• Room 03.002 - CCRCB

    United Kingdom

Accepting PhD Students

20002020

Research output per year

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Research Output

2000
2 Citations (Scopus)
2001

Inhibitors of sortase - potential leads for blocking bacterial adhesion

Martin, L., Scott, C., Vandenbroeck, K., McDowell, A., Lynas, J. F. & Walker, B., May 2001, p. 107-107. 1 p.

Research output: Contribution to conferencePaper

PCR-based detection and identification of Burkholderia cepacia complex pathogens in sputum from cystic fibrosis patients.

McDowell, A., Mahenthiralingam, E., Moore, J. E., Dunbar, K. E. A., Webb, A. K., Dodd, M. E., Martin, L., Millar, B. C., Scott, C., Crowe, M. & Elborn, S., Dec 2001, In : Journal of Clinical Microbiology. 39, 12, p. 4247-4255 9 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2005

Antibody conjugates and therapeutic strategies.

McCarron, P., Olwill, S. A., Marouf, W. M., Buick, R. J., Walker, B. & Scott, C., 01 Dec 2005, In : Molecular interventions. 5(6), 6, p. 368-380 13 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

The structural organization of aurein precursor cDNAs from the skin secretion of the Australian green and golden bell frog, Litoria aurea.

Chen, T., Scott, C., Tang, L., Zhou, M. & Shaw, C., 15 May 2005, In : Regulatory Peptides. 128(1), 1, p. 75-83 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2006

Cathepsin S expression: An independent prognostic factor in glioblastoma tumours - A pilot Study

Scott, C., Flannery, T., McQuaid, S., McGoohan, C., McConnell, R. S., McGregor, G., Mirakhur, M., Hamilton, P., Diamond, J., Cran, G., Walker, B., Martin, L., Ellison, D., Patel, C., Nicholson, C., Mendelow, D., McCormick, D. & Johnston, P., 15 Aug 2006, In : International Journal of Cancer. 119, 4, p. 854-860 7 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Characterisation of the functional domains of SEPT9

Scott, C., Mar 2006, p. 7A-7A.

Research output: Contribution to conferencePaper

Dipeptide Proline diphenyl phosphonates are potent, irreversible inhibitors of seprase (FAPalpha)

Gilmore, B., Lynas, J. F., Scott, C., McGoohan, C., Martin, L. & Walker, B., 28 Jul 2006, In : Biochemical and Biophysical Research Communications. 346(2), 2, p. 436-446 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2007

CD33 reponses are blocked by SOCS3 through accelerated proteasomal-mediated turnover

Scott, C., Orr, S. J., Johnston, J., Morgan, N. M., Elliott, J., Burrows, J. & McVickar, D. W., 01 Feb 2007, In : Blood. 109(3), 3, p. 1061-1068 8 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Detection of cathepsin S cysteine protease in human brain tumour microdialysates in vivo.

Flannery, T., McConnell, R. S., McQuaid, S., McGregor, G., Mirakhur, M., Martin, L., Scott, C., Burden, R., Walker, B., McGoohan, C. & Johnston, P., Apr 2007, In : British Journal of Neurosurgery. 21, 2, p. 204-209 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Development and targeting of nanoparticulate systems for site-specific drug delivery

McCarron, P., Scott, C. & Donnelly, R., Feb 2007, Encyclopedia of Nanoscience and Nanotechnology. Nalwa, H. S. (ed.). American Scientific Publishers, p. 1-20 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunocolloidal Targeting of the Endocytotic Siglec-7 Receptor Using Peripheral Attachment of Siglec-7 Antibodies to Poly(Lactide-co-Glycolide) Nanoparticles

McCarron, P., Donnelly, R., Scott, C., Marouf, W. M., Quinn, D., Buick, R. J. & Orr, S. J., Aug 2007

Research output: Non-textual formWeb publication/site

Inhibition of cathepsin L-like proteases by cathepsin V propeptide

Burden, R., Snoddy, P., Jefferies, C. A., Walker, B. & Scott, C., 01 May 2007, In : Biological Chemistry. 388(5), 5, p. 541-545 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2008

Activity-based selection of a proteolytic species using ribosome display.

