon, S. & Taggart, C. C., 28 Mar 2019, In : European Respiratory Journal. 53, 3, 1801523.

Research output: Contribution to journalArticle

cathepsin S
Cystic Fibrosis
Lung Diseases
Cats
Epithelial Sodium Channels
2018
5 Citations (Scopus)
148 Downloads (Pure)
Open Access
File
Klebsiella Infections
Klebsiella pneumoniae
Gentamicins
Nanoparticles
Microbial Viability
1 Citation (Scopus)
29 Downloads (Pure)

Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe

Cogo, F., Smyth, P., Burden, R., Longley, D. B., Williams, R., Johnston, M., Poreba, M., Rut, W., Groborz, K., Salvesen, G., Drag, M. & Scott, C. J., 13 Dec 2018, In : Nanoscale - Royal Society of Chemistry.

Research output: Contribution to journalArticle

Open Access
File
Caspase 3
Labels
Labeling
Tumors
Pharmacodynamics
226 Downloads (Pure)
Open Access
File
Bacterial Infections
Anti-Bacterial Agents
Staphylococcal Pneumonia
Nanomedicine
Acinetobacter baumannii
3 Citations (Scopus)
62 Downloads (Pure)

Single-Domain Antibody-Functionalized pH-Responsive Amphiphilic Block Copolymer Nanoparticles for Epidermal Growth Factor Receptor Targeted Cancer Therapy

Gibson, T. J., Smyth, P., McDaid, W. J., Lavery, D., Thom, J., Cotton, G., Scott, C. J. & Themistou, E., 21 Aug 2018, In : ACS Macro Letters. 7, 8, p. 1010-1015

Research output: Contribution to journalArticle

Open Access
File
Single-Domain Antibodies
Nanoconjugates
Epidermal Growth Factor Receptor
Antibodies
Block copolymers
112 Downloads (Pure)

USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells

McCann, A. P., Smyth, P., Cogo, F., McDaid, W. J., Jiang, L., Lin, J., Evergren, E., Burden, R. E., Van Schaeybroeck, S., Scott, C. J. & Burrows, J. F., 08 Nov 2018, In : Cell communication and signaling : CCS. 16, 1, p. 77

Research output: Contribution to journalArticle

Open Access
File
Clathrin
Protein-Tyrosine Kinases
Exons
Chemical activation
Apoptosis
2017
15 Citations (Scopus)
425 Downloads (Pure)

Aspirin reduces lipopolysaccharide induced pulmonary inflammation in human models of ARDS

Hamid, U., Krasnodembskaya, A., Fitzgerald, M., Shyamsundar, M., Kissenpfennig, A., Scott, C., Lefrancais, E., Mark R, L., Verghis, R., Scott, J., Simpson, A. J., McNamee, J., McAuley, D. & O'Kane, C. M., 12 Jan 2017, In : Thorax. 72, p. 971-980 10 p.

Research output: Contribution to journalArticle

Open Access
File
Adult Respiratory Distress Syndrome
Aspirin
Lipopolysaccharides
Pneumonia
Bronchoalveolar Lavage
26 Citations (Scopus)
234 Downloads (Pure)

Generating Next-Generation Antibody-Nanoparticle Conjugates through the Oriented Installation of Non-Engineered Antibody Fragments

Greene, M. K., Richards, D. A., Nogueira, J. C. F., Campbell, K., Smyth, P., Fernańdez, M., Scott, C. J. & Chudasama, V., 14 Aug 2017, In : Chemical Science. 1, p. 79-87 9 p.

Research output: Contribution to journalArticle

Open Access
File
Immunoglobulin Fragments
Nanoparticles
Antibodies
Antibody Binding Sites
Ligands
7 Citations (Scopus)
67 Downloads (Pure)
Open Access
File
Salt mines
Transaminases
Amines
Enzymes
Ketones

Method and Kit for Detection of Bacterial Infection

Taggart, C., Weldon, S. & Scott, C., 2017, Patent No. 1509564.9, 06 Feb 2015

Research output: Patent

1 Citation (Scopus)

Microneedles in Nanomedicine Delivery

Tekko, I., Larrañeta, E., Rodgers, A., Scott, C., Kissenpfennig, A. & Donnelly, R., 31 Oct 2017, Nanotechnologies in Preventive and Regenerative Medicine. Elsevier, p. 131 163 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2016
12 Citations (Scopus)
243 Downloads (Pure)

A bioavailable cathepsin S nitrile inhibitor abrogates tumor development

Wilkinson, R. D. A., Young, A., Burden, R. E., Williams, R. & Scott, C. J., 21 Apr 2016, In : Molecular Cancer. 15, 29, 11 p.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Nitriles
Neoplasms
MCF-7 Cells
Apoptosis
7 Citations (Scopus)

Deubiquitylating enzymes in receptor endocytosis and trafficking

McCann, A. P., Scott, C. J., Van Schaeybroeck, S. & Burrows, J. F., 09 Dec 2016, In : Biochemical Journal. 473, 24, p. 4507-4525 19 p.

