Christopher Scott

Research output

Research output per year 2000 2008 2010 2011 2014 2015 2016 2017 2018 2019 2020 2021 2023

• 107 Article
• 5 Poster
• 5 Review article
• 4 Chapter
• 15 More
  • 4 Paper
  • 3 Chapter (peer-reviewed)
  • 3 Abstract
  • 2 Conference contribution
  • 1 Meeting abstract
  • 1 Web publication/site
  • 1 Patent

Research output per year

Research output per year

Search results

• 2023

  Bcl-xL is a key mediator of apoptosis following KRAS^G12C inhibition in KRAS^G12C-mutant colorectal cancer

  Khawaja, H., Briggs, R., Latimer, C. H., Rassel, M., Griffin, D., Hanson, L., Bardelli, A., Di Nicolantonio, F., McDade, S. S., Scott, C. J., Lambe, S., Maurya, M., Lindner, A. U., Prehn, J. H. M., Sousa, J., Winnington, C., LaBonte, M. J., Ross, S. & Van Schaeybroeck, S., 01 Jan 2023, In: Molecular Cancer Therapeutics. 22, 1, p. 135–149 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psychological Inhibition 95%
  • Colorectal Neoplasms 93%
  • Apoptosis 71%
  • Bcl-2-Like Protein 11 50%
  • Holidays 37%
  7 Downloads (Pure)

• Multifunctional low temperature-cured PVA/PVP/citric acid-based hydrogel forming microarray patches: physicochemical characteristics and hydrophilic drug interaction

  Himawan, A., Anjani, Q. K., Detamornrat, U., Vora, L. K., Permana, A. D., Ghanma, R., Naser, Y., Rahmawanty, D., Scott, C. J. & Donnelly, R. F., 15 Mar 2023, In: European Polymer Journal. 186, 16 p., 111836.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Drug interactions 100%
  • Citric acid 94%
  • citric acid 88%
  • Hydrogels 82%
  • Microarrays 69%
  17 Downloads (Pure)

• Where microneedle meets biomarkers: futuristic application for diagnosing and monitoring localized external organ diseases

  Himawan, A., Vora, L. K., Permana, A. D., Sudir, S., Nurdin, A. R., Nislawati, R., Hasyim, R., Scott, C. J. & Donnelly, R. F., 17 Feb 2023, In: Advanced Healthcare Materials. 12, 5, 33 p., 2202066.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Biomarkers 100%
  • Biological Marker 72%
  • Extracellular Fluid 60%
  • Interstitial 56%
  • Fluids 51%
  62 Downloads (Pure)
• 2022

  Cathepsin S (CTSS) activity in health and disease - A treasure trove of untapped clinical potential

  Smyth, P., Sasiwachirangkul, J., Williams, R. & Scott, C. J., Dec 2022, In: Molecular Aspects of Medicine. 88, 101106.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • cathepsin S 100%
  • Cysteine 54%
  • Antigen 53%
  • Health 31%
  • Biological Marker 28%
  62 Downloads (Pure)

• Lysosomal cysteine proteases are mediators of cell death in macrophages following exposure to amorphous silica nanoparticles

  Ishaq, F., Sereesongsaeng, N., Johnston, M. C., Scott, C. J. & Burden, R. E., 01 Apr 2022, In: Chemico-biological interactions. 356, 109882.

  Research output: Contribution to journal › Article › peer-review

  • Cysteine Proteases 100%
  • Silicon Dioxide 92%
  • Nanoparticles 72%
  • Cell Death 61%
  • Macrophages 56%

• One-step manufacturing of liposomal amphotericin B using the twin-screw extrusion method: in vitro comparisons

  Gu, W., Smyth, P., Scott, C., Jones, D., Andrews, G. & Tian, J., 07 Sep 2022.

  Research output: Contribution to conference › Paper › peer-review

• Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study

  Breast Cancer Association Consortium, 06 Sep 2022, (Early online date) In: British Journal of Sports Medicine. 56, 20, p. 1157-1170 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Random Allocation 100%
  • Exercise 66%
  • Breast Neoplasms 65%
  • Sedentary Behavior 36%
  • Confidence Intervals 30%

• USP17 is required for peripheral trafficking of lysosomes

  Lin, J., McCann, A., Sereesongsaeng, N., Burden, J., Alsa'd, A. A. M., Burden, R., Micu, I., Williams, R., Van Schaeybroeck, S., Evergren, E., Mullan, P., Scott, C. & Burrows, J., 26 Jan 2022, In: EMBO Reports.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lysosomes 100%
  • Plasma 60%
  • P62 54%
  • Toxin 31%
  • Cell Membrane 30%
  157 Downloads (Pure)
• 2021

  Antibody therapy in pancreatic cancer: mAb-ye we're onto something?