Quinn, D., Cunningham, S., Walker, B. & Scott, C., 23 May 2008, In : Biochemical and Biophysical Research Communications. 370(1), 1, p. 77-81 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

A novel FK506-like binding protein interacts with the glucocorticoid receptor and regulates steroid receptor signaling.

McKeen, H., McAlpine, K., Valentine, A., Quinn, D., McClelland, K., Byrne, C., O'Rourke, M., Young, S., Scott, C., McCarthy, H., Hirst, D. & Robson, T., Nov 2008, In : Endocrinology. 149(11), 11, p. 5724-5734 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Antibody Targeting of Camptothecin-Loaded PLGA Nanoparticles to Tumor Cells

McCarron, P. A., Marouf, W. M., Quinn, D. J., Fay, F., Burden, R. E., Olwill, S. A. & Scott, C. J., Aug 2008, In : Bioconjugate Chemistry. 19, 8, p. 1561-1569 9 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Cysteine cathepsins in pulmonary diseases

Burden, R. & Scott, C., 2008, Mechanisms of Pulmonary Innate Immunity. Taggart C.C. Greene, C. M. (ed.). Research Signpost, p. 65-95 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Citations (Scopus)

Immunocolloidal targeting of the endocytotic siglec-7 receptor using peripheral attachment of siglec-7 antibodies to poly(lactide-co-glycolide) nanoparticles.

Scott, CJ., Marouf, WM., Quinn, DJ., Buick, RJ., Orr, SJ., Donnelly, RF. & McCarron, PA., Jan 2008, In : Pharmaceutical Research.

Research output: Contribution to journalArticle

Recombinant cathepsin S propeptide attenuates cell invasion by inhibition of cathepsin L-like proteases in tumor microenvironment

Burden, R., Snoddy, P., Buick, R. J., Johnston, J., Walker, B. & Scott, C., Mar 2008, In : Molecular Cancer Therapeutics. 7, 3, p. 538-547 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2009

A novel high throughput technique for identifying monoclonal antibodies capable of death receptor induced apoptosis

Kwok, H. F., Gormley, J. A., Scott, C., Johnston, J. A. & Olwill, S. A., 2009, In : journal of cell death. 2, p. 45-51 7 p.

Research output: Contribution to journalArticle

Antibody-Mediated Inhibition of Cathepsin S Blocks Colorectal Tumor Invasion and Angiogenesis

Burden, R. E., Gormley, J. A., Jaquin, T. J., Small, D., Quinn, D. J., Hegarty, S., Ward, C., Walker, B., Johnston, J. A., Olwill, S. A. & Scott, C. J., 01 Oct 2009, In : Clinical Cancer Research. 15, 19, p. 6042-6051 10 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Expedited Solid-Phase Synthesis of Fluorescently Labeled and Biotinylated Aminoalkane Diphenyl Phosphonate Affinity Probes for Chymotrypsin- and Elastase-Like Serine Proteases

Gilmore, B. F., Quinn, D. J., Duff, T., Cathcart, G. R., Scott, C. J. & Walker, B., 18 Nov 2009, In : Bioconjugate Chemistry. 20, 11, p. 2098-2105 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Multisubstrate adduct inhibitors: Drug design and biological tools

Le Calvez, P. B., Scott, C. & Migaud, M., Dec 2009, In : Journal of Enzyme Inhibition and Medicinal Chemistry . 24, 6, p. 1291-1318 28 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