Research output: Contribution to journalArticle

Ubiquitin
Endocytosis
Enzymes
Degradation
Cell membranes
147 Downloads (Pure)

Encapsulation of the p38 MAPK inhibitor GSK 678361A in nanoparticles for inflammatory‐based disease states

Bains, B., Greene, M. K., McGirr, L., Dorman, J., Farrow, S. & Scott, C., 29 May 2016, In : Journal of Interdisciplinary Nanomedicine. 1, 3, p. 85-92

Research output: Contribution to journalArticle

Open Access
File
p38 Mitogen-Activated Protein Kinases
Protein Kinase Inhibitors
Nanoparticles
Anti-Inflammatory Agents
Macrophages
16 Citations (Scopus)
236 Downloads (Pure)

Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

Hughes, C. S., Colhoun, L. M., Bains, B. K., Kilgour, J. D., Burden, R. E., Burrows, J. F., Lavelle, E. C., Gilmore, B. F. & Scott, C. J., 23 Apr 2016, In : Particle and fibre toxicology. 13, 19, 13 p.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Caspase 1
Macrophages
Biomarkers
Interleukin-1
27 Citations (Scopus)

IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination

Oleszycka, E., Moran, H. B. T., Tynan, G. A., Hearnden, C. H., Coutts, G., Campbell, M., Allan, S. M., Scott, C. J. & Lavelle, E. C., 11 Jan 2016, In : FEBS journal. 283, 1, p. 9-24 16 p.

Research output: Contribution to journalArticle

Inflammasomes
Neutrophil Infiltration
Interleukin-1
Infiltration
Vaccination
20 Citations (Scopus)

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

Hamon, Y., Legowska, M., Hervé, V., Dallet-Choisy, S., Marchand-Adam, S., Vanderlynden, L., Demonte, M., Williams, R., Scott, C. J., Si-Tahar, M., Heuzé-Vourc'h, N., Lalmanach, G., Jenne, D. E., Lesner, A., Gauthier, F. & Korkmaz, B., 15 Apr 2016, In : The Journal of biological chemistry. 291, 16, p. 8486-99 14 p.

Research output: Contribution to journalArticle

Cathepsin C
Pulmonary diseases
Lung Diseases
Serine Proteases
Cats
7 Citations (Scopus)

Strategies for detection and quantification of cysteine cathepsins-evolution from bench to bedside

Hughes, C. S., Burden, R. E., Gilmore, B. F. & Scott, C. J., Mar 2016, In : Biochimie. 122, p. 48-61 14 p.

Research output: Contribution to journalArticle

Cathepsins
Cysteine
Peptide Hydrolases
Sulfhydryl Compounds
Labeling
2 Citations (Scopus)
cathepsin S
Cathepsins
Cysteine
Biotin
Click Chemistry
2015
59 Citations (Scopus)
1254 Downloads (Pure)
Open Access
File
Pseudomonas Infections
Tobramycin
Cystic Fibrosis
Nanoparticles
Pseudomonas aeruginosa
64 Citations (Scopus)

Cathepsin S: therapeutic, diagnostic, and prognostic potential

Wilkinson, R. D. A., Williams, R., Scott, C. J. & Burden, R. E., Aug 2015, In : Biological Chemistry. 396, 8, p. 867-82 16 p.

Research output: Contribution to journalArticle

cathepsin S
Cathepsins
Cysteine
Peptide Hydrolases
Therapeutics
16 Citations (Scopus)
187 Downloads (Pure)

CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

Wilkinson, R., Magorrian, S., Williams, R., Young, A., Small, D., Scott, C. & Burden, R., 22 Aug 2015, In : Oncotarget. p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
protease S
Neoplasms
Tumor Microenvironment

CD74: a potential mediator of resistance in the treatment of Glioblastoma

Magorrian, S., Coulter, J., Flannery, T., Scott, C. & Burden, R., 01 Dec 2015, p. A40 . 1 p.