  Boland, A. J., O'Kane, A. A., Buick, R., Longley, D. B. & Scott, C. J., Aug 2021, In: Biochimica et Biophysica Acta - Reviews on Cancer. 1876, 1, 20 p., 188557.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Neoplasms 100%
  • Antibodies 58%
  • Cerebral Palsy 22%
  • Stromal Cells 21%
  • Therapeutics 17%

• Developing a series of inhaled reversible peptide inhibitors against Cathepsin S

  Suleiman, H., Taggart, C., Scott, C. & Williams, R., 25 Feb 2021, Winter School (Medicine, Dentistry and Biomedical Sciences) Meeting 2021: Proteinases and their Inhibitors.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • cathepsin S 100%
  • Cystic Fibrosis 62%
  • Peptides 40%
  • Cats 35%
  • Cystic Fibrosis Transmembrane Conductance Regulator 26%

• Development of an Inhaled CatS Inhibitor for the Treatment of CF: *This talk won the best talk of the session prize

  Fleming, C., Scott, C., Taggart, C. & Williams, R., 24 Feb 2021.

  Research output: Contribution to conference › Paper › peer-review

  • Cats 100%
  • Lung 63%
  • calcium pantothenate, carboxymethylcellulose, glycerin, silver sulfameter, xylene drug combination 48%
  • cathepsin S 37%
  • Bacterial Load 27%

• Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface

  Tracey, S. R., Smyth, P., Barelle, C. J. & Scott, C. J., Nov 2021, In: Biochemical Society Transactions. 49, 5, p. 2253-2269

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nanomedicine 100%
  • Nanoparticles 34%
  • Nanoparticle 29%
  • Neoplasms 25%
  • Surface 24%
  62 Downloads (Pure)

• Enhanced target-specific delivery of docetaxel-loaded nanoparticles using engineered T cell receptors

  McDaid, W. J., Lissin, N., Pollheimer, E., Greene, M., Leach, A., Smyth, P., Bossi, G., Longley, D., Cole, D. K. & Scott, C. J., 20 Aug 2021, (Early online date) In: Nanoscale. 13, 35, p. 15010-15020

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Antigens 90%
  • Tumors 69%
  • Nanoparticles 66%
  • Antigen 56%
  • Cells 39%
  60 Downloads (Pure)

• Nanomedicine in Pancreatic Cancer: Current Status and Future Opportunities for Overcoming Therapy Resistance

  Greene, M. K., Johnston, M. C. & Scott, C. J., 07 Dec 2021, (Early online date) In: Cancers. 13, 24, 26 p., 6175.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Nanomedicine 100%
  • Pancreatic Neoplasms 74%
  • Nanotechnology 31%
  • Neoplasms 25%
  • Drug Resistance 23%
  117 Downloads (Pure)

• Trafficking of Full-Length and N-Terminally Truncated Cathepsin B in Human Colorectal Carcinoma Cells

  Tamhane, T., Njenga, R. W., Burden, R. E., Büth, H., Maelandsmo, G. M., Haugen, M. H., Scott, C. J. & Brix, K., 15 Dec 2021, (Early online date) In: Applied Sciences. 11, 24, p. e11936 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cells 45%
  • cancer 44%
  • Cysteine 40%
  • nuclei 30%
  • Peptide 27%
  26 Downloads (Pure)
• 2020

  Anti-DLL4 VNAR targeted nanoparticles for targeting of both tumour and tumour associated vasculature

  Leach, A., Smyth, P., Ferguson, L., Steven, J., Greene, M. K., Branco, C. M., McCann, A. P., Porter, A., Barelle, C. J. & Scott, C. J., 21 Jul 2020, In: Nanoscale. 12, 27, p. 14751-14763 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Antigens 100%
  • Ligands 98%
  • Tumors 75%
  • Nanoparticles 73%
  • Antigen 62%
  5 Citations (Scopus)

  53 Downloads (Pure)

• A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

  Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, (Early online date) In: EMBO Reports. 21, e49254.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Death Domain Receptor Signaling Adaptor Proteins 100%
  • Reaction Stoichiometry 50%
  • Apoptosis 38%
  • Caspase 8 36%
  • Death Domain Receptors 9%
  12 Citations (Scopus)