USP17 Regulates Ras Activation and Cell Proliferation by Blocking RCE1 Activity

Burrows, J. F., Kelvin, A. A., McFarlane, C., Burden, R. E., McGrattan, M. J., De la Vega, M., Govender, U., Quinn, D. J., Dib, K., Gadina, M., Scott, C. J. & Johnston, J. A., 03 Apr 2009, In : Journal of Biological Chemistry. 284, 14, p. 9587-9595 9 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2010

Antibody Targeting of Cathepsin S Inhibits Angiogenesis and Synergistically Enhances Anti-VEGF

Ward, C., Kuehn, D., Burden, R. E., Gormley, J. A., Jaquin, T. J., Gazdoiu, M., Small, D., Bicknell, R., Johnston, J. A., Scott, C. J. & Olwill, S. A., 2010, In : PLoS ONE. 5, 9, 8 p., e12543.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Antibody targeting of polymeric nanoparticles for cancer therapy

Scott, C. & Fay, F., Jun 2010, In : Drug Discovery Today. 15, p. 1087-1087 1 p.

Research output: Contribution to journalArticle

Biologic protease inhibitors as novel therapeutic agents.

Scott, C. & Taggart, C., Nov 2010, In : Biochimie. 92(11), 11, p. 1681-1688 8 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Expression and purification of diagnostically sensitive mycobacterial (Mycobacterium bovis) antigens and profiling of their humoral immune response in a rabbit model.

Kwok, H. F., Scott, C., Snoddy, P., Buick, R. J., Johnston, J. A. & Olwill, S. A., Aug 2010, In : Research in Veterinary Science. 89(1), 1, p. 41-47 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Gene delivery using dimethyldidodecylammonium bromide-coated PLGA nanoparticles

Fay, F., Quinn, D. J., Gilmore, B. F., McCarron, P. A. & Scott, C. J., May 2010, In : Biomaterials. 31, 14, p. 4214-4222 9 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Inhibition of Secretion of Interleukin (IL)-12/IL-23 Family Cytokines by 4-Trifluoromethyl-celecoxib Is Coupled to Degradation via the Endoplasmic Reticulum Stress Protein HERP

McLaughlin, M., Alloza, I., Quoc, H. P., Scott, C., Hirabayashi, Y. & Vandenbroeck, K., 05 Mar 2010, In : Journal of Biological Chemistry. 285, 10, p. 6960-6969 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Microneedle-mediated intradermal nanoparticle delivery: Potential for enhanced local administration of hydrophobic pre-formed photosensitisers.

Donnelly, R., Morrow, D., Francois, F., Scott, C., Sharif, A., Thakur, R. S., Garland, M. J. & Woolfson, D., Dec 2010, In : Photodiagnosis and Photodynamic Therapy. 7(4), 4, p. 222-231 10 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Production of recombinant proteins in Escherichia coli using an N-terminal tag derived from sortase.

Caswell, J., Snoddy, P., McMeel, D., Buick, R. J. & Scott, C., Apr 2010, In : Protein Expression and Purification. 70(2), 2, p. 143-150 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
4 Citations (Scopus)

Synthesis of an analogue of the bisphosphonate drug Ibandronate for targeted drug-delivery therapeutic strategies

Camper, N., Scott, C. & Migaud, M., 2010, In : New journal of chemistry. 34, 5, p. 949-955 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The Deubiquitinating Enzyme USP17 Blocks N-Ras Membrane Trafficking and Activation but Leaves K-Ras Unaffected

de la Vega, M., Burrows, J. F., McFarlane, C., Govender, U., Scott, C. J. & Johnston, J. A., 16 Apr 2010, In : Journal of Biological Chemistry. 285, 16, p. 12028-12036 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

The Deubiquitinating Enzyme USP17 Is Highly Expressed in Tumor Biopsies, Is Cell Cycle Regulated, and Is Required for G1-S Progression

McFarlane, C., Kelvin, A. A., de la Vega, M., Govender, U., Scott, C. J., Burrows, J. F. & Johnston, J. A., 15 Apr 2010, In : Cancer Research. 70, null, p. 3329-3339 11 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
Open Access
File
15 Citations (Scopus)
130 Downloads (Pure)
2011