Research output: Contribution to conferenceAbstract

Glioblastoma
Cell Line
Survival
temozolomide
Radiation
6 Citations (Scopus)

Development of a potent and selective cell penetrant Legumain inhibitor

Ness, K. A., Eddie, S. L., Higgins, C. A., Templeman, A., D'Costa, Z., Gaddale, K. K. D., Bouzzaoui, S., Jordan, L., Janssen, D., Harrison, T., Burkamp, F., Young, A., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 01 Dec 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 23, p. 5642-5645

Research output: Contribution to journalLetter

asparaginylendopeptidase
Assays
Cell Survival
Cells
Molecules
45 Citations (Scopus)
318 Downloads (Pure)
Open Access
File
Cross-Priming
Immunization
Langerhans Cells
Nanoparticles
Skin
20 Citations (Scopus)

Laser-engineered dissolving microneedle arrays for protein delivery: potential for enhanced intradermal vaccination

McCrudden, M. T. C., Torrisi, B. M., Al-Zahrani, S., McCrudden, C. M., Zaric, M., Scott, C. J., Kissenpfennig, A., McCarthy, H. O. & Donnelly, R. F., Mar 2015, In : Journal of Pharmacy and Pharmacology. 67, 3, p. 409-425 17 p.

Research output: Contribution to journalArticle

Protein Array Analysis
Ovalbumin
Vaccination
Lasers
Interleukin-4
48 Citations (Scopus)
673 Downloads (Pure)

Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation

Spence, S., Greene, M. K., Fay, F., Hams, E., Saunders, S. P., Hamid, U., Fitzgerald, M., Beck, J., Bains, B. K., Smyth, P., Themistou, E., Small, D. M., Schmid, D., O'Kane, C. M., Fitzgerald, D. C., Abdelghany, S. M., Johnston, J. A., Fallon, P. G., Burrows, J. F., McAuley, D. F. & 2 others, Kissenpfennig, A. & Scott, C. J., 02 Sep 2015, In : Science Translational Medicine. 7, 303, 12 p., 140.

Research output: Contribution to journalArticle

Open Access
File
Sialic Acid Binding Immunoglobulin-like Lectins
N-Acetylneuraminic Acid
Nanoparticles
Inflammation
Sepsis
5 Citations (Scopus)
702 Downloads (Pure)

The utility of animal models in developing immunosuppressive agents

McDaid, J., Scott, C. J., Kissenpfennig, A., Chen, H. & Martins, P. N., 15 Jul 2015, In : European Journal of Pharmacology. 759, p. 295-302 8 p.

Research output: Contribution to journalReview article

File
Immunosuppressive Agents
Animal Models
Autoimmune Diseases
Psychological Stress
Pharmaceutical Preparations
2014
10 Citations (Scopus)
203 Downloads (Pure)

A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17

Jaworski, J., Govender, U., McFarlane, C., De La Vega, M., Greene, M. K., Rawlings, N. D., Johnston, J. A., Scott, C. J. & Burrows, J. F., 15 Jan 2014, In : Biochemical Journal. 457, 2, p. 289-300 12 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Specific Proteases
Cell membranes
Protein Isoforms
Cell Membrane
Enzymes
19 Citations (Scopus)
275 Downloads (Pure)

Efficient Drug Delivery and Induction of Apoptosis in Colorectal Tumors Using a Death Receptor 5-Targeted Nanomedicine

Schmid, D., Fay, F., Small, D. M., Jaworski, J., Riley, J. S., Tegazzini, D., Fenning, C., Jones, D. S., Johnston, P. G., Longley, D. B. & Scott, C. J., Dec 2014, In : Molecular therapy : the journal of the American Society of Gene Therapy. 22, 12, p. 2083-2092 10 p.

Research output: Contribution to journalArticle

Open Access
File
TNF-Related Apoptosis-Inducing Ligand Receptors
Nanomedicine
Colorectal Neoplasms
Apoptosis
Pharmaceutical Preparations
39 Citations (Scopus)

miR-31 Dysregulation in Cystic Fibrosis Airways Contributes to Increased Pulmonary Cathepsin S Production

Weldon, S., McNally, P., McAuley, D. F., Oglesby, I. K., Wohlford-Lenane, C. L., Bartlett, J. A., Scott, C. J., McElvaney, N. G., Greene, C. M., McCray, P. B. & Taggart, C. C., 15 Jul 2014, In : American Journal of Respiratory and Critical Care Medicine. 190, 2, p. 165-174

Research output: Contribution to journalArticle

cathepsin S
Cystic Fibrosis
Lung
Epithelial Cells
Interferon Regulatory Factor-1
23 Citations (Scopus)
183 Downloads (Pure)

Nanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity

Schmid, D., Jarvis, G. E., Fay, F., Small, D. M., Greene, M. K., Majkut, J., Spence, S., McLaughlin, K. M., McCloskey, K. D., Johnston, P. G., Kissenpfennig, A., Longley, D. B. & Scott, C. J., 09 Oct 2014, In : Cell, Death & Disease. 5, 11 p., e1454.