  138 Downloads (Pure)

• Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer

  Sereesongsaeng, N., McDowell, S. H., Burrows, J. F., Scott, C. J. & Burden, R. E., 09 Dec 2020, In: Breast Cancer Research. 22, 1, p. 139

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Breast Neoplasms 47%
  • Proteins 27%
  • Cysteine Proteases 18%
  • Proteasome Endopeptidase Complex 15%
  • Peptide Hydrolases 12%
  1 Citation (Scopus)

  56 Downloads (Pure)

• Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer

  Greene, M. K., Chen, T., Robinson, E., Straubinger, N. L., Minx, C., Chan, D. K. W., Wang, J., Burrows, J. F., Van Schaeybroeck, S., Baker, J. R., Caddick, S., Longley, D. B., Mager, D. E., Straubinger, R. M., Chudasama, V. & Scott, C. J., 11 Sep 2020, In: British Journal of Cancer.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  1 Citation (Scopus)

  134 Downloads (Pure)

• DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models

  Johnston, M., Nicoll, J., Redmond, K., Smyth, P., Greene, M., McDaid, W., Crawford, N., Stott, K., Fox, J., Longley, D. & Scott, C., 10 Aug 2020, In: Journal of Controlled Release. 324, p. 610-619 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • TNF-Related Apoptosis-Inducing Ligand Receptors 100%
  • Pancreatic Neoplasms 67%
  • Nanoparticles 63%
  • Apoptosis 43%
  • Drug 37%
  6 Citations (Scopus)

  161 Downloads (Pure)

• FLIP(L): the pseudo‐caspase

  Smyth, P., Sessler, T., Scott, C. & Longley, D., 24 Feb 2020, In: FEBS journal.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell Death 68%
  • Caspase 8 44%
  • Caspases 38%
  • Apoptotic 36%
  • Enzymes 34%
  9 Citations (Scopus)

  72 Downloads (Pure)

• Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

  NBCS Collaborators, 16 Jun 2020, In: Scientific Reports. 10, 1, p. 9688

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Breast Neoplasms 100%
  • Mutation 87%
  • Homeodomain Proteins 16%
  • Germ-Line Mutation 13%
  • Neoplasm Genes 13%
  39 Downloads (Pure)

• Leading the invasion: The role of Cathepsin S in the tumour microenvironment

  McDowell, S. H., Gallaher, S. A., Burden, R. E. & Scott, C. J., 01 Oct 2020, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1867, 10, 118781.

  Research output: Contribution to journal › Article › peer-review

  • cathepsin S 100%
  • Tumor Microenvironment 66%
  • Peptide Hydrolases 21%
  • Neoplasms 16%
  • Cysteine Proteases 15%
  9 Citations (Scopus)

• pH-Responsive benzaldehyde-functionalized PEG-based polymeric nanoparticles for drug delivery: Effect of preparation method on morphology, dye encapsulation and attachment

  Smyth, P., Gibson, T. J., Irvine, G., Black, G., Lavery, D., Semsarilar, M., Scott, C. J. & Themistou, E., 02 Jan 2020, (Early online date) In: European Polymer Journal. 124, 109471.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Drug delivery 100%
  • Polyethylene glycols 95%
  • Encapsulation 83%
  • Dyes 83%
  • drugs 74%
  4 Citations (Scopus)

  134 Downloads (Pure)

• Procathepsin V is secreted in a TSH regulated manner from human thyroid epithelial cells and is accessible to an activity-based probe

  Al-Hashimi, A., Venugopalan, V., Rehders, M., Sereesongsaeng, N., Hein, Z., Springer, S., Weber, E., Führer, D., Bogyo, M. S., Scott, C. J., Burden, R. E. & Brix, K., 01 Dec 2020, In: International Journal of Molecular Sciences. 21, 23, 23 p., 9140.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thyroid Hormones 88%
  • Thyroid Stimulating Hormone 74%
  • Epithelial Cells 73%
  • hormones 66%
  • Thyroid Epithelial Cells 62%
  3 Citations (Scopus)