Antibody-targeted nanoparticles for cancer therapy

Fay, F. & Scott, C., Mar 2011, In : Immunotherapy. 3, 3, p. 381-394 14 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity

Kwok, H. F., Buick, R. J., Kuehn, D., Gormley, J. A., Doherty, D., Jaquin, T. J., McClurg, A., Ward, C., Byrne, T., Jaworski, J., Leung, K. L., Snoddy, P., McAnally, C., Burden, R. E., Gray, B., Lowry, J., Sermadiras, I., Gruszka, N., Courtenay-Luck, N., Kissenpfennig, A. & 3 others, Scott, C. J., Johnston, J. A. & Olwill, S. A., 14 Dec 2011, In : Molecular Cancer. 10, 147.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Comprehensive Inhibitor Profiling Of The Proteus Mirabilis Metalloprotease Virulence Factor Zapa (Mirabilysin)

Carson, L., Cathcart, G., Scott, C., Hollenberg, M. D., Walker, B., Ceri, H. & Gilmore, B., Aug 2011, In : Biochimie. 93, 10, p. 1824-1827 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Conatumumab (AMG 655) coated nanoparticles for targeted pro-apoptotic drug delivery

Fay, F., McLaughlin, K. M., Small, D. M., Fennell, D. A., Johnston, P. G., Longley, D. B. & Scott, C. J., Nov 2011, In : Biomaterials. 32, 33, p. 8645-8653 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Design, optimisation and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique.

Donnelly, R., Majithiya, R., Morrow, D., Garland, M., Thakur, R. S., Woolfson, D., Scott, C., Demir, Y., Gillen, D., Ryan, E. & Migalska, K., 2011, In : Pharmaceutical Research. 28, 1, p. 41-57 17 p.

Research output: Contribution to journalArticle

181 Citations (Scopus)

Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique

Donnelly, R. F., Majithiya, R., Singh, T. R. R., Morrow, D. I. J., Garland, M. J., Demir, Y. K., Migalska, K., Ryan, E., Gillen, D., Scott, C. J. & Woolfson, A. D., 2011, In : Pharmaceutical Research. 28, 1, p. 41-57 17 p.

Research output: Contribution to journalArticle

181 Citations (Scopus)

Direct transcutaneous targeting of antigen to the specific skin dendritic cell subsets induces antigen specific CD4+and CD8+T cell responses

Zaric, M., Fay, F., Garland, M. J., Poux, C., Lyubomska, O., Scott, C., Donnelly, R. & Kissenpfennig, A., Dec 2011, p. 131-131. 1 p.

Research output: Contribution to conferenceAbstract

The Deubiquitinating Enzyme USP17 is Essential for GTPase Subcellular localization and Cell Motility

de la Vega, M., Kelvin, A. A., Dunican, D. J., McFarlane, C., Burrows, J. F., Jaworski, J., Stevenson, N. J., Dib, K., Rappoport, J. Z., Scott, C. J., Long, A. & Johnston, J. A., Mar 2011, In : Nature Communications. 2, 1, 259.

Research output: Contribution to journalArticle

36 Citations (Scopus)
20 Citations (Scopus)
2012
Open Access
File
84 Citations (Scopus)
355 Downloads (Pure)

Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas.

Burden, R. E., Gormley, J. A., Kuehn, D., Ward, C., Kwok, H. F., Gazdoiu, M., McClurg, A., Jaquin, T. J., Johnston, J. A., Scott, C. J. & Olwill, S. A., Feb 2012, In : Biochimie. 94, 2, p. 487-493 7 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Recent advances in the application of antibodies as therapeutics.

Burden, R. E., Caswell, J., Fay, F. & Scott, C. J., Jan 2012, In : FUTURE MEDICINAL CHEMISTRY. 4, 1, p. 73-86 14 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)