Research output: Contribution to journalArticle

Open Access
File
Camptothecin
Nanoparticles
Topoisomerase I Inhibitors
Leukopenia
Therapeutic Uses
4 Citations (Scopus)

P3 SAR exploration of biphenyl carbamate based Legumain inhibitors

Higgins, C., Bouazzaoui, S., Gaddale Devanna, K., D'Costa, Z., Templeman, A., O'Rourke, M., Young, A., Scott, C., Harrison, T., Mullan, P. & Williams, R., 01 Jun 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 11, p. 2521-2524

Research output: Contribution to journalArticle

asparaginylendopeptidase
Carbamates
Enzymes
diphenyl
23 Citations (Scopus)
195 Downloads (Pure)

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.

D'Costa, Z. C., Higgins, C., Ong, C. W., Irwin, G. W., Boyle, D., McArt, D. G., McCloskey, K., Buckley, N. E., Crawford, N. T., Thiagarajan, L., Murray, J. T., Kennedy, R. D., Mulligan, K. A., Harkin, D. P., Waugh, D. J. J., Scott, C. J., Salto-Tellez, M., Williams, R. & Mullan, P. B., 08 Feb 2014, In : Oncotarget. 5, 6, p. 1609-1620 12 p.

Research output: Contribution to journalArticle

Open Access
File
asparaginylendopeptidase
Cystatin M
Breast Neoplasms
Neoplasms
Cathepsins
6 Citations (Scopus)
293 Downloads (Pure)

USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor

Jaworski, J., de la Vega, M., Fletcher, S. J., McFarlane, C., Greene, M. K., Smyth, A. W., Van Schaeybroeck, S., Johnston, J. A., Scott, C. J., Rappoport, J. Z. & Burrows, J. F., 30 Aug 2014, In : Oncotarget. 5, 16, p. 6964-6975 12 p.

Research output: Contribution to journalArticle

Open Access
File
Clathrin
Endocytosis
Epidermal Growth Factor Receptor
Transferrin
Amino Acid Motifs
2013
48 Citations (Scopus)
275 Downloads (Pure)

Cathepsin S from both tumour and tumour-associated cells promote cancer growth and neovascularisation

Small, D. M., Burden, R. E., Jaworski, J., Hegarty, S. M., Spence, S., Burrows, J. F., McFarlane, C., Kissenpfennig, A., McCarthy, H. O., Johnston, J. A., Walker, B. & Scott, C. J., Nov 2013, In : International Journal of Cancer. 133, 9, p. 2102-2112 11 p.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Growth
Neoplasms
53 Citations (Scopus)

Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N-methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles

Abdelghany, S. M., Schmid, D., Deacon, J., Jaworski, J., Fay, F., McLaughlin, K. M., Gormley, J. A., Burrows, J. F., Longley, D. B., Donnelly, R. F. & Scott, C. J., 11 Feb 2013, In : Biomacromolecules. 14, 2, p. 302-310

Research output: Contribution to journalArticle

Thymidine Monophosphate
Photosensitizing Agents
Photosensitizers
Alginate
Chitosan

Microneedles for vaccine delivery

Donnelly, R., Alzahrani, S., Zaric, M., McCrudden, C., Scott, C. & Kissenpfennig, A., 2013, (Accepted) Encyclopedia of Pharmaceutical Science and Technology. Swarbrick, J. (ed.). 4th ed. informa

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

94 Citations (Scopus)
1 Downloads (Pure)

Skin Dendritic Cell Targeting via Microneedle Arrays Laden with Antigen-Encapsulated Poly-D, L-lactide-co-Glycolide Nanoparticles Induces Efficient Antitumor and Antiviral Immune Responses

Zaric, M., Lyubomska, O., Touzelet, O., Poux, C., Al-Zahrani, S., Fay, F., Wallace, L., Terhorst, D., Malissen, B., Henri, S., Power, U. F., Scott, C. J., Donnelly, R. F. & Kissenpfennig, A., 26 Mar 2013, In : ACS Nano. 7, 3, p. 2042-2055 14 p.

Research output: Contribution to journalArticle

antigens
Antigens
Antiviral Agents
Skin
Nanoparticles

Vaccine delivery using microneedles

Donnelly, R., Alzahrani, S., Zaric, M., Scott, C., McCrudden, C. & Kissenpfennig, A., 2013, (Accepted) Molecular Vaccines: from Prophylaxis to Therapy. Giese, M. (ed.). Springer

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2012
84 Citations (Scopus)
339 Downloads (Pure)
Open Access
File
Pseudomonas Infections
Gentamicins
Nanoparticles
Pseudomonas aeruginosa
Hydrophilicity