  2 Downloads (Pure)

• RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer

  Khawaja, H., Campbell, A., Roberts, J. Z., Javadi, A., O’Reilly, P., McArt, D., Allen, W. L., Majkut, J., Rehm, M., Bardelli, A., Di Nicolantonio, F., Scott, C. J., Kennedy, R., Vitale, N., Harrison, T., Sansom, O. J., Longley, D. B., Evergren, E. & Van Schaeybroeck, S., 29 Oct 2020, (Early online date) In: Cell death and disease. 11, 10, 18 p., 930.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • TNF-Related Apoptosis-Inducing Ligand Receptors 100%
  • GTP Phosphohydrolases 81%
  • Colorectal Neoplasms 57%
  • Cell Death 40%
  • Death Domain Receptor Signaling Adaptor Proteins 28%
  4 Citations (Scopus)

  61 Downloads (Pure)

• Refined construction of antibody-targeted nanoparticles leads to superior antigen binding and enhanced delivery of an entrapped payload to pancreatic cancer cells

  Greene, M., Nogueira, J., Tracey, S., Richards, D., McDaid, W., Burrows, J., Campbell, K., Longley, D., Chudasama, V. & Scott, C., 14 May 2020, (Early online date) In: Nanoscale. 2020, 12, 11647.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Antigens 100%
  • Antibodies 94%
  • Nanoparticles 73%
  • Cells 72%
  • Antigen 62%
  4 Citations (Scopus)

  80 Downloads (Pure)

• Significance of nuclear cathepsin V in normal thyroid epithelial and carcinoma cells

  Al-Hashimi, A., Venugopalan, V., Sereesongsaeng, N., Tedelind, S., Pinzaru, A. M., Hein, Z., Springer, S., Weber, E., Führer, D., Scott, C. J., Burden, R. E. & Brix, K., 01 Dec 2020, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1867, 12, 118846.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thyroid Epithelial Cells 98%
  • Carcinoma 49%
  • Cathepsin B 14%
  • Cell Cycle 13%
  • Cysteine 10%
  2 Citations (Scopus)

  107 Downloads (Pure)
• 2019

  Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications

  Hill, M., Twigg, M., Sheridan, E. A., Hardy, J. G., Elborn, J. S., Taggart, C. C., Scott, C. J. & Migaud, M. E., 02 Aug 2019, In: Pharmaceutics. 11, 8, 12 p., 379.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tobramycin 100%
  • Colistimethate Sodium 98%
  • colistinmethanesulfonic acid 80%
  • Alginates 78%
  • Chitosan 74%
  6 Citations (Scopus)

  145 Downloads (Pure)

• A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

  Wilkinson, R., Burden, R., McDowell, S., McArt, D., McQuaid, S., Bingham, V., Williams, R., Cox, O., O'Connor, R., McCabe, N., Kennedy, R., Buckley, N. E. & Scott, C., 28 Jun 2019, In: Journal of Oncology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • cathepsin S 100%
  • Triple Negative Breast Neoplasms 76%
  • Biomarkers 41%
  • DNA Repair 8%
  • DNA Damage 7%
  7 Citations (Scopus)

  159 Downloads (Pure)

• Application of nanotechnology to target and exploit tumour associated proteases

  Cogo, F., Williams, R., Burden, R. E. & Scott, C. J., 01 Nov 2019, In: Biochimie. 166, p. 112-131

  Research output: Contribution to journal › Review article › peer-review

  • Nanotechnology 100%
  • Peptide Hydrolases 70%
  • Protease Inhibitor 49%
  • Drug 44%
  • Nanomedicine 42%
  2 Citations (Scopus)

• Dissecting the role of Cathepsin S in DNA damage repair deficient tumours.

  Gallaher, S., Burden, R., Williams, R. & Scott, C., Nov 2019.

  Research output: Contribution to conference › Poster

• Identification and SAR exploration of a novel series of Legumain inhibitors

  Eddie, S. L., Gregson, A., Graham, E., Burton, S., Harrison, T., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 15 Jun 2019, In: Bioorganic & Medicinal Chemistry Letters. 29, 12, p. 1546-1548 3 p.

  Research output: Contribution to journal › Article › peer-review

  • asparaginylendopeptidase 100%
  • Dipeptides 75%
  • Dipeptide 58%
  • Probe 35%
  • In Vitro Techniques 25%
  2 Citations (Scopus)

• Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

  Nogueira, J. C. F., Greene, M. K., Richards, D. A., Furby, A. O., Steven, J., Porter, A., Barelle, C., Scott, C. J. & Chudasama, V., 27 Jun 2019, In: Chemical Communications. 55, 53, p. 7671-7674

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nanoconjugates 100%
  • Nanoconjugate 58%
  • Lactic acid 54%
  • Antigens 53%
  • Polyethylene glycols 51%
  9 Citations (Scopus)

  124 Downloads (Pure)

• Repurposing of Cetuximab in antibody-directed chemotherapy-loaded nanoparticles in EGFR therapy-resistant pancreatic tumours

  McDaid, W. J., Greene, M. K., Johnston, M. C., Pollheimer, E., Smyth, P., McLaughlin, K., Van Schaeybroeck, S., Straubinger, R. M., Longley, D. B. & Scott, C. J., 18 Oct 2019, (Early online date) In: Nanoscale. 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epidermal Growth Factor 100%
  • Chemotherapy 86%
  • Antibodies 73%
  • Tumors 59%
  • Nanoparticles 56%
  12 Citations (Scopus)

  232 Downloads (Pure)

• Star polymers with acid-labile diacetal-based cores synthesized by aqueous RAFT polymerization for intracellular DNA delivery

  Gibson, T. J., Smyth, P., Semsarilar, M., McCann, A. P., McDaid, W. J., Johnston, M. C., Scott, C. J. & Themistou, E., 05 Jul 2019, (Early online date) In: Polymer Chemistry. 11, 2, p. 344-357 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Polymerization 100%
  • Acids 80%
  • Polymers 79%
  • Biocompatible Material 79%
  • Methacrylate 74%
  12 Citations (Scopus)

  182 Downloads (Pure)

• Targeting of Cathepsin S Reduces Cystic Fibrosis-like Lung Disease

  Small, D. M., Brown, R. R., Doherty, D. F., Abladey, A., Zhou- Suckow, Z., Delaney, R. J., Kerrigan, L., Dougan, C. M., Borensztajn, K. S., Holsinger, L., Booth, R., Scott, C. J., Lopez Campos, G., Elborn, J. S., Mall, M. A., Weldon, S. & Taggart, C. C., 28 Mar 2019, In: European Respiratory Journal. 53, 3, 1801523.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • cathepsin S 100%
  • Cystic Fibrosis 62%
  • Lung Diseases 57%
  • Cats 53%
  • Transgenic Mice 31%
  17 Citations (Scopus)

  89 Downloads (Pure)
• 2018

  Antibody conjugated nanoparticles as a novel form of antibody drug conjugate chemotherapy

  Johnston, M. C. & Scott, C. J., Dec 2018, In: Drug Discovery Today: Technologies. 30, p. 63-69 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Immunoconjugates 100%
  • Nanoparticles 66%
  • Drug Therapy 44%
  • Antibodies 41%
  • Drug Delivery Systems 10%
  27 Citations (Scopus)

  541 Downloads (Pure)

• Clearance of intracellular Klebsiella pneumoniae infection using gentamicin-loaded nanoparticles

  Jiang, L., Greene, M. K., Insua, J. L., Sa-Pessoa, J., Small, D. M., Smyth, P., McCann, A., Cogo, F., Bengoechea, J. A., Taggart, C. C. & Scott, C. J., 25 Apr 2018, (Early online date) In: Journal of Controlled Release. 279, p. 316

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Klebsiella Infections 100%
  • Clearance 70%
  • Klebsiella pneumoniae 69%
  • Gentamicins 67%
  • Nanoparticles 57%
  16 Citations (Scopus)

  556 Downloads (Pure)

• Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe

  Cogo, F., Smyth, P., Burden, R., Longley, D. B., Williams, R., Johnston, M., Poreba, M., Rut, W., Groborz, K., Salvesen, G., Drag, M. & Scott, C. J., 13 Dec 2018, (Early online date) In: Nanoscale - Royal Society of Chemistry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Probe 100%
  • Label 71%
  • Labels 69%
  • Apoptotic 63%
  • Tumors 56%
  3 Citations (Scopus)

  232 Downloads (Pure)

• Nanodelivery strategies for the treatment of multidrug-resistant bacterial infections

  Jiang, L., Lin, J., Taggart, C., Bengoechea, J. & Scott, C., 04 Sep 2018, (Early online date) In: Journal of Interdisciplinary Nanomedicine. p. 1-11

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Resistance 22%
  354 Downloads (Pure)

• Nanotechnologies for tissue engineering and regeneration

  Ventre, M., Coppola, V., Iannone, M., Netti, P. A., Tekko, I., Larrañeta, E., Rodgers, A. M., Scott, C. J., Kissenpfennig, A., Donnelly, R. F., Maher, S., Losic, D., George, A. & Ramachandran, A., 2018, Nanotechnologies in preventive and regenerative medicine. An emerging big picture . Elsevier, p. 93-206 114 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Nanotechnology 100%
  • Biocompatible Materials 85%
  • Tissue Engineering 81%
  • Regeneration 70%
  • Stem Cells 61%
  10 Citations (Scopus)

• Single-Domain Antibody-Functionalized pH-Responsive Amphiphilic Block Copolymer Nanoparticles for Epidermal Growth Factor Receptor Targeted Cancer Therapy

  Gibson, T. J., Smyth, P., McDaid, W. J., Lavery, D., Thom, J., Cotton, G., Scott, C. J. & Themistou, E., 21 Aug 2018, In: ACS Macro Letters. 7, 8, p. 1010-1015

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epidermal Growth Factor 100%
  • Nanoconjugates 96%
  • Block copolymers 79%
  • Antibodies 73%
  • Nanoparticles 56%
  8 Citations (Scopus)

  243 Downloads (Pure)

• USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells

  McCann, A. P., Smyth, P., Cogo, F., McDaid, W. J., Jiang, L., Lin, J., Evergren, E., Burden, R. E., Van Schaeybroeck, S., Scott, C. J. & Burrows, J. F., 08 Nov 2018, In: Cell communication and signaling : CCS. 16, 1, p. 77

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Oncogenic 100%
  • Mutation 60%
  • Tyrosine Kinase Inhibitor 39%
  • Endocytosis 23%
  • Gefitinib 22%
  6 Citations (Scopus)

  186 Downloads (Pure)
• 2017

  Aspirin reduces lipopolysaccharide induced pulmonary inflammation in human models of ARDS

  Hamid, U., Krasnodembskaya, A., Fitzgerald, M., Shyamsundar, M., Kissenpfennig, A., Scott, C., Lefrancais, E., Mark R, L., Verghis, R., Scott, J., Simpson, A. J., McNamee, J., McAuley, D. & O'Kane, C. M., 12 Jan 2017, (Early online date) In: Thorax. 72, p. 971-980 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Adult Respiratory Distress Syndrome 100%
  • Aspirin 84%
  • Lipopolysaccharides 78%
  • Pneumonia 73%
  • Bronchoalveolar Lavage 71%
  29 Citations (Scopus)

  741 Downloads (Pure)

• Benzaldehyde Functionalized pH Responsive Block Copolymer Nanoparticles for EGFR Targeted Therapy

  Smyth, P., Gibson, T. J., Scott, C. J. & Themistou, E., Aug 2017.

  Research output: Contribution to conference › Abstract

• Design and validation of selective and potent cathepsin S inhibitors as anti-cancer therapy

  Scott, C., Cogo, F. & Williams, R., 11 Mar 2017, QUB Winter School (Medicine, Dentistry and Biomedical Sciences) Meeting 2017: Proteinases and their Inhibitors.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • 3-Pyridyl Group 100%
  • Molecular Modeling 24%
  • Antigen 22%
  • Amide 19%
  • Molecule 9%

• Forming Next-Generation Antibody-Nanoparticle Conjugates through the Oriented Installation of Non-Engineered Antibody Fragments

  Greene, M. K., Richards, D. A., Nogueira, J. C. F., Campbell, K., Smyth, P., Fernańdez, M., Scott, C. J. & Chudasama, V., 14 Aug 2017, (Early online date) In: Chemical Science. 9, 2018, p. 79-87 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nanoparticle 100%
  • Azide 60%
  • Ligand 58%
  • Antigen 56%
  • Bioactivity 48%
  48 Citations (Scopus)

  343 Downloads (Pure)

• Isolation and Characterisation of a Halotolerant ω-Transaminase from a Triassic Period Salt Mine and Its Application to Biocatalysis

  Kelly, S. A., Megaw, J., Caswell, J., Scott, C. J., Allen, C. C. R., Moody, T. S. & Gilmore, B. F., 25 Oct 2017, In: ChemistrySelect. 2, 30, p. 9783-9791 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Amine 100%
  • Pharmaceutical Industry 81%
  • Environment 66%
  • Application 48%
  • Pyridoxal 45%
  12 Citations (Scopus)

  219 Downloads (Pure)

• Method and Kit for Detection of Bacterial Infection

  Taggart, C., Weldon, S. & Scott, C., 2017, Patent No. 1509564.9, 06 Feb 2015

  Research output: Patent